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Psicothema ISSN: 0214-9915 [email protected] Universidad de Oviedo España Arregi, Amaia; Garmendia, Larraitz; Andrade, María Luisa; Sánchez Martín, José R.; Brain, Paul F. Potential effects of psychoactive drugs on primary immune responses to srbc in mice Psicothema, vol. 8, núm. 2, 1996, pp. 309-316 Universidad de Oviedo Oviedo, España Available in: http://www.redalyc.org/articulo.oa?id=72780206 Abstract The impact on primary hemagglutinin titres in response to a challenge with a suspension of sheep red blood cells of treating male and female mice with naloxone or chlordiazepoxide was assessed. Naloxone increased total antibody titres in females but reduced it in males. This mu antagonist increased mercaptoethanol-resistant hemagglutinin titres in both males and females, with males showing the greater increase. Chlordiazepoxide reduced both total and mercaptoethanol-resistant antibody titre in both males and females, males showed a more marked suppression. Interestingly, naloxone is anxiogenic and chlordiazepoxide anxiolytic. The data suggest that treatment with psychoactive drugs is likely to influence disease resistance in organisms, data reminiscent of repeated claims that psychological factors influence immunoresponsiveness. How to cite Complete issue More information about this article Journal's homepage in redalyc.org Scientific Information System Network of Scientific Journals from Latin America, the Caribbean, Spain and Portugal Non-profit academic project, developed under the open access initiative
