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Professor of Medicine: University of Minnesota,
1976 Minneapolis, Minnesota
Professor of Physiology: University of Minnesota,
1976 - 90
Minneapolis, Minnesota
1973 - 76
Professor of Medicine: Albert Einstein College of
Medicine, Bronx, New York
APPOINTMENTS (continued):
1969 - 73
Associate Professor of Medicine: Albert Einstein
College of Medicine, Bronx, New York
1966 - 69
Assistant Professor of Medicine: Albert Einstein
College of Medicine, Bronx, New York
Graduate School, Biological Sciences Council, University of Minnesota
Full Member:
Molecular, Cellular, Developmental Biology and Genetics
1993 Biomedical Sciences
1990 Neuroscience
1989 - 94
Hospital:
Director, Thyroid Research Unit: University of Minnesota,
Minnesota, Minneapolis, Minnesota
Director, Thyroid Research Laboratories: University
Minnesota, Minneapolis, Minnesota
Attending Physician, University Hospitals: University
of Minnesota, Minneapolis, Minnesota
Director, Division of Endocrinology and Metabolism:
Department of Medicine, University of Minnesota,
Minneapolis, Minnesota
Interim Director, Division of Endocrinology
Department of Pediatrics, University of Minnesota,
Minneapolis, Minnesota
Head, Division of Endocrinology: Montefiore Hospital
and Medical Center - Albert Einstein College of Medicine,
Bronx, New York
Attending Physician: Department of Medicine, Montefiore
Hospital and Medical Center, Bronx, New York
Adjunct Attending Physician: Department of Medicine,
Montefiore Hospital and Medical Center, Bronx, New York
Assistant Clinical Professor of Neurology (Endocrinology):
New York University, New York City
Assistant Attending Physician: Department of Medicine,
Montefiore Hospital and Medical Center, Bronx, New York
RESEARCH:
Principal Investigator: USPHS Grant RO1 DK-19812 (formerly
AM-15421, NB03000), Thyroxine-Protein Interaction
Total Direct Costs $1,368,522.00, 3/1/92-2/28/97
(30 years of continued funding)
Principal Investigator: USPHS DK-07203, Training in Diabetes,
1993 1976 1976 1976 - 93
1992 - 93
1968 - 76
1967 - 76
1963 - 67
1962 - 66
1960 - 63
1961 - 97
1977 - 94
Endocrinology and Metabolism, Total Direct Costs
$509,040.00, 7/1/90-6/30/95
Director: Training Grant in Investigative Endocrinology
for the Albert Einstein College of Medicine, USPHS AM-07004
Career Scientist Award: Health Council of the City of New York
1975 - 76
1962 - 72
BOARD CERTIFICATION AND LICENSE:
American Board of Internal Medicine, November 9, 1961
New York State Medical License No. 75478
New York City Radioactive Materials Licenses No. 146-3 and 148.8
Minnesota Medical License No. 23071
AWARDS AND HONORS:
Henry Moses Award (Montefiore Hospital Alumni Association)
Van Meter Award, American Thyroid Association, Rome, Italy
Astwood Lecturer, Endocrine Society, Miami, Florida
Felllow of the American College of Physians
Fellow, American Association for the Advancement of Science
Parke-Davis Distinguished Lectureship Award,
awarded by American Thyroid Association
President, American Thyroid Association
Cecil J. Watson Professor of Medicine
Listed in Good Housekeeping as among top 400 U.S. Physicians
American Thyroid Association Distinguished Service Award
Symposium on Thyroid Hormone Action in Honor of
Dr. Jack H. Oppenheimer, Saint Paul, Minnesota. Sponsored
by Department of Continuing Medical Education
1962
1965
1978
1982
1983
1985 - 86
1986 - 1997
1991
1992
1993
SELECTED LECTURES AND SYMPOSIA:
Invited Lecturer: Laurentian Hormone Conference, Mt. Tremblant, Quebec, August 1968
Second Francis R. Keating Symposium, Mayo Clinic, April 1972
Symposium on L-triiodothyronine, American Thyroid Association, Chicago, October 1972
Organizing Committee, International Hormone Conference, Glasgow, Scotland, 1974
Chairman, Session on Mechanism of Action of Thyroid Hormones, Gordon Conferences,
July 1974
Beth Israel Seminar in Medicine, October 1974
Invited Lecturer in honor of Dr. A. Querido on the 25th Anniversary of his professorship,
University of Leiden, November 1974
Invited Lecturer, Laurentian Hormone Conference, August 1975
Visiting Professor of Medicine, University of Colorado, April 1974
Samuel F. Haines Lecturer & Visiting Faculty Member, Mayo Clinic, October 16-18, 1978
Visiting Professor of Endocrinology, UCLA, December 10-14, 1979
Invited Lecturer, Silver Anniversary, India Institute of Chemical Pathology,
Calcutta, India, 1981
Invited Lecturer, Gordon Conference on Hormone Action, August 1982
Lecturer, Honors Program, New York University, January 1984
Richard Winzler Lecturer, Florida State University, January 1985
Invited Lecturer, Symposium on Iodine Nutrition, Thyroxine, and Brain Development,
New Delhi, India, February 1985
Ray and Robert Krock Lecturer, Whittier Institute, LaJolla, California, September 1986
Endocrine Society Postgraduate Assembly, November 1986
Invited Lecturer, Fuji Hormone Conference, Japan, July 1987
Invited Lecturer, 1st European Congress of Endocrinology, June-July 1987
Invited Lecturer , Symposium on Thyroid Hormone Action, Endocrine Society,
New Orleans, LA, June 1988
Invited Lecturer, Stenbrook Symposium: Hormones, Thermogenesis and Obesity,
University of Wisconsin, Madison, WI, June 1988
Invited Lecturer, 14th International Congress of Biochemistry, Prague, Czechoslovakia,
July 1988
Member, Organizing and Program Committee, 10th International Thyroid Conference,
September 9, 1990
Invited Lecturer: Beth Israel Hospital Seminars in Medicine, Harvard University, Jan.
1990
Organizer, Keystone Symposia on Molecular and Cellular Biology, Thyroid Hormone
Action, March 1991
Rank Prize Fund Lecturer, London, December 1991
SELECTED LECTURES AND SYMPOSIA (continued):
Invited Lecturer, Keystone Symposia on Molecular and Cellular Biology, Steroid/Thyroid
Receptor Gene Super Family, February 1992
Meet the Professor Lecturer - American Thyroid Association, October 1992
Symposium on Thyroid Cancer, Invited Speaker, Endocrine Society National Meeting,
Las Vegas, NV, June 1993
Symposium on Brain Sciences, Plenary Speaker, Minneapolis, MN, October 1993
International Symposium on Thyroid Hormone Action, Ulm, Germany, November 1993
Meet the Professor, Thyroid Hormone Replacement and Suppression, National Meeting of
the American Thyroid Association, Tampa FL, November 1993
John I. Coe Symposium: Thyroid Disease: A Multidisciplinary Approach, Invited Speaker
Hennepin County Medical Center, Minneapolis MN, March, 1995
Invited Speaker, International Symposium on Thyroid Hormone in honor of Drs. Gabriella
Morreale de Escobar and Francisco Escobar del Rey, Madrid, Spain, May 1995
Invited Speaker, 2nd International Workshop on Thyroid Hormone Resistance, Padua,
Italy, May 1995
Invited Speaker, Symposium in honor of Drs. Rall and Robbins, Washington, D.C.,
June, 1995
Annual Speaker, New England Thyroid Club, Worscester, MA, April, 1996
Invited Speaker - Symposium on Metabolism and Thyroid Hormone, Roterdam, The
Netherlands, September 1997
MEMBERSHIP:
American Society for Biochemistry and Molecular Biology
Association of American Physicians
American Society for Clinical Investigation
American Federation for Clinical Research
American Physiological Society
American Thyroid Association
Central Society for Clinical Research
The Endocrine Society
European Thyroid Association (Corresponding Member)
Fellow, American College of Physicians
Phi Beta Kappa
Sigma Xi
EDITORIAL BOARDS:
Endocrinology 1967 - 73
Endocrine Research Communications
Proceedings of the Society for Experimental Biology and Medicine
Journal of Clinical Endocrinology and Metabolism
Editor, Thyroid Today
The Journal of Clinical Investigation
The Journal of Biological Chemistry
Endocrine Reviews
The Journal of Biological Chemistry
1974 - 86
1974 - 80
1976 - 82
1976 1979 - 84
1983 - 88
1988 - 93
1994 - 98
OTHER PROFESSIONAL RESPONSIBILITIES:
Co-Chairman, Endocrinology Teaching Committee, Albert Einstein College of Medicine
Albert Einstein College of Medicine: Admissions, Curriculum, Faculty Affairs,
Academic Freedom and Tenure, AECOM
OTHER PROFESSIONAL RESPONSIBILITIES (continued):
University of Minnesota:
Departmental Promotions
Self Study Task Force, Medical School
Chairman of Committee to Review Administration
Member, Search Committee for the Directorship of the General Clinical Research
Center
Member, University Senate Task Force for the Creation of a Neuroscience Center
Member, Search Committee for the Head, Department of Physiology
Chairman, Search Committee for the Head, Department of Pharmacology
Task Force for the Reorganization of Biological Sciences at the University of
Minnesota
Protocol Committee, General Clinical Research Center
Member, Search Committee for the Head, Department of Neurosurgery
M.D./Ph.D. Training Program Committee
Member, Scientific Advisory Committee, University of Minnesota
Chairman, Search Committee for Director of Pediatric Endocrinology
Chairman, Search Committee, Bone and Mineral Metabolism Clinical Investigator
Chairman, Department of Medicine Clinic Review Committee
Member, Strategic Planning for Research at the University of Minnesota
Member, Endocrine Study Section, National Institutes of Health, 1973 - 77
Member, Committee to Evaluate Research in the Department of Psychiatry
Current Service on University Committees:
Advisory Committee, General Clinical Research Center
Member, NIH Reviewers Reserve Study Section/Multiple Ad Hoc reviews, 1990 Societies:
American Thyroid Association:
Member of various committees and member of Council (1978 - 87; 1985 - 88)
President (1985 - 1986)
Endocrine Society:
Member of various committees and member of Council (1982 - 85)
Founder and Chairman, Public Affairs Committee (1969 - 71)
Member, Nominating Committee (1988 - 89)
PREVIOUS TRAINEES:
Since 1961, a total of 64 postdoctoral and 6 predoctoral Ph.D. candidates.
BIBLIOGRAPHY
(Exclusive of Abstracts)
1.
Oppenheimer JH, Riester WH: Influence of cortisone on leptomeningeal reaction
induced by talc. Proc Soc Exp Biol Med 83:844-847, 1953.
2.
Oppenheimer JH, Tata JR, Rawson RW: Morphological and functional studies of thyroid
tissue cultures. Exp Cell Res 11:368-377, 1956.
3.
Oppenheimer JH, Wise HM, Lasley DA: The role of the thyroid gland in experimental
traumatic shock. J Clin Invest 37:380-388, 1958.
4.
Mansberger AR, Ochsner EW, Jacob SW, Oppenheimer JH, Gillette RW: A new
preparation for the study of experimental shock from massive wounds. II. Evaluation of
various therapeutic regimens with specific reference to the role of antibiotics, fluid
replacement and débridement. Surgery 43:708-720, 1958.
5.
Mansberger AR, Oppenheimer JH, Gillette RW: A new preparation for the study of
experimental shock from massive wounds. III: Effect of local wound treatment on
survival time. Surgery 43:721-729, 1958.
6.
Oppenheimer JH, Knecht AT, Mansberger AR, Gillette RW, Pon DS: A new preparation
for the study of experimental shock from massive wounds. IV: The effect of penicillin
and streptomycin on the quantitative bacteriologic flora of the wound. Surgery 43:730739, 1958.
7.
Gillette RW, Oppenheimer JH, Mansberger AR, Johnson CE, Kookootsedes GJ: A new
preparation for the study of experimental shock from massive wounds. V. Changes in
some serum electrolytes and nitrogenous fraction values. Surgery 43:740-746, 1958.
8.
Gillette RW, Mansberger AR, Oppenheimer JH, Caldwell BF, Neff EG: A new
preparation for the study of experimental shock from massive wounds. VI: Paper
electrophoretic studies of the serum proteins. Surgery 43:747-751, 1958.
9.
Wise HM, Oppenheimer JH, Knecht DT, Beals GS, Yessis M:
experimental wounds. Ann Surg 148:805-810, 1958.
10.
Oppenheimer JH, McPherson HT: The syndrome of the iodide-induced goiter and
myxedema. Am J Med 30:281-288, 1961.
11.
Oppenheimer JH, Fisher LV, Jailer JW:
Disturbance of the pituitary-adrenal
interrelationship in diseases of the central nervous system. J Clin Endocrinol Metab
21:1023-1036, 1961.
12.
Oppenheimer JH, Fisher LV, Nelson KM, Jailer JW: Depression of the serum proteinbound iodine level by diphenylhydantoin. J Clin Endocrinol Metab 21:252-262, 1961.
Absorption from
13.
Kahana L, Lebovitz H, Lusk W, McPherson HT, Davidson ET, Oppenheimer JH, Engel
FL, Woodhall B, Odom G: Endocrine manifestations of intracranial extrasellar lesions. J
Clin Endocrinol Metab 22:304-324, 1962.
14.
Oppenheimer JH, Tavernetti RR:
Studies on the thyroxine-diphenylhydantoin
interaction. Effect of 5,5' diphenylhydantoin on the displacement of L-thyroxine from the
thyroxine-binding globulin (TBG). Endocrinology 71:496-504, 1962.
15.
Oppenheimer JH, Tavernetti RR: Displacement of thyroxine from human thyroxinebinding globulin by analogues of hydantoin. Steric aspects of the thyroxine-binding site.
J Clin Invest 41:2213-2220, 1962.
16.
Surks MI, Oppenheimer JH: Effect of penicillin on thyroxine-binding by plasma
proteins. Endocrinology 72:567-573, 1963.
17.
Squef R, Martinez M, Oppenheimer JH: Use of thyroxine-displacing drugs in identifying
serum thyroxine-binding proteins separated by starch gel electrophoresis. Proc Soc Exp
Biol Med 113:837-840, 1963.
18.
Oppenheimer JH, Squef R, Surks MI, Hauer H: Binding of thyroxine by serum proteins
evaluated by equilibrium dialysis and electrophoretic techniques. Alterations in
nonthyroidal illness. J Clin Invest 42:1769-1781, 1963.
19.
Katz FH, Oppenheimer JH: Idiopathic elevation of serum thyroxine-binding alphaglobulin capacity: report of a case and comment on incidence. Aerospace Med 34:11521153, 1963.
20.
Surks MI, Oppenheimer JH: Postoperative changes in the concentration of thyroxinebinding prealbumin and serum free thyroxine. J Clin Endocrinol Metab 24:794-802,
1964.
21.
Oppenheimer JH, Surks MI: Determination of free thyroxine in human serum:
theoretical and experimental analysis. J Clin Endocrinol Metab 24:785-7893, 1964.
22.
Oppenheimer JH, Surks MI, Smith JC, Squef R: Isolation and characterization of human
thyroxine-binding prealbumin. J Biol Chem 240:173-180, 1965.
23.
Oppenheimer JH, Surks MI, Bernstein G, Smith JC: Metabolism of 131I-labeled
thyroxine-binding prealbumin in man. Science 149:748-751, 1965.
24.
Oppenheimer JH, Bernstein G: Van Meter Prize Essay. The metabolism and
physiological significance of thyroxine-binding prealbumin in man. In: Current Topics
in Thyroid Research (C Cassano, M Andreoli, eds.), Proc 5th Intl Thyroid Conf, Rome.
New York: Academic Press, 1965, pp. 674-694.
25.
Smith JC, Bernstein G, Surks MI, Oppenheimer JH: A method of preparative starch-gel
electrophoresis. Biophys Biochem Acta 115:81-87, 1966.
A
26.
Oppenheimer JH, Martinez M, Bernstein G: Determination of the maximal binding
capacity and protein concentration of thyroxine-binding prealbumin in human serum. J
Lab Clin Med 67:500-509, 1966.
27.
Bernstein G, Oppenheimer JH: Factors influencing the concentration of free and total
thyroxine in patients with nonthyroidal disease. J Clin Endocrinol Metab 26:195-201,
1966.
28.
Oppenheimer JH, Werner SC: Effect of prednisone on thyroxine-binding proteins. J Clin
Endocrinol Metab 26:715-721, 1966.
29.
Oppenheimer JH:
Abnormalities of neuroendocrine functions in man.
In:
Neuroendocrinology (L Martini, WF Ganong, eds.), Vol. 2, New York: Academic Press,
1967, pp. 665-700.
30.
Bernstein G, Hasen J, Oppenheimer JH: Turnover of 131I-thyroxine in patients subjected
to surgical trauma. J Clin Endocrinol Metab 7:741-744, 1967.
31.
Volpert EM, Martinez M, Oppenheimer JH: Radioiodinated impurities in commercial
preparations of 131I-thyroxine and their effect on the measurement of free thyroxine in
human serum by equilibrium dialysis. J Clin Endocrinol Metab 27:421-428, 1967.
32.
Oppenheimer JH, Bernstein G, Hasen J: Estimation of rapidly exchangeable cellular
thyroxine from plasma disappearance curves of simultaneously administered 131Ithyroxine and albumin 125I. J Clin Invest 46:762-777, 1967.
33.
Hollander CS, Scott RL, Burgess JA, Rabinowitz D, Merimee TJ, Oppenheimer JH: Free
fatty acids: a possible regulator of free thyroid hormone levels in man. J Clin Endocrinol
Metab 27:1219-1223, 1967.
34.
Hasen J, Bernstein G, Volpert E, Oppenheimer JH: Analysis of the rapid interchange of
thyroxine between plasma and liver and plasma and kidney in the intact rat.
Endocrinology 82:37-46, 1968.
35.
Bernstein G, Artz SA, Hasen J, Oppenheimer JH: Hepatic accumulation of 125Ithyroxine in the rat: augmentation by phenobarbital and chlordane. Endocrinology
82:406-409, 1968.
36.
Oppenheimer JH, Bernstein G, Surks MI: Increased thyroxine turnover and thyroidal
function after stimulation of hepatocellular binding of thyroxine by phenobarbital. J Clin
Invest 47:1399-1406, 1968.
37.
Oppenheimer JH: Medical progress: role of plasma proteins in the binding, distribution
and metabolism of the thyroid hormones. New Eng J Med 278:1153-1162, 1968.
38.
Hollander CS, Bernstein G, Oppenheimer JH: Abnormalities of thyroxine binding
analbuminemia. J Clin Endocrinol Metab 28:1064-1068, 1968.
39.
Surks MI, Oppenheimer JH: Iodinated lipids: a possible artifact in isotopic equilibration
with dietary iodide. Endocrinology 83:897-899, 1968.
40.
Schwartz HL, Bernstein G, Oppenheimer JH: Effect of phenobarbital administration on
the subcellular distribution of 125I-thyroxine in rat liver: Importance of microsomal
binding. Endocrinology 84:270-276, 1969.
41.
Surks MI, Oppenheimer JH: Formation of iodoprotein during the peripheral metabolism
of 3,5,3'-triiodo-L-thyronine-125I in euthyroid man and rat. J Clin Invest 48:685-695,
1969.
42.
Oppenheimer JH, Surks MI, Schwartz HL: The metabolic significance of exchangeable
cellular thyroxine. In: Recent Progress in Hormone Research (EB Astwood, ed.), New
York: Academic Press, Inc., 1967, 25:381-422.
43.
Schwartz HL, Kozyreff V, Surks MI, Oppenheimer JH: Increased deiodination of Lthyroxine and L-triiodothyronine by liver microsomes from rats treated with
phenobarbital. Nature 221:1262-1263, 1969.
44.
Surks MI, Schwartz HL, Oppenheimer JH: Tissue iodoprotein formation during the
peripheral metabolism of the thyroid hormones. J Clin Invest 48:2168-2175, 1969.
45.
Oppenheimer JH: An unsolved problem: low serum PBI values in patients with chronic
disease. J Chron Dis 22:129-131, 1969.
46.
Kozyreff V, Surks MI, Oppenheimer JH:
Demonstration of membrane-linked
iodoprotein in hepatic microsomes following metabolism of the thyroid hormones.
Endocrinology 86:781-786, 1970.
47.
Oppenheimer JH, Schwartz HL, Shapiro HC, Bernstein G, Surks MI: Differences in
primary cellular factors influencing the metabolism and distribution of 3,5,3'-Ltriiodothyronine and L-thyroxine. J Clin Invest 49:1016-1024, 1970.
48.
Surks MI, Oppenheimer JH: Composition of nonextractable radioactivity formed after
injection of labeled L-thyroxine and 3,5,3'-triiodo-L-thyronine in rats. Endocrinology
87:567-575, 1970.
49.
Oppenheimer JH, Surks MI: Nature, transport in plasma and metabolism of thyroid
hormones. In: The Thyroid (SO Werner, SH Ingbar, eds.), New York: Harper & Row,
1971, pp. 52-65.
50.
Oppenheimer JH, Surks MI: Kinetics of iodine metabolism: hormonal distribution and
turnover. In: The Thyroid (SO Werner, SH Ingbar, eds.), New York: Harper & Row,
1971, pp. 66-78.
51.
Shapiro HC, Surks MI, Oppenheimer JH: Cellular and plasma protein determinants in
the differential distribution and metabolism of D- and L-thyroxine in the rat.
Endocrinology 88:93-101, 1971.
52.
Oppenheimer JH, Shapiro HC, Schwartz HL, Surks MI: Dissociation between thyroxine
metabolism and hormonal action in phenobarbital-treated rats. Endocrinology 88:115119, 1971.
53.
Schwartz HL, Surks MI, Oppenheimer JH: Quantitation of extrathyroidal conversion of
L-thyroxine to 3,5,3'-triiodo-L-thyronine in the rat. J Clin Invest 50:1124-1130, 1971.
54.
Oppenheimer JH: Public education, a responsibility of our scientific societies. Clin Res
19:257-259, 1971.
55.
Kozyreff V, Surks MI, Oppenheimer JH: Formation of nondissociable hormone-protein
complexes during the in vitro incubation of L-thyroxine and 3,5,3'-triiodo-L-thyronine
with hepatic microsomes. Endocrinology 89:749-755, 1971.
56.
Surks MI, Oppenheimer JH: Metabolism of phenolic- and tyrosyl-ring labeled Lthyroxine in human beings and rats. J Clin Endocrinol Metab 33:612-618, 1971.
57.
Schadlow AR, Surks MI, Schwartz HL, Oppenheimer JH: Specific triiodothyronine
binding sites in the anterior pituitary of the rat. Science 176:1252-1254, 1972.
58.
Oppenheimer JH: Thyroid hormones in liver. 2nd F.R. Keating Symposium, Mayo
Clinic, 1972. Mayo Clinic Proc 47:854-863, 1972.
59.
Oppenheimer JH, Koerner D, Schwartz HL, Surks MI: Specific nuclear triiodothyronine
binding sites in rat liver and kidney. J Clin Endocrinol Metab 35:330-333, 1972.
60.
Oppenheimer JH, Surks MI, Schwartz HL: Slow fractional removal of nonextractable
iodine from rat tissue after injection of labeled L-thyroxine and 3,5,3'-triiodo-L-thyronine:
a possible clue to the mechanism of initiation and persistence of hormonal action. J Clin
Invest 51:2796-2807, 1972.
61.
Oppenheimer JH, Schwartz HL, Surks MI: Propylthiouracil inhibits the conversion of Lthyroxine to L-triiodothyronine. An explanation of the antithyroxine effect of
propylthiouracil and evidence supporting the concept that triiodothyronine is the active
thyroid hormone. J Clin Invest 51:2493-2497, 1972.
62.
Surks MI, Schadlow AR, Oppenheimer JH: A new radioimmunoassay for plasma Ltriiodothyronine: measurements in thyroid disease and in patients maintained on
hormonal replacement. J Clin Invest 51:3104-3113, 1972.
63.
Gordon A, Surks MI, Oppenheimer JH: Thyroxine stimulation of amino acid
incorporation into mitochondrial protein: differences between in vivo and in vitro effects.
Acta Endocrinol. 72:684-696, 1973.
64.
Koerner D, Surks MI, Oppenheimer JH: In vitro formation of apparent covalent
complexes between L-triiodothyronine and plasma protein. J Clin Endocrinol Metab
36:239-245, 1973.
65.
Oppenheimer JH: Possible clues in the continuing search for the subcellular basis of
thyroid hormone action. Festschrift of the Mount Sinai Journal of Medicine in Memory
of Dr. Solomon Berson. 40:491-501, 1973.
66.
Oppenheimer JH: Interaction of drugs with thyroid hormone binding sites. Ann NY
Acad Sci 226:333-340, 1973.
67.
Surks MI, Koerner D, Dillmann W, Oppenheimer JH: Limited capacity binding sites for
L-triiodothyronine in rat liver nuclei: localization to the chromatin and partial
characterization of the L-triiodothyronine-chromatin complex. J Biol Chem 248:70667072, 1973.
68.
Oppenheimer JH, Schwartz HL, Dillmann W, Surks MI: Effect of thyroid hormone
analogues on the displacement of 125I-L-triiodothyronine from hepatic and heart nuclei
in vivo: possible relationship to hormonal activity. Biochem Biophys Res Comm 55:544550, 1973.
69.
Surks MI, Schadlow AR, Stock JM, Oppenheimer JH: Determination of iodothyronine
absorption and conversion of L-thyroxine (T4) to L-triiodothyronine (T3) using turnover
rate techniques. J Clin Invest 52:805-811, 1973.
70.
Schwartz HL, Schadlow AR, Faierman D, Surks MI, Oppenheimer JH: Heparin
administration appears to decrease cellular binding of thyroxine. J Clin Endocrinol
Metab 36:598-600, 1973.
71.
Oppenheimer JH, Surks MI: Quantitative aspects of hormone production, distribution,
metabolism, and activity. In: Handbook of Physiology, Chapter 13, vol. III "Thyroid",
Section 7 Endocrinology, (DH Solomon, RO Greer, eds.), Washington, DC: American
Physiological Society, 1974, pp. 197-214.
72.
Oppenheimer JH, Schwartz HL, Surks MI: Tissue differences in the concentration of
triiodothyronine nuclear binding sites in the rat: liver, kidney, pituitary, heart, brain,
spleen, and testis. Endocrinology 95:897-903, 1974.
73.
Stock JM, Surks MI, Oppenheimer JH: Replacement dosage of L-thyroxine in
hypothyroidism: a re-evaluation. New Eng J Med 290:529-533, 1974.
74.
Dillmann W, Surks MI, Oppenheimer JH: Quantitative aspects of iodothyronine binding
by cytosol proteins of rat liver and kidney. Endocrinology 96:492-498, 1974.
75.
Koerner D, Surks MI, Oppenheimer JH:
In vitro demonstration of specific
triiodothyronine binding sites in rat liver nuclei. J Clin Endocrinol Metab 38:706-709,
1974.
76.
Oppenheimer JH: Newer in vitro tests of thyroid function. Diagnostica 32:4-7, 1974.
77.
Oppenheimer JH, Schwartz HL, Koerner D, Surks MI: Limited binding capacity sites for
L-triiodothyronine in rat liver nuclei:
nuclear-cytoplasmic interrelation, binding
constants, and cross-reactivity with L-thyroxine. J Clin Invest 53:768-777, 1974.
78.
Oppenheimer JH, Surks MI: Biochemical basis of thyroid hormone action. In:
Biochemical Actions of Hormones (G Litwach, ed.), Vol. 3, New York: Academic Press,
Inc., 1975.
79.
Surks MI, Oppenheimer JH: Methods for determining the conversion of L-thyroxine (T4)
to L-triiodothyronine (T3). In: Methods in Enzymology (JG Hardman, BW O'Malley,
eds.), Section III, New York: Academic Press, Inc., 1975.
80.
Balsam A, Oppenheimer JH: Pituitary tumor with primary hypothyroidism: possible
etiologic relationship. NY State J Med 75:1737-1741, 1975.
81.
Surks MI, Koerner DH, Oppenheimer JH: In vitro binding of L-triiodothyronine to
receptors in rat liver nuclei: kinetics of binding, extraction properties, and lack of
requirement for cytosol proteins. J Clin Invest 55:50-60, 1975.
82.
Stock JH, Ghatak NR, Oppenheimer JH: Unsuspected meningioma in a patient with
pituitary gigantism. Case report with autopsy findings. Metabolism 24:767-775, 1975.
83.
Oppenheimer JH, Schwartz HL, Surks MI: Nuclear binding capacity appears to limit the
hepatic response to L-triiodothyronine (T3). End Res Comm 2:309-325, 1975.
84.
Oppenheimer JH, Schwartz HL, Surks MI: Determination of common parameters of
iodothyronine metabolism and distribution in man by noncompartmental analysis. J Clin
Endocrinol Metab 41:319-324, 1975. Erratum: Revised calculations of common
parameters of iodothyronine metabolism and distribution by noncompartmental analysis.
J Clin Endocrinol Metab 41:1172-1173, 1975.
85.
Bermudez F, Surks MI, Oppenheimer JH: High incidence of decreased serum
triiodothyronine concentration in patients with nonthyroidal disease. J Clin Endocrinol
Metab 41:27-40, 1975.
86.
Oppenheimer JH, Schwartz HL, Surks MI, Koerner DH, Dillmann W: Physiological
significance of nuclear receptor sites. Proc Int Conf Thyroid Horm Metab, Glasgow,
Scotland, Academic Press, 1975.
87.
Koerner D, Schwartz HL, Surks MI, Oppenheimer JH, Jorgensen EC: Binding of
selected iodothyronine analogues to receptor sites of isolated rat hepatic nuclei: high
correlation between structural requirements for nuclear binding and biological activity. J
Biol Chem 250:6417-6423, 1975.
88.
Oppenheimer JH: Initiation of thyroid hormone action. The Beth Israel Seminars in
Medicine. N Eng J Med 292:1063-1068, 1975.
89.
Jorgenson EC, Dietrich SW, Koerner D, Surks MI, Oppenheimer JH: Thyroid hormones:
comparative structural requirements for activity in vivo and for binding rat liver nuclei.
Proc West Pharmacol Soc 18:389-392, 1975.
90.
Oppenheimer JH, Surks MI: The peripheral action of the thyroid hormones. In: Medical
Clinics of North America, Vol. 59, No. 5 (GN Burrow, ed.), New York: WB Saunders
Co., 1975, pp. 1055-1061.
91.
Surks MI, Oppenheimer JH: Isolation and characterization of thyroid hormone receptors.
In: Hormone-receptor Interaction: Molecular Aspects (GS Levey, ed.), New York:
Marcel Dekker, Inc., 1976, pp. 373-384.
92.
Goslings B, Schwartz HL, Dillmann W, Surks MI, Oppenheimer JH: Comparison of the
metabolism and distribution of L-triiodothyronine and triiodothyroacetic acid in the rat: a
possible explanation of differential hormonal potency. Endocrinology 98:666-675, 1976.
93.
Oppenheimer JH, Surks MI, Schwartz HL, Koerner DH, Dillmann W: Quantitative
relationships between nuclear occupancy and enzyme response to thyroid hormone
administration. In: Biochemical Basis of Thyroid Stimulation and Thyroid Hormone
Action (A Vonzur Muhlen, H Schleusener, eds.), Stuttgart: George Thieme, 1976, pp.
157-168.
94.
Oppenheimer JH, Surks MI, Schwartz HL, Koerner DH, Dillmann W: Evidence in
support of a nuclear site for the initiation of thyroid hormone action. In: Regulation of
Thyroid Function (E Klein and RD Reinwein, eds.), Stuttgart: FK Schatlauer, 1976, pp.
131-141.
95.
Solomon DH, Benotti J, DeGroot LJ, Greer MA, Oppenheimer JH, Pileggi VJ, Robbins J,
Selenkow HA, Sterling K, Volpe R: Revised nomenclature for tests of thyroid hormones
in serum. Letter to the Editor from the Committee on Nomenclature of the American
Thyroid Association. J Clin Endocrinol Metab 42:595-598, 1976.
96.
Dillmann W, Schwartz HL, Silva E, Surks MI, Oppenheimer JH: Effect of alphaamanitin on the induction of hepatic enzymes by triiodothyronine. Proc 7th Int Thyroid
Conf, Boston, 1975. Excerpta Medica, Int Congress Series No. 378, Amsterdam, 1976,
pp. 326-330.
97.
Oppenheimer JH, Schwartz HL, Surks MI, Koerner D, Dillmann W: Nuclear receptors
and initiation of thyroid hormone action. Rec Prog Horm Res 32:529 565, 1976.
98.
Surks MI, Oppenheimer JH: Incomplete suppression of thyrotropin secretion after single
injection of large L-triiodothyronine doses into hypothyroid rats. Endocrinology
99:1432-1441, 1976.
99.
Dillmann WH, Silva E, Surks MI, Oppenheimer JH: Studies of a thyroid hormone and
androgen dependent protein in rat liver cytosol. Acta Endocrinologica 84:548-558, 1977.
100.
Dillmann WH, Schwartz HL, Silva E, Surks MI, Oppenheimer JH: Alpha-amanitin
administration results in a temporary inhibition of hepatic enzyme induction by
triodothyronine: further evidence favoring a long-lived mediator of thyroid hormone
action. Endocrinology 100:1621-1627, 1977.
101.
Surks MI, Oppenheimer JH: Concentration of L-thyroxine and L-triiodothyronine
specifically bound to nuclear receptors in rat liver and kidney: quantitative evidence
favoring a major role of T3 in thyroid hormone action. J Clin Invest 60:555-562, 1977.
102.
Surks MI, Oppenheimer JH: Treatment of hypothyroidism. In: Current Therapy (H
Conn, ed.), Philadelphia: WB Saunders Co., 1977, pp. 508-511.
103.
Oppenheimer JH, Silva E, Schwartz HL, Surks MI: Stimulation of hepatic mitochondrial
a-glycerophosphate dehydrogenase and malic enzyme by L-triiodothyronine:
Characteristics of the response with specific nuclear thyroid hormone binding sites fully
saturated. J Clin Invest 59:517-527, 1977.
104.
Hoffman DP, Surks MI, Oppenheimer JH, Weitzman ED: Response to thyrotropin
releasing hormone: an objective criterion for the adequacy of thyrotropin suppression
therapy. J Clin Endocrinol Metab 44:892-901, 1977.
105.
Silva ES, Astier H, Thakare U, Schwartz HL, Oppenheimer JH: Partial purification of
the triiodothyronine receptor from rat liver nuclei: differences in the chromatographic
mobility of occupied and unoccupied sites. J Biol Chem 252:6799-6805, 1977.
106.
Gorman CA, Becker DV, Greenspan FS, Levy RP, Oppenheimer JH, Rivlin RS, Robbins
J, VanderLaan WP: Breast cancer and thyroid therapy. Statement by the American
Thyroid Association. JAMA 237:1459-1460, 1977.
107.
Oppenheimer JH, Dillmann WH: Molecular mechanisms at the tissue level in
hyperthyroidism. In: Clinics in Endocrinology and Metabolism (R Volpe, DSB Inglis,
eds.), Vol. 7, London: WB Saunders, 1978, pp. 145-165.
108.
Oppenheimer JH, Gurpide E: Quantitation of production, distribution and interconversion
of hormones. In: Metabolic Basis of Endocrinology, XIII, Chapter 152 (L DeGroot et al.,
eds.), New York: Grune & Stratton, 1979, pp. 568-574.
109.
Oppenheimer JH, Dillmann WH: Nuclear receptors for triiodothyronine: a physiological
persepective. In: Receptors and Hormone Action (L Birnbaum, BW O'Malley, eds.),
Vol. III, Academic Press, 1978, pp. 1-33.
110.
Dillmann WH, Mendecki J, Koerner D, Schwartz HL, Oppenheimer JH:
Triiodothyronine-stimulated formation of poly (A) containing RNA and mRNA in rat
liver. Endocrinology 102:568-575, 1978.
111.
Schwartz HL, Oppenheimer JH: Physiologic and biochemical actions of thyroid
hormone. Pharmac Ther B 3:349-376, 1978.
112
Dillmann WH, Schwartz HL, Oppenheimer JH: Selective alterations in hepatic enzyme
response after reduction of nuclear triiodothyronine receptor sites by partial hepatectomy
and starvation. Biophys Res Comm 80:259-266, 1978.
113.
Dillmann WH, Bonner RA, Oppenheimer JH: Glucagon administration decreases hepatic
nuclear triiodothyronine binding capacity. Endocrinology 102:1633-1636, 1978.
114.
Oppenheimer JH, Coulombe P, Schwartz HL, Gutfeld NW: Nonlinear (amplified)
relationship between nuclear occupancy by triiodothyronine and the appearance rate of
hepatic α-glycerophosphate dehydrogenase and malic enzyme in the rat. J Clin Invest
61:987-997, 1978.
115.
Coulombe P, Schwartz HL, Oppenheimer JH: Relationship between the accumulation of
pituitary growth hormone and nuclear occupancy by triiodothyronine in the rat. J Clin
Invest 62:1020-1028, 1978.
116.
Mendecki J, Dillmann WH, Wolley RC, Oppenheimer JH, Koss LG: Effect of thyroid
hormone on the ploidy of rat liver nuclei as determined by flow-cytometry. Proc Soc Exp
Biol Med 158:63-67, 1978.
117.
Schwartz HL, Oppenheimer JH: Nuclear triiodothyronine receptor sites in brain:
probable identity with hepatic receptors and regional distribution. Endocrinology
103:267-273, 1978.
118.
Schwartz HL, Oppenheimer JH: Ontogenesis of 3,5,3'-triiodothyronine receptors in
neonatal rat brain: dissociation between receptor concentration and stimulation of oxygen
consumption by 3,5,3'-triiodothyronine. Endocrinology 103:943-948, 1978.
119.
Oppenheimer JH: Thyroid hormone action at the cellular level. Science 203:971-979,
1979.
120.
Towle HC, Dillmann WH, Oppenheimer JH; Messenger RNA content and complexity of
euthyroid and hypothyroid rat liver. J Biol Chem 254:2250-2257, 1979.
121.
Schuster LD, Schwartz HL, Oppenheimer JH:
Nuclear receptors for 3,5,3'triiodothyronine in human liver and kidney: characterization, quantitation and similarities
to rat receptors. J Clin Endocrinol Metab 48:627-632, 1979.
122.
Towle HC, Dillmann WH, Schwartz HL, Oppenheimer JH: Interaction of thyroid
hormones with target tissues: effects of hepatic mRNA population. Keystone
Conference. Proceedings of Transmembrane Signaling Symposium, New York: Alan R.
Liss, Inc., 1978, pp. 691-701.
123.
Oppenheimer JH, Dillmann WH, Schwartz HL, Towle HC:
Nuclear receptors and
thyroid hormone action: a progress report. Fed Proc 38:2154-2161, 1979.
124.
Dillmann WH, Oppenheimer JH: Glucagon influences the expression of thyroid hormone
action: discrepancy between nuclear triiodothyronine receptor number and enzyme
responses. Endocrinology 105:74-79, 1979.
125.
Schwartz HL, Forciea MA, Mariash CN, Oppenheimer JH: Age-related reduction in
response of hepatic enzymes to 3,5,3' triiodothyronine administration. Endocrinology
105:41-46, 1979.
126.
Bonner RA, Mukai K, Oppenheimer JH: Two unusual variants of Nelson's syndrome. J
Clin Endocrinol Metab 49:23-29, 1979.
127.
Mariash CN, Kaiser FE, Oppenheimer JH: Comparison of the response characteristics of
four lipogenic enzymes to 3,5,3' triiodothyronine administration: evidence for variable
degrees of amplification of the nuclear-3,5,3' triiodothyronine signal. Endocrinology
106:22-27, 1980.
128.
Bantle JP, Dillmann WH, Oppenheimer JH, Bingham C, Runger GC: Common clinical
indices of thyroid hormone action: relationships to serum free 3,5,3'-triiodothyronine
concentration and estimated nuclear occupancy. J Clin Endocrinol Metab 50:286-293,
1980.
129.
Towle HC, Mariash CN, Oppenheimer JH: Changes in the hepatic levels of messenger
ribonucleic acid for malic enzyme during induction by thyroid hormone or diet.
Biochemistry 19:579-585, 1980.
130.
Steffes MW, Oppenheimer JH: The laboratory evaluation of thyroid function. Minnesota
Medicine 62:162-164, 1979.
131.
Mariash CN, Kaiser FE, Schwartz HL, Towle HC, Oppenheimer JH: Synergism of
thyroid hormone and high carbohydrate diet in the induction of lipogenic enzymes in the
rat: mechanisms and implications. J Clin Invest 65:1126-1134, 1980.
132.
Kaiser FE, Mariash CN, Schwartz HL, Oppenheimer JH: Inhibition of malic enzyme
induction of triiodothyronine in the diabetic rat: reversal by fructose feeding.
Metabolism 29:767-772, 1980.
133.
Oppenheimer JH, Schwartz HL: Factors determining the level of activity of 3, 5, 3'triiodothyronine responsive hepatic enzymes in the starved rat. Endocrinology 107:14601468, 1980.
134.
Schwartz HL, Lancer SR, Oppenheimer JH: Thyroid hormones influence starvationinduced hepatic protein loss in the rat: possible role of thyroid hormones in the
generation of labile protein. Endocrinology 107:1684-1692, 1980.
135.
Simat BM, Towle HC, Schwartz HL, Oppenheimer JH:
Difference between
thyroidectomized animals and hypophysectomized in their hepatic ribonucleic acid
response to thyroid hormone. Endocrinology 107:1338-1344, 1980.
136.
Mariash CN, Oppenheimer JH: Mechanisms of thyroid hormone action. Minnesota
Medicine 63:454-456, 1980.
137.
Bantle JP, Oppenheimer JH, Schwartz HL, Hunninghake DB, Probstfield JL, Hanson RF:
TSH response to TRH in euthyroid, hypercholesterolemic patients treated with graded
doses of dextrothyroxine. Metabolism 30:63-66, 1981.
138.
Jump DB, Oppenheimer JH: Thyroid hormone receptor-containing fragment released
from chromatin by deoxyribonuclease I and micrococcal nuclease. Science 209:811-813,
1980.
139.
Seelig S, Schwartz HL, Oppenheimer JH: Limitations in the conventional analysis of the
interaction of triiodothyronine with solubilized nuclear receptor sites: inapparent binding
of triiodothyronine to nonspecific binding sites. J Biol Chem 256:2154-2161, 1981.
140.
Schwartz HL, Oppenheimer JH: Starvation effects on hepatic enzyme response to
triiodothyronine and hepatic protein degradation. In: The Low T3 Syndrome Importance of rT3. Serono Symposia, Rome, 1980.
141.
Oppenheimer JH: Molecular basis of thyroid hormone action. In: Yearbook of Science
and Technology, New York: McGraw Hill Book Co., 1981, p. 395.
142.
Oppenheimer JH, Bantle JP: Thyroid function testing. 44th Annual Course in Surgery,
Breast and Endocrine Surgery, University of Minnesota, 1980.
143.
Towle HC, Mariash CN, Schwartz HL, Oppenheimer JH: Quantitation of rat liver
messenger ribonucleic acid for malic enzyme during induction of thyroid hormone.
Biochemistry 20:3486-3492, 1981.
144.
Forciea MA, Schwartz HL, Towle HC, Mariash CN, Kaiser FE, Oppenheimer JH:
Thyroid hormone-carbohydrate interaction in the rat: correlation between age-related
reductions in the inducibility of hepatic malic enzyme by triiodo-L-thyronine and a high
carbohydrate, fat-free diet. J Clin Invest 67:1739-1747, 1981.
145.
Winkelmann JC, Mariash CN, Towle HC, Oppenheimer JH: Thyroidectomy increases rat
hepatic ferritin iron. Science 213:569-571, 1981.
146.
Oppenheimer JH, Schwartz HL, Mariash CN, Kaiser FE: Evidence for a factor in the
sera of patients with nonthyroidal disease which inhibits iodothyronine binding by solid
matrices, serum proteins, and rat hepatocytes. J Clin Endocrinol Metab 54:757-766,
1982.
147.
Jump DB, Seelig S, Schwartz HL, Oppenheimer JH: Association of thyroid hormone
receptor with rat liver chromatin. Biochemistry 20:6781-6789, 1981.
148.
Seelig S, Oppenheimer JH: Thermodynamics of the triiodothyronine-nuclear receptor
interaction: role of hydrophobicity in triiodothyronine binding to its receptor. J Biol
Chem 257:1378-1382, 1982.
149.
Mariash CN, McSwigan CR, Towle HC, Schwartz HL, Oppenheimer JH: Glucose and
triiodothyronine both induce malic enzyme in the rat hepatocyte culture: evidence that
triiodothyronine multiplies a primary glucose-generated signal. J Clin Invest 68:14851490, 1981.
150.
Oppenheimer JH, Mariash CN, Towle HC, Schwartz HL, Kaiser FE: Interaction of T3
and carbohydrate in the induction of lipogenic enzymes. Life Sciences 28:1693-1699,
1981.
151.
Seelig S, Liaw C, Towle HC, Oppenheimer JH: Thyroid hormone attenuates and
augments hepatic gene expression at a pretranslational level. Proc Natl Acad Sci USA
78:4733-4737, 1981.
152.
Schuster LD, Bantle JP, Oppenheimer JH, Seljeskog EL: Acromegaly: reassessment of
the long-term therapeutic effectiveness of transsphenoidal pituitary surgery. Ann Intern
Med 95:172-174, 1981.
153.
Bantle JP, Seelig S, Mariash CN, Ulstrom RA, Oppenheimer JH: Resistance to thyroid
hormones: a disorder frequently confused with Graves' disease. Arch Intern Med
142:1867-1871, 1982.
154.
Seelig S, Jump DB, Towle HC, Liaw C, Mariash CN, Schwartz HL, Oppenheimer JH:
Paradoxical effects of cycloheximide on the ultra-rapid induction of two hepatic mRNA
sequences by triiodothyronine (T3). Endocrinology 110:671-673, 1982.
155.
Oppenheimer JH: Thyroid function tests in nonthyroidal disease. (Editorial) J Chron Dis
35:697-701, 1982.
156.
Jump DB, Mariash CN, Oppenheimer JH, Conlon-Hollingshead C, Munro H: Evidence
for post-transcriptional effects of T3 on hepatic ferritin synthesis. Biochem Biophys Res
Comm 104:701-707, 1982.
157.
Liaw C, Seelig S, Mariash CN, Oppenheimer JH, Towle HC: Interactions of thyroid
hormone, growth hormone, and high carbohydrate, fat-free diet in regulating several rat
liver messenger ribonucleic acid species. Biochemistry 22:213-221, 1983.
158.
Mariash CN, Seelig S, Oppenheimer JH: A rapid, inexpensive, quantitative technique for
the analysis of two-dimensional electrophoretograms. Analytical Biochemistry 121:388394, 1982.
159.
Oppenheimer JH: The molecular basis of thyroid hormone action: scattered pieces of a
jigsaw puzzle. In: Physiopathology of Endocrine Disease and Mechanisms of Hormone
Action (RJ Soto, A DeNicola, J Blaquier, eds.), New York: Alan R. Liss, Inc., 1981, pp.
45-56.
160.
Oppenheimer JH, Samuels HH, eds.: Molecular Basis of Thyroid Hormone Action. New
York: Academic Press, 1983.
161.
Oppenheimer JH: The nuclear receptor-triiodothyronine complex: relationship to thyroid
hormone distributions, metabolism, and biological action. In: Molecular Basis of
Thyroid Hormone Action (JH Oppenheimer, HH Samuels, eds.), New York: Academic
Press, 1983, pp. 1-34.
162.
Mariash CN, Oppenheimer JH: Thyroid hormone-carbohydrate interaction. In:
Molecular Basis of Thyroid Hormone Action (JH Oppenheimer, HH Samuels, eds.), New
York: Academic Press, 1983, pp. 265-292.
163.
Kaiser FE, Schwartz HL, Mariash CN, Oppenheimer JH: Comparison of age-related
decreases in the basal and carbohydrate inducible levels of liopgenic enzymes in adipose
tissue and liver. Metabolism 32:838-845, 1983.
164.
Mariash CN, Oppenheimer JH: Interrelationship of triiodothyronine concentration,
metabolism, protein binding, and nuclear occupancy in the induction of malic enzyme by
cultured adult rat hepatocytes. Endocrinology 112:80-85, 1983.
165.
Bergman TA, Mariash CN, Oppenheimer JH: Anterior mediastinal mass in a patient with
Graves' disease. J Clin Endocrinol Metab 55:587-588, 1982.
166.
Bantle JP, Beyer S, Oppenheimer JH: Recurrent episodes of spontaneously resolving
hyperthyroidism due to thyroiditis. Minnesota Medicine 66:295-297, 1983.
167.
Mariash CN, Oppenheimer JH: Stimulation of malic enzyme formation in hepatocyte
culture by metabolites: evidence favoring a nonglycolytic metabolite as the proximate
induction signal. Metabolism 33:545-552, 1983.
168.
Mariash CN, Oppenheimer JH: Thyroid hormone-carbohydrate interaction at the hepatic
nuclear level. Fed Proceedings 41:2671-2676, 1982.
169.
Carr FE, Seelig S, Mariash CN, Schwartz HL, Oppenheimer JH: Starvation and
hypothyroidism exert an overlapping influence on rat hepatic messenger RNA activity
profiles. J Clin Invest 72:154, 1983.
170.
Kaiser FE, Orth DN, Mukai K, Oppenheimer JH: A pituitary parasellar tumor with
extracranial metastases and high, partially suppressible levels of adrenocorticotropin and
related peptides. J Clin Endocrinol Metab 57:649-653, 1983.
171.
Oppenheimer JH: Mechanism of thyroid hormone action:
Resident and Staff Physician 29:152-29s, January 1983.
172.
Schwartz HL, Oppenheimer JH: Nuclear receptors in thyroid function.
Medicine (Special Issue), pp. 1-8, October 1982.
173.
Topliss DJ, Mariash CN, Seelig S, Carr FE, Oppenheimer JH: Effects of triiodothyronine
and glucose on cultured rat hepatocyte gene expression. Endocrinology 112:1868-1870,
1983.
174.
Carr FE, Bingham C, Oppenheimer JH, Kistner C, Mariash CN: Quantitative
investigation of hepatic genomic response to hormonal and pathophysiological stimuli by
multivariate analysis of two dimensional mRNA activity profiles. Proc Natl Acad Sci
USA 81:974-978, 1984.
175.
Schwartz HL, Trence D, Jiang NS, Oppenheimer JH: Distribution and metabolism of Land D-triiodothyronine (T3) in the rat: preferential accumulation of L-T3 by hepatic and
cardiac nuclei as a probable explanation of the differential biological potency of T3
enantiomers. Endocrinology 113:1236-1243, 1983.
176.
Seelig S, Mariash CN, Topliss DJ, Oppenheimer JH: Growth hormone acts at a
pretranslational level in hepatocyte cultures. Biochem Biophys Res Comm 115:882-887,
1983.
177.
Jump DB, Oppenheimer JH: Association of thyroid hormone receptors with chromatin.
Mol Cell Biochem 55:159-176, 1983.
178.
Oppenheimer JH, Jump DB, Schwartz HL, Mariash CN, Seelig SS, Towle HC: Evolving
concepts of thyroid hormone action at the nuclear level. In: The Endocrines and the
Liver, Vol. 51 (M Langer, L Chiandussi, IJ Chopra, L Martini, eds.), Serono Symposia.
London: Academic Press, 1982, pp. 171-183.
clinical implications.
Diagnostic
179.
Oppenheimer JH: Evidence for an inhibitor of T4 binding by solid matrices, plasma
proteins and cells in patients with non-thyroidal illness. In: The Endocrines and the
Liver, Vol. 51 (M Langer, L Chiandussi, IJ Chopra, L Martini, eds.), Serono Symposia.
London: Academic Press, 1982, pp. 213-216.
180.
Jump DB, Narayan P, Towle H, Oppenheimer JH: Rapid effects of triiodothyronine on
hepatic gene expression: hybridization analysis of tissue specific triiodothyronineregulation of mRNA-S14. J Biol Chem 259:2789-2797, 1984.
181.
Oppenheimer JH, Schwartz HL, Jump DB, Mariash CN: Recent studies of thyroid
hormone action at the hepatocellular level. In: Peripheral Metabolism of Thyroxine.
Biochemical Background and Clinical Significance Symposium, Reisensburg, F.R.
Germany, 1983, Hormone and Metabolic Research Supplement Series Vol. No. 14,
George Thieme Verlag, Stuttgart, 1984, pp. 6-15.
182.
Carr FE, Jump DB, Oppenheimer JH: Distribution of thyroid hormone responsive
translated products in rat liver polysome and postribosomal ribonucleoprotein
populations. Endocrinology 115:1737-1745, 1984.
183.
Bantle JP, Hunninghake DB, Frantz ID, Kuba K, Mariash CN, Oppenheimer JH:
Comparison of the effectiveness of thyrotropin-suppressive doses of D- and L-thyroxine
in the treatment of hypercholesterolemia. Am J Med 77:475-481, 1984.
184.
Oppenheimer JH: In vitro thyroid function tests: the price of progress. (Editorial) Drug
Therapy 13:51-54, 1983.
185.
Kinlaw WB, Schwartz HL, Mariash CN, Bingham C, Carr FE, Oppenheimer JH: Hepatic
messenger ribonucleic acid activity profiles in experimental azotemia in the rat.
Relationship to food intake and thyroid function. J Clin Invest 74:1934-1941, 1984.
186.
Mariash CN, Jump DB, Oppenheimer JH: T3 stimulates the synthesis of a specific
mRNA in primary hepatocyte culture. Biochem Biophys Res Comm 123:1122-1129,
1984.
187.
Kinlaw WB, Schwartz HL, Oppenheimer JH: Decreased serum triiodothyronine in
starving rats is due primarily to diminished thyroidal secretion of thyroxine. J Clin Invest
75:1238-1241, 1985.
188.
Beyer HS, Carr FE, Mariash CN, Oppenheimer JH: Hepatic messenger ribonucleic acid
activity profile of rats subjected to alterations in thyroidal and adrenocorticol states:
evidence for significant interaction. Endocrinology 116:2669-2676, 1985.
189.
Beyer HS, Bantle JP, Mariash CN, Steffes MW, Seljeskog EL, Oppenheimer JH: Use of
the dexamethasone-adrenocorticotropin test to assess the requirement for continued
glucocorticoid replacement therapy after pituitary surgery. J Clin Endocrinol Metab
60:1012-1018, 1985.
190.
Oppenheimer JH, Schwartz HL: Stereospecific transport of triiodothyronine from plasma
to cytosol and from cytosol to nucleus in rat liver, kidney, brain, and heart. J Clin Invest
75:147-154, 1985.
191.
Mooradian AD, Schwartz HL, Mariash CN, Oppenheimer JH:
Transcellular and
transnuclear transport of 3,5,3'-triiodothyronine in isolated hepatocytes. Endocrinology
117:2449-2456, 1985.
192.
Bantle JP, Oppenheimer JH: Differentiated thyroid carcinoma. In: Hormonally
Responsive Tumors (VP Hollander, ed.), Orlando, Florida: Academic Press, 1985, pp.
539-540.
193.
Oppenheimer JH: Thyroid hormone action at the nuclear level.
102:374-384, 1985.
Ann Intern Med
194.
Jump DB, Oppenheimer JH: High basal expression and 3, 5, 3' triiodothyronine
regulation of ribonucleic acid-S14 in lipogenic tissues. Endocrinology 117:2259-2266,
1985.
195.
Mariash CN, Oppenheimer JH: Interaction of the thyroid hormone and nutritional signals
on thyroid hormone action. Mol Cell Endocrinol 43:3-13, 1985.
196.
Oppenheimer JH: Thyroid function tests: tips on ordering and interpreting. Modern
Medicine, pp. 28-40, October 1985.
197.
Kinlaw WB, Schwartz HL, Towle HC, Oppenheimer JH: Opposing effects of glucagon
and triiodothyronine on hepatic levels of messenger ribonucleic acid-S14 and the
dependence of these effects on circadian factors. J Clin Invest 78:1091-1096, 1986.
198.
Freake HC, Mooradian AD, Schwartz HL, Oppenheimer JH: Stereospecific transport of
triiodothyronine to cytoplasm and nucleus in GH1 cells. Mol Cell Endocrinol 44:25-35,
1986.
199.
Jump DB, Tao T-Y, Towle HC, Oppenheimer JH: Dissociation of hepatic messenger
ribonucleic acid-S14 levels and nuclear transcriptional rates in suckling rats.
Endocrinology 118:1892-1896, 1986.
200.
Oppenheimer JH, Schwartz HL: Thyroid hormone action at the nuclear level. In:
Thyroid Hormone Metabolism (G Hennemann, ed.), New York: Marcel Dekker, 1986,
pp. 383-415.
201.
Wong NCW, Oppenheimer JH: Multihormonal regulation and kinetics of induction of a
hepatic mRNA sequence which is slowly responsive to triiodothyronine. J Biol Chem
261:10387-10393, 1986.
202.
Mariash CN, Seelig S, Schwartz HL, Oppenheimer JH: Rapid synergistic interaction
between thyroid hormone and carbohydrate on mRNA-S14 induction. J Biol Chem
261:9583-9586, 1986.
203.
Cronrath CM, Freake HC, Mariash CN, Oppenheimer JH: Effect of thyroid hormones
and high carbohydrate feeding on gene expression in rat epididymal adipose tissue.
Endocrinology 120:43-48, 1987.
204.
Jump DB, Wong NCW, Oppenheimer JH: Chromatin structure and methylation state of a
thyroid hormone responsive gene in rat liver. J Biol Chem 262:778-784, 1987.
205.
Weirich RT, Schwartz HL, Oppenheimer JH: An analysis of the interrelationship of
nuclear and plasma triiodothyronine in the sea lamprey, lake trout, and rat: evolutionary
considerations. Endocrinology 120:664-677, 1987.
206.
Oppenheimer JH, Schwartz HL, Mariash CN, Jump DB, Kinlaw WB: Current concepts
of thyroid hormone action at the molecular level: possible clues in understanding the role
of thyroid hormone in brain development. International Symposium Workshop on Iodine
Nutrition, Thyroxine and Brain Development, New Delhi, 1987, pp.138-149.
207.
Oppenheimer JH, Towle H: Messenger RNA-S14 as a model of thyroid hormone action
at the hepatocellular level. In: Steroid and Sterol Hormone Action (TC Spelsberg and R
Kumar, eds.), Boston: Martinus Nijhoff Publishing, 1987, pp. 305-317.
208.
Kinlaw WB, Fish, LH, Schwartz HL, Oppenheimer JH: Diurnal variation in hepatic
expression of the rat S14 gene is synchronized by the photoperiod. Endocrinology.
120:1563-1567, 1987.
209.
Kinlaw WB, Towle HC, Tao T-Y, Jump DB, Schwartz HL, Mariash CN, Oppenheimer
JH: Glucagon causes disappearance of a T3 and carbohydrate-inducible rat hepatic
mRNA (mRNA-S14): unexpected circadian dependency of response. In: Frontiers in
Thyroidology Vol. 1 (G Medeiros-Neto and E Gaitan, eds.), New York: Plenum Medical
Book Company, 1986, pp. 693-700.
210.
Mariash CN, Seelig S, Schwartz HL, Oppenheimer JH: Hypothyroidism inhibits the
rapid response of mRNA-S14 to carbohydrate feeding. In: Frontiers in Thyroidology
Vol. 1 (G Medeiros-Neto and E Gaitan, eds.), New York: Plenum Medical Book
Company, 1986, pp. 701-704.
211.
Mariash CN, Kinlaw WB, Schwartz HL, Freake HC, Oppenheimer JH: Interaction of
thyroid hormone and carbohydrates on hepatic gene expression. In: Gene Regulation by
Steroid Hormones III (AK Roy, JH Clark, eds.), Meadow Brook Conference on the
Molecular Mechanism of Steroid Hormone Action. Springer-Verlag, 1987, pp. 273-297.
212.
Freake HC, Oppenheimer JH: Stimulation of S14 mRNA and lipogenesis in brown fat by
hypothyroidism, cold exposure and cafeteria feeding: evidence supporting a general role
for S14 in lipogenesis and lipogenesis in the maintenance of thermogenesis. Proc Natl
Acad Sci 84:3070-3074, 1987.
213.
Fish LH, Schwartz HL, Cavanaugh J, Steffes MW, Bantle JP, Oppenheimer JH:
Replacement dose, metabolism, and bioavailability of levothyroxine in the treatment of
hypothyroidism: role of thiiodothyronine in pituitary feedback in humans. N Eng J Med
316: 764-770, 1987.
214.
Hamblin PS, Santos A, Wong NCW, Schwartz HL, Oppenheimer JH: Triiodothyronine
regulation of multiple rat hepatic genes: Requirement for ongoing protein synthesis.
Molecular Endocrinology 1:397-402, 1987.
215.
Perez-Castillo A, Schwartz HL, Oppenheimer JH: Rat hepatic mRNA-S14 and lipogenic
enzymes during weaning: role of S14 in lipogenesis. Am J Physiology 253:E536-E542,
1987.
216.
Wong NCW, Schwartz, HL, Santos A, Oppenheimer JH: Cycloheximide inhibits S-14
gene transcription and abolishes DNase I hypersensitive S-14 sites in the livers of
euthyroid but not hypothyroid rats. Mol Endocrinol 1:459-464, 1987.
217.
Oppenheimer JH, Schwartz HL, Mariash CN, Kinlaw WB, Wong NCW, Freake, HC:
Advances in our understanding of thyroid hormone action at the cellular level. Endocrine
Reviews 8:288-308, 1987.
218.
Kinlaw WB, Perez-Castillo AM, Fish LH, Mariash CN, Schwartz HL, Oppenheimer JH:
Interaction of dietary carbohydrate and glucagon in the regulation of rat hepatic
messenger ribonucleic acid S14 expression: Role of circadian factors and 3', 5' cyclic
adenosisne monophosphate. Mol Endocrinol 1:609-613, 1987.
219.
Kinlaw WB, Schwartz HL, Oppenheimer JH: Triiodothyronine rapidly reverses
inhibition of S14 gene transcription by glucagon. Endocrinology 123:2255-2260, 1988.
220.
Oppenheimer JH, Kinlaw WB, Schwartz HL, Wong NC, Perez-Castillo AM, Santos A,
Hamblin S, Freake H, Mariash CN: Messenger RNA-S14 as a model of thyroid hormone
action at the hepatocellular level. In: Highlights on Endocrinology (C Christiansen and
BJ Riis, eds.), Proc First European Congress of Endocrinology, Copenhagen, 1987, pp.
405-410.
221.
Oppenheimer JH, Kinlaw WB, Wong NC, Schwartz HL, Mariash CN: Regulation of
gene S-14 by triiodothyronine in liver. In: Molecular Biological Approaches to Thyroid
Research, International Symposium Reisenburg, June 1987, pp1-5, George Thieme
Verlag, Stuttgart., 1987.
222.
Larsen PR, Alexander NM, Chopra IJ, Hay ID, Hershman JM, Kaplan MM, Mariash CN,
Nicoloff JT, Oppenheimer JH, Solomon DH, Surks MI: Revised nomenclature for tests
of thyroid hormones and thyroid-related proteins in serum. J Clin Endocrinol Metab
64:1089, 1987.
223.
Santos A, Perez-Castillo A, Wong NCW, Oppenheimer JH: Labile proteins are necessary
for T3 induction of growth hormone in mRNA normal rat pituitary and rat pituitary tumor
cells. J Biol Chem 262:16880-16884, 1987.
224.
Santos A, Freake HC, Rosenberg ME, Schwartz HL, Oppenheimer JH: Triiodothyronine
nuclear binding capacity in rat tissues correlates with a 6.0 kb and not a 2.6 kb messenger
ribonucleic acid hybridization signal generated by a human c-erbA probe. Mol Endo
2:992-998, 1988.
225.
Freake HC, Santos A, Goldberg Y, Ghysdael J, Oppenheimer JH: Differences in
antibody recognition of the triiodothyronine nuclear receptor and c-erbA products. Mol
Endo 2:986-991, 1988.
226.
Oppenheimer JH, Freake HC, Santos A, Perez-Castillo A, Schwartz HL, Kinlaw WB,
Mariash CN, Strait K: Lipogenesis, thermogenesis, and the induction of mRNA-S14 by
thyroid hormone. Stenbrook Symposium: Hormones, Thermogenesis and Obesity,
University of Wisconsin, Madison,WI, June 1988.
227.
Westphal SA, Mariash CN, Wick M, Oppenheimer JH: Hypercortisolism due to an
automonously functioning pituitary adenoma: limitations in diagnositic test procedures. J
Clin Endocrinol Metab 67:1105-1110, 1988.
228. Day R, Gebhard RL, Schwartz HL, Strait KA, Duane WC, Stone BG, Oppenheimer JH:
Time course of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and
messenger ribonucleic acid, biliary lipid secretion, and hepatic cholesterol content in
methimazole-treated hypothyroid and hypophysectomized rats after triiodothyronine
administration: Possible linkage of cholesterol synthesis to biliary secretion.
Endocrinology 125:459-468, 1989.
229.
Wong NCW, Schwartz HL, Strait K, Oppenheimer JH: Thyroid hormone, carbohydrate,
and age-dependent regulation of a methylation site in the hepatic S14 gene. Mol Endo
3:645-650, 1989.
230.
Wong NCW, Perez-Castillo AM, Sanders MM, Schwartz HL, Oppenheimer JH: Thyroid
hormone and circadian regulation of the binding activity of a liver-specific protein
associated with the 5'-flanking region of the S-14 gene. J Biol Chem 264:4466-4470,
1989.
231.
Oppenheimer JH: Chapter 4: Distribution and metabolism of the thyroid hormones. In:
Thyroid Function and Disease, (G Burrow, JH Oppenheimer, R Volpé, eds.),
Philadelphia: First Edition, Saunders, 1989.
232.
Oppenheimer JH: Chapter 5: Tissue and cellular effect of thyroid hormones and their
mechanism of action. In: Thyroid Function and Disease, (G Burrow, JH Oppenheimer, R
Volpé, eds.), Philadelphia: First Edition, Saunders, 1989.
233.
Oppenheimer JH, Volpé R: Measurement of thyroid function in: Thyroid Function and
Disease, (G Burrow, JH Oppenheimer, R Volpé, eds.) Philadelphia: First Edition,
Saunders, 1989.
234.
Freake HC, Schwartz HL, Oppenheimer JH: The regulation of lipogenesis by thyroid
hormone and its contribution to thermogenesis. Endocrinology 125:2868-2874, 1989.
235.
Kinlaw WB, Ling NC, Oppenheimer JH: Identification of rat S14 protein and
comparison of its regulation with that of mRNA S14 employing synthetic peptide
antisera. J Biol Chem 264:19779-19783, 1989.
236.
Strait KA, Kinlaw WB, Mariash CN, Oppenheimer JH: Kinetics of induction by thyroid
hormone of the two hepatic mRNA's coding for cytosolic malic enzyme in the
hypothyroid and euthyroid states: evidence against an obligatory role of S14 protein in
malic enzyme gene expression. J Biol Chem 264:19784-19789, 1989.
237.
Freake HC, Oppenheimer JH: The role of S14 and lipogenesis in the thermogenic effects
of thyroid hormone. U.C.L.A. Conference Transactions, 1989.
238.
Strait KA, Schwartz HL, Perez-Castillo A, Oppenheimer JH: Quantitation of erbA
mRNA content to tissue triiodothyronine nuclear binding capacity and function in
developing and adult rats. J Biol Chem 265:10514-10521, 1990.
239.
Schueler PA, Schwartz HL, Strait KA, Mariash CN, Oppenheimer JH: Binding of 3,5,3' triiodothyronine (T3) and its analogs to the in vitro translational products of c-erbA
protooncogenes: differences in the affinity of the α and β forms for the acetic acid analog
and failure of the human testis and kidney α-2 products to bind T3. Mol Endo 4: 227234, 1990.
240.
Strait KA, Schwartz HL, Seybold VS, Ling NC, Oppenheimer JH: Immuno-fluourescent
localization of thyroid hormone receptor protein β1 and variant α2 in selected tissues:
cerebellar purkinje cells as a model for ß1 receptor-mediated developmental effects of
thyroid hormone in brain. Proc Natl Acad Sci USA 88:3887-3891, 1991.
241.
Oppenheimer JH: Chapter 10: Thyroid Hormone Action at the Molecular Level. In:
Werner and Ingbar's The Thyroid, (LE Braverman and RD Utiger, eds.), New York: 6th
Edition, Lipincott, 1991, pp. 204-224.
242.
Oppenheimer JH, Schwartz HL, Lane JT, Thompson MP: Functional relationship of
thyroid hormone-induced lipogenesis, lipolysis, and thermogenesis in the rat. J Clin
Invest 87:125-132, 1991.
243.
Lane JT, Godbole M, Strait KA, Schwartz HL, Oppenheimer JH. Prolonged fasting
reduces rat hepatic ß1 thyroid hormone receptor protein without changing the level of its
messenger ribonucleic acid. Endocrinology 129:2881-2885, 1991.
244.
Schwartz HL, Strait KA, Ling NC, Oppenheimer JH: Quantitation of rat tissue thyroid
hormone binding receptor isoforms by immunoprecipitation of nuclear thiiodothyronine
binding capacity. J Biol Chem 267:11794-11799, 1992.
245.
Strait KA, Zou L, Oppenheimer JH: β1 isoform-specific regulation of a triiodothyronineinduced gene during cerebellar development. Mol Endocrinol 6:1874-1880, 1992.
246.
Oppenheimer, JH: Remembrance of an unexpected turn in the road. Endocrinology
130:1761-1762, 1992.
247.Rodd C, Schwartz HL, Strait KA, Oppenheimer JH: Ontogeny of hepatic nuclear
triiodothyronine receptor isoforms in the rat. Endocrinology 131:2559-2564, 1992.
248.Burmeister LA, Goumaz MO, Mariash CN, Oppenheimer JH: Levothyroxine dose
requirements for thyrotropin suppression in the treatment of differentiated thyroid cancer.
J Clin Endocrinol Metab 75:344-350, 1992.
249.Lechan RM, Qi Y, Berrodin TJ, Davis KD, Schwartz HL, Strait KA, Oppenheimer JH, Lazar
MA:
Immunocytochemical delineation of thyroid hormone receptor ß2-like
immunoreactivity in the rat central nervous sytem. Endocrinology 132:2461-2469, 1993.
250.
Schwartz HL, Strait KA, Oppenheimer JH: Chapter: Molecular mechanisms of thyroid
hormone action: a physiological perspective. In: Clinics in Laboratory Medicine,
Philadelphia: Saunders, 1993, pp. 543-561.
251.
Oppenheimer JH, Schwartz HL, Strait KA: Chapter: An integrated view of thyroid
hormone activity in vivo. In: Molecular Endocrinology: Basic Concepts and Clinical
Correlations, B Weintraub Ed., Raven Press.
252.
Goumaz MO, Schwartz HL, Oppenheimer JH, Mariash CN: Kinetic model of the
response of precursor and mature rat hepatic mRNA-S14 to thyroid hormone. Am J
Physiol 266 (Endocrinol Metab 29):1001-1011, 1994.
253.
Oppenheimer JH, Schwartz HL, Strait KA: Thyroid hormone action 1994: The plot
thickens. Euro J Endocrinol 130:15-24, 1994.
254.
Zou L, Hagen S, Strait KA, Oppenheimer JH: Identification of thyroid hormone response
elements in Pcp--2 ,a developmentally regulated gene of cerebellar purkinje cells. J Biol
Chem 269:13346-13352, 1994.
255.
Carlson DJ, Strait KA, Schwartz HL, Oppenheimer, JH: Immunofluorescent localization
of thyroid hormone receptor isoforms in glial cells of rat brain. Endocrinology 135:18311836, 1994.
256.
Schwartz HL, Lazar MA, Oppenheimer JH: Widespread distribution of immunoreactive
thyroid hormone β2 receptor. J Biol Chem 40:24777-24782, 1994.
257
Oppenheimer JH, Braverman LE, Toft A, Jackson IM, Ladenson PW: Thyroid hormone
treatment - when and what. J Clin Endocrinol Metab 80:2873-2882, 1995.
258.
Oppenheimer JH: Closing remarks, Symposium on thyroid hormone action and thyroid
disease. Thyroid 3:395-396, 1994.
259.
Oppenheimer JH, Schwartz HL, Strait KA: Molecular Basis of Thyroid Hormone
Action. Werner and Ingbar’s The Thyroid, 7th Edition Lipincott.-Raven , 1997. pp: 162184
260.
Freake HC, Oppenheimer JH: Thermogenesis and thyroid function. Ann Rev Nutr
15:263-91, 1995.
261.
Carlson DJ, Strait KA, Schwartz HL, Oppenheimer JH: Thyroid hormone receptor
isoform content in cultured type 1 and type 2 astrocytes. Endocrinology 137:911-917,
1996.
262.
Hagen SG, Larson RJ, Strait KA, Oppenheimer JH: A Purkinje cell protein-2 intronic
thyroid hormone response element binds developmentally regulation thyroid hormone
receptor-nuclear protein complexes. J Mol Neuro 7:245-255, 1996.
263.
Sood A, Schwartz HL, Oppenheimer JH: Tissue-specific regulation of malic enzyme by
thyroid hormone in the neonatal rat. Biochem Biophys Res Comm 222:287-291, 1996.
264.
Fang S, Schwartz HL, Oppenheimer JH: Isoform-specific 3,5,3'-triiodothyronine receptor
binding capacity and messenger ribonucleic acid content in rat adenohypophysis: effect of
thyroidal state and comparison with extrapituitary tissues. Endocrinology 137:32283233, 1996.
265.
Strait KA. Carlson DJ, Schwarttz, HL, Oppenheimer JH. Transient stimulation of myelin
basic protein gene expression in oligodendrocytes: A model for T3-induced brain
development. Endocrinology 138:635-641, 1997.
266.
Schwartz HL, Ross ME, Oppenheimer JH: Lack of effect of thyroid hormone on late
fetal rat brain development. Endocrinology 1997.
267.
Anderson GW, Hagen SG, Larson RJ, Schwartz HL, Mariash CN, Oppenheimer JH:
Purkinje Cell Protein-2 Cis-elements mediate repression of hormonal transcriptional
activation. Mol Cell Endo 131:79-87, 1997
268.
Oppenheimer JH, Schwartz HL: Molecular basis of thyroid hormone dependent brain
development. Endocrine Review 138:3119-3124, 1997
269.
Sandhofer C, Schwartz, HL, Mariash CN, Forrest D, and Oppenheimer JH: Beta receptor
isoforms are not essential for thyroid hormone-dependent acceleration of Pcp-2 and
myelin basic protein gene expression in the developing brains of neonatal mice. Mol Cell
Endo 137: 109-115, 1998.
270.
Oppenheimer JH: Efforts to understand the molecular basis of thyroid hormone-regulated
brain development. Thyroid International 4: 15-21, 1997.
271
Anderson GW, Larson RJ, Oas DR, Sandhofer CR, Schwartz HL, Mariash CN, and
Oppenheimer JH: Chicken Ovalbumin Upstream Promoter-Transcription Factor (COUPTF) modulates expression of the Purkinje cell protein-2 cell. Endocrinology 273:1639116399, 1998.
05/99
Major Scientific Contributions (Publication # indicated)
1.
Discovery of the effect of phenytoin (diphenylhydantoin) in lowering serum thyroid
hormone (12, 14, 15).
2.
Development of first practical technique for measuring the free thyroxine concentration in
serum (18), together with theoretical and experimental verification of dilution effect (21).
3.
Isolation and characterization of thyroxine-binding prealbumin (now known as
transthyretin) (22).
4.
Elucidation of the relationship between free and total thyroxine in patients with
nonthyroidal disease (27).
5.
Recognition and measurement of rapidly exchangeable pools of thyroxine and
triiodothyronine (32, 34, 47).
6.
Recognition and quantitation of the effect of phenobarbital on the turnover of thyroxine
(36, 40, 43, 44).
7.
Confirmation and quantitation of T4 to T3 conversion in the rat (53).
8.
Discovery of specific nuclear T3 receptors (57, 58, 59, 67, 72, 87) their characterization
(67, 68, 81) and kinetic interrelationship with extranuclear T3 pools (77).
9.
Evidence that thyroid hormone is initiated at the nuclear level (119, 114, 115).
10.
Discovery of the effect of propylthiouracil in inhibiting T4 to T3 conversion and the
inference that T3 and not T4 is the thyroid hormone (6, 101).
11.
Application of turnover technique for determining the absorption and distribution of
levothyroxine and its conversion to T3 in human beings (69). Reevaluation of the then
prevalent guidelines in the use of l levothyroxine for replacement treatment in
hypothyroidism (73).
12.
Initial description of the low T3 syndrome in patients with nonthyroidal disease (85).
13.
Molecular mechanism underlying thyroid hormone-stimulated lipogenesis (129, 131, 154,
164., 212, 235, 242).
14.
Identification of the S14 gene as a primary target for rapid thyroid hormone action and as
model for the study of the molecular basis of thyroid hormone-stimulated lipogenesis
(154, 194, 212, 229, 235).
15.
Identification of molecular mechanisms underlying thyroid hormone-dependent brain
development (238, 240, 24, 245, 254).
16.
Guidelines for the selection of the optimal dose of levothyroxine in TSH-suppressive
treatment of patients with differentiated thyroid cancer (248).