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References Alessio HM, Cao G, Cutler RG. Total antioxidant protection following Vit E and C
supplementation and submaximal exercise. Med Sci Sports Exerc 24: S16, 1992.
Alessio HM, Goldfarb AH. Cao G. Exercise~Induced oxidative stress before and after
Vitamin C Supplementation. Med Sci Sports Exerc 25: 208-214,1997.
Anderson R, Lukey PT. A biological role for ascorbate in the selective neutralization of
extracellular, phagocyte derived reactive oxidants. Ann NYAcad Sci 498: 219~247, 1987.
Anderson R, Oosthuizen R, Maritz R, Van Rensburg AJ. The effects of increasing weekly
doses of ascorbate on certain cellular and humoral immune functions in normal volunteers.
Am } Clin Nutr 33: 71~, 1980.
Anderson R, Smit MJ, Joone GK, Van Staden AM. Vitamin C and Cellular Immune
Functions: Protection against hypochlorous acid~mediated inactivation of glyceraldehyde-3~
phosphate dehydrogenase and ATP generation in human leukocytes as a possible
mechanism of ascorbate immunostimulation. Ann NY Acad Sci 587: 33~48, 1989.
Anderson R, Theron AJ. Effects of Ascorbate on Leukocytes. S Afr Med} 56: 394-9, 1979.
Anderson R, Van Antwerpen VL. Vitamins in the maintenance of optimum immune functions
and prevention of phagocyte-mediated tissue damage and carcinogenesis. Bibliotheca Nutrio
et Dieta 52: 66-74, 1995.
Anderson R. Mechanisms of Vitamin C-mediated anti-inflammatory and immunomodulatory
activity. Bibliotheca Nutrio et Dieta 55: 135-147,2001.
Anderson R. Phagocyte-derived oxidants as mediators of inflammation-associated damage. S
Afr} Sci 87: 594-596, 1991.
Anderson R. Ascorbate-mediated stimulation of neutrophil motility and lymphocyte
transformation by inhibition of the peroxidaseIH20jhalide system in vitro and in vivo. Am }
Cl Nutr 34: 1906-1911, 1981.
Anderson R. Effects of Ascorbate on Normal and Abnormal Leukocyte Functions. In Hanck
A. (ed). Vitamin C. New Clinical Applications in Immunology, Lipid Metabolism and Cancer.
Bern: Hans Huber Publishers, pp 23-52, 1982.
Anderson R. Phagocyte-derived oxidants as mediators of inflammation-associated damage.
S Afr} Sci 87: 594-596, 1991.
Anderson R. The activated neutrophil-formidable forces unleashed. S Aft Med} 85: 1024
1027,1995.
Ashton T, Young IS, Peters JR, Jones E, Ejackson SK., Davies B, Rowlands CC. Electron
spin resonance spectroscopy, exercise, and oxidative stress: an ascorbic acid intervention
study. } Appl Physiol 87: 2032-6, 1999.
Attwood EC, Robey ED, Ross H, Bradley F, Kramer n. Determination of platelet and
leukocyte vitamin C levels found in normal subjects. Clin Chim Acta 54: 95~ 105, 1974.
Azenabor AA, Hoffman-Goetz L. Intrathymic and intrasplenic oxidative stress mediates
thymocyte and splenocyte damage in acutely exercised mice. } Appi Physioi 86: 1823-7,
1999.
108 Babior BM. Oxidants from Phagocytes: agents of defence and destruction. Blood 64: 959
964, 1984.
Baggiolini M. Novel aspects of inflammation: Interleukin-8 and related chemotactic
cytokines. ClinicalInvestig 71: 812-814, 1993.
Barnes PJ, Adcock I. Anti-inflammatory actions of steroids: molecular mechanisms. Trends
Pharmacol Sci 14: 436-441, 1993.
Barnes PJ, Karin M. Nuclear factor kB
a pivotal transcription factor in chronic
inflammatory diseases. New Engl J Med 336: 1066-1071, 1997.
Adrenergic modulation of human
Bazzoni G, Dejana E, Del Mashcio A.
polymorphonuclear leukocyte activation. Potentiating effect of adenosine. Blood 77:
2042-2048, 1991.
Bendich A. Vitamins and Immunity. J Nutr 122: 601-3, 1992.
Bendich A, Machlin LJ, Scandura 0, Burton GW, Wayner DDM. The anti-oxidant role of
Vitamin C. Adv Free Rad Bioi Med 2: 419-44, 1986.
Bendich A, Cohen M. Ascorbic acid safety: analysis of factors affecting iron absorption.
Toxiol Lett 51: 189-201, 1990.
Benoni G, Bellavite P, Adami A, Chrumbolo S, Lippi G, Brocco G, Giulini GM, Cuzzolin
L. Changes in several neutrophil functions in basketball players before, during and after a
sports season: Int J Sports Med 16: 34-37, 1995.
Bergholm R, Makimattila S, Valkonen M, Liu ML, Lahdenpera S, Taskinen MR,
Malmberg P, Yki-Jarvininen H. Intense physical training decreases
Sovijarvi, A,
circulating antioxidants and endothelium-dependant vasodilation in vivo. Artheroscierosis,
145: 341-349, 1999.
Berglund B, Hemmingson P. Infectious disease in elite cross country skiers: a one-year
incidence study. Clin Sports Med 2: 19-23, 1990.
Bessel-Lorck C. Erkaeltungsprophylaxe bei Jugendlichen im Skilager (Common cold
prophylaxis in young people at a ski camp). Med Welt 44: 2126-2127, 1959.
Bieri JG, Tolliver TJ, Catignani GL. Simultaneous determination of retinol and a
tocopherol in serum and plasma by liquid chromatography. Clin Chem 29: 708-712, 1983.
Bijur GN, Briggs B, Hitchcock CL, Williams MV. Ascorbic acid-dehydroascorbate induces
cell cycle arrest at G21M DNA damage checkpoint during oxidative stress. Environ Mol
Mutagen 33: 144-52, 1999.
Blannin AK, Robson PJ, Walsh NP, Clark AM. Glennon L, Gleeson M. The effect of
exercising to exhaustion at different intensities on saliva immunoglobulin A, protein and
electrolyte secretion. 1m J Sports Med 19: 547-52, 1998.
Bloem, MW, Wedel M, Egger RJ, Speek AJ, Schrijer J, Saowakontha S, Scheurs W. Mild
Vitamin A deficiency and risk of upper respiratory tract disease and diarrhoea in pre-school
and school children in North Eastern Thai1and. Am J Epidemiol 131: 20332-339, 1990.
Borish, L. IL-I0: Evolving concepts. J Allergy Clin Immunol 101: 293-297, 1998.
Bowie AG, O'Neill LA. Vitamin C inhibits NF-kappa B activation by TNF via the activation
of p38 mitogen-activated protein kinase. J Immunol 165: 7180-8, 2000.
Brenner I, Shek, PN, Zamecnik J, Shepard RJ, Stress hormones and the immunological
responses to heat and exercise. Int J Sports Med 19: 130-143, 1998.
109 Child RB, Wilkinson OM, Fallowfield JL, Donnelly AB. Elevated serum antioxidant capacity
and plasma malondialdehyde concentration in response to a simulated half marathon run.
Med Sci Sports Exerc 11: 1603-1607, 1998.
Childs A, Jacobs C, Kaminski T, Halliwell B, Leeuwwenburgh C. Supplementation with
vitamin C and N-acetyl-cysteine increases oxidative stress in humans after an acute muscle
injury induced by eccentric exercise. Free Rad Bioi Med 31: 745-753, 2001.
Chojkier M, Houglum K, Solis-Herruzo J, Brenner DA. Stimulation of collagen gene
expression by ascorbic acid in cultured human fibroblasts. A role for lipid peroxidation?
J Bioi Chem 264: 16957-16962, 1989.
Chow CK, Arriess, GR, Changchit C. Increased vitamin E content in the lungs ofcigarette
smoked rats. Ann NY A cad Sci 570: 425-427, 1989.
Chretien JH, Garagusi VF. Correction of corticosteroid-induced defects ofpolymorhonuclear
neutrophil function by ascorbic acid J Reticuioendothei Soc 14: 280-286, 1973.
Clarkson PM, Nosaka K, Braun, B. Muscle function after exercise-induced muscle damage
and rapid adaptation. Med Sci Sports Exerc 24: 5112-520, 1992.
Clarkson PM, Thompson HS. Anti-oxidants: what role do they play in physical activity and
health? Am J Clin Nutr 72: 637S-46S, 2000.
Cooke MS, Evans MD, Podmore 10, Herbert KE, Mistry N, Mistry P, Hickenbotham PT,
Hussieni A, Griffiths HR, Lunec J. Novel repair action of vitamin C upon in vivo oxidative
DNA damage. FEBS Letters 439: 363-7, 1998.
Cooper DY, Rosendahl O. Action of noradrenaline and ascorbic acid on C-21 hydroxylation
of steroids by adrenocortical microsomes. Arch Biochem 96: 331-335, 1962
Coutsoudis A, Kiepiela P, Coovadia HM, Broughton M: Vitamin A supplementation enhances
specific IGA antibody levels and total lymphocyte numbers while improving morbitity in
measels. Paed Infect Dis J 11: 203-9, 1992.
Crary B, Hanser B, Boreseynco M, Kuts I, Hoban C, Ault KA, Weiner L, Benson H.
Epinephrine induced change in the distribution of lymphocyte subsets in humans. J Immuno
131: 1178-1181, 1983.
Cupps TR, Fauci AS. Corticosteroid-mediated immunoregulation in man. ImmunolOgical
Rev 65: 133-55,1982.
Curham GC, Willet WC, Speiser FE. Intake of vitamins B6 & C and the risk of kidney
stones on women. J Am Ass Nephrol 10: 840-5, 1999.
Davies KJA, Quintanilha AT, Brooks GA, Packer L. Free radicals and tissue damage
produced by exercise. Biochem Biophys Res Com 107: 1198-1205, 1987.
De la Fuente M, Fernandez MD, Buegos MS, Soler A, Prieto A, Miquel 1. Immune
function in aged women is improved by ingestion of vitamins C and E. Can J Physioi 76:
373-380, 1998.
De Waal MR, Abrams J, Bennett B, Figdor CG, de Vries JE. Interieukin-IO (IL-I0) inhibits
cytokine synthesis by human monocytes: an autoregulatory role of IL-I0 produced by
monocytes. J Exp Med 174: 1209-12120, 1991.
Dekkers, C, van Dooren LJP, Kemper HCG. The Role of Antioxidant Vitamins and
Enzymes in the Prevention of Exercise Induced Muscle Damage. Sports Med 21: 213-238,
1996.
111 Dhariwal K, Wasko P, Hartzell W, Levine M. Ascorbic acid within chromaffm granules. J
Bioi Chem 264: 15404-15409, 1989.
Dietrich M, Block G, Hudes M, Morrow JD, Norkus EP, Traber MG, Cross CE, Packer L.
Antioxidant supplementation decreases lipid peroxidation biomarker F(2)-isoprostanes in
plasma of smokers. Cancer Epidemiol Biomarkers Prev 11: 7-13, 2002.
Dill DB, Costill DL. Calculation of percentage changes of blood, plasma and red cells in
dehydration. J App Physioi 37: 247-248,1974.
Drenth JPH, Van Uum SHM, Van Deuren M, Pesman GJ, Van der Ven-Jongekrijg J, Van
der Meer JWM. Endurance run increases circulating IL-6 and IL-lra, but downregulates ex
vivo TNF-a and IL-lb production. J Appi Physioi 79: 1497-503, 1995.
Dufaux B, Order U. Plasma elastase, aI-antitrypsin, neopterin, tumour necrosis factor a ,
and soluble interleukin-2 receptor after prolonged exercise. Int J Sports Med 10: 434- 438,
1989.
Duthie GA, Maughan RJ, Morrice PC, Arthur RJ. Anti-oxidant adaptation to exercise. In:
Biochemistry of Exercise IX, Maughan RJ. Shirreffs SM( Eds): Champaign II: Human
Kinetics, pp 465-470, 1996.
Duthie GA, Robertson JD, Maughan, RJ, Morrice PC. Blood Anti-oxidant Status and
Eryhrocyte Lipid Peroxidation following distance running. Arch Biochem Biophys 282: 78
83, 1990.
Dwenger A, Funck M, Lueken B, Schweitzer G, Lehmann U. Effect of ascorbic acid on
neutrophil functions and hypoxanthine/xanthine oxidase-generated, oxygen-derived
radicals. EurJClin Chem Clin Biochem 30: 187-91, 1992.
Dziedziak W. The effect of incremental cycling on physiological functions of peripheral
blood granlocytes. BioI Spt 7: 239-247,1990.
Ehrhart-Bornstein M, Hinson JP, Borstein SR, Scherbaum WA, Vinson GP. Intra-adrenal
interactions in the regulation of adrenocortical steroidogenesis. Endocrine Rev 19: 101-143,
1998.
EI-Hag A, Clark RA. Down regulation of human natural killer cell activity against tumours
by the neutrophil myeloperoxidase system and hydrogen peroxide. J. Immunoi 133: 3291
8, 1984.
El-Hag A, Lipsky PE, Bennett M, Clark RA. Immunomodulation by neutrophil
myeloperoxidase and hydrogen peroxide; differential susceptibility of human lymphocyte
functions. J Immunol 136: 3320-6, 1986.
Enwonwu CO, Sawiris P, Chanaud N. Effect of marginal ascorbic acid deficiency on saliva
level ofcortisol in the guinea pig. Arch Orai Bioi 40: 737-42, ] 995.
Eskola J, Ruuskanen 0, Soppi E, Viljanen MK, Jarvinen M, Toivonen M, Kouvalainen K
Effect of sport stress on lymphocyte transformation and antibody formation. Clin & Experiml
Immunol 32: 339-345, 1978.
Evans R, Currie L, Campbell A. The distribution of ascorbic acid between various ceHular
components of blood in normal individuals, and its relation to the plasma concentration. Brit J
Nutr 47: 473, 1982.
Fahlman MM, Engels HJ, Morgan AL, Kolokouri I. Mucosal IgA resoponse to repeated
Wingate tests in Females. Int J Sports Med 22: 127-131,2001.
112 Farr A, Salman HK, Krautman BA, Gonzales LA, Macdonald A. Effect of high level
vitamin C dosage at 32 hours prior to slaughter on processing parameters of broiler
chickens. Poultry Sci 67 (suppl): 85 (abstr)
Farrell P, Garthwaite T, Gustafson A. Plasma adrenocorticotropin and cortisol responses to
submaximal and exhaustive exercise. J Appl Physiol 55: 1441-4, 1983.
Fishbaine B, Butterfield G. Ascorbic Acid Status of running and sedentary men In!. J Vit
Nutr Res 54: 273, 1984.
Frei B, Stocker R, Ames BN. Anti-oxidant defences and lipid peroxidation in human blood
plasma. Proc Natl Acad 85: 9748-9752, 1988.
Frei B, England L, Ames BN. Ascorbate is an outstanding anti-oxidant in human blood
plasma. Proc Nat. Acad Sci 85: 6377-6381, 1989.
Frei B. Reactive oxygen species and anti-oxidant vitamins: mechanisms of action. Am J
Med 97: 5S-13S, 1994.
Friden J. Muscle soreness after exercise: implications of morphological changes. Int J
Sports Med 5: 57-66, 1984.
Gabriel H, Kindermann W. The acute immune response to exercise; what does it mean? Int
J Sports Med 18: S28-41, 1997.
Gabriel H, Muller H-J, Kettler K, Brechttel L, Urhausen A, Kindermann W. Increased
phagocytic capacity of the blood, but decreased phagocytic activity per individual
circulating neutrophil after an ultradistance run. Eur J Appl Physio 71: 281-284, 1995.
Gabriel H, Muller HJ, Urhausen A, Kindermann W. Suppressed PMA-induced oxidative
burst and unimpaired phagocytosis of circulating granulocytes one week after a long
endurance run. Int J Sports Med 15: 441-445, 1994.
Galbo H. Hormonal and metabolic adaptation to exercise. George Thieme Verslag,
Stuttgart, 1983.
Garry PJ, Appenzeller O. Vitamins A and C and endurance races. Annal Sports Med 1:
82-84, 1983.
Gerster H. No contribution of ascorbic acid to renal calcium oxalate stones. Annal Nutr Mel
41: 269-82, 1997.
Gerster H. High dose vitamin C a risk for persons with high iron stores? Int J Vii Nutr Res 69:
67-82, 1999.
Glathaar BE, Romig DR, Moser U. The role of ascorbic acid in carcinogenesis. Adv Exper
Med & Bioi 206: 357-77, 1986.
Gleeson M, Maughan R (abstract). Acute effect of exercise on ascorbate content of plasma
and lymphocytes. Proc Nutr Sci 73: 501-505, 1987.
Gleeson M, McDonald W, Pyne DB, Cripps AW, Francis JL, Fricker PA, Clancy RL.
Salivary IgA levels and infection risk in elite swimmers. Med. Sci Sports Exerc 31: 67-73,
1999.
Gleeson M, McDonald WA, Cripps AW, Pyne DB, Clancy RL, Fricker PA, Exercise, stress,
and mucosal immunity of long term intensive training in elite swimmers, Clin Exp Immunol
102: 210-216, 1995.
Gleeson M, Walsh NP, Blannin AK, Robson PJ, Cook L, Donnelly AB, Day SH. The effect
of severe eccentric exercise -induced muscle damage on plasma elastase, glutamine and
zinc concentrations. Eur J Appl Physiol 77: 543- 546, 1998.
113 Gleeson M. Epstein-Barr Virus in Association with Respiratory Illness in Elite Athletes. In :
Rimmer J.S. & Katelaris C.H (eds). Proceedings of the XVII International Congress of
Allergology and Clinical Immunology, Hogrefe & Huber Publishers, Seattle, 2000c.
Gleeson M. Mucosal Immune Responses & Risk of Illness in Elite Athletes. Exerc Immunoi
Rev 6: 5-42, 2000b.
Gleeson M. Mucosal immunity and respiratory illness in elite athletes. Int J Sports Med 21:
S33-43, 2000a.
Gleeson, M, Robertson J, Maughan R. Influence of exercise on ascorbic acid status in
man. Clin Sci 73: 501-505, 1987.
Goldfarb AG. Antioxidants: role of supplementation to prevent exercise-induced oxidative
stress. Med Sci Sports Exerc 25: 232-236, 1992.
Goldfarb AH. Nutritional antioxidants as therapeutic and preventive modalities in exercise
induced muscle damage. Can J Appi Physioi 24: 249-66, 1999.
Goralczyk R, Moser UK, Matter U, Weiser H. Regulation of steroid hormone metabolism
requires L-ascorbic acid. Annal NY Acad Sci 669: 349-51, 1992.
Green HN, MedUanby E. Vitamin A as an anti-infective agent. BJM 2: 691-696, 1928
Green RL, Kaplan SS, Rabin BS, Stanitski CL, Zdziarski U, Immune Function in Marathon
Runners. Annal Allerg 47: 73-75, 1981.
Greenberger MJ, Strieter RM, Krunkel SL, Danforth JM, Goodman RE, Stadiford TJ.
Neutralisation of IL-l 0 increases survival in a murine model of Klebsiella pneumoniae. J
Immunol 155: 722-9, 1995.
Grimble RF.
Effect of anti oxidative vitamins on immune function with clinical
applications. IntJVitNutrRes 67: 312-320,1997.
Guyton AC. Textbook of Medical Physiology, Tenth Edition, WB Saunders Company,
2000.
Hadden JW, Hadden EM, Middelton E. Lymphocytye blast transformation: Demonstration
of adrenergic receptors in human peripheral lymphocytes. Cell Immunol 1: 583-595, 1970.
Hagerman FC, Hikida RS, Staron RS, Sherman WM, Costill DL. Muscle damage in
Marathon Runners. Phys Sports Med 12: 39-46, 1984.
Hagler I, Herman RH. Oxalate metabolism. Am J CI Nutr 26: 758-65, 1973.
Halliwell B. Vitamin C: anti-oxidant or pro-oxidant in vivo? Free Rad Res 25: 439-454,
1996.
Hallberg L. The role of vitamin C in improving the critical iron balance situation in women.
Int J ViI Nutr Res Supp 27: 177-187, 1985.
Hansen JB, Wilsgaard 1, Osterud B. Biphasic changes in leukocytes induced by strenuous
exercise. Eur J Appl Physiol 62: 157-161, 1991.
Hanson PG, Flaherty DK. Immunological responses to training in conditioned runners. Clin
Sc 60: 225-218, 1981.
Hayono M, Saba RI, Dorfman RI, Hechter O. Some aspects of the biogenesis of adrenal
hormones. Recent Prog Horm Res 12: 79-123, 1956.
Heath GW, Ford ES, Craven TE, Macera CA, Jackson KL, Pate RR. Exercise and the
incidence of upper respiratory tract infections. Med Sci Sports Exerc 23: 152-157, 1991.
114 Heath GW, Macera CA, Nieman DC. Exercise and upper respiratory tract infection: Is there a relationship? Sports Med 14: 353-356, 1992. Heiss F. Unfallverhutung beim Sport. Shomdorf, K Hoffman, pp 17-19, 1971. HemiUi H. Vitamin C and the common cold. Br J Nutr 65: 3-16, 1992. HemiUi H. Does Vitamin C alleviate the symptoms of the common cold? A review of the current evidence. ScandJ Infect Dis 26: ]-6,1994. HemiUi H. Vitamin C intake and susceptibility to the common cold. J Nutr 77: 59, 1997.
RemiU! H. Vitamin C and common cold incidence: a review of studies with subjects under heavy stress. Int J Sports Med 17: 379-384, 1996a. Hemila H. Vitamin C and Infectious Diseases. In Poaletti R., Sies. H., Bug., J., Grossi E., Poli., (eds) Vitamin C. The state of the art in disease prevention sixty years after the Nobel
Prize, Springer-Verslag. Italia, Milano, pp74, 1998. Hemi!a H. Vitamin C Supplementation and Common Cold Symptoms: Problems with Inaccurate Reviews. Nutr 12: 804-806, 1996. Hemi1a H. Vitamin C supplementation and common cold symptoms; factors affecting the magnitude ofthe benefit. Med Hypotheses 52:171-8, ] 999. HemiUi H. Douglas RM. Vitamin C and acute respiratory infections. Int J Tubercul Lung Dis 3: 756-61, 1999.
Herbaczynska-Cedro K, Wartanowicz M, Panczenko-Kresowska B, Cedro K, Klosiewicz
Wasek B, Wasek W. Inhibitory effect of vitamins C and E on the free radical production in
human polymorphonuclear leukocytes. Europ J CIin Invest 24: 316-9, 1994.
Herbaczynska-Cedro K. Supplementation with Vitamin C and E suppresses leucocyte oxygen
free radical production in patients with myocardial infarction. Eur Heart J 71: 245-9, 1995.
Herbert V. Viewpoint. Does mega- do more good than harm, or more harm than good? Nutr
Today, 29-32, JanlFeb 1993.
Herbert V. Pro-oxidant effects of anti-oxidant vitamins. Introduction. J Nutr 126: 1197
2000S, 19%.
Himmelstein SA, Robergs RA, Koehler KM, Lewis SL, Qualls CR. Vitamin C
supplementation and upper respiratory tract infections in marathon runners, JEPon line , 1(2),
1998.
Hornig D. Requirements of vitamin C in man. S Aft Med J 3: 294-296,1981.
Ho FM, Liu CS, Huang PJ, Shiah SG, Lin-Shiah SY. Nitric oxide prevents apoptosis of
human endothelial cells from high glucose exposure during early stage. J Cell Biochem 75:
258-63, 1999.
Horton JW, White DJ, Mass DL, Hybki DP, Hauddek S, Giroir B. Antioxidant vitamin
theraiypy alters burn trauma-mediated cardiac NF-kappaB activation and cardiomyocyte
cytokine secretion. J Trauma-Injury, Infect, CrU Care 50: 397-406,2001.
Hughes DA. Effects of dietary antioxidants on the immune function of middle-aged adults.
Proc Nutr Soc 58: 79-84, ] 999.
Hunt C, Chakaravorty NK, Annan G, Habibzadeh N, Schorah CJ. The clinical effects of
vitamin C supplementation in elderly hospitalized with acute respiratory infections. Int J Vit
Nutr Res 64: 202-209, 1994.
115 Klein M. A randomised, controlled trial of Vitamin A in children with severe measles. New
Engl J Med 323: 160-164, 1990.
Hurst TL, Bailey DM, Powell JR, Williams C. Immune function changes in downhill
running following ascorbic acid supplementation. (Abstract) Med Sci Sports Exerc, 2002,
in press.
Huupponen, MRH, Makinen LH, Sen CK, Rankinen T, Vaisanen S, Rauramao R. The effect
of N-Acetylcysteine on exercise induced priming of human neutrophils. A
Chemiluminescence Study. Int J Sports Med 416: 399-403, 1995.
Jacob RA, Burri BJ. Oxidative damage and defense. Am J Clin Nutr 63(suppl): 985S-90S,
1996.
Jacob RA, KeHey DS, Pianalto FS. Immunocompetence and oxidant defense during
ascorbate depletion of healthy men. Am J Clin Nutr 54 (suppl): 1302S-9S, 1991.
Janeway CA, Travers P. Immunobiology. The Immune System in Health and Disease (2nd
Edition). London. Current Biology Ltd. 1996.
Jariwalla RJ, Harakeh S. Antiviral and immunomodulatory activities of ascorbic acid. Subcell
Biochem 25: 215-231,1996.
Jenkins J. The effect of ascorbic acid on adrenal stroid synthesis in vitro. Endocrinol 70:
267-271, 1962.
Jonas E, Dwenger A, Hager A. In vitro effect of ascorbic acid on neutrophil-endothelial cell
interaction. J Biolumin Chemilumin 8: 15-20, 1993.
Jones RB, Satterlee DG, Cadd GG. Timidity in Japanese quail: Effects of vitamin C and
divergent selection for adrenocortical response. PhYSiology & Behaviour 67: 117-120,
1999.
Kanter M, Nolte L, Holloszky 1. Effects of an anti-oxidant vitamin mixture on lipid
peroxidation at rest and post-exercise. J Appl Physiol 74: 965-969, 1993.
Kappel M, Hansen MB, Diamant JOL, Jergensen A, Gyhrs A, Pedersen BK. Effects of an
acute bolus growth hormone infusion on the human immune system. Horm Metabol Res
25: 579-585, 1993.
Katayama T, Momota Y, Watanaba Y, Kato N. Elevated concentrations of a-tocophero~
ascorbic acid and serum lipids in rats fed polychlorinated biphenyls, chlorobutanol, or
phenobarbitaL J Nutr Biochem 2: 92-96, 1991.
Kato, N, Momota Y, Kusuhara T. Changes in distribution of a-tocopherol and cholesterol
in serum lipoproteins and tissues of rats by dietary PCB and dietary level of protein. J Nutr
Sci Vitaminol 35: 655-660, 1989.
Kawai Y, Iwane H, Takanami Y, Shimomitsu T, Katsumura T. Evaluation of anti-oxidant
capacity of serum after strenuous endurance exercise. Med Sci Sports 28(5) suppl
(abstract): 541, 1996.
Keast D, Arnstein D, Harper W, Fry RW, Morton AR, Depression of plasma glutamine
concentration after exercise stress and its possible influence on the immune system. Med J
Aust 162: 15-18, 1995.
Keast D, Cameron K, Morton AR. Exercise and the Immune response. Sports Med 5: 248
267, 1988.
Kehrer JP. Free radicals as mediators of tissue injury and disease. Crit Rev Toxiol 23: 20
48, 1993.
116 Kimbarowski JA, Mokrow NJ. Coloured precipitation reaction of the urine according to
Kimbarowski (FARK) as an index of the effect of ascorbic acid during treatment of viral
influenza [Fabige Ausfullungsreaktion des Hams nach Kimbarowski (F ARK), als Index der
Wirkung von Ascorbinsaure bei Behandlung der Virusgrippe] Deutsche Gesundheitswesen.
22(Sl): 2413-8, 1967.
Kitabchi AE. Ascorbic Acid in steroidgenesis. Nature 215: 138S-1386, 1967.
Kodama M, Kodama T, Murakami M, Kodama M. Vitamin C infusion treatment enhances
cortisol production ofthe adrenal via the pituitary ACTH route. In Vivo 8: 1079-8S, 1994.
Kodama M, Inoue F, Kodama T, Kodama M. Intraperitoneal administration of ascorbic
acid delays turn-over of 3H-Iabelled cortisol in the plasma of an ODS rat, but not in the
Wistar rat. Evidence in support of the cardinal role of vitamin C in the progression of
glucocorticoid synthesis. In Vivo 10: 97-102, 1996.
Kolb E. Some recent discoveries of metabolism and function of ascorbic acid (Review). Z
Gesamte Inn Med 45: 20S-10, 1990.
Konig D, Grathwwohl D, Weinstock C, Northoff H, Berg A. Upper respiratory tract
infections in athletes: Influence of lifestyle, type of sport, training effects and
immunostimulant intake. Exerc Immunol Rev 6: 102-120, 2000.
Konig D, Wagner C-H, Elmadfa I, Berg A. Exercise and Oxidative Stress: Significance of
Antioxidants with reference to inflammatory, muscular and systemic stress. Exerc Immunol
Rev 7: 108-133,2001.
Koz M, Erbas D, Bilgihan A, Aricioglu A. Effects of acute swimming exercise on muscle
and erythrocyte malondialdehyde, serum myoglobin and plasma ascorbic acid
concentrations. Can J Physiol Pharmacol 70: 1392 - 139S, 1992.
Krause R, Patruta S, Daxbock F, Fladerer P, Biegelmayer C, Wewnisc A. Effect of vitamin
C on neutrophil function after high intensity exercise. EurJ Clin Invest 31: 258-63,2001.
Lambert MI, Dennis SC. Delayed Onset Muscle Soreness: SA J Sports Med 1:18-20, 1994.
Laney PH, Levy JA, Kipp DE. Plasma cortisol and adrenal ascorbic acid levels after ACTH
treatment with a high intake of ascorbic acid in the guinea pig. Ann Nutr Metab 34: 85-92,
1990.
Lee WL, Downey GP. Leukocyte elastase: physiological functions and role in acute lung
injury. Am J Resp Crit Care Med 164: 896-904, 2001.
Lehr HA, Frei B, Arfors KE. Vitamin C prevents cigarette smoke-induced leukocyte
aggregation and adhesion to endothelium in vivo. hoc Natl Acad Sci USA 91: 7688-7699,
1994.
Levine M, Duruvala C, Park JP, Rumsey SC, Wang Y. Does vitamin C have a pro-oxidant
effect? Nature 395: 231, Sept 1998.
Levine M. New concepts in the biology and biochemistry of ascorbic acid. N Eng J Med
314: 892-901, 1986.
Levine M, Asher A, Pollqrd H, Zinder O. Ascorbic acid and catelcholamine secretion from
cultured chromaffin cells. J Bioi Chem 258: 1311-S.1983
Lewicki R, Tchorzewski H, Denys A, Kowalska M, Golinska A. Effects of Physical
Exercise some parameters of immunity in conditioned sportsmen. Int J Sports Med 8: 309
314,1987.
117 Liakakos D, Douglas D, Ikkos C, Anoussakis C, Vlachos P, Jouramani G. Inhibitory effect
of ascorbic acid (vitamin C) on cortisol secretion following adrenal stimulation in children.
Clin Chim Acta 65: 251-255, 1975.
Liesen H, Kleiter K, Muucke S, Order U, Widenmayer W, Riedel H. Leukozyten und
Lymphozyten Subpopulationen bei den Spielen der Feldhockeynationalmanschaft wahrend
der Olympiavorbereitung. Dtsch Z Sportsmed 40: 41-52, 1988.
Lindzey J, Korach K. Steroid Hormones. In Endocrinology: basic and clinical principles, P
Com (ed). Totowa, NY Human Press, pp 49-60, 1997.
Lipscomb HS, Nelson DR. Dynamic changes in ascorbic acid and corticosteroids in adrenal
vein blood after ACTH. Endocrinol 66: 1441476, 1960.
Liu ML, Bergholm R, Kimattila S, Lahdenperii S, Valkonen M, Hilden H, Yki-Jarvininen
H, Taskinen MR. A marathon run increases the susceptibility of LDL to oxidation in vitro
and modifies plasma antioxidants. Am JPhysiol 276: El083-El091, 1999.
Lloberas N, Torras J, Herrero-Fresneda I, Cruzado JM, Riera M, Hurtado I, Griny6 JM
FASEB J, 10: 1096,2002.
MacArthy DA, Dale MM. The leucocytosis of exercise-a review and model. Sports Med 6:
333-363, 1988.
Machlin LJ, Bendich A. Free radical tissue damage: protective role of anti-oxidant nutrients
FASEB J 1: 441-445, 1985.
MacKinnon LT, Chick TW, Van As A, Tomasi TB. Decreased secretory immunoblobulins
following intense endurance exercise. Sports Train Med Rehab 1: 209-218,1989.
MacKinnon LT, Ginn E, Seymour GJ. Decreased salivary immunoglobin A secretion rate
after intense interval exercise in elite kayakers. Eur J Applied Physioi 67: 180-184, 1993a.
MacKinnon LT, Ginn E, Seymour GJ. Temporal relationship between exercise-induced
decreases in salivary IgA and subsequent appearance of upper respiratory tract infection in
elite athletes. Aust J Sc Med Sports 25: 94-99, 1993b.
MacKinnon LT, Hooper S. Mucosal (Secretory) Immune System responses to exercise of
varying intensity and during overtraining. Int J Sports Med 15: S 179-183, 1994.
MacKinnon LT, Jenkins DJ. Decreased salivary immunoglobin A after intense interval
exercise before and after training. Med Sci Sports Exerc 25: 678·683, 1993.
MacKinnon LT. Advances in Exercise Immunology. Human Kinetics, Champaign, 1999.
MacKinnon LT. Current challenges and future expectations in Exercise Immunology: back
to the future. Med Sci Sports Exerc 26: 191- 194, 1994.
MacKinnon LT. Exercise and Natural Killer Cells. What is the relationship? Sports Med 7:
141-149, 1989.
Maderasco EG, Woronick CL, Hickingbotham N, Jacobs L, Bhagavan H. A randomized
trial of replacement anti-oxidant vitamin therapy for neutrophil locomotory dysfunction in
blunt trauma. J Trauma 31: 1142-1150, 1991.
Mandrup-Paulsen T, Nerup J, Reimers JI, Pociot F, Andersen HU, Karlsen A, Bjerre U,
Bergholdt R. Cytokines and the endocrine system. I. The immuneendocrine network. Eur J
Endocrinol 133: 660-670, 1995.
Malo C, Wilson JX. Glucose modulates vitamin C transport in adult human small instestinal
brush border vesicles. J Nutr 130: 63-9, 2000.
118 Mars M, Govender S, Weston A, Naidoo V, Chuturgoon A. High intensity exercise: a cause
of lymphocyte apoptosis? Biochem Biophys Res Com 249: 366-370, 1998.
Marx C, Ehrhart-Bornstein M, Scherbaum WA, Bomstein SR. Regulation of adrenocortical
function by cytokines- relevance for immune-endocrine interaction. Horm Metab Res 30:
41' 6-420, 1998.
Maxwell SRJ, Jekeman P, Thomason H. Changes in plasma antioxidant status during
eccentric exercise and the effect of vitamin supplementation. Free Radical Research Commun
19: 191-202, 1993.
McKee JS, Harrison PC, Riskowski GL. Effects of supplemental ascorbic acid on the
energy conversion of broiler chicks during heat stress and feed withdrawal. Poulty Sci 76:
1278-86, 1997.
Mink KA, Dick EC, Jennings LC, Inhorn SL. Amelioration of rhinovirus colds by vitamin C
supplementation. Proc Int Symp Med Virology, Anaheim, California, 1987.
Moffat AC, Patterson DA, Currey S, Owen P. Inhibition in vitro of cyclic 3'5'nuc1eotide
phospodiesterase activity by drugs. Eur J Toxicol 5: 160-162, 1972.
Moolla ME. The effect of supplemental anti-oxidants on the incidence and severity of
upper respiratory tract infections in ultra-marathon runners. Unpublished M Phil
dissertation, University of Cape Town, 1996.
Moore AR, WiHoughby DA. The role of cAMP regulation in controlling inflammation.
Clin Exp Immunol 101: 387-389, 1995.
Moorthy AV, Zimmerman SW. Human leukocyte responses to an endurance run. Eur J
App/ Physio/ 38: 271-276, 1978.
Moser U, Bendich A. Vitamin C. In: Handbook of Vitamins (2nd edition). Machlin LJ (ed).
Marcel Dekker Inc. pp 198-232, 1991.
Moser U, Weber F. Uptake ofascorbic acid by human granulocytes.Int J Vit Nutr. Res. 54:
47-53, 1984.
Moser UK. Physiology and metabolism of ascorbic acid. In: Wenk C, Fenster R, VOlker L
(eds): Ascorbic Acid in Domestic Animals: Proceedings of the Shecond Symposium,
Base~ F. Hoffmann-La Roche, 3-16, 1992.
Moser U. Uptake of ascorbic acid by leukocytes. Ann NYAcad Sc 498: 200-15, 1987.
Moshage H. Cytokines and the hepatic acute phase response. J Pathol 181: 257-166, 1997.
Mukaida N, Matsumoto T, Yokoi K, Harada A, Matsushima K. Inhibition of neutrophil
mediated acute inflammation injury by an anti-body against interleukin-8 (IL-8). Inflam Res
47: 151-7, 1998.
Muns G. Effect of long distance running on polymorphonuclear neutrophil function of the
upper airways. Int J Sports Med 15: 96-99, 1993.
Muns GI, Rubinstein I, Singer P. Neutrophil chemotactic activity is increased in nasal
secretions oflong distance runners. Int J Sports Med 171: 56-59, 1996.
Nagatomi R, Kaifu T, Okutsu M, Zhang X, Kanemi 0, Ohmori H. Modulation of the
immune system by the Autonomic Nervous System and its implications in immunonological
changes after training. Exerc Immun Rev 6: 54-74, 2000.
Nathan N, Vandoux JC, Feiss P: Role of Vitamin C on adreno-cortical effects of etomidate
(French). Annales Francaises de Anesthesie et de Reanimation 10: 329-32, 1991.
119 Nehlsen-Cannarella SL, Fagoaga OR, Nieman DC, Henson DA, Butterworth DE, Schmidt
RL., Bailey EM., Warren BJ., Utter A, Davis JM. Carbohydrate and the cytokine response
to 2.5 hours ofrunning. J Appl Physiol 82: 1662-7, 1997.
Nelson-Cannarella SL, Nieman DC, Balk-Lamberton AJ, Markoff PA, Chritton DB,
Gusewitch G, Lee JW. The effects of moderate exercise training on immune response, Med
Sci Sports Exerc 23: 64, 1991.
Nielsen HB, Secher NH, Christensen NJ, Pedersen BK, Lymphocytes and NK cel] activity
during repeated bouts of maximal exercise. Am J Physiol 271 (Regulatory Integrative
comparative Physiology, 40): R 222-R227, 1996a.
Nielsen, HB, Secher NH, Kappel M, Hanel B, Pedersen BK. Lymphocyte, NK and LAK
Cell Responses to Maximal Exercise. Int J Sports Med 17: 60-65, 1996b.
Nieman DC, Berk LS, Simpson-Westerberg M, Arabatzis K, Youngberg S, Tan SA, Lee
JW, Eby WC. Effects of Long- Endurance Running on Immune System Parameters and
Lymphocyte in Experienced Marathoners. Int J Sports Med 10: 317-323, 1989b.
Nieman DC, Henson DA, Butterworth DE, Warren BJ, Davis JM, Fagoaga OR, Nelson
Cannarella SL. Vitamin C supplementation does not alter the immune response to 2.5 hours of
running. Int J Sports Nutr 7: 173-84, 1997.
Nieman DC, Henson DA, Gusewitch G, Warren BJ, Dotson RC, Butterworth DE, Nelson
CannareUa SA. Physical activity and immune function in elderly women. Med Sc Sports
Exerc 25: 823-831, 1993.
Nieman DC, Henson DA, McAnulty SR, McAnulty L, Swick NS, Utter AC, Vinci DM,
Opiela SJ, Morrow JD. Influence of vitamin C supplementation on oxidative and immune
changes after an ultramarathon. J Appl Physiol 92: 1970-77, 2002.
Nieman DC, Johansen LM, Lee JW, Arabatzis K. Infectious episodes in runners before and
after the Los Angeles Marathon. J Sports Med Phys Fitness 30: 316, 1990a.
Nieman DC, Johansen LM, Lee JW. Infectious episodes in runners before and after a road
race. J Sports Med Phys Fitness 30: 289-294, 1989a.
Nieman DC, Miller AR, Henson DA, Warren BJ, Gusewitch G, Johnson RL, Davis JM,
Butterworth DE, Herring JL, Nelson Cannarella SL. Effect of high- versus moderate
intensity exercise on lymphocyte sUbpopulations and proliferative response. Int J Sports
Med 15: 199-212, 1994.
Nieman DC, Nehlsen-Cannarella SL, Donohue KM, Chritton DB, Haddock BL, Stout RW,
Lee JW. The effects of acute moderate exercise on leukocyte and lymphocyte
sUbpopulations. Med Sci Sports Exerc 23: 578-586, 1991.
Nieman DC, Nehlsen-Cannarella SL, Fagoaga OR, Henson DA, Utter A, Davis JH.,
Williams F., Butterworth DE. Influence of mode and carbohydrate on the cytokine response
to heavy exertion. Med Sci Sports Exerc 30: 671-8, 1998.
Nieman DC, Nehlsen-Cannarella SL, Henson DA, Warren BJ. Granulocyte monocyte
phagocytosis, but not oxidative burst is increased after 2.5h of running (Abstract). Med. Sci.
Sports Exerc.(Suppl) 28: 191- 194, 1996.
Nieman DC, Nehlsen-Cannarella SL, Markoff PA, Balk-Lamberton H, Yang H, Chritton
DBW, Lee JW, Arabatzis K. The effects of moderate exercise training on natural killer
cells and upper respiratory tract infections. Int J Sports Med 11: 467-473, 1990b.
Nieman DC, Pedersen BK. Exercise and Immune function. Recent developments. Sports
Med 27: 73-80, 1999.
120 Nieman DC, Peters, EM, Henson DA, Nevines EI, Thompson MM. Influence of Vitamin C
supplementation on cytokine changes following an ultramarathon. J Interferon & Cytokine
Res 20 (11): 1029-35,2000.
Nieman DC, Simandle S, Henson DA, Warren BI, Suttles 1, Davis 1M, Buckley KS, Able
IC, Butterworth DE, Fagoago OR, Nelson-Cannarella SL. Lymphocyte Proliferate
Response to 2.5 hours of Running Int J Sports Med 16: 404408, 1995.
Nieman DC, Tan SA, Lee JW, Berk LS. Complement and immunoglobin levels in athletes
and sedentary controls. Int J Sports Med 10: 124, 1989c.
Nieman DC. Carbohydrates and the Immune Response to prolonged Exertion. In:
Nieman D.C., Pederson BK (eds): Nutrition and exercise Immunology, CRC Press,
Florida, 2000.
Nieman DC. Exercise, Infection and Immunity. Int J Sports Med 15: S 131-9, 1995.
Nieman DC. Exercise, upper respiratory infections and the immune system. Med Sci Sports
Exerc 26: 128, 1994. Nieman DC. Physical Activity, fitness and infection, in Exercise and Health; a concensus of Current Knowledge~ Bouchard, C., Ed., Human Kinetics Publishers, Champaign, 1993. Northhof HC, Wienstock A, Berg A. The cytokine response to strenuous exercise. Int J Sports Med 15: S167-171. 1994. Nussdorfer GG, Mazzochi G. Immune-endocrine interactions in the mammalian adrenal
gland: facts and hypotheses. Int Rev Cytol 183: 143-184, 1998. Odumosu A. Ascorbic Acid and cortisol metabolism in hypovitaminosis C in guineapigs Int J Vit Nutr Res 52: 176-85, 1982. Ohno H, Oh-ishi S, Ookawara T, Kizaki T, Miyazaki H, Haga S, Nakao C, Sato Y, Radak,
Z: Physical exercise and superoxide dismutases. Medicina Sportiva 2: 219-229, 1998.
Orr CWM. Studies on ascorbic acid. I. Factors influencing the ascorbate-mediated
inhibition ofcatalase. Biochem 6: 2295- 3000, 1967.
Ortega E, Collazos ME, Maynar M, Barriga C, De la Fuente M. Stimulation of the
phagocytic function of neutrophiJs in sedentary men after acute moderate exercise. Eur 1.
Appl Physiol 66: 60-64, 1993.
Osterback L, Qvamberg Y. A Prospective Study of Respiratory Infections in 12-year-old
children actively engaged in Sports. Acta Physioi Scand 76: 944, 1987.
Ostrowski K, Herman C, Bangash A, Scherling P, Nielsen IN, Pedersen BK. A trauma-like
elevation of plasma cytokines in humans in response to treadmill running. J Physioi 513:
889-94, 1998a.
Ostrowski K, Rohde T, Asp S, Schjerling P, Pedersen BK. The cytokine balance and
strenuous exercise: TNF-a., IL-lf3, IL-6, IL-lra, sTNF-r2 and IL-tO. J Physioi (London)
515:287-291,1999.
Ostrowski K, Rohde T, Zacho M, Asp S, Pedersen BK. Evidence that interleukin-6 is
produced in human skeletal muscle during prolonged running. J Physiol (Lond) 508:
949-53, 1998b.
Ostrowski K, Rohde T, Asp S, Schjerling P, Pedersen BK. Chemokines are elevated in
plasma after strenuous exercise in humans. Eur J Appi Physioi 84: 244-5, 2001.
121 Otsuka M, Matsuzawa M, Ha TY, Arakawa N. Contribution of a high dose of L-ascorbic
acid to carnitine synthesis in guinea pigs fed high fat diets. J Nutr Sci Vitamlnol 45: 163
171, 1999.
Packer L. Oxidants, antioxidant nutrients and the athlete. J Sports Sci 15: 353-363, 1997.
Packer L. Oxygen radicals and anti-oxidants in endurance exercise, in Benzi G., Packer L.,
Silliprandi N. (eds). Biochemical Aspects of physical exercise. Elserivier, Amsterdam,
1986.
Padh H. Cellular functions of ascorbic acid. Biochem Cell Bioi 68: 1166-73, 1990.
Pardue SL, Thaxton JP. Ascorbic acid and physiological stress. In Wegger I, Tagwerker FJ,
Moustgaard J (eds). Proceedings of Workshop on Ascorbic Acid in Domestic Animals,
Copenhagen: The Royal Danish Agriculture Society, 25-31, 1984a.
Pardue SL, Thaxton JP. Evidence for amelioration of steroid-mediated immunosuppression
by ascorbic acid. Poultry Sci 63: 1262-1268, 1984b.
Pardue SL, Thaxton JP, Brake J Role of ascorbic acid exposed to high environmental
temperature. J Appl Phys 58: 1511-6. 1985a.
Pardue SL, Thaxton JP, Brake J Influence of supplemental ascorbic acid on broiler
performance following exposure to high environmental temperature. Poultry Sci 64: 1334
8, 1985b.
P~th G, Bornstein SR, Ehrhart-Bohrnstein M, Scherbaum W A. Interleukin 6 and Interleukin-6
receptor in the Human Adrenal Gland: Expression and effects on Steroidgenesis. J Cl End
Met 82: 23443-2349, 1997.
Pauling L. The significance of the evidence about ascorbic acid and the common cold. Proc
Nat Acad Sci 68: 2678, 1971.
Pedersen BK, Bruunsgaard H, Klokker M, Kappel M, MacLean DA, Nielsen HB, Rohde T,
Ullum H, Zacho M. Exercise induced immunomodulation-possible roles of neuroendocrine
and metabolic factors. Int J Sports Med 18 (Suppl): S2-7, 1997.
Pedersen BK, Bruunsgaard H, Ostowski K, Krabbe K, Hansen H, Krzywkowski K. Toft A,
Sondergaard SR, Petersen EW. Ibfelt T, Schjerling P. Cytokines in Aging and Exercise. Int.
J Sports Med 21: S4-S9, 2000.
Pedersen BK, Ostowski K, Rohde T, Bruunsgaard H. The cytokine response to strenuous
exercise. Can J Physiol Pharm 76: 505-11, 1998b.
Pedersen BK, Tvede N. Christensen LD. Klarlund K. Kragbag S, Halkaejr-Kristenen J.
Natural killer cell activity in peripheral blood of trained and untrained persons. In! J Sports
Med 10: 129-131, 1989.
Pedersen BK, Ullum H. N K Response to Physical Activity: possible mechanisms of action.
Med Sci Sports Exerc 26: 140, 1994.
Pederson BK, Tvede N, Klarlund K, Christensen LD, Hanse F R, Galbo H, Kharazmi A,
Halkjer-Kristenen 1. Indomethacin in vitro and in vivo abolishes post-exercise suppression
of natural killer cell activity in peripheral blood. Int J Sports Med 11: 127-132, 1990.
Pederson BK. Rohde T. Ostowski K. Recovery of the Immune System after exercise. Acta
Physiologlca Scand 162: 325-332, 1998a.
Pederson EW, Ostowski K, Ibfedt T, Richelle M, Offord E, Halkjer-Kristenen J, Pederson
BK Effect of vitamin supplementation on cytokine response and on muscle damage after
strenuous exercise. Am J Phylol Cell Physiol 289: 1570-5,2001.
122 Peters EM, Anderson R, Nieman DC, Fickl H, Jogessar V. Vitamin C supplementation
attenuates the increase in circulating cortisol, adrenaline and anti-inflammatory polypeptides
following ultramarathon running. Int J Sports Med 22: 537-543, 2001b.
Peters EM, Anderson R, Theron AJ. Attenuation of the increase in circulating cortisol and
enhancement of the acute phase response in vitamin C-supplemented ultramarathon runners.
Int J Sports Med 22: 120-126, 2001a.
Peters EM, Bateman ED. Ultramarathon running and upper respiratory tract infections. S
64: 582-584, 1983.
Aft Med J
Peters EM, Campbell A, Pawley L. Vitamin A fails to increase resistance to upper
respiratory infection in distance runners. S Aft J Sports Med 7: 3-7, 1992.
Peters EM, Goetzsche 1M, Grobbelaar B, Noakes TO. Vitamin C supplementation reduces
the incidence of post-race symptoms of upper respiratory tract infection in ultradistance
runners. Am J Cl Nutr 57: 170, 1993.
Peters EM, Goetzsche JM, Joseph LE, Noakes TO. Vitamin C as effective as combinations
of anti-oxidant nutrients in reducing the incidence of upper respiratory tract infections in
ultradistance runners. S Aft J Sports Med 4: 23-27, 1996.
Peters EM. Exercise, immunology and upper respiratory tract infections. Int J Sports Med
18: S69, 1997.
Peters EM. Altitude fails to increase susceptibility of ultramarathon runners to upper
respiratory tract infections. S Aft J Sports Med 5: 4-8, 1990.
Peters EM. Anti-oxidant nutrient supplementation and prolonged exercise. The Leech 62(2),
1993.
Peters EM. Exercise induced toxicity...is anti-oxidant supplementation the answer?
Micronutrients, May, 1996.
Peters-Futre EM. Exercise, Vitamin C and Phagocyte Function. The Missing Link. Exerc
Immunol Rev 3: 32-52, 1997.
Petrova IV, Kuzmin SN, Kurashakova TS, Suzdailnitskii RS, Perskin BB. Neutrophil
phagocytic activity and the humeral factors of local immunity under intensive physical
loading. Zhurnal Mikrobiologii Epidermiologii Immunobiologii 12: 53-57, 1983.
Pettipher ER, Labasi, 1M, Salter ED, Stam E1, Cheng JB, Griffiths RJ. Regulation of
tumour necrosis factor production by adrenal hormones in vivo: insights into the anti
inflammatory activity ofrolipram. Brit J Pharmacol 117: 1530-1534, 1996.
Pincemail1. Camus G, Roesgen A, Dreezen E, Bertrand Y, Lismonde M, Deby-Dupont,
C. Deby C. Exercise induces pentane production and neutrophil activation in humans.
Effects ofpropanolol. Europ J Appl Physiol 61: 319- 322, 1990.
Pitt H A, Costrini A. M. Vitamin C prophylaxis in marine recruits. JAMA 241: 908-911,
1979.
Pizza FX, Cavender 0, Stockard A, Baylies H, Beighle A. Anti-inflammatory doses of
ibuprofen: effect on neutrophils and exercise induced muscle injury. Int J Sports Med 20:
98-102, 1999.
Pizza FX, Flynn MG, Boone JB, Rodriguez-Zayas JR, Andres FF. Serum haptoglobin and
ferritin during a competitive running and swimming season. Int J Sports Med 18: 233-7,
1997.
123 Pizza FX, Mitchell JB, Davis BH, Starling RD, Holtz RW, Bigelow N. Eexercise-induced
muscle damage: effect on circulating leukocyte and lymphocyte subsets. Med Sci Sports
Exerc 27: 363-70, 1995.
Playfair JHL. Immunology at a Glance. Blackwell Scientific Publications, Oxford, 1979.
Podmore ID, Grriffiths HR, Herbert KE, Minstry N,
J. Pro-oxidant effect of Vitamin. Nature 392: 559, April 9, 1998.
Minstry
P,
Lunec
Poulsen HE, Weiman A, Salonen KN, Loft S, Cadet J, Douki T, Ravanat JL. Does Vitamin
C have a pro-oxidant effect? Nature 395: 231, September, 1998.
Pyne DB, Baker MS, PA Fricker, McDonald W A, Telford RD, Weideman MJ. Effects of
an intensive 12 wk training program by elite swimmers on neutrophil oxidative activity.
Med Sci Sports Exerc 27: 536-542, 1995.
Pyne DB, Baker MS, Telford RD, Weideman MJ. Neutrophil oxidative activity is
differentially effected by moderate and intense interval exercise. Med Sci Sports Exerc 25:
SI02,1993.
Pyne DB, Gleeson M, Effects of intensive exercise training on immunity in athletes. Int J
Sports Med 19 (Supp3): S 183, 1998.
Pyne DB, McDonald WA, Gleeson M, Flanagan A, Clancy RL, Fricker P A. Mucosal
Immunity, respiratory illness, and competitive performance in elite swimmers. Med Sci
Sports Exerc 33(3): 348-53, 2000.
Pyne DB. Regulation of neutrophil function during exercise. Sports Med 17: 245-58, 1994.
Rahman I, MacNee W. Role of transcription factors in inflammatory lung diseases. Thorax
53: 601-612, 1998.
Redmann A, Mobius K, Hiller HH, Oelkers W, Bahr V. Ascorbate depletion prevents
aldosterone stimulation by sodium deficiency in the guinea pig. Eur J Endocrinol 133:
499-506, 1995.
Reid MR, Drummond PO, MacKinnon LT. The effect of moderate aerobic exercise and
relaxation on secretory Immunoglobulin A. Int J Sports Med 22: 132-137,2001.
Ritzel G. Critical analysis of the role of Vitamin C in the prophylaxis and treatment of the
common cold (In German) Helvetica Medica Acta 28: 63-68, 1961.
Ritzel G. Ascorbic acid and the common cold (letter) JAMA 235:1108, 1976.
Robertson JD, Maughan RJ, Duthie GG, Morrice PC. Increased blood antioxidant systems
of runners in response to training load. Clin Sc 80: 611-618, 1991.
Rivers, JM. Safety of high level vitamin C ingestion. Ann NY Acad Sci 498: 445-454, 1987.
Robson PJ, Blannin AK, Walsh NP, Castell LM, Gleeson M. Effects of exercise intensity,
duration and recovery on in vitro neutrophil function in male athletes. Int J Sports Med 20:
128-35, 1999.
Rodriquez AB, Barriga C, de LaFuente M. Phagocytic function of blood neutrophils in
sedentary young people after physical exercise. Int J Sports Med 12: 276-280, 1991.
Rokitzki L, Hinkel S, Klemp C, Cufi 0, Keul J. Dietary, serum and urine ascorbic acid
status in male athletes. Int J Sports Med 15: 435-440, 1994a.
Rokitzki L, Logeman E, Sagredos AN, Murphy M, Wetzel-Roth W, Keul J: Lipid
peroxidation and antioxidant vitamins under extreme endurance stress. Acta Physio/ Scand
151: 149-58, 1994b.
124 Ryan AJ, Darymple W, Dull BH, Kaden W, Lerman SJ. Round Table, upper respiratory
tract infections in sports. Phys Sports Med 3: 29, 1975.
Sabiston BH, Radomski MW. Health problems and vitamin C in Canadian Northern Military
Operations. DCIEM Report NO 74-R-I012. Downsvew, Ontario, Defence Research Board,
1974.
Sagone AL, Kamps S, Campbell R. Photochem Photobiol 28: 909-915, 1987.
Salonen JT, Nyyssonen K, Korpela H, Tuomilehto J, Seppanen R, Salonen R. High stored
iron levels are associated with excess risk of myocardial infarction in Eastern Finnish men.
Circulation 2: 803, 1992.
Sanchez-Quesada JL, Jorba 0, Payes A, Otal C, Serra-Grima R, Gonzalez-Sastre F,
Ordonez-Llanos J. Ascorbic acid inhibits the increase in low-density lipoprotein (LDL)
susceptibility to oxidation and the proportion of electronegative LDL induced by intense
aerobic exercise. Coron Artery Dis 9: 249-55, 1998.
Satterlee 00, Aquilera-Quintana I, Munn BJ, Krautrnann BA. Vitamin C amelioration of
the adrenal stress response in broiler chickens being prepared for slaughter. Comp Biochem
Physio/ 94: 569-574, 1989.
Satterlee DG, Jones RB, Ryder FH. Effects of ascorbyl-2-polyphosphate on adrenocortical
activation and fear-related behaviour in broiler chickens. Poultry Sci 73: 194-20 I, 1994.
Satterlee DG. Ascorbic acid and physiological stress in poultry. In: Wenk G, Fenster R,
Volker R(eds). Ascorbic Acid in Domestic Animals: Proceedings of the Second
Symposium. Basel: F.Hoffinann-La Roche, 1992: pp 43-59.
Saywer DW, Donowitz GR, Mandell GL. Polymorphonuclear neutrophils: an effective
antimicrobial force. Rev Infect Dis 11: S 1532-S 1544, 1989.
Schane JA, Johnson SR, Vandenakker CB, Delayed Onset muscle soreness and plasma CK
and LDH activities after downhill running. Med Sci Sports Exerc 15: 51-56, 1983.
Schmidt KA, Hagmaeier V, Hornig DH, Vulleumier JP, Rutishauser G. Urinary oxalate
excretion after large intakes of ascorbic acid in man. Am J Cl Nutr 34: 305-311, 1981.
Schmidt KA, Steinhilber D, Moser U, Roth HJ. L-ascorbic acid modulates 5-lipogenase
activity in human polymorphonuclear leukocytes. Int Ach Allergy Appl Immunol 85(4),
441-5, 1988.
Schouten WJ, Vershuur R, Kemper HCG. Habitual physical activity, strenuous exercise,
and salivary immunoglobin A levels in young adults: The Amsterdam Growth and Health
Study. Int J Sports Med 9: 289-293, 1988.
Schouten WJ, Vershuur R, Kemper HCG. Physical activity and Upper Respiratory Tract
Infections in a normal Population of young men and women: The Amsterdam Growth and
Health Study. Int J Sports Med 9: 451-5, 1988.
SchrOder H, Navarro E, Tramullas A, Mora J, Galiano D. Nutrition anti-oxidant status and
oxidative stress in professional basketball players: effects of a three compound anti-oxidative
supplement. Int J Sports Med 21: 146-50,2000.
Schwager J, Schulze J. Influence of ascorbic acid on the response to mitogens and
interleukin production of porcine lymphocytes. Int J Vit & Nutr Res 67: 10-6, 1997a.
Schwager J, Schulze J. Dependence of growth, bone metabolism and functions of
polymorphonuclear leukocytes on ascorbic acid in pigs. Int J Vit & Nutr Res 68: 48-58,
1997b.
125 Schwager J, Schulze 1. Modulation of interleukin production by ascorbic acid.
ImmunolImmunopathol 64: 45-57, 1998.
Vet
Schwellnus M, Kiesig M, Derman W, Noakes TD. Fusafungine reduces symptoms of upper
respiratory tract in runners after a 56 km race. Med Sci Sports Exerc 29: S296, 1997.
Sen CK. Oxidants and Anti-oxidants in Exercise. J Appl Physiol 79: 675-86, 1995.
Senecsko F. White blood cell count and adherence in sportsmen and non-training subjects.
Acta Physiol. Pol 34: 5-6, 1983.
Shek PN, Sabiston BH, Burguet A, Radomski MW. Strenuous Exercise and Immunological
Changes. A multiple- Time Point Analysis of Leukocyte Subsets, CD4/CD8 Ratio,
Immunoglobulin Production and NK Response. Int J Sports Med 16: 466-474, 1995.
Shephard RJ, Shek PN. Impact of physical activity and sport on the immune system. Rev
Environ Health 11: 133, 1996.
Shephard RJ, Shek PN. Heavy Exercise, Nutrition and Immune Function: Is there a
connection? Int J Sports Med 16: 491-496, 1995.
Shephard RJ. Rhind S, Shek PN. Exercise and the Immune system. Natural Killer Cells,
Interleukins and Related Responses. Sports Med 18(5): 340-369, 1994.
Sbilotri PG, Bhat KS. The effect of mega doses of vitamin C on bacteriocidal activity of
leukocytes. Am J CI Nutr 30: 1077, 1977.
Sbimuzi K. Effects of ascorbic acid on the cholesterol side chain cleavage system in the rat
ovary.BiochemJ 103: 16-17, 1967.
Siegel BV, Leibovitz B. The Multifactorial Role of Vitamin C in Health and Disease. In:
Hanck A (ed). Vitamin C. New Clinical Application in immunology, lipid metabolism and
cancer. Bern, Hans Huber Publishers, pp 9-21, 1982.
Siegel BV, Morton JI. Vitamin C and the immune response. Experientia 33: 393-394, 1971.
Sies H. Oxidative stress: Introduction. In: Sies H(ed). Oxidative stress: Oxidants and Anti
oxidant. New York: Academic Press, 1991.
Siushansian R, Tao L, Dixon SJ, Wilson JX. Cerebral astrocytes transport ascorbic acid and
dehydroascorbic acid through distinct mechanisms regulated by cyclic AMP. J
Neurochemistry 68(6): 2378-85, 1997.
Skinkai S, Watanabe S, Asai H, Shek PN. Cortisol response to exercise and post-exercise
suppression of blood lymphocyte subset counts. Int J Sports Med 17: 597-603, 1996.
Smith JW, Telford RD, Mason IB, Weiderman MJ. Exercise, training, and neutrophil
microbicidal activity. Int J Sports Med 11: 179-187, 1990.
Smith JW, Weidermann MJ. The exercise and immunity
neuroendocrine/cytokine hypothesis. Med Sci Res 18: 749-753, 1990.
paradox:
A
Sorichter S, Puschendorf B, Mair J. Skeletal muscle injury induced by eccentric muscle
action. Muscle proteins as markers of muscle fibre injury. Exerc Immunol Rev 5: 5-21,
1999.
Sotiriou S, Gispert S, Cheng J, Wang Y, Chen A, Hoogstraten-Miller S, MiUer GF, Kwon
0, Levine M, Guttentag SH, Nussbaum RL. Ascorbic-acid transporter Slc23al is essential
for vitamin C transport into the brain and for perinatal survival. Nat Med 8: 445-5, 2002.
Sprenger H, Jacobs C, Nain M, Gressner AM, Prinz H, Weserman W, Gemsa D. Enhanced
release of cytokines, interleukin-2 receptors, and neopterin after long-distance running. CUn
ImmunolImmunopathol 63: 188-195, 1992.
126 Stanislaw P, Klapcinska B. Effectiveness of supplementation of physically active male
subjects with anti-oxidant vitamins. Medicina Sportiva 4: E98, 2000.
StOckl J, Vetr H, Majdic 0, Zlabinger G, Keuchler E, Knapp W. Human major group
rhinoviruses downmodulate the accessory function of monocytes by inducing II-I O. J CUn
Invest 104: 957-965, 1999.
Strachan AF, Noakes TD, Kotzenberg G, Nel AE, de Beer FC. C-Reactive Protein during
long distance running. Brit Med J 289: 1249-1251, 1984.
Sulimovici S, Boyd GS. The effect of ascorbic acid in vitro on the rat ovarian cholesterol
side chain cleavage enzyme system. Steroids 12: 127-49, 1968.
Sumbaev VV, Iasinskaia 1M. Effect of ascorbic acid on uric acid formation in men and
animals. Ukrainskii Biokhimicheskii Zhurnal 69: 116-20, 1997.
Suzuki K, Totsuka M, Nakaj S, Yamada M, Kudo S, Liu Q, Sugawara K, Yamaya K, Sato
K. Endurance exercise causes interaction among stress hormones, cytokines, neutrophil
dynamics, and muscle damage. J Appl Physiol 87: l360-1367, 1999.
Suzuki K, Yamada M, Kurakake S, Okamura N, Yamada K, Liu Q, Kudoh S, Kowatari K,
Sugawara K. Circulating cytokines and hormones with immunosuppressive but neutrophil
priming potentials rise after endurance exercise in humans. Eur J Appl Physio 81: 281-7,
2000.
Suzuki K, Nnaganuma S, Totsuka M, Suzuki K.-J, Mochizuki M, Shiraishi M, Nakaji S,
Sugawara K. Effects of Exhaustive Endurance Exercise and its One-week Daily Repetition
on Neutrophil Count and Functional Status in Untrained Men. 1m J Sports Med 17: 205
212, 1996.
Tabata I, Ogita M, Miyachi M, Shibayama H. Effect oflow blood glucose on plasma CFR,
ACTH, and cortisol during prolonged physical exercise. J Appl Physiol 71: 1807-1812,
1991.
Taga K, Cherney B, Tosato G. IL-10 inhibits apototic cell death in human T cells starved of
lL-2. Int Immunol 5: 1599-608, 1993.
Taylor C, Rodgers G, Godma C, Baynes RD, Bothwell TH, Bezwoda WR, Kramer F,
Hattingh J. Hematologic iron-related, and acute phase protein responses to sustained
strenous exercise. J Appl Physiol 62: 464-469, 1987.
Thompson D, Williams M, Kingsley M, Nicholas CW, Lakomy F, McArdle F, Jackson MJ.
Muscle soreness and damage parameters after prolonged intermittent shuttle-running
following acute vitamin C supplementation. Int J Sports Med 22: 68-75, 2001a
Thompson D, Williams C, McGregor SJ, Nicholas CW, McArdle F, Jackson MJ, Powell JR.
Prolonged vitamin C supplementation and recovery from demanding exercise. Int J Sports
Nutr Exerc Met 11: 466-481, 2001 b
Tolbert BM. Metabolism and function of ascorbic acid and its metabolites. Int J Vit Nutr
Res 27: 121-l32, 1985.
Tomasi TB, Trudeau FB, Czerwinski D, Erredge S: Immune parameters in athletes before
and after strenuous exercise. J Clin Immunol 2: 173-178, 1982.
Van Antwerpen L, Theron AJ, Meyer MS, Richards GA, Wolmarans L, Booysen U, Van
Der Merwe CA, Sluis -Cremer CK, Anderson R. Cigarette smoke-mediated oxidant stress,
phagocytes, vitamin C, vitamin E, and tissue injury. Ann N Y Acad Sc 686: 53-645, 1993.
Van der Pol] T, Coyle SM, Barbosa CC, Lowry SF. Epinephrine inhibits tumour necrosis
factor -a and potentiates interleukin 10 production during human endoxemia. J Clin Invest
127 97: 713-719,1996.
Vasankari n, Kujala U, Sarna S, Ahotupa M. Effects of ascorbic acid and carbohydrate
ingestion on exercise induced oxidative stress. J Sports Med & Phys Fitness 38: 281-5,
1998.
Vasankari n, Kujala U, Vasankari TM, Abotupa M. Reduced oxidised LDL levels after a
10 month exercise program. Med Sc Sports Exerc 30: 1496-1501, 1998.
Vasankari n, Kujala U, Vasankari TM, Vuorimaa T, Abotupa M. Increased serum and lowdensity-lipoprotein anti-oxidant potential after anti-oxidant supplementation in endurance
atbletes. Am J Cl Nutr 65: 1052-6, 1997.
Viguie C, Frei B, Shigenega M, Ames B, Packer L, Brooks G. Antioxidant status and
indices of oxidative stress during consecutive days of exercise. J Appl Physiol. 75: 566-72,
1993.
Von Weiss M, Fubrmansky J, Lulay R, Weiker H. Haufigkeit und Ursache von
Immunoglobinmangel bei Sportlem. Dtsch Z Sportsmedizin 36: 146-153, 1985.
Wagmer PG, Jorgenson MS, Arden WA, Jackson BA, Stimulus secretion coupling in
porcine adrenal chromaffin cells: acute effects of glucocorticoids. J Neuroscience Res 57:
643-50,1999.
Walsh NP, Blannin AK, Clark AM, Cook L, Robson PJ, Gleeson M. The effects of highintensity intermittent exercise on saliva [gA, total protein and alpha-amylase. J Sports Sci
17: 129-34, 1999.
Warhol MJ, Siegel AJ, Evans WJ, Silverman LM. Skeletal muscle injury and repair in
marathon runners after competition. Am J Path 118: 331-339, 1985.
Washko P, Rotrosen D, Levine M. Ascorbic acid in human neutrophils. Am J Clin Nutr
54 (suppl): 122IS-7S, 1991.
Washko P, Rotrosen D, Levine M. Ascorbic acid transport and accumulation in human
neutrophils. J BioI Chem 264: 18996-19002, 1989.
Weight LM, Alexander D, Jacobs P. Strenuous Exercise: Analogous to the acute phase
response? Clin Sci 81: 677-683,1991.
Weinstock C, Konig D, Harnischmacher R, Keul J, Berg A, Northoff H. Effect of
exhaustive exercise stress on the cytokine response. Med Sci Sports Exerc 29: 345-54,
1997.
Weiss M, Schneider EM, Tarnow J, Mettler S, Krone M, Teschemacher A., Lemoine H. Is
inhibition of oxygen radical production of neutrophils by sympatbomimetics mediated via
beta-2 adrenoreceptors? J Pharmacal Exp Therapeut 278: 1105-1113, 1996.
Weiss SJ. Tissue Destruction by Neutrophils. New Eng J Med 320:365-376, 1989.
WolfG. Uptake of ascorbic acid by human neutrophils. Nutr Rev 51: 337-8. 1993.
Wong CW, Smith SE, Thong YH, Opdebeeck JP, Thorton JR. Effects of Exercise stress on
various immune functions in horses. Am J Vet Res 53: 1414-1417, 1992.
Yamada M, Suzuki K, Kudo S, Totsuka M, Simoyama T, Nakaji S, Sugawara K. Effect of
exhaustive exercise on human neutrophils in athletes. Luminescence 15: 15-20, 2000.
Zembron-Lacvny A, Szyszka K. Exercise modification of the pro-oxidant-anti-oxidant
equilibrium. Medicina Spartiva 4: 247-255, 2000.
Zoschke DC, Messner RP. Suppression of human lymphocyte mitogenesis mediated by
phagocyte-released reactive oxygen-species: comparative activities in normals and in
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