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Publications by Brown, Matthew A.
Schachna, L and Brown, MA (2006) Australian data do not support current Pharmaceutical
Benefits Scheme criteria for use of tumour necrosis factor-alpha inhibitors in ankylosing
spondylitis. Internal Medicine Journal, 36 11: 755-756. doi:10.1111/j.1445-5994.2006.01185.x
Hsieh, H. J., Palmer, C. G. S., Harney, S., Newton, J. L., Wordsworth, P., Brown, M. A. and
Sinsheimer, J. S. (2006) The v-MFG test: Investigating maternal, offspring and maternal-fetal
genetic incompatibility effects on disease and viability. Genetic Epidemiology, 30 4: 333-347.
doi:10.1002/gepi.20148
Chou, C. T., Timms, A. E., Wei, J. C. C., Tsai, W. C., Wordsworth, B. P. and Brown, M. A.
(2006) Replication of association of IL1 gene complex members with ankylosing spondylitis in
Taiwanese Chinese. Annals of The Rheumatic Diseases, 65 8: 1106-1109.
doi:10.1136/ard.2005.046847
Brown, M. A. (2006) Non-major-histocompatibility-complex genetics of ankylosing spondylitis.
Best Practice and Research: Clinical Rheumatology, 20 3: 611-621.
doi:10.1016/j.berh.2006.03.005
Bruges-Armas, Jacome, Couto, Ana Rita, Timms, Andrew, Santos, Margarida R., Bettencourt,
Bruno Filipe, Peixoto, Maria Jose, Colquhoun, Katherine, McNally, Eugene G., Carneiro, Victor,
Herrero-Beaumont, Gabriel and Brown, Matthew A. (2006) Ectopic calcification in the Azores Clinical and radiological manifestations of Diffuse Idiopathic Skeletal Hypertosis and
Chondrocalcinosis families. Arthritis and Rheumatism, 54 4: 1340-1349. doi:10.1002/art.21727
Harrison, P., Pointon, J., Farrar, C., Brown, M. A. and Wordsworth, B. P. (2006) Effects of
PTPN22 C1858T polymorphism on susceptibility and clinical characteristics of British
Caucasian rheumatoid arthritis patients. Rheumatology, 45 8: 1009-1011.
doi:10.1093/rheumatology/kei250
Harney, S. M. J., Timperley, J., Daly, C., Harin, A., James, T., Brown, M. A., Banning, A. P.,
Fox, K., Donnelly, S. and Wordsworth, B. P. (2006) Brain natriuretic peptide is a potentially
useful screening tool for the detection of cardiovascular disease in patients with rheumatoid
arthritis. Annals of the Rheumatic Diseases, 65 1: 136-136. doi:10.1136/ard.2005.040634
Pointon, J., Jaakkola, E., Beynon, O., Harvey, D., Laiho, K., Kauppi, M., Kaarela, K.,
Tuomilehto, J., Wordsworth, B. P. and Brown, M. A. (2006). CD14 variants in Finnish families
with ankylosing spondylitis. In: G. Pasero, P. E. Phillips and V. Pipitone et al., Proceeding of the
Fifth International Congress on Spondyloarthropathies. Fifth International Congress on
Spondyloarthropathies, Gent, Belgium, (476-476). October 12-14, 2006.
Sims, A., Timms, A. E., Pointon, J., Chou, C. T., Gladman, D. D., Inman, R., Maksymowych,
W., Rahman, P., Reveille, J. D., Wordsworth, B. P., Xu, H., Gergely, P. and Brown, M. A.
(2006). IL-1 gene family members are associated with ankylosing spondylitis in both Caucasian
and Asian populations: a meta-analysis. In: G. Pasero, P. E. Phillips and V. Pipitone et al.,
Clinical and Experimental Rheumatology. Fifith International Congress on
Spondyloarthropathies, Gent, Belgium, (463-463). October 12-14, 2006.
Sims, A., Pointon, J., Timms, A. E., Bradbury, L. A., Wordsworth, B. P. and Brown, M. A.
(2006). Mapping of the IL-1 gene cluster in susceptibility to ankylosing spondylitis. In: G.
Pasero, P. E. Phillips and V. Pipitone et al., Clinical and Experimental Rheumatology. Fifth
International Congress on Spondyloarthropathies, Gent, Belgium, (477-477). October 12-14,
2006.
Brown, M. A. (2006). Progress in mapping genes involved in ankylosing spondylitis. In: G.
Pasero, P. E. Phillips and V. Pipitone et al., Clinical and Experimental Rheumatology. Fifth
International Congress on Spondyloarthropathies, Gent, Belgium, (460-460). October 12-14,
2006.
Timms, AE, Zhang, Y, Russell, RGG and Brown, MA (2002) Genetic studies of disorders of
calcium crystal deposition. Rheumatology, 41 7: 725-729. doi:10.1093/rheumatology/41.7.725
Milicic, A, Lee, D, Brown, MA, Darke, C and Wordsworth, BP (2002) HLA-DR/DQ haplotype
in rheumatoid arthritis: Novel allelic associations in UK Caucasians. Journal of Rheumatology,
29 9: 1821-1826.
Miles, LJ, Duncan, EL, Crane, AM, Wass, JAH and Brown, MA (2002) Linkage studies of
RANK, RANKL and OPG in the control of bone mineral density.. Journal of Bone And Mineral
Research, 17 S322-S322.
Williams, C. J., Zhang, Y., Timms, A., Bonavita, G., Caeiro, F., Broxholme, J., Marchegiani, R.,
Reginato, A., Russell, R. G. G., Wordsworth, B. P., Carr, A . J. and Brown, M. A. (2002)
Autosomal dominant familial calcium pyrophosphate dihydrate deposition disease (CPPDD) is
caused by mutation in the transmembrane protein ANKH.. American Journal of Human
Genetics, 71 4: 432-432.
Williams, CJ, Zhan, Y, Timms, A, Bonavita, G, Caeiro, F, Broxholme, J, Cuthbertson, J, Jones,
Y, Marchegiani, R, Reginato, A, Russell, GR, Wordsworth, P, Carr, AJ and Brown, MA (2002)
Autosomal dominant familial calcium pyrophosphate dihydrate deposition disease (CPPDD) is
caused by mutation in the transmembrane protein ank.. Arthritis And Rheumatism, 46 9: S591S591.
Williams, CJ, Zhang, Y, Timms, A, Bonavita, G, Caeiro, F, Broxholme, J, Cuthbertson, J, Jones,
Y, Marchegiani, R, Reginato, A, Russell, RGG, Wordsworth, BP, Carr, AJ and Brown, MA
(2002) Autosomal dominant familial calcium pyrophosphate dihydrate deposition disease is
caused by mutation in the transmembrane protein ANKH. American Journal of Human Genetics,
71 4: 985-991. doi:10.1086/343053
Harney, S, Newton, J, Milicic, A, Brown, MA and Wordsworth, BP (2003) Non-inherited
maternal HLA alleles are associated with rheumatoid arthritis. Rheumatology, 42 1: 171-174.
doi:10.1093/rheumatology/keg059
Jevon, M, Hirayama, T, Brown, MA, Wass, JAH, Sabokbar, A, Ostelere, S and Athanasou, NA
(2003) Osteoclast formation from circulating precursors in osteoporosis. Scandinavian Journal of
Rheumatology, 32 2: 95-100. doi:10.1080/03009740310000102
Duncan, Emma L., Cardon, Lon R., Sinsheimer, Janet S., Wass, John Ah and Brown, Matthew
A. (2003) Site and gender specificity of inheritance of bone mineral density. Journal of Bone
And Mineral Research, 18 8: 1531-1538. doi:10.1359/jbmr.2003.18.8.1531
Timms, AE, Zhang, Y, Bradbury, L and Brown, MA (2003) Investigation of the role of ANKH
in ankylosing spondylitis. Arthritis And Rheumatism, 48 10: 2898-2902. doi:10.1002/art.11258
Miles, LJ, Blumsohn, A, Eastell, R, Duncan, EL, Wass, JAH and Brown, MA (2003) Heritability
and familial correlations of the bone synthesis marker, serum N-terminal COL1A1, propeptide
(P1NP).. Journal of Bone And Mineral Research, 18 S124-S124.
Miles, LJ, Colley, J, Blumsohn, A, Eastell, R, Duncan, EL, Olavesen, M, Wass, JAH and Brown,
MA (2003) COL1A1 sp1 promoter polymorphism influences serum n-terminal COL1A1
propeptide (P1NP) levels.. Journal of Bone And Mineral Research, 18 S211-S211.
Ebeling, PR, Smith, R and Brown, MA (2003) Fibrogenesis imperfecta ossium - Symptomatic
and histologic improvement with melphalan therapy.. Journal of Bone And Mineral Research, 18
S415-S415.
Sims, AM, Wordsworth, BP and Brown, MA (2004) Genetic susceptibility to ankylosing
spondylitis. Current Molecular Medicine, 4 1: 13-20. doi:10.2174/1566524043479284
Newton, J. L., Harney, S. M. J., Wordsworth, B. P. and Brown, M. A. (2004) A review of the
MHC genetics of rheumatoid arthritis. Genes and Immunity, 5 3: 151-157.
doi:10.1038/sj.gene.6364045
Koay, MA, Duncan, EL, Ralston, SH, Compston, JE, Cooper, C, Keen, R, Langdahl, BL,
MacLelland, A, O'Riordan, J, Pols, HA, Reid, DM, Uitterlinden, AG, Wass, AH and Brown, MA
(2004) Influence of LRP5 gene polymorphisms on the normal variation of bone mineral density.
Journal of Bone And Mineral Research, 19 10: 1619-1627. doi:10.1359/JBMR.040704
Newton, J, Kwiatkowski, D, Wordsworth, P and Brown, MA (2004) Distribution of TNFA
haplotypes in healthy Caucasians: comment on the articles by Newton et al and Zeggini et al Reply. Arthritis And Rheumatism, 50 6: 2035-2036. doi:10.1002/art.20455
Jaakkola, E, Herzberg, I, Crane, AM, Pointon, JJ, Laiho, K, Kauppi, M, Kaarela, K,
Wordsworth, BP, Tuomilehto, J and Brown, MA (2004) A novel human leucocyte antigenDRB1 genotyping method based on multiplex primer extension reactions. Tissue Antigens, 64 1:
88-95. doi:10.1111/j.1399-0039.2004.00241.x
Newton, JL, Harney, SMJ, Timms, AE, Sims, AM, Rockett, K, Darke, C, Wordsworth, BP,
Kwiatkowski, D and Brown, MA (2004) Dissection of class III major histocompatibility
complex haplotypes associated with rheumatoid arthritis. Arthritis And Rheumatism, 50 7: 21222129. doi:10.1002/art.20358
Timms, AE, Crane, AM, Sims, AM, Cordell, HJ, Bradbury, LA, Abbott, A, Coyne, MRE,
Beynon, O, Herzberg, I, Duff, GW, Calin, A, Cardon, LR, Wordsworth, BP and Brown, MA
(2004) The interleukin 1 gene cluster contains a major susceptibility locus for ankylosing
spondylitis. American Journal of Human Genetics, 75 4: 587-595. doi:10.1086/424695
Meisel, C, Newton, JL, Harney, SM, Wordsworth, BP and Brown, MA (2004) Gene expression
profiling of treatment response to anti-TNF-alpha therapy in rheumatoid arthritis. Arthritis And
Rheumatism, 50 9: S120-S120.
Zhang, Y, Johnson, K, Wordsworth, P, Russell, G, Carr, A, Terkeltaub, RA and Brown, MA
(2004) ANKH mutations cause both familial and sporadic calcium pyrophosphate dihydrate
chondrocalcinosis and increase ANKH transcription/2 translation.. Arthritis And Rheumatism,
50 9: S240-S240.
Sims, AM, Cordell, HJ, Barnardo, M, Herzberg, I, Bradbury, L, Calin, A, Wordsworth, BP,
Darke, C and Brown, MA (2004) MHC class II and III genes are associated with ankylosing
spondylitis independent of HLA-B27.. Arthritis And Rheumatism, 50 9: S259-S259.
Koay, M. Audrey, Woon, Peng Y., Zhang, Yun, Miles, Lisa J., Duncan, Emma L., Ralston,
Stuart H., Compston, Juliet E., Cooper, Cyrus, Keen, Richard, Langdahl, Bente L., MacLelland,
Alasdair, O'Riordan, Jeffrey, Pols, Huibert A., Reid, David M., Uitterlinden, Andre G., Wass,
John A.H. and Brown, Matthew A. (2004) Influence of LRP5 polymorphisms on normal
variation in BMD. Journal of Bone And Mineral Research, 19 10: 1619-1627.
doi:10.1359/JBMR.040704
Steer, S, Miles, LJ, Lad, B, Grumley, J and Brown, MA (2004) Osteoprotegerin genetic variants
are associated with both susceptibility to rheumatoid arthritis and rate of joint erosion. Journal of
Bone And Mineral Research, 19 S69-S69.
Miles, LJ, Beynon, O, Woon, PY, Blumsohn, A, Duncan, EL and Brown, MA (2004)
Polymorphisms within the osteoprotegerin (OPG) gene are associated with both serum OPG
levels and bone mineral density.. Journal of Bone And Mineral Research, 19 S129-S129.
Brown, MA (2004) Mutation of perinatal myosin heavy chain. New England Journal of
Medicine, 351 24: 2556-2556.
Koay, MA and Brown, MA (2005) Genetic disorders of the LRP5-Wnt signalling pathway
affecting the skeleton. Trends In Molecular Medicine, 11 3: 129-137.
doi:10.1016/j.molmed.2005.01.004
Harney, S., Wordsworth, B. P. and Brown, M. A. (2005) HLA-DR-DQ haplotypes and
genotypes in Finnish patients with rheumatoid arthritis. Annals of the Rheumatic Diseases, 64 4:
655-655.
Zhang, Y and Brown, MA (2005) Genetic studies of chondrocalcinosis. Current Opinion In
Rheumatology, 17 3: 330-335. doi:10.1097/01.bor.0000157042.19740.f4
Zhang, Y, Johnson, K, Russell, RGG, Wordsworth, BP, Carr, AJ, Terkeltaub, RA and Brown,
MA (2005) Association of sporadic chondrocalcinosis with a-4-basepair g-to-a transition in the 5
'-untranslated region of ANKH that promotes enhanced expression of ANKH protein and excess
generation of extracellular inorganic pyrophosphate. Arthritis And Rheumatism, 52 4: 11101117. doi:10.1002/art.20978
Harney, SMJ, Vilarino-Guell, C, Meisel, C, Wordsworth, BP and Brown, MA (2005) Non-DRB1
MHC genes associated with rheumatoid arthritis are also differentially expressed. Rheumatology,
44 I42-I42.
Harney, SMJ, Timperley, J, Daly, C, Harin, A, James, T, Brown, MA, Fox, K, Banning, A,
Donnelly, SO and Wordsworth, BP (2005) Brain natriuretic peptide (BNP) is a potentially useful
screening tool for the detection of cardiovascular disease in patients with rheumatoid arthritis
(RA). Rheumatology, 44 I84-I84.
Koay, AM, Vilarino-Guell, C, Brown, MA and Ebeling, PR (2005) LRP5 polymorphisms are
associated with osteoporosis in males. Bone, 36 S395-S396.
Koay, AM, Vilarino-Guell, C, Leary, SD, Steer, CD, Brown, MA and Tobias, JH (2005) LRP5
gene polymorphisms influence bone mineralization and growth in children. Bone, 36 S396-S397.
Brown, MA (2005) Genetic studies of osteoporosis - A rethink required. Calcified Tissue
International, 76 5: 319-325. doi:10.1007/s00223-004-0179-9
Vilarino-Guell, C, Steer, CD, Brown, MA and Tobias, JH (2005) Estrogen receptor-alpha
polymorphisms affect cortical bone growth in childhood in a site-dependent manner. Journal of
Bone And Mineral Research, 20 7: 1293-1293.
Harney, SMJ, Meisel, C, Sims, AM, Woon, PY, Wordsworth, BP and Brown, MA (2005)
Genetic and genomic studies of PADI4 in rheumatoid arthritis. Rheumatology, 44 7: 869-872.
doi:10.1093/rheumatology/keh614
Steer, S, Miles, LJ, Scott, DL, Lad, B, Grumley, J and Brown, MA (2005) Susceptibility to
rheumatoid arthritis is associated with genetic variation in RANKL. Arthritis And Rheumatism,
52 9: S237-S237.
Harney, S. M. J., Vilarino-Guell, C., Meisel, C., Sims, A. M., Pointon, J. J., Wordsworth, B. P.
and Brown, M. A. (2005). Genomic and genetic analysis suggests involvement of MHC class III
genes in rheumatoid arthritis. In: Abstracts of the American College of Rheumatology 69th
annual meeting and the Association of Rheumatology Health Professionals 40th annual meeting.
69th Annual Scientific Meeting of the American College of Rheumatology; 40th Annual
Scientific Meeting of the Association of Rheumatology Health Professionals, San Diego, CA,
U.S.A., (S239-S239). 12-17 November 2005.
Sims, AM, Timms, AE, Bradbury, LA, Wordsworth, BP and Brown, MA (2005) Fine-mapping
of the IL-1 gene cluster pinpoints genetic associations with ankylosing spondylitis.. Arthritis And
Rheumatism, 52 9: S241-S241.
Carter, KW, Pluznhnikov, A, Timms, AE, Miceli-Richard, C, Jin, L, Wordsworth, BP, Hugot,
JP, Bourgain, C, Cox, NJ, Palmer, LJ, Breban, M, Reveille, JD and Brown, MA (2005) Metaanalysis in ankylosing spondylitis (AS) - Genomewide linkage map including 589 affected
sibling pairs.. Arthritis And Rheumatism, 52 9: S241-S241.
Brown, MA (2005) Antibody treatments of inflammatory arthritis. Current Medicinal Chemistry,
12 25: 2943-2946. doi:10.2174/092986705774462842
Koay, MA, Yeung, S, Brown, MA and Ebeling, PR (2005) LRP5 genetic variants influence bone
mineral density in men. Journal of Bone And Mineral Research, 20 9: S158-S158.
Vilarino-Guell, C, Woon, PY, Miles, LJ, Duncan, EL, Steer, CD, Tobias, JH, Wass, JA, Brown,
MA, FAMOS Consortium and ALSPAC Study (2005). PTHR1 polymorphisms influence BMD
variation through effects on the growing skeleton. In: Twenty-Eighth Annual Meeting of the
American Society for Bone and Mineral Research. ASBMR 27th Annual Meeting, Nashville,
TN, U.S.A., (S340-S340). 23-27 September 2005. doi:10.1002/jbmr.5650201306
Harney, SJ, Vilarino-Guell, C, Meisel, C, Sims, A, Pointon, JJ, Wordsworth, BP and Brown, MA
(2005) MHC class III genes in rheumatoid arthritis and the differential association of HLADRB1 alleles with disease. Tissue Antigens, 66 5: 367-368.
Carter, KW, Pluzhnikov, A, Timms, AE, Miceli-Richard, C, Jin, L, Wordsworth, BP, Bourgain,
C, Cox, NJ, Palmer, LJ, Breban, M, Reveille, JD and Brown, MA (2005) Meta-analysis in
ankylosing spondylitis (AS) - Genomewide linkage map including 589 affected sibling pairs.
Tissue Antigens, 66 5: 368-369.
Sims, A, Cordell, HJ, Barnardo, M, Herzberg, I, Bradbury, L, Calin, A, Wordsworth, BP, Darke,
C and Brown, MA (2005) Mapping of MHC class II and III genes associated with Ankylosing
spondylitis independent of HLA-B27. Tissue Antigens, 66 5: 544-544.
Brown, MA (2005). Successful approaches in genetics of musculoskeletal diseases. In: 25th
European Workshop for Rheumatology Research: Meeting Abstracts. 25th European Workshop
for Rheumatology Research, Glasgow, United Kingdom, (S2-S2). 24-27 February 2005.
doi:10.1186/ar1511
Tobias, JH, Steer, CD, Ness, AN, Vilarino-Guell, C and Brown, MA (2006) Estrogen receptor
alpha regulates volumetric bone density in late pubertal girls.. Journal of Bone And Mineral
Research, 21 S30-S30.
Bradbury, LA, Barlow, S, Geoghanen, F, Schofield, P, Wass, JAH, Russell, RGG and Brown,
MA (2006). The ROSI study (Risedronate in adults with osteogenesis imperfecta type 1):
Improved BMD but high fracture rate persists. In: Journal of Bone and Mineral Research.. 28th
Annual Meeting of the American Society for Bone and Mineral Research, Philadelphia, PA,
USA, (S115-S115). 15-19 September 2006.
Couto, AR, Armas, JB, Brown, MA, Peach, CA, Wordsworth, P and Zhang, Y (2006) Mutations
in the gene LEMD3 in patients with osteopoikilosis and melorheostosis - Evidence for genetic
heterogeneity. Rheumatology, 45 I24-I24.
Harrison, P., Pointon, J. J., Farrar, C., Ziel, V., Harin, A., Jess, C., Brown, M. A. and
Wordsworth, B. P. (2006). HLA-DRB1 influence on anti-TNF treatment in British caucasian
rheumatoid arthritis patients. In: BSR Annual Meeting and BHPR Spring Meeting: Poster
Presentations. British Society for Rheumatology Annual Meeting 2006, Glasgow, U.K., (i50i50). 2-5 May 2006.
Pointon, J. J., Beynon, O. C., Jaakkola, E., Laiho, K., Kauppi, M., Kaarela, K., Tuomilehto, J,
Brown, M. A. and Wordsworth, P. (2006) CD14 variants in UK and Finnish ankylosing
spondylitis families. Rheumatology, 45 I59-I60.
Pointon, JJ, Timms, AE, Bradbury, L and Brown, MA (2006) Analysis of positional candidate
genes in ankylosing spondylitis: A possible role for ENPP1. Rheumatology, 45 I60-I60.
Zhang, Y., Brown, M. A., Peach, C. A., Russell, G. and Wordsworth, P. (2006). Lack of genetic
association of the ENPP1 and TNAP genes with chondrocalcinosis. In: BSR Annual Meeting and
BHPR Spring Meeting: Poster Presentations. British Society for Rheumatology Annual Meeting
2006, Glasgow, U.K., (i76-i77). 2-5 May 2006.
Brown, MA, Haughton, MA, Grant, SFA, Gunnell, AS, Henderson, NK and Eisman, JA (2001)
Genetic control of bone density and turnover: Role of the collagen 1 alpha 1, estrogen receptor,
and vitamin D receptor genes. Journal of Bone And Mineral Research, 16 4: 758-764.
doi:10.1359/jbmr.2001.16.4.758
Laval, SH, Timms, A, Edwards, S, Bradbury, L, Brophy, S, Milicic, A, Rubin, L, Siminovitch,
KA, Weeks, DE, Calin, A, Wordsworth, BP and Brown, MA (2001) Whole-genome screening in
ankylosing spondylitis: Evidence of non-MHC genetic-susceptibility loci. American Journal of
Human Genetics, 68 4: 918-926. doi:10.1086/319509
Milicic, A, Brown, MA and Wordsworth, BP (2001) Polymorphism in codon 17 of the CTLA-4
gene (+49 A/G) is not associated with susceptibility to rheumatoid arthritis in British Caucasians.
Tissue Antigens, 58 1: 50-54. doi:10.1034/j.1399-0039.2001.580110.x
Hamersma, J, Cardon, LR, Bradbury, L, Brophy, S, van der Horst-Bruinsma, I, Calin, A and
Brown, MA (2001) Is disease severity in ankylosing spondylitis genetically determined?.
Arthritis and Rheumatism, 44 6: 1396-1400. doi:10.1002/1529-0131(200106)44:6<1396::AIDART233>3.0.CO;2-A
MacKay, Kirsten, Eyre, Stephen, Myerscough, Anne, Milicic, Anita, Barton, Anne, Laval,
Steven, Barrett, Jenny, Lee, Dorothea, White, Sarah, John, Sally, Brown, Matthew A., Bell,
John, Silman, Alan, Ollier, William, Wordsworth, Paul and Worthington, Jane (2002) Wholegenome linkage analysis of rheumatoid arthritis susceptibility loci in 252 affected sibling pairs in
the United Kingdom. Arthritis and Rheumatism, 46 3: 632-639. doi:10.1002/art.10147
Atoyebi, W, Brown, M, Wass, J, Littlewood, TJ and Hatton, C (2002) Lymphoplasmacytoid
lymphoma presenting as severe osteoporosis. American Journal of Hematology, 70 1: 77-80.
doi:10.1002/ajh.10095
Crane, AM, Bradbury, L, van Heel, DA, McGovern, DPB, Brophy, S, Rubin, L, Siminovitch,
KA, Wordsworth, BP, Calin, A and Brown, MA (2002) Role of NOD2 variants in
spondylarthritis. Arthritis And Rheumatism, 46 6: 1629-1633. doi:10.1002/art.10329
Brown, MA, Crane, AM and Wordsworth, BP (2002) Genetic aspects of susceptibility, severity,
and clinical expression in ankylosing spondylitis. Current Opinion In Rheumatology, 14 4: 354360. doi:10.1097/01.BOR.0000017927.78715.B4
Timms, AE, Sathananthan, R, Bradbury, L, Athanasou, NA and Brown, MA (2002) Genetic
testing for haemochromatosis in patients with chondrocalcinosis. Annals of The Rheumatic
Diseases, 61 8: 745-747. doi:10.1136/ard.61.8.745
Brown, M. A., Wordsworth, B. P. and Reveille, J. D. (2002) Genetics of ankylosing spondylitis.
Clinical And Experimental Rheumatology, 20 6: S43-S49.
Milicic, A, Misra, R, Agrawal, S, Aggarwal, A, Brown, MA and Wordsworth, BP (2002) The
F158V polymorphism in Fc gamma RIIIA shows disparate associations with rheumatoid arthritis
in two genetically distinct populations. Annals of The Rheumatic Diseases, 61 11: 1021-1023.
doi:10.1136/ard.61.11.1021
Newton, Julia, Brown, Matthew A., Milicic, Anita, Ackerman, Hans, Darke, Chris, Wilson,
Jonathan N., Wordsworth, B. Paul and Kwiatkowski, Dominic (2003) The effect of HLA-DR on
susceptibility to rheumatoid arthritis is influenced by the associated lymphotoxin alpha-tumor
necrosis factor haplotype. Arthritis and Rheumatism, 48 1: 90-96. doi:10.1002/art.10719
Goedecke, V., Crane, A. M., Jaakkola, E., Kaluza, W., Laiho, K., Weeks, D. E., Wilson, J.,
Kauppi, M., Kaarela, K., Tuomilehto, J., Wordsworth, B. P. and Brown, M. A. (2003)
Interleukin 10 polymorphisms in ankylosing spondylitis. Genes and Immunity, 4 1: 74-76.
doi:10.1038/sj.gene.6363930
Wynne, F, Drummond, FJ, Daly, M, Brown, M, Shanahan, F, Molloy, MG and Quane, KA
(2003) Suggestive linkage of 2p22-25 and 11q12-13 with low bone mineral density at the lumbar
spine in the Irish population. Calcified Tissue International, 72 6: 651-658. doi:10.1007/s00223002-2086-2
Brown, MA, Bradbury, L, Hamersma, J, Timms, A, Laval, S, Cardon, L and Calin, A (2003)
Identification of major loci controlling clinical manifestations of ankylosing spondylitis. Arthritis
And Rheumatism, 48 8: 2234-2239. doi:10.1002/art.11106
Jaakkola, E, Crane, AM, Laiho, K, Herzberg, I, Sims, AM, Bradbury, L, Calin, A, Brophy, S,
Kaarela, K, Wordsworth, BP and Brown, MA (2004) The effect of transforming growth factor
beta 1 gene polymorphisms in ankylosing spondylitis. Rheumatology, 43 1: 32-38.
doi:10.1093/rheumatology/keg457
Brophy, S, Hickey, S, Menon, A, Taylor, G, Bradbury, L, Hamersma, J, Brown, M and Calin, A
(2004) Concordance of disease severity among family members with ankylosing spondylitis?.
Journal of Rheumatology, 31 9: 1775-1778.
Shore, Eileen M., Xu, Meiqi, Feldman, George J., Fenstermacher, David A., Brown, Matthew
A., Kaplan, Frederick S., Cho, Tae-Joon, Choi, In Ho, Connor, J. Michael, Delai, Patricia,
Zasloff, Michael, Glaser, David L., LeMerrer, Martine, Smith, Roger, Morhart, Rolf, Rogers,
John G., Triffitt, James T. and Urtizberea, J. Andoni (2006) A recurrent mutation in the BMP
type I receptor ACVR1 causes inherited and sporadic fibrodysplasia ossificans progressiva.
Nature Genetics, 38 5: 525-527. doi:10.1038/ng1783
Jaakkola, Elisa, Herzberg, Ibi, Laiho, Kari, Barnardo, Martin C.N.M., Pointon, Jennifer J.,
Kauppi, Markku, Kaarela, Kalevi, Tuomilehto-Wolf, Eva, Tuomilehto, Jaakko, Wordsworth, B.
Paul and Brown, Matthew A. (2006) Finnish HLA studies confirm the increased risk conferred
by HLA-B27 homozygosity in ankylosing spondylitis. Annals of The Rheumatic Diseases, 65 6:
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Panos, Tobin, Martin D., Ziegler, Andreas, Thompson, John R., Schunkert, Heribert, for the
WTCCC and the Cardiogenics Consortium, Bradbury, Linda A. and Brown, Matthew A. (2007)
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Sheila, Gwilliam, Rhian, Jacob, Jemima, Nimmo, Elaine, Drummond, Hazel, Lees, Charlie,
Onnie, Clive, Hanson, Catherine, Blaszczyk, Katarzyna, Ravindrarajah, Radhi, Hunt, Sarah,
Varma, Dhiraj, Hammond, Naomi, Lewis, Gregory, Attlesey, Heather, Watkins, Nick,
Ouwehand, Willem, Strachan, David, McArdle, Wendy, Lewis, Cathryn, Lobo, Alan, Sanderson,
Jeremy, Jewell, Derek, Deloukas, Panos, Mansfield, John, Mathew, Christopher, Satsangi, Jack,
Parkes, Miles, Bradbury, Linda, Brown, Matthew and Pointon, Jennifer (2009) Investigation of
Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.
Gastroenterology, 136 2: 523-529.e3. doi:10.1053/j.gastro.2008.10.032
Harvey, David, Pointon, Jennifer J., Evans, David M., Karaderi, Tugce, Farrar, Claire, Appleton,
Louise H., Sturrock, Roger D., Stone, Millicent A., Oppermann, Udo, Brown, Matthew A. and
Wordsworth, B. Paul (2009) Investigating the genetic association between ERAP1 and
ankylosing spondylitis. Human Molecular Genetics, 18 21: 4204-4212. doi:10.1093/hmg/ddp371
Maksymowych, W. P. and Brown, M. A. (2009) Genetics of ankylosing spondylitis and
rheumatoid arthritis: where are we at currently, and how do they compare?. Clinical and
Experimental Rheumatology, 27 4 (supp 55): S20-S25.
Ban, Maria,, Goris, An, Lorentzen, Aslaug, Baker, Amie, Mihalova, Tania, Ingram, Gillian,
Booth, David, Heard, Robert, Stewart, Graeme, Bogaert, Elke, et al, Wellcome Trust Case
Control Consortium, Bradbury, Linda and Brown, Matthew (2009) Replication analysis
identifies TYK2 as a multiple sclerosis susceptibility factor. European Journal of Human
Genetics, 17 10: 1309-1313. doi:10.1038/ejhg.2009.41
Brown, Matthew (2009) Genetics and the pathogenesis of ankylosing spondylitis. Current
Opinion in Rheumatology, 21 4: 318-323. doi:10.1097/BOR.0b013e32832b3795
Conrad, Donald, Pinto, Dalila, Redon, Richard, Feuk, Lars, Gokcumen, Omer, Zhang, Yujun,
Aerts, Jan, Andrews, Daniel, Barnes, Chris, Campbell, Peter, et al, Wellcome Trust Case Control
Consortium, Brown, Matthew and Bradbury, Linda (2009) Origins and functional impact of copy
number variation in the human genome. Nature, 464 7289: 704-712. doi:10.1038/nature08516
Dehghan, Abbas, Yang, Qiong, Peters, Annette, Basu, Saonli, Bis, Joshua, Rudnicka, Alicja,
Kavousi, Maryam, Chen, Ming-Huei, Baumert, Jens, Lowe, Gordon, et al, Wellcome Trust Case
Control Consortium, Brown, Matthew and Bradbury, Linda (2009) Association of novel genetic
loci with circulating fibrinogen levels: A genome-wide association study in 6 population-based
cohorts. Circulation: Cardiovascular Genetics, 2 2: 125-133.
doi:10.1161/CIRCGENETICS.108.825224
Craddock, Nick, Hurles, Matthew E., Cardin, Niall, Pearson, Richard D., Plagnol, Vincent,
Robson, Samuel, Vukcevic, Damjan, Barnes, Chris, Brown, Matthew A. and The Wellcome
Trust Case Control Consortium (2010) Genome-wide association study of CNVs in 16,000 cases
of eight common diseases and 3,000 shared controls. Nature, 464 7289: 713-720.
doi:10.1038/nature08979
Duan, Ran, Leo, Paul, Bradbury, Linda, Brown, Matthew and Thomas, Gethin (2010) Gene
expression profiling reveals a down-regulation in immune-associated genes in AS patients.
Annals of the Rheumatic Diseases, 69 9: 1724-1729. doi:10.1136/ard.2009.111690
Erdmann, Jeanette, Grosshennig, Anika, Braund, Peter, Konig, Inke, Hengstenberg, Christian,
Hall, Alistair, Linsel-Nitschke, Patrick, Kathiresan, Sekar, Wright, Ben, Tregouet, DavidAlexandre, et al, Wellcome Trust Case Control Consortium, Bradbury, Linda and Brown,
Matthew (2009) New susceptibility locus for coronary artery disease on chromosome 3q22.3.
Nature Genetics, 41 3: 280-282. doi:10.1038/ng.307
Hamshere, M. L., Green, E. K., Jones, I. R., Moskvina, V., Kirov, G., Grozeva. D., Nikolov, I.,
Vukcevic, D., Caesar, S., Gordon-Smith, K., Fraser, C., Russell, E., Breen, G., St Clair, D.,
Collier, D. A., Young, A. H., Ferrier, I. N., Farmer, A., McGuffin, P., Wellcome Trust Case
Control Consortium, Brown, M. A., Bradbury, L., Holmans P. A., Owen, M. J., O'Donovan, M.
C. and Craddock, N. (2009) Genetic utility of broadly bipolar schizoaffective disorder as a
diagnostic concept. British Journal of Psychiatry, 195 1: 23-29. doi:10.1192/bjp.bp.108.061424
Holmans, P., Green, E. K., Pahwa, J. S., Ferreira, M. A. R., Purcell, S. M., Sklar, P., Wellcome
Trust Case Control Consortium, Brown, Matthew A., Bradbury, Linda, Owen, M. J.,
O'Donnovan, M. C. and Craddock, N. (2009) Gene ontology analysis of GWA study data sets
provides insights into the biology of bipolar disorder. American Journal of Human Genetics, 85
1: 13-24. doi:10.1016/j.ajhg.2009.05.011
Imielinski, M., Baldassano, R. N., Griffiths, A., Russell, R. K., Annese, V., Dubinsky, M.,
Kugathasan, S., Bradfield, J. P., Walters, T. D., et al, International IBD Genetics Consortium,
Brown, Matthew A. and Bradbury, Linda (2009) Common variants at five new loci associated
with early-onset inflammatory bowel disease.. Nature Genetics, 41 12: 1335-1340.
doi:10.1038/ng.489
Jallow, M., Teo, Y. Y., Small, K. S., Rockett, K. A., Deloukas, P., Clark, T. G., Kivinen, K.,
Bojang, K. A., Conway, D. J., Pinder, M., et al, Wellcome Trust Case Control Consortium,
Brown, Matthew A. and Bradbury, Linda (2009) Genome-wide and fine-resolution association
analysis of malaria in West Africa. Nature Genetics, 41 6: 657-665. doi:10.1038/ng.388
Kirov, G., Grozeva, D., Norton, N., Ivanov, D., Mantripragada, K. K, Holmans, P., International
Schizophrenia Consortium, Wellcome Trust Case Control Consortium, Craddock, N., Owen, M.
J., O'Donovan, M. C., Brown, Matthew A. and Bradbury, Linda (2009) Support for the
involvement of large copy number variants in the pathogenesis of schizophrenia. Human
Molecular Genetics, 18 8: 1497-1503. doi:10.1093/hmg/ddp043
Lindgren, Cecilia M., Heid, Iris M., Randall, Joshua C., Lamina, Claudia, Steinthorsdottir,
Valgerdur, Qi, Lu, Speliotes, Elizabeth K, Thorleifsson,Gudmar, Willer, Cristen J., Herrera,
Blanca M., Jackson, Anne U., Lim, Noha, Scheet, Paul, Soranzo, Nicole, Amin, Najaf,
Aulchenko, Yurii S., Chambers, John C., Drong, Alexander, Luan, Jian'an, Lyon, Helen N.,
Rivadeneira, Fernando, Sanna, Serena, Timpson, Nicholas J., Zillikens, M. Carola, Zhao, Jing
Hua, Almgren, Peter, Bandinelli, Stefania, Bennett, Amanda J., Bergman, Richard N.,
Bonnycastle, Lori L., Bumpstead, Suzannah J., Chanock, Stephen J., Cherkas, Lynn, Chines,
Peter, Coin, Lachlan, Cooper, Cyrus, Crawford, Gabriel, Doering, Angela, Dominiczak, Anna,
Doney, Alex S. F., Ebrahim, Shah, Elliott, Paul, Erdos, Michael R., Estrada, Karol, Ferrucci,
Luigi, Fischer, Guido, Forouhi, Nita G., Gieger, Christian, Grallert, Harald, Groves, Christopher
J., Grundy, Scott, Guiducci, Candace, Hadley, David, Hamsten, Anders, Havulinna, Aki S.,
Hofman, Albert, Holle, Rolf, Holloway, John W., Illig, Thomas, Isomaa, Bo, Jacobs,Leonie C.,
Jameson, Karen, Jousilahti, Pekka, Karpe, Fredrik, Kuusisto, Johanna, Laitinen, Jaana, Lathrop,
G. Mark, Lawlor, Debbie A. L., Mangino, Massimo, McArdle, Wendy L., Meitinger, Thomas,
Morken, Mario A., Morris, Andrew P., Munroe, Patricia, Narisu, Narisu, Nordstrom, Anna,
Nordstrom , Peter, Oostra, Ben A., Palmer, Colin N. A., Payne, Felicity, Peden, John F.,
Prokopenko, Inga, Renstrom, Frida, Ruokonen, Aimo, Salomaa, Veikko, Sandhu, Manjinder S.,
Scott, Laura J., Scuteri, Angelo, Silander, Kaisa, Song, Kijoung, Yuan, Xin, Stringham, Heather
M., Swift, Amy J., Tuomi, Tiinamaija, Uda, Manuela, Vollenweider, Peter, Waeber, Gerard,
Wallace, Chris, Walters, G. Bragi, Weedon, Michael N., The Wellcome Trust Case Control
Consortium, Witteman, Jacqueline C. M., Zhang, Cuilin, Zhang, Weihua, Caulfield, Mark J.,
Collins, Francis S., Davey Smith, George, Day, Ian N. M., Franks, Paul W., Hattersley, Andrew
T., Hu, Frank B., Jarvelin, Marjo-Riitta, Kong, Augustine, Kooner, Jaspal S., Laakso, Markku,
Lakatta, Edward, Mooser, Vincent, Morris, Andrew D., Peltonen, Leena, Samani, Nilesh J.,
Spector, Timothy D., Strachan, David P., Tanaka, Toshiko, Tuomilehto, Jaakko, Uitterlinden,
Andre G., van Duijn, Cornelia M., Wareham, Nicholas J., Watkins, Hugh, Waterworth, Dawn
M., Boehnke, Michael, Deloukas, Panos, Groop, Leif, Hunter. David J., Thorsteinsdottir, Unnur,
Schlessinger, David, Wichmann, H.-Erich, Frayling, Timothy M., Abecasis, Goncalo R.,
Hirschhorn, Joel N., Loos, Ruth J. F., Stefansson, Kari, Mohlke, Karen L., Barroso, Ines,
McCarthy, Mark I., Brown, Matthew A. and Bradbury, Linda (2009) Genome-wide association
scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS
Genetics, 5 6: e1000508-1-e1000508-13. doi:10.1371/journal.pgen.1000508
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Case Control Consortium, Brown, Matthew A., Bradbury, Linda, Owen, M. J. and O'Donovan,
M. C. (2009) Gene-wide analyses of genome-wide association data sets: evidence for multiple
common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk..
Molecular Psychiatry, 14 3: 252-260. doi:10.1038/mp.2008.133
Myocardial Infarction Genetics Consortium, Brown, Matthew A. and Linda Bradbury (2009)
Genome-wide association of early-onset myocardial infarction with single nucleotide
polymorphisms and copy number variants. Nature Genetics, 41 3: 334-341. doi:10.1038/ng.327
Newton-Chen, C., Johnson, T., Gateva, V., Tobin, M. D., Bochud, M., Coin, L., Najjar, S. S.,
Zhao, J. H., et al, Wellcome Trust Case Control Consortium, Brown, Matthew A. and Bradbury,
Linda (2009) Genome-wide association study identifies eight loci associated with blood
pressure.. Nature Genetics, 41 6: 666-676. doi:10.1038/ng.361
Nolte, Ilja M., Wallace, Chris, Newhouse, Stephen J., Waggott, Daryl, Fu, Jingyuan, Soranzo,
Nicole, Gwilliam, Rhian, Deloukas, Panos, Savelieva, Irina, Zheng, Dongling, Dalageorgou,
Chrysoula, Farrall, Martin, Samani, Nilesh J., Connell, John, Brown, Morris, Dominiczak, Anna,
Lathrop, Mark, Zeggini, Eleftheria, Wain, Louise V., The DCCT/EDIC Research Group,
Newton-Cheh, Christopher, Eijgelsheim, Mark, Rice, Kenneth, de Bakke, Paul I. W., Pfeufer,
Arne, Sanna, Serena, Arking, Dan E., Asselbergs, Folkert W., Spector, Tim D., Carter, Nicholas
D., Jeffery, Steve, Tobin, Martin, Caulfield, Mark, Snieder, Harold, Paterson, Andrew D.,
Munroe, Patricia B., Jamshidi, Yalda, The Wellcome Trust Case Control Consortium, Brown,
Matthew A. and Bradbury, Linda (2009) Common genetic variation near the phospholamban
gene is associated with cardiac repolarisation: Meta-analysis of three genome-wide association
studies. PLoS One, 4 7: e6138-1-e6138-10. doi:10.1371/journal.pone.0006138
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Wellcome Trust Case Control Consortium, Brown, Matthew A., Linda Bradbury and et al (2009)
Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23..
Human Molecular Genetics, 18 14: 2693-2699. doi:10.1093/hmg/ddp193
Perry, J. R. B., McCarthy, M. I., Hattersley, A. T., Zeggini, E., Wellcome Trust Case Control
Consortium, Brown, Matthew A., Linda Bradbury, Weedon, M. N. and Frayling, T. M. (2009)
Interrogating type 2 diabetes genome-wide association data using a biological pathway-based
approach. Diabetes, 58 6: 1463-1467. doi:10.2337/db08-1378
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Linda Bradbury (2009) Microduplications of 16p11.2 are associated with schizophrenia.. Nature
Genetics, 41 11: 1223-1229. doi:10.1038/ng.474
Repapi, E., Sayers, I., Wain, L. V., Burton, P. R., Johnson, T., Obeidat, M., Zhao, J. H.,
Ramasamy, A., Evans, David M., Wellcome Trust Case Control Consortium, Brown, Matthew
A. and Bradbury, Linda (2009) Genome-wide association study identifies five loci associated
with lung function. Nature Genetics, 42 1: 36-45. doi:10.1038/ng.501
Tregouet, D. A., Konig, I. R., Erdmann, J,, Munteanu, A., Braund, P. S., Hall, A. S.,
Grosshennig, A., Linsel-Nitschke, P., et al, Wellcome Trust Case Control Consortium, Brown,
Matthew A. and Linda Bradbury (2009) Genome-wide haplotype association study identifies the
SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nature Genetics,
41 3: 283-285. doi:10.1038/ng.314
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Guillaume, Lim, Noha, Lyon, Helen N., McCarroll, Steven N., Papadakis, Konstantinos, Qi, Lu,
Randall, Joshua C., Roccasecca, Rosa Maria, Sanna, Serena, Scheet, Paul, Weedon, Michael N.,
Wheeler, Eleanor, Zhao, Jing Hua, Jacobs, Leonie C., Prokopenko,, Soranzo, Nicole, Tanaka,
Toshiko, Timpson, Nicholas J., Almgran, Peter, Bennett, Amanda, Bergman, Richard N.,
Bingham, Sheila A., Bonnycastle, Lori L., Brown, Morris, Bertt, Noel P., Chines, Peter, Coin,
Lachlan, Collins, Frances S., Connell, John M., Cooper, Cyrus, Smith, George Davey, Dennison,
Elaine M., Deodhar, Parimal, Elliott, Paul, Erdos, Michael R., Estrada, Karol, Evans, David M.,
Gianniny, Lauren, Gieger, Christian, Gillson, Christopher J., Guiducci, Candace, Hackett,
Rachel, Hadley, David, Hall, Alistair S., Havulinna, Aki S., Hebebrand, Johannes, Hofman,
Albert, Isomaa, Bo, Jacobs, Kevin B., Johnson, Toby, Jousilahti, Pekka, Jovanovic, Zorica, Kaw,
Kay-Tee, Kraft, Peter, Kuokkanen, Mikko, Kuusisto, Johanna, Laitinen, Jaana, Lakatta, Edward
G., Luan, Jian'an, Luben, Robert N., Mangino, Massimo, McArdle, Wendy L., Meitinger,
Thomas, Mulas, Antonella, Munroe, Patricia B., Narisu, Narisu, Ness, Andrew R., Northstone,
Kate, O'Rahilly, Stephenen, Purmann, Carolin, Rees, Matthew G., Ridderstråle, Martin, Ring,
Susan M., Rivadeneira, Fernando, Ruokonen, Aimo, Sandhu, Manjinder, Saramies, Jouko, Scott,
Laura J., Scuteri, Angelo, Silander, Kaisa, Sims, Matthew A., Song, Kijoung, Stephens,
Jonathan, Stevens, Suzanne, Stringham, Heather M., Tung, Y. C. Loraine, Valle, Timo T., Van
Duijn, Cornelia M., Vimaleswaran, Karani, Vollenweider, Peter, Waeber, Gerard, Wallace,
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Erich, McCarthy, Mark I., Boehnke, Michael, Barroso, Ines, Abecasis, Goncalo, Hirschhorn, Joel
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associated with body mass index highlight a neuronal influence on body weight regulation.
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Thomas, Gethin P., Tseng, Hsu-Wen, Pettit, Allison, Glant, Tibor T., McRae, Allan and Brown,
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Reveille, John D., Ward, Michael M., Lee, MinJae, Rahbar, Mohammad, Ardjomand-Hessabi,
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Michael H. (2013). Opiate Use In Patients With Ankylosing Spondylitis. In: Abstract
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Okada, Yukinori, Wu, Di, Terao, Chikashi, Ikari, Katsunori, Kochi, Yuta, Ohmura, Koichiro,
Suzuki, Akari, Yamanaka, Hisashi, Denny, Joshua C., Greenberg, Jeffrey D., Graham, Robert R.,
Brown, Matthew A., Bae, Sang-Cheol, Worthington, Jane, Padyukov, Leonid, Klareskog, Lars,
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Budu-Aggrey, Ashley, Bowes, John, Ho, Pauline, Bluett, James, Hebert, Harry, Marzo-Ortega,
Helena, Morgan, Ann W., Brown, Matthew A., McManus, Ross, McHugh, Neil, FitzGerald,
Oliver M., Bruce, Ian N. and Barton, Anne (2013). Investigating a Novel Locus For Psoriatic
Arthritis. In: Abstract Supplement 2013 Annual Meeting. 77th Annual Meeting of the American
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Rauch, Tibor A., Tryniszewska, Beata, Vida, Andras, Ocsko, Timea, Szanto, Sandor,
Rosenzweig, Holly L., Brown, Matthew A., Thomas, Gethin P., Mikecz, Katalin and Glant,
Tibor T. (2013). Identification Of Genetic and Epigenetic Alterations In Spondyloarthritis. In:
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Robinson, Philip, Wang, Yang, Lau, Eugene, Keith, Patricia, Kenna, Tony and Brown, Matthew
A. (2013). ERAP2 Functional Knockout In Humans Does Not Alter ER Stress Or Evidence Of
HLA-B27 Misfolding In Ankylosing Spondylitis.. In: Special Issue: 2013 Annual Meeting
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van der Heijde, Desiree, Maksymowych, Walter P., Sieper, Joachim, Lambert, Robert, Brown,
Matthew A., Rathmann, Suchitrita S., Anderson, Jaclyn K. and Pangan, Aileen L. (2013).
Relationship Between MRI and Clinical Remission In Patients With Non-Radiographic Axial
Spondyloarthritis After Two Years Of Adalimumab Therapy. In: Abstract Supplement 2013
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Feletar, Marie, Foley, Peter and Brown, Matthew A. (2008) Developments in psoriasis and
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doi:10.1016/j.ddmec.2008.05.001
O'Gorman, C., Freeman, S., Taylor, B. V., Butzkueven, H., Australian and New Zealand MS
Genetics Consortium (ANZgene), Broadley S. A., Bahlo, M., Booth, D. R., Brown, M. A., Foote,
S. J., Griffiths, L. R., Kilpatrick, T. J., Lechner-Scott, J., Moscato, P., Perreau, V. M., Scott, R.
J., Stankovich, J., Stewart, G. J., Chapman, C., Marriot, M., Tanner, M., Tubridy, N. and Wiley,
J. (2011) Familial recurrence risks for multiple sclerosis in Australia. Journal of Neurology,
Neurosurgery and Psychiatry, 82 12: 1351-1354. doi:10.1136/jnnp.2010.233064
Keller, Margaux F., Saad, Mohamad, Bras, Jose, Bettella, Francesco, Nicolaou, Nayia, SimonSanchez, Javier, Mittag, Florian, Buchel, Finja, Sharma, Manu, Gibbs, J. Raphael, Schulte,
Claudia, Moskvina, Valentina, Durr, Alexandra, Holmans, Peter, Kilarski, Laura L., Guerreiro,
Rita, Hernandez, Dena G., Brice, Alexis, Ylikotila, Pauli, Stefansson, Hreinn, Majamaa, Kari,
Morris, Huw R., Williams, Nigel, Gasser, Thomas, Heutink, Peter, Wood, Nicholas W., Hardy,
John, Martinez, Maria, Singleton, Andrew B., Nalls, Michael A., for International Parkinson's
Disease Geonomics Consortium (IPDGC), for The Welcome Trust Case Control Consortium 2
(WTCCC2) and Brown, Matthew A. (2012) Using genome-wide complex trait analysis to
quantify 'missing heritability' in Parkinson's disease. Human Molecular Genetics, 21 22: 49965009. doi:10.1093/hmg/dds335
Mechelli, Rosella, Umeton, Renato, Policano, Claudia, Annibali, Viviana, Coarelli, Giulia,
Ricigliano, Vito A. G., Vittori, Danila, Fornasiero, Arianna, Buscarinu, Maria Chiara,
International Multiple Sclerosis Genetics Consortium, Wellcome Trust Case Control
Consortium,2, Romano, Silvia, Salvetti, Marco, Ristori, Giovanni and Brown, Matthew A.
(2013) A "candidate-interactome" aggregate analysis of genome-wide association data in
multiple sclerosis. PLoS One, 8 5: . doi:10.1371/journal.pone.0063300
Strange, Amy, Bellenguez, Celine, Sim, Xueling, Luben, Robert, Hysi, Pirro G., Ramdas, Wishal
D., van Koolwijk, Leonieke M. E., Freeman, Colin, Pirinen, Matti, Su, Zhan, Band, Gavin,
Pearson, Richard, Vukcevic, Damjan, Langford, Cordelia, Deloukas, Panos, Hunt, Sarah, Gray,
Emma, Dronov, Serge, Potter, Simon C., Tashakkori-Ghanbaria, Avazeh, Edkins, Sarah,
Bumpstead, Suzannah J., Blackwell, Jenefer M., Bramon, Elvira, Brown, Matthew A., Casas,
Juan P., Corvin, Aiden, Duncanson, Audrey, Jankowski, Janusz A. Z., Markus, Hugh S.,
Mathew, Christopher G., Palmer, Colin N. A., Plomin, Robert, Rautanen, Anna, Sawcer, Stephen
J., Trembath, Richard C., Wood, Nicholas W., Barroso, Ines, Peltonen, Leena, Healey, Paul,
McGuffin, Peter, Topouzis, Fotis, Klaver, Caroline C. W., van Duijn, Cornelia M., Mackey,
David A., Young, Terri L., Hammond, Christopher J., Khaw, Kay-Tee, Wareham, Nick, Wang,
Jie Jin, Wong, Tien Y., Foster, Paul J., Mitchell, Paul, Spencer, Chris C. A., Donnelly, Peter,
Viswanathan, Ananth C., The Blue Mountains Eye Study (BMES) and The Wellcome Trust Case
Control Consortium 2 (WTCCC2) (2013) Genome-wide association study of intraocular pressure
identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus. Human Molecular
Genetics, 22 22: 4653-4660. doi:10.1093/hmg/ddt293
Oei, Ling, Estrada, Karol, Duncan, Emma L., Christiansen, Claus, Liu, Ching-Ti, Langdahl,
Bente L., Obermayer-Pietsch, Barbara, Riancho, José A., Prince, Richard L., van Schoor,
Natasja M., McCloskey, Eugene, Hsu, Yi-Hsiang, Evangelou, Evangelos, Ntzani, Evangelia,
Evans, David M., Alonso, Nerea, Husted, Lise B., Valero, Carmen, Hernandez, Jose L., Lewis,
Joshua R., Kaptoge, Stephen K., Zhu, Kun, Cupples, L. Adrienne, Medina-Gómez, Carolina,
Vandenput, Liesbeth, Kim, Ghi Su, Lee, Seung Hun, Castaño-Betancourt, Martha C., Oei,
Edwin H. G., Martinez, Josefina, Daroszewska, Anna, van der Klift, Marjolein, Mellström,
Dan, Herrera, Lizbeth, Karlsson, Magnus K., Hofman, Albert, Ljunggren, Östen, Pols, Huibert
A. P., Stolk, Lisette, van Meurs, Joyce B. J., Ioannidis, John P. A., Zillikens, M. Carola, Lips,
Paul, Karasik, David, Uitterlinden, André G., Styrkarsdottir, Unnur, Brown, Matthew A., Koh,
Jung-Min, Richards, J. Brent, Reeve, Jonathan, Ohlsson, Claes, Ralston, Stuart H., Kiel, Douglas
P. and Rivadeneira, Fernando (2014) Genome-wide association study for radiographic vertebral
fractures: a potential role for the 16q24 BMD locus. Bone, 59 20-27.
doi:10.1016/j.bone.2013.10.015
Schmidts, Miriam, Vodopiutz, Julia, Christou-Savina, Sonia, Cortés, Claudio R., McInerneyLeo, Aideen M., Emes, Richard D., Arts, Heleen H., Tüysüz, Beyhan, D'Silva, Jason, Leo,
Paul J., Giles, Tom C., Oud, Machteld M., Harris, Jessica A., Koopmans, Marije, Marshall,
Mhairi, Elçioglu, Nursel, Kuechler, Alma, Bockenhauer, Detlef, Moore, Anthony T., Wilson,
Louise C., Janecke, Andreas R., Hurles, Matthew E., Emmet, Warren, Gardiner, Brooke,
Streubel, Berthold, Dopita, Belinda, Zankl, Andreas, Kayserili, Hülya, Scambler, Peter J.,
Brown, Matthew A., Beales, Philip L., Wicking, Carol, UK10K, Duncan, Emma L. and
Mitchison, Hannah M. (2013) Mutations in the gene encoding IFT dynein complex component
WDR34 cause Jeune asphyxiating thoracic dystrophy. American Journal of Human Genetics, 93
5: 932-944. doi:10.1016/j.ajhg.2013.10.003
Halbritter, Jan, Bizet, Albane A., Schmidts, Miriam, Porath, Jonathan D., Braun, Daniela A.,
Gee, Heon Yung, McInerney-Leo, Aideen M., Krug, Pauline, Filhol, Emilie, Davis, Erica E.,
Airik, Rannar, Czarnecki, Peter G., Lehman, Anna M., Trnka, Peter, Nitschke, Patrick, BoleFeysot, Christine, Schueler, Markus, Knebelmann, Bertrand, Burtey, Stephane, Szabo, Attila J.,
Tory, Kalman, Leo, Paul J., Gardiner, Brooke, McKenzie, Fiona A., Zankl, Andreas, Brown,
Matthew A., Hartley, Jane L., Maher, Eamonn R., Li, Chunmei, Leroux, Michel R., Scambler,
Peter J., Zhan, Shing H., Jones, Steven J., Kayserili, Hulya, Tuysuz, Beyhan, Moorani,
Khemchand N., Constantinescu, Alexandru, Krantz, Ian D., Kaplan, Bernard S., Shah, Jagesh V.,
Hurd, Toby W., Doherty, Dan, Katsanis, Nicholas, Duncan, Emma L., Otto, Edgar A., Beales,
Philip L., Mitchison, Hannah M., Saunier, Sophie and Hildebrandt, Friedhelm (2013) Defects in
the IFT-B Component IFT172 Cause Jeune and Mainzer-Saldino Syndromes in Humans.
American Journal of Human Genetics, 93 5: 915-925. doi:10.1016/j.ajhg.2013.09.012
McInerney-Leo, Aideen M., Marshall, Mhairi S., Gardiner, Brooke, Benn, Diana E., McFarlane,
Janelle, Robinson, Bruce G., Brown, Matthew A., Leo, Paul J., Clifton-Bligh, Roderick J. and
Duncan, Emma L. (2014) Whole exome sequencing is an efficient and sensitive method for
detection of germline mutations in patients with phaeochromcytomas and paragangliomas.
Clinical Endocrinology, 80 1: 25-33. doi:10.1111/cen.12331
Mayes M.D., Bossini-Castillo L., Gorlova O., Martin J.E., Zhou X., Chen W.V., Assassi S., Ying
J., Tan F.K., Arnett F.C., Reveille J.D., Guerra S., Teruel M., Carmona F.D., Gregersen P.K.,
Lee A.T., Lopez-Isac E., Ochoa E., Carreira P., Simeon C.P., Castellvi I., Gonzalez-Gay M.A.,
Zhernakova A., Padyukov L., Alarcon-Riquelme M., Wijmenga C., Brown M., Beretta L.,
Riemekasten G., Witte T., Hunzelmann N., Kreuter A., Distler J.H.W., Voskuyl A.E.,
Schuerwegh A.J., Hesselstrand R., Nordin A., Airo P., Lunardi C., Shiels P., Van Laar J.M.,
Herrick A., Worthington J., Denton C., Wigley F.M., Hummers L.K., Varga J., Hinchcliff M.E.,
Baron M., Hudson M., Pope J.E., Furst D.E., Khanna D., Phillips K., Schiopu E., Segal B.M.,
Molitor J.A., Silver R.M., Steen V.D., Simms R.W., Lafyatis R.A., Fessler B.J., Frech T.M.,
Alkassab F., Docherty P., Kaminska E., Khalidi N., Jones H.N., Markland J., Robinson D.,
Broen J., Radstake T.R.D.J., Fonseca C., Koeleman B.P. and Martin J. (2014) Immunochip
analysis identifies multiple susceptibility loci for systemic sclerosis. American Journal of Human
Genetics, 94 1: 47-61. doi:10.1016/j.ajhg.2013.12.002
Thomas, Gethin P., Duan, Ran, Pettit, Allison R., Weedon,Helen, Kaur, Simranpreet, Smith,
Malcolm and Brown, Matthew A. (2013) Expression profiling in spondyloarthropathy synovial
biopsies highlights changes in expression of inflammatory genes in conjunction with tissue
remodelling genes. BMC Musculoskeletal Disorders, 14 . doi:10.1186/1471-2474-14-354
Wang, Joanne H., Pappas, Derek, De Jager, Philip L., Pelletier, Daniel, de Bakker, Paul I. W.,
Kappos, Ludwig, Polman, Chris H., The Australian and New Zealand Multiple Sclerosis
Genetics Consortium, Bahlo, Melanie, Booth, David R., Broadley, Simon A., Brown, Matthew
A., Foote, Simon J., Griffiths, Lyn R., Kilpatrick, Trevor J., Lechner-Scott, Jeanette, Moscato,
Pablo, Perreau, Victoria M., Rubio, Justin P., Scott, Rodney J., Stankovich, Jim, Stewart,
Graeme J., Taylor, Bruce V., Wiley, James, Danoy, Patrick, Butzkueven, Helmut, Slee, Mark,
Greer, Judith M., Kermode, Allan, Carroll, William, Chibnik, Lori B., Hafler, David A.,
Matthews, Paul M., Hauser, Stephen L, Baranzini, Sergio E. and Oksenberg, Jorge R. (2011)
Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data..
Genome Medicine, 3 1: 3.1-3.10. doi:10.1186/gm217
Terwisscha van Scheltinga, A. F., Bakker, S. C., Van Haren, N. E. M., Derks, E. M., BuizerVoskamp, J. E., Cahn, W., Ripke, S., Ophoff, R. A., Kahn, R. S., Psychiatric Genomic-Wide
Association Study (GWAS) Consortium, Visscher, P. M., Mowry, B. J., Brown, M. A. and
McGrath, J. J. (2013) Schizophrenia genetic variants are not associated with intelligence.
Psychological Medicine, 43 12: 2563-2570. doi:10.1017/S0033291713000196
Bentley, Liz, Esapa, Christopher T., Nesbit, M. Andrew, Head, Rosie A., Evans, Holly, Lath,
Darren, Scudamore, Cheryl L., Hough, Tertius A., Podrini, Christine, Hannan, Fadil M., Fraser,
William D., Croucher, Peter I., Brown, Matthew A., Brown, Steve D. M., Cox, Roger D. and
Thakker, Rajesh V. (2014) An N-ethyl-n-nitrosourea induced corticotropin-releasing hormone
promoter mutation provides a mouse model for endogenous glucocorticoid excess.
Endocrinology, 155 3: 908-922. doi:10.1210/en.2013-1247
Okada, Yukinori, Wu, Di, Trynka, Gosia, Raj, Towfique, Terao, Chikashi, Ikari, Katsunori,
Kochi, Yuta, Ohmura, Koichiro, Suzuki, Akari, Yoshida, Shinji, Graham, Robert R., Manoharan,
Arun, Ortmann, Ward, Bhangale, Tushar, Denny, Joshua C., Carroll, Robert J., Eyler, Anne E.,
Greenberg, Jeffrey D., Kremer, Joel M., Pappas, Dimitrios A., Jiang, Lei, Yin, Jian, Ye,
Lingying, Su, Ding-Feng, Yang, Jian, Xie, Gang, Keystone, Ed, Westra, Harm-Jan, Esko, Tonu,
Metspalu, Andreas, Zhou, Xuezhong, Gupta, Namrata, Mirel, Daniel, Stahl, Eli A., Diogo,
Dorothee, Cui, Jing, Liao, Katherine, Guo, Michael H., Myouzen, Keiko, Kawaguchi, Takahisa,
Coenen, Marieke J.H., van Riel, Piet L.C.M., van De Laar, Mart A.F.J., Guchelaar, Henk-Jan,
Huizinga, Tom W.J., Dieude, Philippe, Mariette, Xavier, Bridges, S. Louise, Zhernakova,
Alexandra, Toes, Rene E.M., Tak, Paul P., Miceli-Richard, Corinne, Bang, So-Young, Lee, HyeSoon, Martin, Javier, Gonzalez-Gay, Miguel A., Rodriguez-Rodriguez, Luis, RantapaaDahlqvist, Solbritt, Arlestig, Lisbeth, Choi, Hyon K., Kamatani, Yoichiro, Galan, Pilar, Lathrop,
Mark, RACI consortium, GARNET consortium, Visscher, Peter M. and Brown, Matthew A.
(2014) Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature, 506
7488: 376-381. doi:10.1038/nature12873
Kenna, Tony J. and Brown, Matthew A. (2013) Immunopathogenesis of ankylosing spondylitis.
International Journal of Clinical Rheumatology, 8 2: 265-274. doi:10.2217/ijr.12.84
McInerney-Leo, Aideen M., Marshall, Mhairi S., Gardiner, Brooke, Coucke, Paul J., Van Laer,
Lut, Loeys, Bart L., Summers, Kim M., Symoens, Sofie, West, Jennifer A., West, Malcolm J.,
Wordsworth, B. Paul, Zankl, Andreas, Leo, Paul J., Brown, Matthew A. and Duncan, Emma L.
(2013) Whole exome sequencing is an efficient, sensitive and specific method of mutation
detection in osteogenesis imperfecta and Marfan syndrome. BoneKEy Reports, 2 456: 1-9.
doi:10.1038/bonekey.2013.190
Shahijanian, Fernando, Parnell, Grant P., Mckay, Fiona C., Gatt, Prudence N., Shojoei, Maryam,
O'Connor, Kate S., Schibeci, Stephen D, Brilot, Fabienne, Liddle, Christopher, Batten, Marcel,
Stewart, Graeme J., Booth, David R., ANZgene Multiple Sclerosis Genetics Consortium and
Brown, Matt (2014) The CYP27B1 variant associated with an increased risk of autoimmune
disease is underexpressed in tolerizing dendritic cells. Human Molecular Genetics, 23 6: 14251434. doi:10.1093/hmg/ddt529
Zhang, Lei, Choi, Hyung Jin, Estrada, Karol, Leo, Paul J., Li, Jian, Pei, Yu-Fang, Zhang,
Yinping, Lin, Yong, Shen, Hui, Liu, Yao-Zhong, Liu, Yongjun, Zhao, Yingchun, Zhang, JiGang, Tian, Qing, Wang, Yu-ping, Han, Yingying, Ran, Shu, Hai, Rong, Zhu, Xue-Zhen, Wu,
Shuyan, Yan, Han, Liu, Xiaogang, Yang, Tie-Lin, Guo, Yan, Zhang, Feng, Guo, Yan-fang,
Chen, Yuan, Chen, Xiangding, Tan, Lijun, Zhang, Lishu, Deng, Fei-Yan, Deng, Hongyi,
Rivadeneira, Fernando, Duncan, Emma L., Lee, Jong Young, Han, Bok Ghee, Cho, Nam H.,
Nicholson, Geoffrey C., McColskey, Eugene, Eastell, Richard, Prince, Richard L., Eisman, John
A., Jones, Graeme, Reid, Ian R., Sambrook, Philip N., Dennison, Elaine M., Danoy, Patrick,
Yerges-Armstrong, Laura M., Streeten, Elizabeth A., Hu, Tian, Xiang, Shuanglin, Papasian,
Christopher J., Brown, Matthew A., Shin, Chan Soo, Uitterlinden, André G. and Deng, Hong-
Wen (2014) Multi-stage genome-wide association meta-analyses identified two new loci for
bone mineral density. Human Molecular Genetics, 23 7: 1923-1933. doi:10.1093/hmg/ddt575
Psychosis Endophenotypes International Consortium, Wellcome Trust Case-Control Consortium
and Brown, Matthew A. (2014) A genome-wide association analysis of a broad psychosis
phenotype identifies three loci for further investigation. Biological Psychiatry, 75 5: 386-397.
doi:10.1016/j.biopsych.2013.03.033
Ferreira, Manuel A. R., Matheson, Melanie C., Tang, Clara S., Granell, Raquel, Ang, Wei., Hui,
Jennie, Kiefer, Amy K., Duffy, David L., Baltic, Svetlana, Danoy, Patrick, Bui, Minh, Price,
Loren, Sly, Peter D., Eriksson, Nicholas, Madden, Pamela A., Abraham, Michael J. A., Holt,
Patrick G., Heath, p Andrew C., Hunter, Michael, Musk, Bill, Robertson, Colin F., Le Souef,
Peter, Montgomery, Grant W., Henderson, A. John, Tung, Joyce Y., Dharmage, Shyamali C.,
Brown, Matthew A., James, Alan, Thompson, Philip J., Pennell, Craig, Martin, Nicholas G.,
Evans, David M., Hinds, David A., Hopper, John L. and Australian Asthma Genetics
Consortium Collaborators (2013) Genome-wide association analysis identiﬕes 11 risk variants
associated with the asthma with hay fever phenotype. Journal of Allergy And Clinical
Immunology, 133 6: 1564-1571. doi:10.1016/j.jaci.2013.10.030
Brown, Matthew A. (2013). Epidemiology and genetics of rheumatic diseases. In Raashid
Luqmani, James Robb, Daniel Porter and Benjamin Joseph (Ed.), Textbook of Orthopaedics,
Trauma and Rheumatology 2nd ed. (pp. 53-60) Amsterdam, Netherlands: Elsevier Health
Sciences.
Costello, Mary-Ellen, Elewaut, Dirk, Kenna, Tony J. and Brown, Matthew A. (2013) Microbes,
the gut and ankylosing spondylitis. Arthritis Research and Therapy, 15 3: 214.1-214.10.
doi:10.1186/ar4228
Brown, Matt (2013) Genomics and the Future of Medical Practice. Australasian Biotechnology,
23 3: 19-19.
Pimental da Couto, A. and Brown, Matthew A. (2013). Articular chondrocalcinosis. In Michael
F. Murray, Mark W. Babyatsky, Monica A. Giovanni, Fowzan S. Alkuraya and Douglas R.
Stewart (Ed.), Clinical Genomics: Practical Applications in Adult Patient Care (pp. 704-708)
United States: McGraw-Hill Professional Pub.
Gensler, L. S., Haroon, N., Reveille, J. D., Learch, T. J., Brown, M. A., Weisman, M. H., Inman,
R. D. and Ward, M. M. (2013). Socioeconomic Status Predicts Radiographic Progression in
Ankylosing Spondylitis. In: Annual European Congress of Rheumatology EULAR 2013, Spain,
(533-533). 12–15 June 2013. doi:10.1136/annrheumdis-2013-eular.1595
Benham, Helen, Rehaume, Linda M., Hasnain, Sumaira Z., Velasco, Jared, Baillet, Athan C.,
Ruutu, Merja, Kikly, Kristine, Wang, Ran, Tseng, Hsu-Wen, Thomas, Gethin P., Brown,
Matthew A., Strutton, Geoffrey, McGuckin, Michael A. and Thomas, Ranjeny (2014)
Interleukin-23 mediates the intestinal response to microbial beta-glucan and the development of
spondyloarthritis pathology in SKG mice. Arthritis and Rheumatology, 66 7: 1755-1767.
doi:10.1002/art.38638
Lazarus, Syndia, McInerney-Leo, Aideen M., McKenzie, Fiona A., Baynam, Gareth, Broley,
Stephanie, Cavan, Barbra V., Munns, Craig F., Pruijs, Johannes Egbertus Hans, Sillence, David,
Terhal, Paulien A., Pryce, Karena, Brown, Matthew A., Zankl, Andreas, Thomas, Gethin and
Duncan, Emma L. (2014) The IFITM5 mutation c.-14C > T results in an elongated transcript
expressed in human bone; and causes varying phenotypic severity of osteogenesis imperfecta
type V. BMC Musculoskeletal Disorders, 15 107: 1-6. doi:10.1186/1471-2474-15-107
Pahau, Helen, Brown, Matthew A., Paul, Sanjoy, Thomas, Ranjeny and Videm, Vibeke (2014)
Cardiovascular disease is increased prior to onset of rheumatoid arthritis but not osteoarthritis:
the population-based Nord-Trøndelag health study (HUNT). Arthritis Research and Therapy,
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