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Brochure More information from http://www.researchandmarkets.com/reports/74444/ Nanobiotechnology Applications, Markets and Companies Description: Nanotechnology is the creation and utilization of materials, devices, and systems through the control of matter on the nanometer-length scale (a nanometer is one billionth of a meter. Nanobiotechnology, an integration of physical sciences, molecular engineering, biology, chemistry and biotechnology holds considerable promise of advances in pharmaceuticals and healthcare. The report starts with an introduction to various techniques and materials that are relevant to nanobiotechnology. It includes some of the physical forms of energy such as nanolasers. Some of the technologies are scaling down such as microfluidics to nanofluidic biochips and others are constructions from bottom up. Application in life sciences research, particularly at the cell level sets the stage for role of nanobiotechnology in healthcare in subsequent chapters. Some of the earliest applications are in molecular diagnostics. Nanoparticles, particularly quantum dots, are playing important roles. In vitro diagnostics, does not have any of the safety concerns associated with the fate of nanoparticles introduced into the human body. Numerous nanodevices and nanosystems for sequencing single molecules of DNA are feasible. Various nanodiagnostics that have been reviewed will improve the sensitivity and extend the present limits of molecular diagnostics. An increasing use of nanobiotechnology by the pharmaceutical and biotechnology industries is anticipated. Nanotechnology will be applied at all stages of drug development - from formulations for optimal delivery to diagnostic applications in clinical trials. Many of the assays based on nanobiotechnology will enable highthroughput screening. Some of nanostructures such as fullerenes are themselves drug candidates as they allow precise grafting of active chemical groups in three-dimensional orientations. The most important pharmaceutical applications are in drug delivery. Apart from offering a solution to solubility problems, nanobiotechnology provides and intracellular delivery possibilities. Skin penetration is improved in transdermal drug delivery. A particularly effective application is as nonviral gene therapy vectors. Nanotechnology has the potential to provide controlled release devices with autonomous operation guided by the needs. Nanomedicine is now within the realm of reality starting with nanodiagnostics and drug delivery facilitated by nanobiotechnology. Miniature devices such as nanorobots could carry out integrated diagnosis and therapy by refined and minimally invasive procedures, nanosurgery, as an alternative to crude surgery. Applications of nanobiotechnology are described according to various therapeutic systems. Nanotechnology will markedly improve the implants and tissue engineering approaches as well. Of the over 1,000 clinical trials of nanomedicines, approximately 100 are selected and tabulated in major therapeutic areas. Other applications such as for management of biological warfare injuries and poisoning are included. Contribution of nanobiotechnology to nutrition and public health such as supply of purified water are also included. There is some concern about the safety of nanoparticles introduced in the human body and released into the environment. Research is underway to address these issues. As yet there are no FDA directives to regulate nanobiotechnology but as products are ready to enter market, these are expected to be in place. Future nanobiotechnology markets are calculated on the basis of the background markets in the areas of application and the share of this market by new technologies and state of development at any given year in the future. This is based on a comprehensive and thorough review of the current status of nanobiotechnology, research work in progress and anticipated progress. There is definite indication of large growth of the market but it will be uneven and cannot be plotted as a steady growth curve. Marketing estimates are given according to areas of application, technologies and geographical distribution starting with 2015. The largest expansion is expected between the years 2020 and 2025. Profiles of 248 companies, out of over 500 involved in this area, are included in the last chapter along with their 180 collaborations.The report is supplemented with 44 Tables, 29 figures and 820 references to the literature. Contents: Part I: Applications & Markets 0. Executive Summary 1. Introduction Nanomedicine Basics of nanobiotechnology European Union definition of nanomaterials Nanoscale time and light Nanolasers Relation of nanobiotechnology to nanomedicine Landmarks in the evolution of nanomedicine Nanomedicine as a part of evolution of medicine 2. Nanotechnologies Introduction Classification of nanobiotechnologies Nanoparticles Gold nanoparticles Cubosomes Fluorescent nanoparticles Fullerenes Lipoparticles Magnetic nanoparticles Nanoparticles assembly into micelles Nanoshells Polymer nanoparticles Quantum dots Silica nanoparticles Synthetic high density lipoprotein nanoparticles Hybrid nanoparticles Bacterial structures relevant to nanobiotechnology Nanostructures based on bacterial cell surface layers Bacterial magnetic particles Carbon nanotubes Medical applications of nanotubes Dendrimers Properties Applications DNA nanostructures Potential applications of DNA octahedron Nanowires Nanopores Nanoporous silica aerogel Nanostructured silicon Nanoparticle conjugates DNA-nanoparticle conjugates Networks of gold nanoparticles and bacteriophage Protein-nanoparticle combination Polymer nanofibers Virus-like particles Measurement of nanoparticle size and distribution Nanomaterials for biolabeling DNA Nanotags Fluorescent lanthanide nanorods Magnetic nanotags Molecular computational identification Nanophosphor labels Organic nanoparticles as biolabels Quantum dots as labels SERS nanotags Silica nanoparticles for labeling antibodies Silver nanoparticle labels Micro- and nano-electromechanical systems BioMEMS Microarrays and nanoarrays Dip Pen Nanolithography for nanoarrays Applications of dip-pen nanolithography Protein nanoarrays Single-molecule protein arrays Microfluidics and nanofluidics Nanotechnology on a chip Microfluidic chips for nanoliter volumes Use of nanotechnology in microfluidics 2D nanofluidics Construction of nanofluidic channels Nanoscale flow visualization Moving (levitation) of nanofluidic drops with physical forces Electrochemical nanofluid injection Nanofluidics on nanopatterned surfaces Nano-interface in a microfluidic chip Nanofluidic channels for study of DNA Visualization and manipulation on nanoscale 3D single-molecule microscopy with nanoscale accuracy 4Pi microscope Atomic force microscopy AFM basics Advantages of AFM AFM as nanorobot Force sensing Integrated Readout and Active Tip Cantilever technology CytoViva® Microscope System Fluorescence Resonance Energy Transfer Fluorescence by Unbound Excitation from Luminescence Magnetic resonance force microscopy and nanoscale MRI Multiple single-molecule fluorescence microscopy Near-field scanning optical microscopy Nano-sized light source for single cell endoscopy Nanoparticle characterization by Halo? LM10 technology Nanoscale scanning electron microscopy Use of SEM to reconstruct 3D tissue nanostructure Optical Imaging with a Silver Superlens Partial wave spectroscopy Photoactivated localization microscopy Scanning probe microscopy Single-molecule photon localization microscopy STED microscopy Super-resolution microscopy for in vivo cell imaging 3D-SIM Nanomicroscopy for live cell tomography RESOLFT Nanoscopy Ultra-nanocrystalline diamond Visualizing atoms with high-resolution transmission electron microscopy Surface plasmon resonance Nanotechnology and phototherapy 3. Nanotechnologies for Basic Research Relevant to Medicine Introduction Nanotechnology and biology NanoSystems Biology Nanobiology and the cell Biosensing of cellular responses Control of T cell signaling activity Measuring mass of single cells Nanostructures involved in endocytosis Nanoparticles for in vivo study of cells Nanotechnology-based live-cell single molecule assays Quantum dots for stem cell labeling Quantum dot/antibody conjugates for in vivo cytometric imaging Quantum dots for study of apoptosis Ribosome as a Brownian nanomachine Single cell injection by nanolasers Study of complex biological systems Tissue-engineering for studying effects of nanoparticles on cells Molecular motors Nanomotor made of nucleic acids phi29 DNA packaging nanomotor Light-activated ion channel molecular machines Application of AFM for biomolecular imaging Future insights into biomolecular processes by AFM 4Pi microscopy to study DNA double-strand breaks Nanoscale DNA imaging Multi-isotope imaging mass spectrometry Applications of biomolecular computing in life sciences Microbial nanomaterials Use of bacteria to construct nanomachines Bacteriophage nanoshells Natural nanocomposites Nanotechnology in biological research QDs for biological research Molecular biology and nanotechnology Structural DNA nanotechnology RNA nanotechnology Genetically engineered proteins for nanobiotechnology Single molecule studies 3D single-molecular imaging by coherent X-ray diffraction imaging Nanoscale NMR for imaging single molecules Optical trapping and single-molecule fluorescence Nanochemistry Nanoscale pH Meter Nanolaser applications in life sciences Nanoelectroporation Nanomanipulation Nanomanipulation by combination of AFM and other devices Surgery on living cells using AFM with nanoneedles Optoelectronic tweezers Optical manipulation of nanoparticles Manipulation of DNA sequence by use of nanoparticles as laser light antennas Nanomanipulation of single molecule Fluorescence-force spectroscopy Nanomanipulation for study of mechanism of anticancer drugs Nanotechnology in genomic research Nanotechnology for separation of DNA fragments Nanotechnology-based DNA sequencing Role of nanobiotechnology in identifying single nucleotide polymorphisms Nanobiotechnology for study of mitochondria Nanomaterials for the study of mitochondria Study of mitochondria with nanolaser spectroscopy Role of nanotechnology in proteomics research Study of proteins by atomic force microscopy Single cell nanoprobe for studying gene expression of individual cells Nanoproteomics Dynamic reassembly of peptides High-field asymmetric waveform ion mobility mass spectrometry Multi Photon Detection Nanoflow liquid chromatography Nanopore-based protein sequencing Nanopores for phosphoprotein analysis Nanoproteomics for study of misfolded proteins Nanotube electronic biosensor for proteomics Protein nanocrystallography QD-protein nanoassembly Proteomics at single molecule level Study of protein synthesis and single-molecule processes Protein expression in individual cells at the single molecule level Single-molecule mass spectrometry using nanotechnology Biochips for nanoscale proteomics Protein biochips based on fluorescence planar wave guide technology Nanofilter array chip Role of nanotechnology in study of membrane proteins Nanoparticles for study of membrane proteins Study of single protein interaction with cell membrane Quantum dots to label cell surface proteins Study of single membrane proteins at subnanometer resolution Nanoparticle-protein interactions Protein engineering on nanoscale Nanowires for protein engineering A nanoscale mechanism for protein engineering Role of nanoparticles in self-assembly of proteins Role of nanotechnology in peptide engineering Manipulating redox systems for nanotechnology Self-assembling peptide scaffold technology for 3D cell culture Nanobiotechnology and ion channels AFM for characterization of ion channels Aquaporin water channels Nanopatch™ for study of ion channels at single molecule level Remote control of ion channels through magnetic-field heating of nanoparticles Role of nanobiotechnology in engineering ion channels Nanotechnology and bioinformatics 3D nano-map of synapse 4. Nanomolecular Diagnostics Introduction Nanodiagnostics Rationale of nanotechnology for molecular diagnostics Nanoarrays for molecular diagnostics Fullerene photodetectors for chemiluminescence detection on microfluidic chip Microfluidics and nanotech tools for single cell analysis Nanofluidic/nanoarray devices to detect a single molecule of DNA Protein nanoarrays Protein nanobiochip Silver nanorod array for on-chip detection of microbes and chemicals AFM for molecular diagnostics Nanofountain AFM probe AFM for immobilization of biomolecules in high-density microarrays AFM for nanodissection of chromosomes Nanoparticles for molecular diagnostics 3DNA® Dendrimers for diagnostics Carbon nanotubes Gold nanoparticles Quantum dots for molecular diagnostics QDs for detection of pathogenic microorganisms Bioconjugated QDs for multiplexed profiling of biomarkers Imaging of living tissue with QDs Use of nanocrystals in immunohistochemistry Magnetic nanoparticles Magnetic nanoparticles for bioscreening Monitoring of implanted NSCs labeled with nanoparticles Perfluorocarbon nanoparticles to track therapeutic cells in vivo Superparamagnetic nanoparticles for cell tracking SPIONS for real-time tracking of viral delivery SPIONs for calcium sensing Magnetic nanoparticles for labeling molecules Study of living cells by SPIONs Imaging applications of nanoparticles CT image enhancement by nanoparticles Dendritic nanoprobes for imaging of angiogenesis Functionalized MWCNTs as ultrasound contrast agents Nanoparticles as contrast-enhancing agents for MRI Gadolinium-loaded dendrimer nanoparticles for tumor-specific MRI Gadonanotubes for MRI Gold nanorods and nanoparticles as imaging agents In vivo imaging using nanoparticles Manganese oxide nanoparticles as contrast agent for brain MRI Magnetic nanoparticles as contrast agents for MRI of pancreas Nanoparticles as contrast agent for MRI Optical molecular imaging using targeted magnetic nanoprobes QDs for biological imaging SPIONs combined with MRI Concluding remarks and future prospects of nanoparticles for imaging Applications of nanopore technology for molecular diagnostics Nanopore technology for detection of single DNA molecules Nanocytometry DNA-protein and -nanoparticle conjugates Resonance Light Scattering technology Nanobarcodes technology Nanobarcode particle technology for SNP genotyping QD nanobarcode for multiplexed gene expression profiling Biobarcode assay for proteins Single-molecule barcoding system for DNA analysis Nanoparticle-based colorimetric DNA detection method Nanoparticle-based up-converting phosphor technology Surface-Enhanced Resonant Raman Spectroscopy Near-infrared (NIR)-emissive polymersomes Nanobiotechnology for detection of proteins Captamers with proximity extension assay for proteins Immunoliposome-PCR Nanobiosensors Cantilevers as biosensors for molecular diagnostics Advantages of cantilever technology for molecular recognition Antibody-coated nanocantilevers for detection of microorganisms Cantilevers for direct detection of active genes Carbon nanotube biosensors Carbon nanotube sensors coated with ssDNA and electronic readout Carbon nanotubes sensors wrapped with DNA and optical detection FRET-based DNA nanosensor Ion channel switch biosensor technology Electronic nanobiosensors Electrochemical nanobiosensor Metallic nanobiosensors Nanomaterial-based sensors for diagnosis from exhaled breath Quartz nanobalance biosensor Viral nanosensor PEBBLE nanosensors Detection of cocaine molecules by nanoparticle-labeled aptasensors Nanosensors for glucose monitoring Nanobiosensors for protein detection Optical biosensors Laser nanosensors Nanoshell biosensors Plasmonics and SERS nanoprobes Optical mRNA biosensors Surface Enhanced Micro-optical Fluidic Systems Nanoparticle-enhanced sensitivity of fluorescence-based biosensors Nanowire biosensors Nanowire biosensors for detection of cancer biomarkers Nanowire biosensors for detection of single viruses Nanowires for detection of genetic disorders Nanowires biosensor for detecting biowarfare agents Concluding remarks and future prospects of nanowire biosensors Future issues in the development of nanobiosensors Applications of nanodiagnostics Nanotechnology for detection of biomarkers Nanotechnology for genotyping of single-nucleotide polymorphisms Nanoparticles for detecting SNPs Nanopores for detecting SNPs Nanobiotechnologies for single molecule detection Protease-activated QD probes Labeling of MSCs with QDs Nanotechnology for point-of-care diagnostics Nanotechnology-based biochips for POC diagnosis Carbon nanotube transistors for genetic screening POC monitoring of vital signs with nanobiosensors Nanodiagnostics for the battle field and biodefense An integrated nanobiosensor Nanodiagnostics for integrating diagnostics with therapeutics Concluding remarks about nanodiagnostics Clinical trials of nanodiagnostics Future prospects of nanodiagnostics 5. Nanopharmaceuticals Introduction Nanobiotechnology for drug discovery Nanofluidic devices for drug discovery Gold nanoparticles for drug discovery Tracking drug molecules in cells SPR with colloidal gold particles Use of QDs for drug discovery Advantages of the use of QDs for drug discovery Drawbacks of the use of QDs for drug discovery QDs for imaging drug receptors in the brain Lipoparticles for drug discovery Biosensor for drug discovery with Lipoparticles Magnetic nanoparticles assays Analysis of small molecule-protein interactions by nanowire biosensors Cells targeting by nanoparticles with attached small molecules Role of AFM for study of biomolecular interactions for drug discovery Nanoscale devices for drug discovery Laboratories-on-a-chip Lab-on-Bead Nanotechnology for drug design at cellular level Role of nanobiotechnology in microbial biofabrication Nanobiotechnology-based drug development Dendrimers as drugs Fullerenes as drug candidates Nanobodies Companies involved in nanobodies Preclinical studies and human clinical trials of nanoparticles Role of nanobiotechnology in the future of drug discovery Nanobiotechnology in drug delivery Ideal properties of material for drug delivery Improved absorption of drugs in nanoparticulate form Interaction of nanoparticles with human blood Nanoscale devices delivery of therapeutics Nanobiotechnology solutions to the problems of drug delivery Nanocomposites for protein delivery Nanosuspension formulations Nanotechnology for solubilization of water-insoluble drugs Nanotechnology-based refilling of drug delivery depots through circulation Self-assembled nanostructures with hydrogels for drug delivery Nanomaterials and nanobiotechnologies used for drug delivery Viruses as nanomaterials for drug delivery Bacteria-mediated delivery of nanoparticles and drugs into cells Cell-penetrating peptides Nanoparticle-based drug delivery Cationic nanoparticles Ceramic nanoparticles Cyclodextrin nanoparticles for drug delivery Dendrimers for drug delivery DNA-assembled dendrimers for drug delivery Fullerenes for drug delivery Amphiphilic fullerene derivatives Fullerene conjugates for intracellular delivery of peptides Gold nanoparticles as drug carriers Layered double hydroxide nanoparticles Micelles for drug delivery Nanocomposite membranes for magnetically triggered drug delivery Nanocrystals Nanocrystalline silver Elan's NanoCrystal technology Biorise system Nanodiamonds Polymer nanoparticles Biodegradable PEG nanoparticles for penetrating the mucus barrier PLGA-based nanodelivery technologies Polymeric micelles Chitosan nanoparticles QDs for drug delivery Special procedures in nanoparticle-based drug delivery Coated nanoparticles for penetrating cell membranes without damage Combinatorial synthesis of nanoparticles for intracellular delivery Drug delivery using “Particle Replication in Nonwetting Templates” Encapsulating water-insoluble drugs in nanoparticles Filomicelles vs spherical nanoparticles for drug delivery Flash NanoPrecipitation Magnetic nanoparticles for drug delivery Nanoparticles bound together in spherical shapes Perfluorocarbon nanoparticles for imaging and targeted drug-delivery Prolonging circulation of nanoparticles by attachment to RBCs Self-assembling nanoparticles for intracellular drug delivery Trojan nanoparticles Therapeutic protein delivery from nanoparticle-protein complexes Triggered release of drugs from nanoparticles Liposomes Basics of liposomes Stabilization of phospholipid liposomes using nanoparticles Lipid nanoparticles Applications of lipid nanoparticles Polymerized liposomal nanoparticle Solid lipid nanoparticles Lipid nanocapsules Lipid emulsions with nanoparticles Nanostructured organogels Niosomes Limitations of liposomes for drug delivery Liposomes incorporating fullerenes Arsonoliposomes Liposome-nanoparticle hybrids Nanogels Nanogel-liposome combination Nanospheres Nanotubes Carbon nanotubes for drug delivery CNT-liposome conjugates for drug delivery into cells Lipid-protein nanotubes for drug delivery Halloysite nanotubes for drug delivery Nanocochleates Nanobiotechnology and drug delivery devices Nano-encapsulation Nanotechnology-based device for insulin delivery Nanoporous materials for drug delivery devices Nanopore membrane in implantable titanium drug delivery device Measuring the permeability of nanomembranes Nanovalves for drug delivery Nanochips for drug delivery Nanobiotechnology-based transdermal drug delivery Introduction Delivery of nanostructured drugs from transdermal patches Effect of mechanical flexion on penetration of bucky balls through the skin Ethosomes for transdermal drug delivery NanoCyte transdermal drug delivery system Safety issues of applications of nanomaterial carriers on the skin Transdermal administration of lipid nanocapsules Transdermal nanoparticle preparations for systemic effect Nasal drug delivery using nanoparticles Mucosal drug delivery with nanoparticles Future prospects of nanotechnology-based drug delivery Nanomolecular valves for controlled drug release Nanosponge for drug delivery Nanomotors for drug delivery 6. Role of Nanotechnology in Biological Therapies Introduction Nanotechnology for delivery of proteins and peptides Nanobiotechnology for vaccine delivery Bacterial spores for delivery of vaccines Dendrimer-RNA nanoparticle vaccines Lipid nanoparticles for immunostimulatory RNA delivery Nanoparticles for DNA vaccines Nanoparticle-based adjuvants for vaccines Nanospheres for controlled release of viral antigens Nanotechnology for oral vaccines Proteosomes™ as vaccine delivery vehicles Targeted Synthetic Vaccine Particle (tSVP™) technology Virus-mimetic nanovesicles as an antigen-delivery system Nanobiotechnology for gene therapy Nanoparticle-mediated gene therapy Calcium phosphate nanoparticles as nonviral vectors Carbonate apatite nanoparticles for gene delivery DNA nanoparticles Gelatin nanoparticles for gene delivery Immunolipoplex for delivery of p53 gene Lipid nanoparticles for targeted delivery of nucleic acids Nanoparticles for imaging and intracellular delivery of nucleic acids Nanoparticles linked to viral vectors for photothermal therapy Nanoparticles for p53 gene therapy of cancer Nanoparticles with virus-like function as gene therapy vectors Nanobiolistics for nucleic acid delivery Photo-controlled in vivo activation of biomolecules by nanoparticles Silica nanoparticles for gene delivery Targeted nanoparticle-DNA delivery to the cardiovascular system Dendrimers for gene transfer Cochleate-mediated DNA delivery Nanorod gene therapy Nanomagnets for targeted cell-based cancer gene therapy NanoNeedles for delivery of genetic material into cells Application of pulsed magnetic field and superparamagnetic nanoparticles Nanobiotechnology for antisense drug delivery Antisense nanoparticles Dendrimers for antisense drug delivery Polymer nanoparticles for antisense delivery system Nanoparticle-mediated siRNA delivery Chitosan-coated nanoparticles for siRNA delivery Delivery of siRNA by nanosize liposomes Delivery of gold nanorod-siRNA nanoplex to dopaminergic neurons Polymer-based nanoparticles for siRNA delivery Polyethylenimine nanoparticles for siRNA delivery siRNA-PEG nanoparticle-based delivery Polycation-based nanoparticles for siRNA delivery Calando's technology for targeted delivery of anticancer siRNA Quantum dots to monitor RNAi delivery RNAi-based nanomedicines for gene silencing in hematological malignancies Self-assembling nanoplatform for delivery of siRNA Topical delivery of siRNA-nanoparticle conjugates 7. Nanodevices & Techniques for Clinical Applications Introduction Clinical nanodiagnostics Nano-endoscopy Application of nanotechnology in radiology High-resolution ultrasound imaging using nanoparticles Nanobiotechnology in tissue engineering Nanoscale surfaces for stem cell culture 3D nanofilament-based scaffolds Electrospinning technology for nanobiofabrication Nanomaterials for tissue engineering Carbon nanotubes for artificial muscles Nanofibers for tissue engineering of skeletal muscle Nanobiotechnology combined with stem cell-based therapies Nanomaterials for combining tissue engineering and drug delivery Nanobiotechnology for organ replacement and assisted function Exosomes for drug-free organ transplants Nanobiotechnology and organ-assisting devices Nanosurgery Miniaturization in surgery Nanotechnology for hemostasis during surgery Minimally invasive surgery using catheters Nanorobotics Nanoscale laser surgery 8. Nanooncology Introduction Nanobiotechnology for detection of cancer Aptasensor for electrochemical detection of exosomes Aptamer-nanoparticle combinations for cancer diagnostics and therapeutics Dendrimers for sensing cancer cell apoptosis Detection of circulating cancer cells DNA nanospheres for isolation of CTCs Magnetic nanoparticles for capturing CTCs Nano-Velcro technology for capturing CTCs Gold nanoparticles for cancer diagnosis Gold nanorods for detection of metastatic tumor cells Magnetoacoustic detection of cancer using superparamagnetic nanoparticles Nanosensors for cancer diagnosis Differentiation between normal and cancer cells by nanosensors Implanted biosensor for cancer Nanotubes for detection of cancer proteins Nanobiochip sensor technique for analysis of oral cancer biomarkers Nanodots for tracking apoptosis in cancer Nanolaser spectroscopy for detection of cancer in single cells Nanoparticles designed for dual-mode imaging of cancer Nanotechnology-based single molecule assays for cancer QDs for detection of tumors QD-based test for DNA methylation Nanobiotechnology for early detection of cancer to improve treatment Nanobiotechnology-based drug delivery in cancer Nanoparticle formulations for drug delivery in cancer Anticancer drug particles incorporated in liposomes Cerasomes Doxorubicin nanocarriers Encapsulating drugs in polymeric nanoparticles Encapsulating drugs in hydrogel nanoparticles Exosomes Folate-linked nanoparticles Gold nanoparticles stabilized with resveratrol Iron oxide nanoparticles Lipid based nanocarriers Micelles for drug delivery in cancer Minicells for targeted delivery of nanoscale anticancer therapeutics Nanoconjugates for subcutaneous delivery of anticancer drugs Nanomaterials for delivery of poorly soluble anticancer drugs Nanoparticle formulation for enhancing anticancer efficacy of cisplatin Nanoparticle formulations of paclitaxel Nanoparticles containing albumin and antisense oligonucleotides Niosomes for anticancer drug delivery Pegylated nanoliposomal formulation Peptide-linked nanoparticle delivery Poly-2-hydroxyethyl methacrylate nanoparticles Polypeptide-doxorubicin conjugated nanoparticles Protosphere nanoparticle technology Zinc oxide nanoparticles for drug delivery in cancer Nanoparticles for targeted delivery of anticancer therapeutics Bacteriophage capsid-based nanoparticles for targeted cell-delivery Canine parvovirus as a nanocontainer for targeted drug delivery Carbon magnetic nanoparticles for targeted drug delivery in cancer Carbon nanotubes for targeted drug delivery to cancer cells Chitosan nanoparticles for targeted anticancer drug delivery CRLX101 for targeted anticancer drug delivery Cyclosert system for targeted delivery of anticancer therapeutics DNA aptamer-micelle for targeted drug delivery in cancer Fullerenes for enhancing tumor targeting by antibodies Gold nanoparticles for targeted drug delivery in cancer Hepatic artery infusion of LDL-DHA nanoparticles for liver cancer Magnetic nanoparticles for remote-controlled drug delivery to tumors Mesoporous silica nanoparticles Monitoring of targeted delivery by nanoparticle-peptide conjugates Nanobees for targeted delivery of cytolytic peptide melittin Nanobody-shell polymeric micelles for targeted drug delivery Nanogel-based stealth cancer vaccine targeting macrophages Nanovehicles for targeted delivery of paclitaxel Nanocell for targeted drug delivery to tumor Nanodiamonds for local delivery of chemotherapy at site of cancer Nanoimmunoliposome-based system for targeted delivery of siRNA Nanoparticle-mediated targeting of MAPK signaling pathway Nanoparticles for targeted antisense therapy of cancer Nanoparticles for delivery of suicide DNA to prostate tumors Nanoparticles for targeted delivery of concurrent chemoradiation Nanoparticle-based therapy targeted to cancer metastases Nanoparticle-mediated delivery of multiple anticancer agents Nanostructured hyaluronic acid for targeted drug delivery in cancer Perfluorocarbon emulsion for targeted chemotherapeutic delivery Polymer nanoparticles for targeted drug delivery in cancer Polymersomes for targeted cancer drug delivery Quantum dots and quantum rods for targeted drug delivery in cancer Remote controlled drug delivery from magnetic nanocrystals Targeted delivery of nanoparticulate drugs into lymphatic system Targeted drug delivery with nanoparticle-aptamer bioconjugates Use of T cells for delivery of gold nanoparticles to tumors Dendrimers for anticancer drug delivery Application of dendrimers in boron neutron capture therapy Application of dendrimers in photodynamic therapy Dendrimer-based synthetic vector for targeted cancer gene therapy Poly-L-lysine dendrimer as antiangiogenetic agent RNA nanotechnology for delivery of cancer therapeutics Delivery of siRNAs for cancer Combination delivery systems for nanoparticle penetration into tumor tissue Nanotechnology-based cancer therapy Devices for nanotechnology-based cancer therapy Convection-enhanced delivery with nanoliposomal CPT-11 Nanoengineered silicon for brachytherapy Anticancer effect of nanoparticles Antiangiogenic therapy using nanoparticles Cytotoxic effects of cancer nanoparticles Gold nanoparticles for inhibiting tumor growth Nanoshell-based cancer therapy Nanobody-based cancer therapy Nanosecond pulsed electric fields for cancer therapy Nanoparticles combined with physical agents for tumor ablation Boron neutron capture therapy using nanoparticles Gold nanoparticles combined with radiation therapy Laser-induced cancer destruction using nanoparticles Nanoparticle-mediated thermal ablation of cancer Temperature-sensitive liposomes for cancer destruction Ultrasound radiation of tumors combined with nanoparticles Nanomedicines combined with molecular targeted anticancer therapeutics Impact of nanotechnology-based imaging in management of cancer Cornell dots for cancer imaging Nanoparticles and optoacoustic imaging in management of cancer Nanoparticle-MRI for tracking dendritic cells in cancer therapy Nanoparticle-CT scan Nanosensor device as an aid to cancer surgery Nanoparticle-based imaging in oncology clinical trials QDs aid lymph node mapping in cancer Single wall carbon nanotubes for targeted imaging of tumors Nanoparticles for targeted therapy of tumors Nanocarriers with TGF-ß inhibitors for targeting cancer Nanobombs for cancer Nanoparticle-based anticancer drug delivery to overcome MDR Time-delayed, dual-drug nanoparticle delivery system Combination of diagnostics and therapeutics for cancer Aptamer conjugated magnetic nanoparticles Biomimetic nanoparticles targeted to tumors Dendrimer nanoparticles for targeting and imaging tumors Gold nanoparticle plus bombesin for imaging and therapy of cancer Gold nanorods for diagnosis plus photothermal therapy of cancer Gold nanotubes for diagnosis plus photothermal therapy of cancer Magnetic nanoparticles for imaging as well as therapy of cancer Micelles for targeted drug delivery and PET imaging in cancer Nanobialys for combining MRI with delivery of anticancer agents Nanoparticles, MRI and thermal ablation of tumors pHLIP nanotechnology for detection and targeted therapy of cancer QD conjugates combine cancer imaging, therapy and sensing Silica nanoparticles for combining diagnosis with cancer therapy Squalene-based nanocomposites for tumor imaging and therapy Radiolabeled carbon nanotubes for tumor imaging and targeting Ultrasonic tumor imaging and targeted chemotherapy by nanobubbles Nanorobotics for management of cancer Bacterial nanorobots for targeting cancer DNA robots for targeting cancer Fullerenes for protection against chemotherapy-induced cardiotoxicity Concluding remarks and future prospects of nanooncology 9. Nanoneurology Introduction Nanobiotechnology for neurophysiological studies Use of nanoelectrodes in neurophysiology Nanowires for monitoring brain activity Gold nanoparticles for in vivo study of neural function Nanodiagnosis and nanoparticle-based brain imaging Applications of nanotechnology in molecular imaging of the brain Nanoparticles and MRI for macrophage tracking in the CNS Nanoparticles for tracking stem cells for therapy of CNS disorders Multifunctional NPs for diagnosis and treatment of brain disorders Nanotechnology-based drug delivery to the CNS Nanotechnology-based drug delivery for neurodegenerative disorders Nanoencapsulation for delivery of vitamin E for Alzheimer disease Selegiline-PEG nanoparticles targeting Aß fibrils in Alzheimer disease Nanoparticles for drug delivery across BBB Carbon nanotubes for drug delivery to the CNS Nanovesicles for transport across BBB Polymeric nanoparticles as carriers for CNS drug delivery Mechanism of the nanoparticle-mediated transport of the drugs across the BBB Transcytosis of transferrin-containing nanoparticles across the BBB Nanotechnology-based strategies for drug delivery across BBB G-Technology® LipoBridge? technology Nanotechnology-based drug delivery to brain tumors Multifunctional nanoparticles for treating brain tumors Nanoparticles for delivery of drugs to brain tumors across BBB NP delivery across the BBB for imaging and therapy of brain tumors Intravenous gene delivery with nanoparticles into brain tumors PLA nanoparticles for controlled delivery of BCNU to brain tumors NP-based targeted delivery of chemotherapy across the BBB Nanoparticles as nonviral vectors for CNS gene therapy Silica nanoparticles for CNS gene therapy Cationic lipids for CNS gene therapy Polyethylenimine-based nanoparticles for CNS gene therapy Dendrimers for CNS gene therapy Carbon nanotubes for CNS gene therapy Nanoparticle-based drug delivery to the inner ear Nanotechnology-based devices and implants for CNS Nanobiotechnology and neuroprotection Neuroprotection due to antioxidant effect of nanoparticles Neuroprotective nanoparticles that inhibit neuroinflammation Neuroprotective nanoparticles that inhibit Aß formation Nanobiotechnology for regeneration and repair of the CNS Nanowire neuroprosthetics with functional membrane proteins Nanotube-neuron electronic interface Role of nanobiotechnology in regeneration and repair following CNS trauma Nanofibers as an aid to CNS regeneration by neural progenitor cells Peptide nanostructures for repair of the CNS Nanobiotechnology for repair and regeneration following TBI Nanoparticles for repair following SCI Repair of SCI by nanoscale micelles Nanobiotechnology-based devices for restoration of neural function Nanobiotechnology-based artificial retina Role of nanomedicine in treatment of neurodegenerative disorders Nanoneurosurgery Femtolaser neurosurgery Nanofiber brain implants Nanoparticles as an aid to neurosurgery Nanoscaffold for CNS repair Electrospun nanofiber tubes for regeneration of peripheral nerves Bucky balls for brain cancer Application of nanobiotechnology to pain therapeutics 10. Nanocardiology Introduction Nanotechnology-based cardiovascular diagnosis Detection of biomarkers of myocardial infarction in saliva by a nanobiochip Nanobiosensors for detection of cardiovascular disorders Use of magnetic NPs as MRI contrast agents for cardiac imaging Perfluorocarbon NPs for combining diagnosis with therapy in cardiology Cardiac monitoring in sleep apnea Detection and treatment of atherosclerotic plaques in the arteries Monitoring for disorders of blood coagulation Nanotechnology-based therapeutic delivery in cardiology Controlled delivery of nanoparticles to injured vasculature IGF-1 delivery by nanofibers to improve cell therapy for myocardial infarction Injectable peptide nanofibers for myocardial ischemia Liposomal nanodevices for targeted cardiovascular drug delivery Low molecular weight heparin-loaded polymeric nanoparticles Magnetic antibody-linked nanoparticles to deliver cells to the heart Nanoparticles for cardiovascular imaging and targeted drug delivery Nanofiber-based scaffolds with drug-release properties NP-based systemic drug delivery to prevent cardiotoxicity Nanotechnology-based therapeutics for cardiovascular diseases Nanolipoblockers for atherosclerotic arterial plaques Nanotechnology approach to the vulnerable plaque as cause of cardiac arrest Nanotechnology for regeneration of the cardiovascular system Nanotechnology for cardiac revascularization Nanocomposite hydrogels for myocardial tissue engineering Nanotechnology-based stents Restenosis after percutaneous coronary angioplasty Drugs encapsulated in biodegradable nanoparticles Magnetic nanoparticle-coated DES Magnetic nanoparticles encapsulating paclitaxel targeted to stents Nanocoated DES Nanopores to enhance compatibility of DES Application of nanotechnology in cardiac catheterization 11. Nanopulmonology Introduction Nanoparticles for pulmonary drug delivery Systemic drug delivery via pulmonary route Nanoparticle drug delivery for effects on the respiratory system Fate and toxicology of nanoparticles delivered to the lungs Nanoparticle drug formulations for spray inhalation Nanobiotechnology for improving insulin delivery in diabetes Inhalation of glucose-sensitive NP for regulated release of insulin Pulmonary delivery of insulin by surface acoustic wave technology Nanotechnology-based treatment of pulmonary disorders Management of cystic fibrosis Nanobiotechnology-based gene transfer in CF Nonviral DNA nanoparticle-mediated CFTR gene transfer Liposome-mediated CFTR gene transfer Magnetofection for enhancing nonviral gene transfer to the airways NP-based delivery of antibiotics for treatment of pulmonary infections in CF Nanotechnology-based treatment of chronic obstructive pulmonary disease Nanotechnology-based treatment of pulmonary inflammation 12. Nanoorthopedics Introduction Application of nanotechnology for bone research Reducing reaction to orthopedic implants Enhancing the activity of bone cells on the surface of orthopedic implants Synthetic nanomaterials as bone implants NanoBone implants NanoCeram? fibers NanoBone versus BioOss Nanoparticles for repairing bone cracks Nanotechnology-based bone regeneration Delivery of growth factors for bone repair and regeneration Carbon nanotubes as scaffolds for bone growth Aligning nanotubes to improve artificial joints Cartilage regeneration by nanoparticle-based hydrogels Cartilage disorders of knee joint Role of nanotechnology in engineering of a replacement for cartilage Nanotechnology as an aid to arthroscopy Scanning force arthroscope 13. Nanoophthalmology Introduction Nanocarriers for ocular drug delivery Nanoparticle-based topical drug application to the eye Chitosan nanoparticles for topical drug application to the eye Polylactide nanoparticles for topical drug application to the eye Ophthalmic drug delivery through nanoparticles in contact lenses Nanoparticles for intraocular drug delivery DNA nanoparticles for nonviral gene transfer to the eye Nanotechnology for treatment for age-related macular degeneration Nanotechnology-based therapeutics for eye disorders Use of dendrimers in ophthalmology Nanotechnology for prevention of neovascularization Nanoparticles as nonviral vectors for gene therapy of retinal disorders Nanobiotechnology for treatment of glaucoma 14. Nanomicrobiology Introduction Nanodiagnosis of infections Detection of viruses Cantilever beams for detection of single virus particles Carbon nanotubes as biosensors for viruses Electric fields for accelerating detection of viruses QD fluorescent probes for detection of respiratory viral infections Verigene Respiratory Virus Plus Assay Surface enhanced Raman scattering for detection of viruses Detection of bacteria Nanoparticle-based methods for bacterial detection QDs for detection of bacterial infections Role of nanobiotechnology in diagnosis of fungal infections Magnetic nanoparticle-based technique for detection of fungi Nano-amplification technique for the detection of fungal pathogens Role of nanobacteria in human diseases Nature of nanobacteria Nanobacteria and kidney stone formation Nanobacteria in cardiovascular disease Nanotechnology-based microbicidal agents Carbon nanotubes as antimicrobial agents Gold and silver nanoparticles as antibacterial agents Gold nanoparticles for targeted delivery of antibacterial agents Nanoemulsions as microbicidal agents Nanoparticles for overcoming antibiotic resistance Nanoformulations of antifungal agents Nanoscale bactericidal powders Nanotubes for detection and destruction of bacteria Nanoscale surface structure for antibacterial defense Silver nanoparticle coating as prophylaxis against infection Nanobiotechnology and virology Study of interaction of nanoparticles with viruses Study of pathomechanism of viral diseases Transdermal nanoparticles for immune enhancement in HIV Nanofiltration to remove viruses from plasma transfusion products Nanotechnology-based antiviral agents Dendrimer-based intracellular delivery of antibodies Dendrimers as nonviral vectors in dendritic cell-based immunotherapies Fullerenes as antiviral agents Gold nanorod-based delivery of RNA antiviral therapeutics Nanocoating for antiviral effect Nanoviricides Nanocarrier-mediated siRNA delivery for treatment of HIV/AIDS Silver nanoparticles as antiviral agents siRNA lipid nanoparticle for the treatment of Ebola virus infection. 15. Miscellaneous Healthcare Applications of Nanobiotechnology Introduction Nanoimmunology Systemic lupus erythematosus Inflammatory diseases Rheumatoid arthritis Nanohematology Artificial red cells Feraheme Nanoparticle-based drug delivery for gastrointestinal disorders Ginger nanoparticles for IBS Nanoparticles for targeted therapeutic delivery to the liver Nanonephrology Nanobiotechnology-based renal dialysis Nanotechnology-based human nephron filter for renal failure Blood-compatible membranes for renal dialysis Ceramic filter for renal dialysis Nanotechnology for wound healing Nanotechnology-based products for skin disorders Cubosomes for treating skin disorders of premature infants. Nanoparticles for improving targeted topical therapy of skin Nanoparticle-based sun screens Nanoengineered bionic skin Topical nanocreams for inflammatory disorders of the skin Nanobiotechnology for disorders of aging Personal care products based on nanotechnology Nanotechnology for hair care Nanodentistry Bonding materials Dental caries Nanospheres for dental hypersensitivity Nanomaterials for dental filling Nanomaterials for dental implants Nanodiamonds for root canal repair Nanomedical aspects of oxidative stress Nanoparticle antioxidants Fullerene-based antioxidants Ceria nanoparticles as neuroprotective antioxidants Antioxidant nanoparticles for treating diseases due to oxidative stress Nanotechnology and homeopathic medicines Nanoparticles as antidotes for poisons Nanoparticles for chemo-radioprotection Role of nanobiotechnology in biodefense Nanoparticles to combat microbial warfare agents Removal of toxins from blood Nanobiotechnology for public health Nanotechnology for water purification Nanofiltration to remove viruses from water Nanostructured membranes for water purification Nanotechnologies for water remediation Nanotechnology-based photochemical water purification Magnetic nanoscavengers for water purification Nanobiotechnology and nutrition Nanobiotechnology and food industry Role of nanobiotechnology in personalized nutrition 16. Nanobiotechnology and Personalized Medicine Introduction Role of nanobiotechnology in personalized management of cancer Nanotechnology-based personalized medicine for cardiology Nanobiotechnology for therapeutics design and monitoring Smart nanosystems for personalized medicine Nanosystems that respond to disease environments 17. Nanotoxicology Introduction Fate of nanoparticles in the human body In vitro testing for toxicity of nanoparticles Stem cell lines for testing toxicity of nanoparticles Variations in safety issues of different nanoparticles Carbon nanotube safety Fullerene toxicity Gold nanoparticle toxicity Quantum dot safety issues Effects of nanoparticles on various body systems Pulmonary effects of nanoparticles Neuronanotoxicology Nanoparticle deposits in the brain Nanoparticles and neurodegeneration Effect of nanoparticles on the heart Blood compatibility of nanoparticles Carbon nanoparticle-induced platelet aggregation Compatibility of lipid-based nanoparticles with blood and blood cells Transfer of nanoparticles from mother to fetus Cytotoxicity of nanoparticles Indirect DNA damage caused by nanoparticles across cellular barriers Measures to reduce toxicity of nanoparticles Reducing toxicity of carbon nanotubes A screening strategy for the hazard identification of nanomaterials Concluding remarks on safety issues of nanoparticles Research into environmental effects of nanoparticles Environmental safety of aerosols released from nanoparticle manufacture Role of US government agencies in research on safety of nanoparticles Work at NanoSafety Laboratories Inc UCLA Center for Biological and Environmental Nanotechnology European NEST project for risk assessment of exposure to nanoparticles Nanoparticles and food safety Titanium dioxide nanoparticles in food Regulatory viewpoint on nanoparticles in food Use of water nanostructures for inactivation of foodborne microorganisms Public perceptions of the safety of nanotechnology Evaluation of consumer exposure to nanoscale materials Safety of nanoparticle-based cosmetics Regulations in the European Union Nanotechnology-based sunscreens Cosmetic industry’s white paper on nanoparticles in personal care Skin penetration of nanoparticles used in sunscreens Titanium dioxide in cosmetics 18. Ethical and Regulatory Aspects of Nanomedicine Introduction Ethical and social implications of nanobiotechnology Nanoethics Nanotechnology patents Quantum dot patents relevant to healthcare applications Challenges and future prospects of nanobiotechnology patents Legal aspects of nanobiotechnology Nanotechnology standards Preclinical testing of nanometerials for biological applications FDA regulation of nanobiotechnology products FDA and nanotechnology-based medical devices FDA’s Nanotechnology Task Force FDA collaboration with agencies/organizations relevant to nanotechnology Regulation of nanotechnology in the European Union Safety recommendations of the Royal Society of UK European Commission and safety of nanocosmetics 19. Research and Future of Nanomedicine Introduction Nanobiotechnology research in the academic centers Clinical trials of nanomedicines Future potential of nanomedicine US Federal funding for nanobiotechnology Nanomedicine initiative of NIH NIH Nanomedicine Center for Nucleoprotein Machines NCI Alliance for Nanotechnology in Cancer Research in cancer nanotechnology sponsored by the NCI Global Enterprise for Micro-Mechanics and Molecular Medicine Nano2Life European Technology Platform on NanoMedicine 20. Nanobiotechnology Markets Introduction Markets according to areas of applications Markets for nanomedicine Markets for nanodiagnostics Markets for biochips/microarrays Imaging agents Pharmaceuticals Role of nanobiotechnology in drug delivery market Nanobiotechnology in life sciences research market Markets according to technologies Markets for nanomaterials Markets for biomedical nanodevices Markets for nanosensors Markets for nanotools Geographical distribution of markets Nanobiotechnology in the US Nanobiotechnology in the European Union Nano2Life European Technology Platform on NanoMedicine Nanobiotechnology in Australia Nanobiotechnology in Asia Japan South Korea China Taiwan India Nanobiotechnology in Russia Nanobiotechnology in the developing world Venture capital investment in nanotechnology Big pharma and nanotechnology Impact of nanobiotechnology on markets for current pharmaceuticals Unmet needs in nanobiotechnology Drivers for the development of nanobiotechnology markets Strategies for developing markets for nanobiotechnology Collaborations of industry with academic research centers Collaborations of pharmaceutical and nanotechnology companies Collaboration of chemical industry and the government Cost-benefit of nanotechnology-based drug delivery Education of healthcare professionals Education of the public 21. References Tables Table 1-1: Dimensions of various objects in nanoscale Table 1-2: Historical landmarks in the evolution of nanomedicine Table 1-3: Nanomedicine in the 21st century Table 2-1: Classification of basic nanomaterials and nanobiotechnologies Table 2-2: Applications of S-layers in nanobiotechnology Table 2-3: Potential applications of dendrimers in nanomedicine Table 2-4: Nanomaterials for biolabeling Table 2-5: Applications of cantilever technology Table 2-6: Applications of optical nanoscopy Table 3-1: Nanomaterials for the study of mitochondria Table 4-1: Classification of applications of nanotechnologies in molecular diagnostics Table 4-2: Nanobiotechnologies for single molecule detection Table 4-3: Clinical trials of nanodiagnostics Table 5-1: Basic nanobiotechnologies relevant to drug discovery Table 5-2: Companies involved in nanobodies Table 5-3: Nanomaterials used for drug delivery Table 5-4: Liposome-nanoparticle hybrid systems Table 6-1: Examples of application of nanoparticles for gene therapy Table 8-1: Classification of nanobiotechnology approaches to drug delivery in cancer Table 8-2: Approved anticancer drugs using nanocarriers Table 9-1: Neuroprotective nanoparticles Table 9-2: Role of nanobiotechnology in regeneration and repair following CNS trauma Table 9-3: Nanoparticles for targeted drug delivery in neurodegenerative disorders Table 13-1: Nanoparticles used for drug delivery in ophthalmology Table 15-1: Experimental studies and clinical trials of nanomedicines for rheumatoid arthritis Table 15-2: Applications of nanotechnologies in food and nutrition sciences Table 16-1: Examples of nanosystems that respond to disease environments Table 18-1: FDA-approved nanotechnology based drugs Table 19-1: Academic institutes/laboratories involved in nanobiotechnology Table 19-2: Clinical trials of nanotechnology-based therapies Table 20-1: Nanobiotechnology markets according to areas of application 2015-2025 Table 20-2: Markets for nanobiotechnology according to technologies 2015-2025 Table 20-3: Geographical distribution of nanobiotechnology markets 2015-2025 Table 20-4: Drivers for the development of nanobiotechnology markets Table 20-5: Strategies for developing markets for nanobiotechnology Table 20-6: Cost-benefit of nanotechnology-based drug delivery Figures Figure 1-1: Sizes of biologically entities relevant to the brain Figure 2-1: The core, branching and surface molecules of dendrimers Figure 2-2: Imaging and size distribution of nanoparticles with TEM Figure 2-3: Schematic representation of Dip Pen Nanolithography (DPN) Figure 2-4: Surface plasmon resonance (SPR) technology Figure 3-1: Concept of nanopore-based sequencing Figure 3-2: Nanopore-based sequence-specific detection of DNA Figure 4-1: Microfluidics and nanotech tools for single cell analysis Figure 4-2: Scheme of bio-barcode assay Figure 4-3: Scheme of an optical mRNA biosensor Figure 4-4: Nanowire biosensor for cancer diagnosis Figure 5-1: Application of nanobiotechnology at various stages of drug discovery Figure 5-2: Bacteria plus nanoparticles for drug delivery into cells Figure 5-3: Schematic image of a lipid nanoparticle Figure 6-1: Nucleic acid delivery with lipid nanoparticle (LPN) technology Figure 6-2: Nanocochleate-mediated drug delivery Figure 8-1: Use of micelles for drug delivery Figure 9-1: Nanodiagnostics for neurological disorders Figure 9-2: A concept of targeted drug delivery to GBM across the BBB Figure 10-1: Magnetic nanoparticle-coated stent Figure 14-1: Schematic representation of NanoViricide attacking a virus particle Figure 14-2: Nanocarrier-mediated siRNA delivery for treatment of HIV/AIDS Figure 15-1: Nanodiamond-based root canal filling Figure 16-1: Relationship of nanobiotechnology to personalized medicine Figure 16-2: Role of nanobiotechnology in personalized management of cancer Figure 20-1: Components of the $1 trillion market for nanotechnologies in 2015 Figure 20-2: Nanobiotechnology markets according to applications 2015-2025 Figure 20-3: Geographical distribution of nanobiotechnology markets 2015-2025 Figure 20-4: Unmet needs in nanobiotechnology applications Part II: Companies 22. Nanobiotech Companies Introduction Classification of companies Profiles of companies Collaborations Tables Table 22-1: Companies with nanoarray and nanofluidic technologies Table 22-2: Companies that provide microscopes for nanobiotechnology Table 22-3: Companies providing services and products for nanobiotechnology industry Table 22-4: Companies that provide nanotechnologies for life sciences research Table 22-5: Companies developing nanomolecular diagnostics Table 22-6: Companies involved in nanobiotechnology-based drug discovery and development Table 22-7: Companies involved in nanobiotechnology-based drug delivery Table 22-8: Companies using nanotechnology-based antiinfective agents Table 22-9: Companies using nanotechnology for healthcare and therapeutics Table 22-10: Collaborations of companies in nanobiotechnology Ordering: Order Online - http://www.researchandmarkets.com/reports/74444/ Order by Fax - using the form below Order by Post - print the order form below and send to Research and Markets, Guinness Centre, Taylors Lane, Dublin 8, Ireland. 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