Download Dr. Ramsdell`s CV - University of South Carolina School of Medicine

ANN FRANCES RAMSDELL
CURRICULUM VITAE
OFFICE ADDRESS:
Medical University of South Carolina
Department of Regenerative Medicine and Cell Biology
173 Ashley Ave Suite 601
Charleston, SC 29425
PHONE: (843) 792-1620 FAX: (843) 792-0664
EMAIL: [email protected]
University of South Carolina School of Medicine
Department of Cell Biology and Anatomy
6439 Garners Ferry Road
Bldg 1, B-22
Columbia, SC 29208
PHONE: (803) 216-3892 FAX: (803) 216-3846
EMAIL: [email protected]
EDUCATION:
1988-1991
1991-1996
B.S. (Biology)
Ph.D. (Cell Biology)
(mentor: Dr. Roger
Markwald)
College of Charleston
Charleston, SC 29424
Medical University of South
Carolina
POSTDOCTORAL TRAINING:
1997
Post-doctoral Fellow
Harvard Medical School/MA
(mentor: Dr. Mark Fishman) General Hospital
1997-2000
Post-doctoral Fellow
University of Utah Huntsman
(mentor: Dr. Joe Yost)
Cancer Institute
FACULTY APPOINTMENTS:
1997
Research Associate
Medical University of South Carolina
Dept. of Cell Biology and Anatomy
2000-2006
Assistant Professor
University of South Carolina
School of Medicine
Dept. of Cell Biology and Anatomy
and joint appointment with
College of Arts and Sciences
Program in Women’s and Gender Studies
2002-2007
Assistant Professor (dual appointment with USC)
Medical University of South Carolina
Dept. of Cell Biology and Anatomy
2006-present
2008-present
Associate Professor (with tenure)
University of South Carolina
School of Medicine
Dept. of Cell Biology and Anatomy
and joint appointment with
College of Arts and Sciences
Program in Women’s and Gender Studies
Associate Professor (dual appointment with USC)
Medical University of South Carolina
Dept. of Regenerative Medicine and Cell Biology
EXTRAMURAL GRANTS:
ACTIVE:
2011-2013
National Institutes of Health NICHD R21 ($275,000/2 yr direct)
(NCE through 3/31/13)
PD/PI: Ramsdell (3.6 calendar months)
“Mammary Gland Laterality in Normal and Neoplastic Development”
PAST EXTRAMURAL FUNDING:
2000-2002
National American Heart Association Scientist Development Grant
($65,000 yr/direct)
PI: Ramsdell (3 calendar months)
“Cellular and Molecular Mechanisms of Cardiac Left-Right
Development”
2004-2007
National Science Foundation MCB-0421929 ($16,945/yr direct)
PI: Darden (subcontract to Ramsdell, 1 calendar month)
“Salamander Blue Cone/Green Rod Visual Pigment Gene
Characterization”
2002-2006
National Institutes of Health R01 HL73270 ($200,000/yr direct)
PI: Ramsdell (5.4 calendar months)
“Left-Right Axis Determination and Cardiac Development”
2005-2008
National Institutes of Health R01 HL73190 ($225,000/yr direct)
PI: Eisenberg (Co-investigator, Ramsdell 1 calendar month)
“Non-Canonical WNT Signal Transduction and Cardiogenesis”
2007-2012
National Institutes of Health HLBI K02 86737 ($75,000/yr direct)
PI: Ramsdell (1.2 calendar months)
“Development of Xenopus as a Model of Human Congenital Heart
Disease”
INTRAMURAL GRANTS:
ACTIVE:
2013-2014
USC School of Medicine Research and Development Funds ($15,000/1 yr
direct)
PI: Ramsdell (1.8 calendar months)
“Laterality of Mammary Stem Cells and Microenvironment During
Development and Neoplasia”
PAST INTRAMURAL FUNDING:
2001-2002 USC Research and Productive Scholarship Award
PI: Ramsdell
“Identification of a Type I Activin-Like Kinase Receptor that Is Required
for Cardiac Left-Right Development”
2003-2004 Medical University of South Carolina University Research Council Grant
($20,549 direct)
PI: Ramsdell (1.8 calendar months)
“Endoderm: A Molecular Regulator of Vertebrate Left-Right Asymmetry”
2008-2009
MUSC University Research Council Grant
($40,000 direct)
PI: Ramsdell (2.4 calendar months)
“Request for Interim Funding for NIH R01 HL-073270 Left-Right Axis
Determination and Cardiac Development”
AWARDS:
1990
1991
1995
1997
1998
1998-2000
2004
2006
2006
2006
Medical University of South Carolina Student Research Day,
1st place undergraduate platform
Medical University of South Carolina Student Research Day,
1st place graduate platform
American Association of Anatomists Jan Langman Award,
1st place national graduate platform
American Association of Anatomists Outstanding
Dissertation Award Honorable Mention
NIH Individual National Research Service Award (declined
because of move to Univ. UT)
American Heart Association Western States Fellowship
USC Women’s and Gender Studies Faculty Award for
Teaching Excellence
American Association of Anatomists Young Faculty Travel
Award
USC School of Medicine Research Advancement Award
MUSC Health Science Foundation Developing Scholar
Award
COMMITTEE MEMBERSHIP:
University
2013201220122012
2005-2012
USC WGST Awards Committee
USC WGST Personnel Committee
USC SOM Grade Change Committee
USC SOM Women in Science and Medicine Committee
Medical University of SC Women Scholars Initiative Steering
Committee
2005-2010
2002
2001-2007
2001
2001
2000-2006
2000-2002
2000-2002
Medical University of SC Women Scholars Initiative Mentoring
sub-committee (co-chair)
USC Women’s Studies Conference Planning Committee
USC Women’s Studies Graduate Committee
USC LCME Basic Science Internal Review Committee
USC Biomedical Sciences Graduate Admission Committee
Committee on Women, USC School of Medicine (Chair 20012002)
USC Cell Biology & Anatomy Seminar Committee
USC Cell Biology & Anatomy Faculty Search Committee
Hollings Cancer Center Service Activities
MUSC “Changing What’s Possible” video interview, March 2010
MUSC “Changing What’s Possible” television commercial, April 2010
Presentation at the Hollings Cancer Center Monthly Staff Meeting, January 2011
Presentation at the Hollings Cancer Center Advisory Board, March 2011
Opening Remarks at the Hollings Cancer Center Clinical Trials Awareness Campaign
Appreciation Lunch, March 2011
Presentation at the Hollings Cancer Center Citizen’s Advisory Council, April 2011
Hollings Cancer Center video interview, April 2011
MUSC “The Catalyst” print interview on clinical trials, April 2011
Hollings Cancer Center team member, May 2011 Dragon Boat
Presentation at the Hollings Cancer Center Citizen’s Advisory Council New Member
Orientation, August 2011
WTMA 1250 AM “The Morning Buzz” radio interview with Richard Todd (Hollings
Cancer Center signature fundraising event, Gourmet and Grapes), October 2011
WCBD News 2 television interview with Carolyn Murray, October 2011
Hollings Cancer Center representative at the Brighton’s “Power of Pink” event, October
20, 2001, Charleston, SC
Presentation at The Point Is” (a local fundraising group), November 2011, Johns Island,
SC
Hollings Cancer Center promotional photo shoot, Waterfront Park, September 14, 2012,
Charleston, SC
Speaker, “Pink Partini”, Tanger Outlet fundraiser for breast cancer research, September
27, 2012, North Charleston, SC
Opening remarks, Susan G. Komen Lowcountry Race for the Cure Survivor Ceremony,
October 2012, Daniel Island, SC
Interviewee, Charelston Regional Business Journal “Clinical Trials”, September 2013
TEACHING:
Undergraduate Education:
2000-
Women’s Health (USC WGST 113), primary teaching assignment (35
contact hours/ fall or spring semester)
2002
Fundamentals of Scientific Inquiry (USC SCHC 285A), lecturer
Graduate Studies Education:
2001-2002 Integrated Biomedical Systems (USC SOM BMSC 705), lecturer
(4 contact hours/spring semester)
2002-2005 Developmental Biology (MUSC MCBP 762), lecturer
(4 contact hours/fall semester; course is offered in alternate years)
2004-2006 Research in Cardiovascular Disease (USC SCCC 302D), lecturer
(1 contact hour/fall semester)
2004-2007 Graduate Cell Biology (USC BMSC 702), lecturer
primary teaching assignment (5 contact hours/spring semester)
2000-2002 Special Topics in Embryology (USC ANAT 715), primary teaching
and 2004assignment (12 contact hours/ fall or spring semester)
2007
2014Cardiovascular Development (USC SOM BMSC 730), lecturer (2 contact
hours)
TRAINEES AND STUDENTS:
2013Huda Atiya, USC SOM Biomedical Sciences doctoral student
2011Jacqulyne Robichaux, MUSC MCBP doctoral student
2003-2004 Yumei Chen, Ph.D., postdoctoral fellow
2000-2003 Lisha Whitaker, masters student, USC Biomedical Sciences Program
First Place winner of the 2002 USC School of Medicine Newton
Graduate Student Research Symposium
Graduated 12/2002 and enrolled in Univ. of GA Veterinary School
2001-2003 Ekaterina Mironova, doctoral student, USC Biomedical Sciences
Program
Second Place winner of the 2002 Medical University of SC Student
Research Day graduate platform session
(student remained at USC with a new mentor after my lab relocated)
2001-2003 Chris Wells, undergraduate, USC Biology/Pre-med major
2001-2003 Laura Edwards, undergraduate, USC Women’s Studies/Pre-Med Programs
Recipient of the 2002 USC Arney Robinson Childs Award for
undergraduate research. Graduated 2003 and enrolled at Northeastern
University School of Law
Summer Research Students
2003 Sidney Wong, Charleston Academic Magnet High School Senior Thesis
2004 Edreca Thompson, MUSC Summer Undergraduate Research Program
2004 Octavius Coleman, MUSC Summer Health Professionals Program
2005 John Johnson, MUSC Summer Undergraduate Research Program
2006 Ashley Procopio Allen, MUSC Summer Health Professionals Program
2007 Natalie Holder, MUSC Summer Undergraduate Research Program
2008 Megan Lee, MUSC Summer Health Professionals Program
2008 David Bowen, MUSC Summer Health Professionals Program
PRESENTATIONS:
Submitted:
1992
Platform session, 74th Annual Endocrine Society Meeting, San Antonio, TX
“Activation of a TGF-a positive feedback loop results in growth inhibition of
GH4 cells”
1996 Seminar, Department of Cell Biology and Anatomy, Medical University of South
Carolina, Charleston, SC
“Homogenetic induction of endocardial cushion tissue in the embryonic chick
heart”
1996
Platform session, Weinstein Cardiovascular Development Conference,
Philadelphia, PA
“Induction of endocardial cushion tissue is a progressive homogenetic event”
1998 Platform session, Weinstein Cardiovascular Development Conference, Nashville,
TN
“TGF-related signaling in left lateral vegetal cells initiates the vertebrate leftright axis”
2000 Platform session, 2000 Keystone Symposium on Molecular Biology of the
Cardiovascular System, Salt Lake City, UT
“Cardiac looping and the left-right axis: antagonism of left-side Vg1 activity
by a right-side BMP/ALK2 pathway”
2001 Platform session, Minisymposium on Induction of Heart Development, 2001
Experimental Biology, Orlando, FL
“Identification of novel genes and multiple signaling pathways that regulate
cardiac left-right development”
2002
Platform session, Minisymposium on TGF in Heart and Vascular
Development, 2002 Experimental Biology, New Orleans, LA
“The activin-like kinase receptor-4 modulates left-right axis determination in
Xenopus”
2006
Platform session, Minisymposium on Growth and Development, Experimental
Biology, San Francisco, CA
“Left-right lineage analysis in the embryonic Xenopus heart reveals a novel
framework linking congenital cardiac defects and laterality disease”
Invited:
1996
Invited short talk, Heart Development Spring Symposium, Medical College of
Georgia “Homogenetic induction of endocardial cushion tissue”
1999 Invited seminar, University of South Carolina School of Medicine, Columbia, SC
“Identification of multiple genes and signaling pathways in cardiac left-right
development”
2001
Invited talk, Cardiovascular Developmental Biology Center Annual Spring
Symposium, Medical University of South Carolina, Charleston, SC
“Multiple pathways in cardiac left-right development”
2001 Invited seminar, Columbia College, Columbia, SC
“How the body tells left from right”
2001 Invited seminar, South Carolina Cancer Center, University of South Carolina,
Columbia, SC
“Mechanisms of generating cardiac left-right asymmetry”
2001
2005
2006
2008
2008
2012
Invited seminar, University of North Carolina at Charlotte, Charlotte, NC
“Mechanisms underlying the generation of cardiac left-right asymmetry”
Invited talk, Cardiovascular Developmental Biology Center Spring Symposium,
Medical University of South Carolina, Charleston, SC
“Left-right axis determination and cardiac development in Xenopus”
Invited talk, Southeastern American Association for Laboratory Animal
Science, Charleston, SC. “Xenopus husbandry and care”
Invited talk, Cardiovascular Developmental Biology Center Spring Symposium,
Medical University of South Carolina, Charleston, SC
“Left-right axis determination and cardiac development”
Invited seminar, University of Kansas Medical Center School of Medicine,
Department of Anatomy and Cell Biology, Kansas City, MO
“The TGF paradox: Arbiter of cardiac left-right asymmetry and symmetry in
vertebrate development”
Invited symposium speaker, Gordon Research Conference on Mammary Gland
Biology, Barga (Lucca), Italy
“The laterality of breast cancer: Has embryonic patterning left one side more
susceptible to disease?”
EXTRAMURAL PROFESSIONAL ACTIVITIES
2002-present, Ad hoc reviewer for The Anatomical Record
2004-present, Ad hoc reviewer for Developmental Dynamics
2005-present, Ad hoc reviewer for Developmental Biology
2006-present, Ad hoc reviewer for Development
2008
Ad hoc reviewer for Science
2002-2003
2000-2003
2004
2005
2006
2006
2011-present
PUBLICATIONS:
Peer-reviewed journal articles
Reviewer, American Association of Anatomists
Outreach
Grant Proposals (Chair 2003)
American Association of Anatomists, National
Advisory Board of Young Anatomists
American Association of Anatomists Society Officer
and Board Nominations Committee
National American Heart Association Basic Cell and
Molecular Biology 2 study section
American Association of Anatomists Membership
Committee
Organizer and Chair, American Association of
Anatomists Growth and Development Minisymposium,
2006 Experimental Biology meeting
Reviewer, ZRG1F05 NIH study section
Fuseler J.W., Robichaux J.P., Atiyah H.I., and Ramsdell A.F. (2014) Morphometric and
fractal dimension analysis identifies early neoplastic changes in mammary epithelium
of MMTV-cNeu mice. Anticancer Research in press.
Veltmaat J.M., Ramsdell A.F., Sterneck E. (2013) Positional variations in mammary
gland development and breast cancer. Journal of Mammary Gland Biology and
Neoplasia 18:179-88
Martin L.K., Bratoeva M., Bernanke J.M., Redmond M.C., Ramsdell A.F., Eisenberg
C.A., and Eisenberg L.M. (2012). Inhibition of heart formation by lithium is an
indirect result of the disruption of tissue organization within the embryo. Development,
Growth and Differentiation 54:153-66.
Martin L.K., Mezentseva N.V., Bratoeva M., Ramsdell A.F., Eisenberg, C.A., and
Eisenberg L.M. (2011) Canonical WNT signaling enhances stem cell expression in the
developing heart without a corresponding inhibition of cardiogenic differentiation.
Stem Cells and Development 20:1973-83.
Ramsdell A. F., Bernanke, J. M., and Trusk, T. C. (2006) Left-right lineage analysis of
the embryonic Xenopus heart reveals a novel framework linking congenital cardiac
defects and laterality disease. Development 133:1399-1410.
Ramsdell, A.F., Bernanke, J.M., Johnson, J., and Trusk, T.C. (2005) Left-right lineage
analysis of AV cushion tissue in normal and laterality defective Xenopus hearts. The
Anatomical Record 287:1176-1182.
Ramsdell, A.F. (2005). Left-right asymmetry and congenital cardiac defects: getting to
the heart of the matter in vertebrate left-right axis determination. Developmental
Biology 288:1-20.
Tiedeken J., Ramsdell J.S., and Ramsdell, A.F. (2005) Developmental toxicity of
domoic acid in zebrafish (Danio rerio). Neurotoxicology and Teratology 27:711-717.
8. Chen, Y., Whitaker, L. L., and Ramsdell, A. F. (2005) Developmental analysis of
activin-like kinase-4 (ALK4) expression in Xenopus laevis. Developmental Dynamics
232:393-398.
Chen, Y., Mironova, E., Whitaker, L. L., Edwards, L., Yost, H. J., and Ramsdell, A. F.
(2004) ALK4 functions as a receptor for multiple TGF-related ligands to regulate to
left-right axis determination and mesoderm induction in Xenopus. Developmental
Biology 268:280-294.
Ramsdell, A.F. and Yost, H.J. (1999) Cardiac looping and the vertebrate left-right axis:
antagonism of left-sided Vg1 activity by a right-sided ALK2-dependent BMP pathway.
Development 126: 5195-5205.
Ramsdell, A.F. and Yost, H.J. (1998) Molecular mechanisms of vertebrate left-right
development. Trends in Genetics 14:459-465.
Ramsdell, A.F., Moreno-Rodriguez, R.A., Wienecke, M.M., Sugi, Y., Turner, D.K.,
Mjaatvedt, C.H. and Markwald, R.R. (1998) Identification of an autocrine signaling
pathway that amplifies induction of endocardial cushion tissue in the avian heart. Acta
Anatomica 162:1-15.
Ramsdell, A.F. and Markwald, R.R. (1997) Induction of endocardial cushion tissue in
the avian heart is regulated, in part, by TGF3-mediated autocrine signaling.
Developmental Biology 188: 64-74.
Book Chapters
1. Ramsdell, A.F. and Yost, H.J. (2001) Cardiac looping and the left-right axis:
integrating morphological, molecular, and genetic analyses of vertebrate left-right
asymmetry. In: Formation of the Heart and Its Regulation, (Tomanek, R. J. and
Runyan, R. B., eds.) New York, NY: Springer-Verlag pp. 45-73.
2. Mjaatvedt, C.H., Yamamura, H., Wessels, A., Ramsdell, A., Turner, D. and
Markwald, R.R. (1998) Mechanisms of segmentation, septation, and remodeling of the
tubular heart: endocardial cushion fate and cardiac looping. In: Heart Development
(Harvey, R. and Rosenthal, N., eds.) San Diego, CA: Adademic Press pp. 159-177.
3. Ramsdell, A.F., Krug, E.L. and Markwald, R.R. (1997) Regulation of valvuloseptal
morphogenesis. In: Microscopy of Reproduction and Development: A Dynamic
Approach, Volume I (Pietro M. Motta, ed.) Rome, Italy: Universita di Roma, pp. 307317.
Book reviews and newsletter articles (not peer-reviewed)
1. Ramsdell, A.F. (2004) A laboratory guide to the mammalian embryo. The Quarterly
Review of Biology 79:426.
2. Ramsdell, A.F. (2001) High Marks for Undergraduate Mentoring in Biomedical
Research. In: American Association of Anatomists Quarterly Newsletter, Vol. 10, p. 3435.
3. Ramsdell, A.F. (2000) Women In Anatomy: The Challenges Continue. In: American
Association of Anatomists Quarterly Newsletter, Vol. 9, p. 16-17.