Download Gene Section DIRC1 (disrupted in renal carcinoma 1) in Oncology and Haematology

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in Oncology and Haematology
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Gene Section
Short Communication
DIRC1 (disrupted in renal carcinoma 1)
Anita Bonné, Eric Schoenmakers, Ad Geurts van Kessel
Department of Human Genetics, University Medical Center Nijmegen, Nijmegen, the Netherlands (AB, ES,
AGvK)
Published in Atlas Database: June 2004
Online updated version: http://AtlasGeneticsOncology.org/Genes/DIRC1ID499.html
DOI: 10.4267/2042/38100
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence.
© 2004 Atlas of Genetics and Cytogenetics in Oncology and Haematology
Identity
Implicated in
HGNC (Hugo): DIRC1
Location: 2q33
t(2;3)(q33;q21) in hereditary renal cell
cancer
DNA/RNA
The DIRC1 gene contains 2 exons and spans
approximately 57 kb of genomic DNA.
Disease
Familial renal cell cancer.
Cytogenetics
Disruption of the gene because of the t(2;3)
translocation.
Protein
References
Description
Druck T, Podolski J, Byrski T, Wyrwicz L, Zajaczek S, Kata G,
Borowka A, Lubinski J, Huebner K. The DIRC1 gene at
chromosome 2q33 spans a familial RCC-associated
t(2;3)(q33;q21) chromosome translocation. J Hum Genet.
2001;46(10):583-9
Description
104 amino acids.
Expression
Expression in adult placenta, testis, ovary, prostate, and
in fetal kidney, spleen, and skeletal muscle.
Podolski J, Byrski T, Zajaczek S, Druck T, Zimonjic DB,
Popescu NC, Kata G, Borowka A, Gronwald J, Lubinski J,
Huebner K. Characterization of a familial RCC-associated
t(2;3)(q33;q21) chromosome translocation. J Hum Genet.
2001;46(12):685-93
Function
Unknown.
This article should be referenced as such:
Bonné A, Schoenmakers EFPMG, Geurts van Kessel A.
DIRC1 (disrupted in renal carcinoma 1). Atlas Genet Cytogenet
Oncol Haematol. 2004; 8(3):222.
Atlas Genet Cytogenet Oncol Haematol. 2004; 8(3)
222