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HET-CAM BRD: Appendix D5 Substance Name CASRN Substances Used in Accuracy Analysis (IS(B) Analysis Method) In Vitro Conc. Tested In Vivo Conc. Tested Chemical Class Carboxylic acid Carboxylic acid In Vivo Physical Form Tested Acetic acid 64-19-7 10% n.a. Acetic acid 64-19-7 100% n.a. Acetone 67-64-1 100% 100% Ketone Liquid Allyl alcohol 107-18-6 100% 100% Alcohol 2-Aminophemol 95-55-6 Amine, Phenol Inorganic salt, Onium Polycyclic compound pH Property In Vivo (GHS) of Interest Classification1 GHS Category 1 Subclass2 March 2006 In Vivo (EPA) 3 Classification In Vivo (EU) Classification 4 In Vitro Classification Reference (IS(B))5 Solution R41 Severe CEC (1991) Liquid R41 Severe CEC (1991) R36 Severe Liquid R36 Severe Solid Nonirritant Nonirritant R36 Severe Nonirritant Nonirritant SCNM Slight R41 Severe CEC (1991) Category 2A Category II Gilleron et al. (1997) Gilleron et al. (1996) Gilleron et al. (1996) Gilleron et al. (1997) Gilleron et al. (1996) Gilleron et al. (1997) 100% 100% Ammonium nitrate 6484-52-2 100% 100% Anthracene 120-12-7 100% 100% L-Aspartic acid 70-47-3 100% 100% Amino acid Solid Benzalkonium chloride 8001-54-5 100% n.a. Onium Unknown Cationic Surfactant Benzalkonium chloride 8001-54-5 100% 5% Onium Solution Cationic Surfactant Category 1/Category 2A 2 Category I R41/R36 Severe Gilleron et al. (1997) Benzalkonium chloride 8001-54-5 100% 10% Onium Solution Cationic Surfactant Category 1 4 Category I R41 Severe Gilleron et al. (1997) Benzalkonium chloride 8001-54-5 100% 1% Onium Solution Cationic Surfactant Category 1 1 Category I R41 Severe Gilleron et al. (1997) Benzethonium chloride 121-54-0 100% 100% Amine, Onium Solid Cationic Surfactant R41 Severe Gilleron et al. (1996) Brij 35 9002-92-0 100% n.a. Alcohol Solid Nonionic Surfactant Nonirritant Slight CEC (1991) Solid Category 2B Category III Solid SCNM SCNM Butanol Butanol 2-Butoxyethyl acetate 2-Butoxyethyl acetate 71-36-3 71-36-3 10% 100% n.a. n.a. Alcohol Alcohol Solution Liquid R36 R36 Severe Severe CEC (1991) CEC (1991) 112-07-2 10% n.a. Ester Solution Nonirritant Slight CEC (1991) 112-07-2 100% n.a. Ester Liquid Nonirritant Slight CEC (1991) Butyl acetate 123-86-4 100% 100% Ester Liquid Nonirritant Severe Gilleron et al. (1997) Nonirritant D-33 Category III HET-CAM BRD: Appendix D5 Substance Name CASRN Substances Used in Accuracy Analysis (IS(B) Analysis Method) In Vitro Conc. Tested In Vivo Conc. Tested Chemical Class In Vivo Physical Form Tested Imide, Organic sulfur compound Solid Category 1 Solid pH Property In Vivo (GHS) of Interest Classification1 Captan 90 concentrate 133-06-2 100% 100% 4-Carboxybenzaldehyde 619-66-9 100% 100% Cetylpyridinium bromide 140-72-7 100% 0.10% Cetylpyridinium bromide 140-72-7 100% 10% Cetylpyridinium bromide 140-72-7 100% 6% Chlorhexidine 55-56-1 100% 100% Amidine Cyclohexanol 108-93-0 100% 100% Alcohol Cyclohexanone 108-94-1 100% 100% Deoxycholic acid, sodium salt 302-95-4 100% 100% Diacetone alcohol 123-42-2 100% 100% Ketone Liquid Dibenzoyl-Ltartaric acid 2743-38-6 100% 100% Carboxylic acid, Ester Solid Category 1 Dibenzyl phosphate 1623-08-1 100% 100% Ester Solid Category 2A Dibutyltin chloride 683-18-1 100% n.a. Organic salt Solid 2,6Dichlorobenzoyl chloride 4659-45-4 100% 100% Acyl halide Liquid 2,4-Dicholor-5sulfamolyl-benzoic 2736-23-4 acid 100% 100% Amide, Organic sulfur compound Solid Carboxylic acid, Aldehyde Heterocyclic compounds, Onium Heterocyclic compounds, Onium Heterocyclic compounds, Onium Ketone, Cyclic hydrocarbon Alcohol, Carboxylic acid, Organic salt GHS Category 1 Subclass2 March 2006 In Vivo (EPA) 3 Classification In Vivo (EU) Classification 4 In Vitro Classification Reference (IS(B))5 Category I R41 Severe Gilleron et al. (1997) Category 2A Category II R36 Slight Gilleron et al. (1997) Category III Nonirritant Severe Gilleron et al. (1997) 4 Solution Cationic Surfactant Nonirritant Solution Cationic Surfactant Category 1 4 SCNM R41 Severe Gilleron et al. (1997) Solution Cationic Surfactant Category 1 2 Category I R41 Severe Gilleron et al. (1997) Solid Category 1 4 SCNM SCNM Severe Liquid Category 1 2 Category I R41 Severe Nonirritant Severe Gilleron et al. (1996) R36 Severe Gilleron et al. (1996) Nonirritant Severe SCNM R41 Severe Category II R36 Severe R41 Severe CEC (1991) SCNM Severe Gilleron et al. (1997) Nonirritant Slight Gilleron et al. (1996) Liquid Solid Nonionic Surfactant Category 2A D-34 2 Category II Gilleron et al. (1997) Gilleron et al. (1997) Gilleron et al. (1996) Gilleron et al. (1996); Gilleron et al. (1997) Gilleron et al. (1997) HET-CAM BRD: Appendix D5 Substances Used in Accuracy Analysis (IS(B) Analysis Method) In Vitro Conc. Tested In Vivo Conc. Tested Chemical Class In Vivo Physical Form Tested 657-24-9 100% 100% Amidine Solid 595-37-9 100% 100% Carboxylic acid Liquid SCNM 110-03-2 100% 100% Alcohol Solid Category 1 Dimethyl sulfoxide 67-68-5 10% n.a. Dimethyl sulfoxide 67-68-5 100% Dimethyl sulfoxide 67-68-5 100% Substance Name Dimethyl biguanidine 2,2Dimethylbutanoic acid 2,5-Dimethylhexanediol CASRN pH Property In Vivo (GHS) of Interest Classification1 GHS Category 1 Subclass2 March 2006 In Vivo (EPA) 3 Classification In Vivo (EU) Classification 4 In Vitro Classification Nonirritant Moderate Gilleron et al. (1996) Category I SCNM Severe Gilleron et al. (1997) Category I R41 Severe Gilleron et al. (1997) Organic sulfur Solution compound Nonirritant Slight CEC (1991) n.a. Organic sulfur compound Liquid Nonirritant Severe CEC (1991) 100% Organic sulfur compound Liquid Nonirritant Severe Gilleron et al. (1996) Solid Nonirritant Nonirritant Gilleron et al. (1996) Nonirritant Severe Nonirritant Severe Nonirritant Severe Nonirritant Severe 25105-12EDTA dipotassium 9 100% 100% Amine, Carboxylic acid, Organic salt Ethanol 64-17-5 100% 100% Alcohol Liquid 2-Ethoxyethanol 110-80-5 100% 100% Alcohol Liquid Ethyl acetate 141-78-6 100% 100% Ester Liquid Liquid Category 2A Nonirritant 1 Category III Category III Ethylacetoacetate 141-97-9 100% 100% Carboxylic acid, Ketone 2-Ethyl-1-hexanol 104-76-7 100% 100% Alcohol Liquid Category 2A Category II R36 Severe 609-14-3 100% 100% Ketone, Ester Liquid Category 2B Category III Nonirritant Severe 3938-95-2 100% 100% Ester Liquid Nonirritant Category III Nonirritant Severe Solid Nonirritant Category III Nonirritant Slight Nonirritant Moderate R36 Severe Ethyl-2-methylacetoacetate Ethyl trimethyl acetate Reference (IS(B))5 Fomesafen 72128-020 100% 100% Imide, Ether, Nitro compound Furan 110-00-9 100% 100% Heterocycle Liquid Gammabutyrolactone 96-48-0 100% 100% Heterocycle, Lactone Liquid Category 2A D-35 Category II Gilleron et al. (1996); Gilleron et al. (1997) Gilleron et al. (1996) Gilleron et al. (1997) Gilleron et al. (1996) Gilleron et al. (1997) Gilleron et al. (1997) Gilleron et al. (1997) Gilleron et al. (1997) Gilleron et al. (1996) Gilleron et al. (1996); Gilleron et al. (1997) HET-CAM BRD: Appendix D5 Substance Name Gluconolactone CASRN 90-80-2 Glycerol Glycerol 19285-837 56-81-5 56-81-5 Glycerol 56-81-5 DL-Glutamic acid 3Glycidopropyltrim 2530-83-8 ethoxysilane Hexadecyltrimethy lammonium 57-09-0 bromide Substances Used in Accuracy Analysis (IS(B) Analysis Method) In Vitro Conc. Tested In Vivo Conc. Tested Chemical Class In Vivo Physical Form Tested 100% 100% Carboxylic acid, Lactone, Carbohydrate Solid Nonirritant Slight 100% 100% Amino acid Solid Nonirritant Nonirritant 10% 100% n.a. n.a. Alcohol Alcohol Solution Liquid Nonirritant Nonirritant Slight Severe 100% 100% Alcohol Liquid Nonirritant Severe 100% 100% Ether, Organosilicon compound Liquid Nonirritant Slight Gilleron et al. (1996) 100% 100% Organic salt, Onium Liquid R36 Severe Gilleron et al. (1996) pH Property In Vivo (GHS) of Interest Classification1 Nonirritant GHS Category 1 Subclass2 In Vivo (EPA) 3 Classification Category IV Cationic Surfactant In Vivo (EU) Classification 4 In Vitro Classification Reference (IS(B))5 Gilleron et al. (1996) Gilleron et al. (1996) CEC (1991) CEC (1991) Gilleron et al. (1997) Acyclic hydrocarbon Acyclic hydrocarbon Acyclic hydrocarbon Liquid Nonirritant Slight Gilleron et al. (1996) Solution Nonirritant Severe CEC (1991) Liquid Nonirritant Slight CEC (1991) Alcohol Liquid Category 2A Category II R36 Severe Gilleron et al. (1997) Undiluted Undiluted Formulation Solution Nonirritant Category III Nonirritant Slight Gettings et al. (1991) Undiluted Undiluted Formulation Solution Nonirritant Category IV Nonirritant Moderate Gettings et al. (1991) Undiluted Undiluted Formulation Solution Nonirritant Category IV Nonirritant Moderate Gettings et al. (1991) Hexane 110-54-3 100% 100% n-Hexane 110-54-3 10% n.a. n-Hexane 110-54-3 100% n.a. Hexanol 111-27-3 100% 100% Hydroalcoholic Formulation 1-5% Alcohol Containing Formulation (PROD-00187) Hydroalcoholic Formulation 210% Alcohol Containing Formulation (PROD-00183) Hydroalcoholic Formulation 315% Alcohol Containing Formulation (PROD-00186) March 2006 D-36 HET-CAM BRD: Appendix D5 Substance Name Hydroalcoholic Formulation 420% Alcohol Containing Formulation (PROD-00185) Hydroalcoholic Formulation 533% Alcohol Containing Formulation (PROD-00184) Hydroalcoholic Formulation 640% Alcohol Containing Formulation (PROD-00189) Hydroalcoholic Formulation 755% Alcohol Containing Formulation (PROD-00188) Hydroalcoholic Formulation 865% Alcohol Containing Formulation (PROD-00180) Hydroalcoholic Formulation 983% Alcohol Containing Formulation (PROD-00181) Hydroalcoholic Formulation 1090% Alcohol Containing Formulation (PROD-00182) CASRN In Vitro Conc. Tested Substances Used in Accuracy Analysis (IS(B) Analysis Method) In Vivo Conc. Tested Chemical Class In Vivo Physical Form Tested pH Property In Vivo (GHS) of Interest Classification1 GHS Category 1 Subclass2 March 2006 In Vivo (EPA) 3 In Vivo (EU) Classification Classification 4 In Vitro Classification Reference (IS(B))5 Undiluted Undiluted Formulation Solution Nonirritant Category IV Nonirritant Moderate Gettings et al. (1991) Undiluted Undiluted Formulation Solution Nonirritant Category III Nonirritant No Data Gettings et al. (1991) Undiluted Undiluted Formulation Solution Category 1 1 Category I R41 Severe Gettings et al. (1991) Undiluted Undiluted Formulation Solution Category 1 1 Category I R41 Severe Gettings et al. (1991) Undiluted Undiluted Formulation Solution Category 2B Category II Nonirritant Severe Gettings et al. (1991) Undiluted Undiluted Formulation Solution Category 2A Category II SCNM Severe Gettings et al. (1991) Undiluted Undiluted Formulation Solution Category 1 Category I R41 Severe Gettings et al. (1991) D-37 1 HET-CAM BRD: Appendix D5 Substance Name CASRN Substances Used in Accuracy Analysis (IS(B) Analysis Method) In Vitro Conc. Tested In Vivo Conc. Tested Chemical Class In Vivo Physical Form Tested pH Property In Vivo (GHS) of Interest Classification1 Imidazole 288-32-4 100% 100% Heterocycle Solid Iminodibenzyl 494-19-9 100% 100% Heterocycle Solid Isobutanol 78-83-1 100% 100% Alcohol Liquid Category 2A Isopropanol 67-63-0 100% 100% Alcohol Liquid Category 2A NLauroylsarcosine, sodium salt 7631-98-3 100% 100% Aminde, Amine Salt Solid Laurylsulfo betaine 14933-085 100% 100% Amine, Onium Unknown Magnesium carbonate 56378-724 100% 100% Alcohol Solid Maneb 12427-382 100% 100% Amine, Organic salt, Urea Solid 67-56-1 100% 100% Alcohol 2-Methoxyethanol 109-86-4 10% n.a. 2-Methoxyethanol 109-86-4 100% Methanol Category 1 Gilleron et al. (1996); Gilleron et al. (1997) Gilleron et al. (1996) Gilleron et al. (1997) Gilleron et al. (1997) Severe Category III SCNM Severe Anionic Surfactant Nonirritant Severe Gilleron et al. (1996) Zwitterion ic Surfactant R36 Moderate Gilleron et al. (1996) Nonirritant Slight Gilleron et al. (1996) SCNM Nonirritant Gilleron et al. (1997) Liquid Nonirritant Severe Gilleron et al. (1996) Alcohol Solution Nonirritant Moderate CEC (1991) n.a. Alcohol Liquid Nonirritant Severe Liquid 100% 100% Ester Liquid Category 2A 100% 100% Ester, Nitrile Liquid 100% 100% Cyclic hydrocarbon 100% 100% 100% 100% MYRJ 45 Reference (IS(B))5 R36 Methyl acetate 108-10-1 In Vitro Classification Category II 100% Category I Classification 4 Nonirritant 100% Methyl isobutyl ketone Classification In Vivo (EU) Nonirritant SCNM 4 3 Severe 2-Methoxyethanol 109-86-4 Methyl 105-34-0 cyanoacetate Methylcyclopentan 96-37-7 e Methyl ethyl 78-93-3 ketone Subclass2 In Vivo (EPA) R41/R36 Alcohol, Ether 79-20-9 GHS Category 1 March 2006 Category III Nonirritant Severe Category II R36 Severe Category 2A Category II R36 Severe Liquid Nonirritant Category III Nonirritant Severe Ketone Liquid Category 2A Category III R36 Severe 100% Ketone Liquid Nonirritant Category III Nonirritant Severe 100% Unknown Solid Nonirritant Nonirritant Nonionic Surfactant D-38 CEC (1991) Gilleron et al. (1996) Gilleron et al. (1997) Gilleron et al. (1997) Gilleron et al. (1997) Gilleron et al. (1997) Gilleron et al. (1996); Gilleron et al. (1997) Gilleron et al. (1996) HET-CAM BRD: Appendix D5 Substance Name CASRN In Vitro Conc. Tested Substances Used in Accuracy Analysis (IS(B) Analysis Method) In Vivo Conc. Tested 1-Naphthalene acetic acid 86-87-3 100% 100% 1-Naphthalene acetic acid, Na salt 61-31-4 100% 100% 1-Nitropropane 108-03-2 100% 100% Octanol 111-87-5 100% 100% Oil/Water Emulsion-HZA Oil/Water Emulsion-HZC Oil/Water Emulsion-HZE Oil/Water Emulsion-HZF Oil/Water Emulsion-HZH Oil/Water Emulsion-HZI Oil/Water Emulsion-HZJ Oil/Water Emulsion-HZL Oil/Water Emulsion-HZM Oil/Water Emulsion-HZN Oil/Water Emulsion-HZO Oil/Water Emulsion-HZR Oil/Water Emulsion-HZS Chemical Class Carboxylic acid, Polycyclic compound Organic salt, Carboxylic acid salt, Polycyclic compound Acyclic hydrocarbon, Nitro compound Alcohol In Vivo Physical Form Tested pH Property In Vivo (GHS) of Interest Classification1 GHS Category 1 Subclass2 March 2006 In Vivo (EPA) 3 Classification In Vivo (EU) Classification 4 In Vitro Classification Reference (IS(B))5 Solid Category 1 NC Category I SCNM Moderate Gilleron et al. (1997) Solid Category 1 1 Category I R41 Severe Gilleron et al. (1997) Nonirritant Slight Gilleron et al. (1996) Liquid Liquid Category 2A Category II R36 Severe Undiluted Undiluted Formulation Solution Nonirritant Category III Nonirritant Slight Undiluted Undiluted Formulation Solution Nonirritant Category III Nonirritant Slight Undiluted Undiluted Formulation Solution Nonirritant Category IV Nonirritant Slight Undiluted Undiluted Formulation Solution Nonirritant Category III Nonirritant Slight Undiluted Undiluted Formulation Solution Nonirritant Category III Nonirritant Severe Undiluted Undiluted Formulation Solution Nonirritant Category IV Nonirritant Nonirritant Undiluted Undiluted Formulation Solution Nonirritant Category IV Nonirritant Slight Undiluted Undiluted Formulation Solution Nonirritant Category III Nonirritant Severe Undiluted Undiluted Formulation Solution Nonirritant Category III Nonirritant Severe Undiluted Undiluted Formulation Solution Nonirritant Category IV Nonirritant Slight Undiluted Undiluted Formulation Solution Nonirritant Category IV Nonirritant Nonirritant Undiluted Undiluted Formulation Solution Category 1 Category I R41 Severe Undiluted Undiluted Formulation Solution Nonirritant Category IV Nonirritant Moderate D-39 1 Gilleron et al. (1996); Gilleron et al. (1997) Gettings et al. (1994) Gettings et al. (1994) Gettings et al. (1994) Gettings et al. (1994) Gettings et al. (1994) Gettings et al. (1994) Gettings et al. (1994) Gettings et al. (1994) Gettings et al. (1994) Gettings et al. (1994) Gettings et al. (1994) Gettings et al. (1994) Gettings et al. (1994) HET-CAM BRD: Appendix D5 Substance Name CASRN Oil/Water Emulsion-HZT Oil/Water Emulsion-HZU Oil/Water Emulsion-HZV Oil/Water Emulsion-HZW Oil/Water Emulsion-HZY In Vitro Conc. Tested Substances Used in Accuracy Analysis (IS(B) Analysis Method) In Vivo Conc. Tested Chemical Class In Vivo Physical Form Tested pH Property In Vivo (GHS) of Interest Classification1 GHS Category 1 Subclass2 March 2006 In Vivo (EPA) 3 In Vivo (EU) Classification Classification 4 In Vitro Classification Reference (IS(B))5 Undiluted Undiluted Formulation Solution Nonirritant Category IV Nonirritant Slight Undiluted Undiluted Formulation Solution Nonirritant Category IV Nonirritant Slight Undiluted Undiluted Formulation Solution Nonirritant Category III Nonirritant Nonirritant Undiluted Undiluted Formulation Solution Nonirritant Category III Nonirritant Moderate Undiluted Undiluted Formulation Solution Nonirritant Category IV Nonirritant Severe SCNM SCNM SCNM Severe Gettings et al. (1994) Gettings et al. (1994) Gettings et al. (1994) Gettings et al. (1994) Gettings et al. (1994) Gilleron et al. (1997) Gilleron et al. (1996) Gilleron et al. (1996) Parafluoraniline 371-40-4 100% 100% Amine Liquid 2,4-Pentadione 123-54-6 100% 100% Ketone Liquid Nonirritant Moderate 1-Phenyl-3pyrazolidine 92-43-3 100% 100% Heterocycle Solid Nonirritant Nonirritant Polyethylene glycol 400 25322-683 100% 100% Alcohol, Ether Liquid Nonionic Surfactant Nonirritant Severe Gilleron et al. (1997) Polyoxyethylene 23 lauryl ether 9002-92-0 100% 100% Alcohol Solid Nonionic Surfactant Nonirritant Slight Gilleron et al. (1996) Potassium cyanate 590-28-3 100% 100% Inorganic salt Solid SCNM SCNM SCNM Severe Gilleron et al. (1997) Solid Category 1 Category I R41 Severe Gilleron et al. (1996); Gilleron et al. (1997) Nonirritant Slight Nonirritant Category IV Promethazine HCl 58-33-3 100% 100% Amine, Heterocycle, Organic sulfur compound Propyl-4hydroxybenzoate 94-13-3 100% 100% Carboxylic acid, Phenol Solid Pyridine 110-86-1 100% 100% Heterocycle Liquid Category 1 4 Category I R41/R36 Severe Quinacrine 69-05-6 100% 100% Solid Category 1 3 Category I R41/R36 Moderate Gilleron et al. (1996); Gilleron et al. (1997) Sodium dodecyl sulfate 151-21-3 10% n.a. R36 Severe CEC (1991) Amine, Heterocycle, Polycyclic compound Organic salt, Carboxylic acid salt Solution Anionic Surfactant D-40 1 Gilleron et al. (1996) Gilleron et al. (1996); Gilleron et al. (1997) HET-CAM BRD: Appendix D5 Substances Used in Accuracy Analysis (IS(B) Analysis Method) In Vivo Physical Form Tested In Vitro Conc. Tested In Vivo Conc. Tested Chemical Class 151-21-3 100% n.a. Organic salt, Carboxylic acid salt Sodium hydroxide 1310-73-2 100% 1% Alkali Solution Category 2B Sodium hydroxide 1310-73-2 100% 10% Alkali Solution Category 1 Sodium lauryl sulfate 151-21-3 100% 3% Sodium lauryl sulfate 151-21-3 100% 15% Sodium lauryl sulfate 151-21-3 1% 1% Sodium oxalate 62-76-0 100% 100% 10486-007 100% 100% Substance Name Sodium dodecyl sulfate Sodium perborate Surfactant Based Formulation 1HZA Surfactant Based Formulation 2HZB Surfactant Based Formulation 3HZC Surfactant Based Formulation 4HZD Surfactant Based Formulation 5HZE Surfactant Based Formulation 6HZF CASRN Solid Organic salt, Carboxylic Solution acid salt Organic salt, Carboxylic Solution acid salt Organic salt, Carboxylic Solution acid salt Organic salt, Carboxylic Solid acid salt Inorganic salt, Boron Solid containing compound pH Property In Vivo (GHS) of Interest Classification1 GHS Category 1 Subclass2 In Vivo (EPA) 3 Classification Anionic Surfactant Anionic Surfactant Nonirritant Anionic Surfactant Category 1 Anionic Surfactant Nonirritant 4 NC March 2006 In Vivo (EU) Classification 4 In Vitro Classification Reference (IS(B))5 R41 Severe CEC (1991) Category III R36 Severe Category I R41 Severe Category III Nonirritant Severe Gilleron et al. (1997) Category I SCNM Severe Gilleron et al. (1997) Category IV Nonirritant Severe Vinardell and Macián (1994) Gilleron et al. (1997) Gilleron et al. (1997) Category 1 4 Category I R41 Severe Gilleron et al. (1997) Category 1 4 Category I R41 Severe Gilleron et al. (1997) 10% Undiluted Formulation Solution Category 1 1 Category I R41 Severe Gettings et al. (1996) 10% Undiluted Formulation Solution Category 1 1 Category I R41 Moderate Gettings et al. (1996) 10% Undiluted Formulation Solution Category 1 1 Category I R41 Severe Gettings et al. (1996) 10% Undiluted Formulation Solution Category 2B Category III Nonirritant Moderate Gettings et al. (1996) 10% Undiluted Formulation Solution SCNM Category I SCNM Severe Gettings et al. (1996) 10% Undiluted Formulation Solution Category 1 Category I R41 Severe Gettings et al. (1996) D-41 1 HET-CAM BRD: Appendix D5 Substance Name Surfactant Based Formulation 7HZG Surfactant Based Formulation 8HZH Surfactant Based Formulation 9-HZI Surfactant Based Formulation 10HZJ Surfactant Based Formulation 11HZK Surfactant Based Formulation 12HZL Surfactant Based Formulation 13HZM Surfactant Based Formulation 14HZN Surfactant Based Formulation 15HZP Surfactant Based Formulation 16HZQ Surfactant Based Formulation 17HZR Surfactant Based Formulation 18HZS Surfactant Based Formulation 19HZT Surfactant Based Formulation 20HZU CASRN In Vitro Conc. Tested Substances Used in Accuracy Analysis (IS(B) Analysis Method) In Vivo Conc. Tested Chemical Class In Vivo Physical Form Tested pH Property In Vivo (GHS) of Interest Classification1 GHS Category 1 Subclass2 March 2006 In Vivo (EPA) 3 Classification In Vivo (EU) Classification 4 In Vitro Classification Reference (IS(B))5 Category I R41 Moderate Gettings et al. (1996) Category IV Nonirritant Slight Gettings et al. (1996) Category I R41 Severe Gettings et al. (1996) Category IV Nonirritant Moderate Gettings et al. (1996) 1 Category I R41 Severe Gettings et al. (1996) Category 1 1 Category I R41 Severe Gettings et al. (1996) Solution Category 1 1 Category I R41 Slight Gettings et al. (1996) Undiluted Formulation Solution Category 1 1 Category I R41 Moderate Gettings et al. (1996) 10% Undiluted Formulation Solution Nonirritant Category III Nonirritant Slight Gettings et al. (1996) 10% Undiluted Formulation Solution Nonirritant Category III Nonirritant Slight Gettings et al. (1996) 10% Undiluted Formulation Solution Category 1 1 Category I R41 Moderate Gettings et al. (1996) 10% Undiluted Formulation Solution Category 1 1 Category I R41 Severe Gettings et al. (1996) 10% Undiluted Formulation Solution Nonirritant Category IV Nonirritant Slight Gettings et al. (1996) 10% Undiluted Formulation Solution Category 2B Category III R36 Moderate Gettings et al. (1996) 10% Undiluted Formulation Solution Category 1 10% Undiluted Formulation Solution Nonirritant 10% Undiluted Formulation Solution Category 1 10% Undiluted Formulation Solution Nonirritant 10% Undiluted Formulation Solution Category 1 10% Undiluted Formulation Solution 10% Undiluted Formulation 10% D-42 1 1 HET-CAM BRD: Appendix D5 Substance Name CASRN Surfactant Based Formulation 21HZV Surfactant Based Formulation 22HZW Surfactant Based Formulation 23HZX Surfactant Based Formulation 24HZY Surfactant Based Formulation 25HZZ In Vitro Conc. Tested Substances Used in Accuracy Analysis (IS(B) Analysis Method) In Vivo Conc. Tested Chemical Class In Vivo Physical Form Tested pH Property In Vivo (GHS) of Interest Classification1 GHS Category 1 Subclass2 March 2006 In Vivo (EPA) 3 Classification In Vivo (EU) Classification 4 In Vitro Classification Reference (IS(B))5 10% Undiluted Formulation Solution Category 1 1 Category I R41 Moderate Gettings et al. (1996) 10% Undiluted Formulation Solution Category 1 1 Category I R41 Moderate Gettings et al. (1996) 10% Undiluted Formulation Solution Category 1 1 Category I R41 Severe Gettings et al. (1996) 10% Undiluted Formulation Solution Category 1 1 Category I R41 Severe Gettings et al. (1996) 10% Undiluted Formulation Solution Nonirritant Category IV Nonirritant Slight Gettings et al. (1996) Nonirritant Category III Nonirritant Slight R36 Severe Nonirritant Severe Nonirritant Severe Nonirritant Nonirritant Slight Slight Gilleron et al. (1997) CEC (1991) CEC (1991) R41 Severe CEC (1991) R41 Moderate CEC (1991) Category III Nonirritant Severe Category I R41 Severe Nonirritant Moderate Nonirritant Slight Nonirritant Slight CEC (1991) Nonirritant Severe CEC (1991) Tetraamino 5392-28-9 pyrimidine sulfate 100% 100% Amine, Heterocycle Solid Thiourea 62-56-6 100% 100% Organic sulfur compound Solid Toluene 108-88-3 100% n.a. Toluene 108-88-3 100% 100% Triacetin Triacetin Tributyltin chloride Tributyltin chloride Trichloroacetic acid Trichloroacetic acid 1,2,3Trichloropropane 1,2,4Trichloropropane 102-76-1 102-76-1 10% 100% n.a. n.a. 1461-22-9 10% n.a. 1461-22-9 100% n.a. 76-03-9 100% 30% 76-03-9 100% 3% 96-18-4 100% 100% 95-63-6 100% 100% Triethanolamine 102-71-6 10% n.a. Triethanolamine 102-71-6 100% n.a. Polycyclic Liquid compound Polycyclic Liquid compound Ester Solution Ester Liquid Organometalli Solution c compound Organometalli Solid c compound Carboxylic Liquid acid Carboxylic Liquid acid Acyclic Liquid hydrocarbon Cyclic Liquid hydrocarbon Amine, Solution Alcohol Amine, Liquid Alcohol Nonirritant Category III Nonirritant Category 1 D-43 4 Gilleron et al. (1996); Gilleron et al. (1997) Gilleron et al. (1996); Gilleron et al. (1997) CEC (1991) Gilleron et al. (1997) Gilleron et al. (1997) Gilleron et al. (1996) Gilleron et al. (1996) HET-CAM BRD: Appendix D5 Substance Name CASRN Substances Used in Accuracy Analysis (IS(B) Analysis Method) In Vitro Conc. Tested In Vivo Conc. Tested Chemical Class In Vivo Physical Form Tested 100% 100% Amine, Alcohol Liquid pH Property In Vivo (GHS) of Interest Classification1 Triethanolamine 102-71-6 Triton X-100 9002-93-1 Undiluted 5% Ether Liquid Nonionic Categorry Surfactant 2A/Category 2B Triton X-100 9002-93-1 Undiluted 10% Ether Liquid Nonionic Surfactant Triton X-155 9010-44-0 100% Alcohol, Ether Liquid Nonionic Surfactant Liquid Nonionic Surfactant Tween 20 9005-64-5 100% 100% 100% Ester, Ether Category 1 Nonirritant GHS Category 1 Subclass2 4 March 2006 In Vivo (EPA) 3 Classification In Vivo (EU) Classification 4 In Vitro Classification Reference (IS(B))5 Nonirritant Severe Gilleron et al. (1996) Category III Nonirritant/R36 Severe Gilleron et al. (1997) Category II SCNM Severe Gilleron et al. (1997) Nonirritant Slight Gilleron et al. (1996) Severe Vinardell and Macián (1994); Gilleron et al. (1997) Category III Nonirritant Abbreviations: CASRN = Chemical Abstracts Service Registry Number; Conc. = Concentration; EPA = U.S. Environmental Protection Agency; EU = European Union; GHS = Globally Harmonized System; n.a. = not applicable, SCNM - Study Criteria Not Met. 1 Eye Irritant Category 1 = irreversible effects on the eye/serious damage to the eye; Category 2A = reversible effects on the eye/irritating to the eyes; Category 2B = reversible effects on the eye/mildly irritating to the eyes; Nonirritant = not an eye irritant 2 NICEATM-defined subgroups assigned based on the lesions that drove classification of a GHS Category 1 substance. 1: based on lesions that are persistent; 2: based on lesions that are severe (not including corneal opacity score equal to 4); 3: based on lesions that are severe (not including corneal opacity score equal to 4) and persistent; 4: corneal opacity score equal to 4 at any time; NC: No subclassification could be made based on the data. 3 Toxicity Category I for the Primary Eye Irritation Study = Corrosive, or corneal involvement or irritation not reversible within 21 days; Category II = Corneal involvement or irritation clearing in 8-21 days; Category III = Corneal involvement or irritation clearing in 7 days or less; Category IV = Minimal effects clearing within 24 hr. 4 Risk phrase R41 = risk of serious damage to the eyes; R36 = irritating to the eyes; nonirritant = not an eye irritant. 5 IS(B) represents irritation scores that were calculated using the method described in Kalweit et al. (1987). D-44