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LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034 M.Sc. DEGREE EXAMINATION – BIOMEDICAL INSTRUMENTATION FOURTH SEMESTER – APRIL 2014 BI 4808 - BIOMEDICAL INFORMATICS Date : 29/03/2014 Time : 01:00-04:00 Dept. No. Answer all of the following Max. : 100 Marks Section - A 10 x 2 = 20 1.Give note on MSA editors and formatters. 2.Comment on FASTA. 3.What are profiles? 4.What is eMOTIF analysis? 5.Define database similarity search. 6.Write short note on connection table. 7.What is SMILES format for Isopropyl alcohol and benzene? 8.Differentiate e- value and p-value. 9.Expand OMIM and HCGD 10.Name the two strategies for in-silico drug design. Answer any four of the following. Section – B 4 x10 = 40 11.Discuss about the features available in NCBI . 12.Write detailed notes on tools available for structural analysis and prediction of proteins. 13.Explain the components of GenScan, Uniprot of PDB servers in detail. 14.Elaborate on various phases of clinical trials in drug discovery. 15.Describe the Needleman and Wunsch and Smith - Waterman algorithm. 16.Justify the role of Telehealth-Information in patient care and monitoring system. Answer any two of the following. Section - C 2 x 20 = 40 17.What do you understand by health informatics and its various aspects? 18.Write in detail objectives and the strategies involved in molecular approach to drug discovery. 19.Write notes on: a. PIR-PRED b. Digital libraries c. Rasmol d. Clustal W 20.Elaborate on clinical genetic databases and databases of human mutations . ********