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2016 EMS REFRESHER Care of the Newly Born And Neonate 2015 AHA Update January 31st, 2016 Andrew Walter MD Introduction The likelihood of serious neurologic injury or even death is higher when delivery occurs in the nondelivery room setting. Decisions made in the first few minutes after delivery will carry life-long consequences. We will begin with a review of newborn physiology, and resuscitation guidelines, with attention to the 2015 AHA guidelines for neonatal resuscittion, followed by non-resuscitation emergencies, and case studies. Epidemiology 6% of field deliveries require life support As the birth weight goes down, the incidence of complications increase 80% of infants 3lbs 5 oz require some type of resuscitation Only 1% of all newborns will require cardiac compression/meds Preparation for Delivery Resuscitation-Oriented History 1) Are there twins?? 2) When are you due?? 3) What is the color of the amniotic fluid?? Delivery Assessment Term gestation? Good tone? Breathing and crying? Preparation of Equipment Although most newly born infants will require no specific care, assume the infant will be depressed. At a minimum, equipment should include: Neonatal resuscitator (< 750 ml) Term and pre-term masks Suction equipment Laryngoscope and ET tubes/O2 source Preparation of Equipment Provision of a warm environment Ideally, a preheated radiant warmer Practically, a supply of towels, thermal wrap or mother’s abdomen Thermal mattress, hat, or plastic bag to the preemie’s neck As the newborn’s body temperature drops, its’ oxygen requirements raise exponentially Preparation The key to successful resuscitation is anticipation At least two personnel are needed for the resuscitation of the severely depressed and asphyxiated newborn On person for ventilation, and if necessary, intubation. Another for monitoring heart rate, and if necessary, chest compressions APGAR Score Traditionally, assigned at 1 and 5 minutes Gives shorthand information about the newborn’s condition, changes in its’ status, and is a general predictor of outcome Has limitations Should not be used as a guide to resuscitative efforts Keys to resuscitation include heart rate, and respiratory status APGAR Score APGAR Score Transition Birth process single most dangerous event that most of us will ever go through Transition from fetal circulation to neonatal circulation Fetal/Neonatal Physiology Fetal Physiology Immediate Care of the Newborn Most full-term newborns are healthy and require no specific treatment, other than drying and keeping warm However, initial steps in caring for the newly born can prevent secondary and avoidable complications in an otherwise healthy newborn These steps provide a beginning point for resuscitation Dry and Warm the Baby Dry and Warm the Baby The newly born can lose tremendous amounts of heat through evaporation and radiation, unless rapidly dried Drying is important, even if the baby is depressed/asphyxiated, and in need of immediate resuscitation Warming the newly born will dramatically reduce tissue oxygen requirements Positioning the Newborn Positioning the Newborn Positioning the Newborn Positioning the Newborn The newborn’s head is disproportionately large when compared to the older child and adult This will lead to flexion of the neck when the newborn is in the supine position and lead to airway compromise Clearing the Airway Newborns are born with copious airway (amniotic) fluid, and even in a vigorous baby, may cause airway compromise Fetal lungs are not really ‘collapsed,’ but filled with fluid Most of this fluid is literally ‘squeezed’ out during the passage through the birth control Clearing the Airway Clearing the Airway Assess Breathing Most newborns will be crying lustily as proof of their breathing. The heart rate will be over 100 beats/min A newly born who is not breathing may be in either primary or secondary apnea In primary apnea, drying and stimulation will cause a start-up in breathing In secondary apnea, spontaneous ventilation will only start with the use of positive pressure ventilation Primary vs. Secondary Apnea When apnea is discovered following the initial steps of positioning, drying and suctioning, always assume the newborn is in secondary apnea, and proceed to bag-mask ventilation When the HR is less than 100 beats/min, proceed to PPV Primary Apnea Primary Apnea: When the fetus/newborn is asphyxiated, there will be an initial increase in respiratory effort and heart rate. This will be followed by an episode of apnea. At this time, simple stimulation will result in resumption of breathing, as in the act of drying and positioning Secondary Apnea When asphyxia is allowed to continue after primary apnea, the infant responds with gasping respirations, falling heart rate and blood pressure The infant then takes a ‘last breath’ and enters into secondary apnea Death will ensue unless resuscitation is begun immediately Primary vs. Secondary Apnea Assessing Heart Rate In the newly born, a low heart rate is a sign of hypoxia, NOT intrinsic heart disease Even if the newly born appears to be breathing, the adequacy of ventilation is assessed by evaluating the heart rate If the heart rate is <100/min, the respiratory efforts are inadequate, and positive pressure ventilation should be started Assessing the Heart Rate Assess Color Until the newly born has established regular ventilation, central cyanosis should be expected If the newborn is breathing regularly and has a heart rate >100/min, and continues to be centrally cyanotic, blow-by O2 may be given, with O2 tubing or a face mask application Peripheral cyanosis requires no treatment Central Cyanosis Peripheral Cyanosis Pink Pink and Warm Special Considerations Meconium aspiration syndrome Asphyxia Diaphragmatic Hernia Pneumothorax Hypoventilation due to low ventilatory pressure B-strep pneumonia/sepsis Congenital anomalies Meconium Aspiration Syndrome The management of meconium stained fluid has changed over time. Routine De-Lee suctioning on the perineum no longer recommended Routine intubation is no longer recommended in the lusty, crying infant Routine intubation not even recommended in the depressed infant, prior to PPV Meconium Meconium Aspiration Syndrome Asphyxia EMS dispatch to home of 17 y/o with severe abdominal pain On arrival, patient in advanced labor, and is crowning on exam Resuscitation oriented history Imminent delivery of term infant, with clear amniotic fluid Depressed Newly Born Upon delivery, newborn is apneic with a heart rate <100/min Most newborns who require resuscitation have been faced with ongoing hypoxia and acidosis This is reversed with positive pressure ventilation Indications for Assisted Ventilation Apnea unresponsive to drying, stimulation, and suctioning Always assume apnea in the newborn is secondary apnea, and begin positive pressure ventilation Heart rate <100 beats per minute Persistent central cyanosis with 100% O2 Self Inflating Bag Flow vs. Self Inflating Bags Ventilation Masks Positioning of Airway Jaw Thrust Maneuver in Newborn Positive Pressure Ventilation Positive Pressure Ventilation After positioning and rapidly drying the infant, the mask is placed firmly over the face, avoiding the eyes Begin ventilating with the ‘breathe……two……three’ approach, delivering about 40 to 60 breaths per minute Verify chest rise Re-evaluate every 30 seconds Newly Born’s First Breath Pressures needed for the initial breath may be a many as three times the pressure of subsequent breaths Initial pressures may need to be 60 cm of water pressure to overcome the resistance of retained lung fluid Another approach with a flow inflating bag is deliverance of 5 seconds of prolonged pressure Indications for Intubation Ineffective bag-mask ventilation Meconium stained amniotic fluid in the face of a depressed newborn Need for prolonged positive-pressure ventilation Intubation Intubation Severe Asphyxia EMS dispatch to a ‘term delivery in the toilet’ Upon arrival, we find an apneic and cyanotic term newborn, heart rate of 40 Application of positive pressure ventilation for 30 seconds does not improve the heart rate Indications for Chest Compression Heart rate <60/min Chest Compressions Chest Compressions If using bag valve mask ventilation, one should coordinate ventilation with compressions Deliver 3 compressions, then a pause for a ventilation Assume 120 events per minute of CPR, 90 compressions and 30 breaths Continue CPR until heart rate is over 60 and rising Continue ventilation until heart rate is >100/min and newborn is breathing spontaneously Indications for Medications Heart rate <60 beats per minute despite adequate ventilation with 100% O2 for 30 seconds, and another 30 seconds of chest compression Epinephrine is the drug of choice IV administration is recommended, but may be problematic in the newly born Golden Minute 60 seconds to complete initial steps, evaluating condition, and beginning ventilations if needed. Important not to cause delay. Assess respirations (apnea, gasping or labored breathing) and heart rate less than 100/min. The MOST SENSITIVE indicator of a successful response to each intervention is an increase in heart rate. Newborn Resuscitation First 30 seconds: should have provided warmth, positioning of infant, clearing of the airway, drying, stimulating and reposition the infant O2 may be given as necessary In the first 30 seconds, should already have come to some idea if further intervention is needed Is there meconium, is the infant crying, vigorous and pink?? Newborn Resuscitation During the next 30 seconds, evaluate respirations, heart rate and color Apnea is treated with positive pressure ventilation HR <100 is treated with positive pressure ventilation Newborn Resuscitation After another 30 seconds, begin chest compressions if HR is <60/min (one minute after birth) After another 30 seconds of CPR, consider epinephrine if HR remains <60/min Epinephrine (1:10,000 or 0.1 mg/ml) in a dose of 0.01-0.03 mg/kg (0.1-0.3ml/kg) ET dose: 0.3-1ml/kg Volume Expansion Given with poor response to resuscitation Given with concerns about blood loss or hypovolemia Crystalloid preferred 10ml/kg given over ? 10 minutes PALS/NRP Inverted Pyramid Always needed: Dry, warm, position, suction and stimulation Rarely needed: Chest compressions and medications In the middle is 02 and the need for positive pressure ventilation Of 100 newborns, only 10% will require some type of extra assistance Of the same 100 newborns, only 1% will require resuscitation Special Considerations EMS dispatch to tier with volunteer service They had been called for precipitous delivery of term newborn On arrival infant is tachypneic, tachycardic and cyanotic despite blow by O2 One side of the chest appears enlarged and the abdomen is concave Diaphragmatic Hernia Diaphragmatic Hernia Special Considerations EMS unit returning to base after successfully resuscitating newborn infant Infant had required several minutes of positive pressure ventilation, but no chest compressions Infant crying and pink initially, but now sudden deterioration with cyanosis, respiratory distress and falling heart rate Sudden Deterioration in Newly Born having needed Initial Resuscitation Special Considerations Special Considerations Special Considerations EMS dispatch to home delivery gone awry On arrival, term infant is apneic, cyanotic. Begins to receive positive pressure ventilation with an appropriate sized Ambu bag No chest rise is noted What is your initial approach?? Hypoventilation due to Low Ventilatory Pressure Recall first breath may require 3X as much pressure as subsequent breaths And lungs will not ‘open’ unless this pressure is delivered Difficulties with Ventilation Special Considerations Special Considerations Special Considerations EMS called to transport newborn from small outlying hospital Recurrent episodes of cyanosis and apnea Nursery nurse states ‘strangest thing………is fine when he is crying, but when he quiets down, turns blue and stops breathing’ ‘So we just kept him crying’ Chonal Atresia Choanal Atresia Neonatal Transport Called to transfer one month old from small community hospital with respiratory distress Presented with difficulty feeding and sweating On exam, tachycardic and tachypneic Requiring supplemental O2 to maintain sats Murmur noted on exam, harsh and holosystolic Ventricular Septal Defect EMS Call Called to home of pre-term infant, home from the NICU for only a couple of weeks Trouble with breathing, tachycardic and tachypneic Murmur also noted, to and fro type murmur, a machinery type murmur EMS Call Called to home of 3 week old, ‘Not acting right’ per mom. Poor feeding, and possible apneic event Siblings with respiratory ‘colds’ Infant with weak cry, limp and poor capillary refill RSV Bronchiolitis/Pneumonia/Shock 2015 AHA GUIDELINES Newborn Resuscitation DCC or delayed cord clamping Continued emphasis on maintaining temperature, as admission temp is a direct predictor of mortality and all things bad In hypothermic infant, no preference of fast vs slow rewarming In meconium staining, routine intubation and suctioning no longer advised 2015 GUIDELINES Heart rate determination: three lead ECG monitor preferred over pulse ox, and both preferred over clinical assessment Room air resuscitation in term infants In preterm, no apparent benefit/detriment with O2 vs RA resuscitation Initial breaths requiring increased pressure, shown in animal, but not human models LMA use in 34 weeks and greater gestation, but med usage and use with compressions has not been studied 2015 GUIDELINES CPAP has been shown to avoid intubation and the need for PPV Chest Compressions: OK to increase to 100% O2 Low glucose levels associated with poorer outcomes, and elevated glucose levels seem to be neuro-protective, but no recommendations have been made CESSATION OF EFFORTS Apgar 0 at 10 minutes Malformation incompatible with life