Download Mitoxantrone

Drug – Mitoxantrone
Office for Human Research Studies
DANA-FARBER / HARVARD CANCER CENTER
Mitoxantrone
FDA Approved
Risks Associated with Mitoxantrone
Frequent (Between a 10-50% chance that this will happen)
 Condition in which the number of white blood cells circulating in the blood is
abnormally low. This increases the risk of infection, which may be serious or life
threatening.
 Low number of red blood cells that can causes tiredness and shortness of
breath. May require a blood transfusion.
 Low number of platelets, which may cause bleeding and bruising. Bleeding may
be serious or life threatening and may required a blood transfusion.
 Hairloss
 Skin irritation, rash
 Diarrhea, which is frequent, loose watery stools, which can cause dehydration
and may require hospitalization and treatment with intravenous fluids. Severe
and prolonged diarrhea can be life-threatening.
 Headache
 Feeling sick to the stomach, vomiting
 Sores in the mouth and esophagus, which may be painful and cause difficulty
swallowing.
 Pain
Occasional (Between a 1-10% chance that this will happen).
 The heart is not able to pump blood properly, which can cause weakness and
tiredness, fluid retention, and fluid build-up in the lungs, which can cause
shortness of breath.
 A reaction at the site where an injection (shot) was given, which may cause some
redness and swelling
 Abnormally high levels of enzymes produced by the liver meaning that your liver
is not functioning properly and can cause fatigue, and jaundice (yellowing of the
skin and eyes). Although this is usually mild and reversible, this can be serious or
life threatening.
 Changes in color and thickness, darkening of the nail bed, thickening, shedding
CF Builder Generated Version: 05.27.2016
DFCI IRB Approved Version: 05.20.2016
Drug – Mitoxantrone
Rare (Less than a 1% chance that this will happen)
 Irregular menstrual periods
 A second cancer related to the treatment of your first cancer. This usually occurs
years after treatment for the first cancer.
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