Download Lina H.K. LIM

Lina H.K Lim B.Sc. (London), Ph.D. (London) Assistant Professor Department of Physiology, NUS Immunology Program Yong Loo Lin School of Medicine Centre for Life Sciences, Level 3 (Immunology), #03‐06J 28 Medical Drive Phone: 6516 5515 E‐mail : [email protected] MAJOR RESEARCH INTERESTS A major focus of our research is to understand the regulation of immune responses and signaling processes by novel proteins with regards to cancer development, progression and metastasis as well as asthma. Current projects include: ™ Regulation Of T Cell/B Cell Function and Apoptosis: Importance In The Development Of Asthma ™ Differential Tumor Infiltrating Leukocyte Function Influencing Cancer Development and Progression ™ Molecular Mechanisms Of Cancer Cell Movement and Migration ™ Novel Signaling Partners Involved In Inflammation and Cancer ™ MicroRNAs In Cancer and Inflammation ™ Identification Of Novel Chemicals/Drugs For Use In The Treatment Of Cancer/ Asthma RECENT PUBLICATIONS Henderson RB*, Lim LHK*, Tessier PA, Gavins FNE, Mathies M, Perretti M, Hogg N. The use of LFA‐1 deficient mice to determine the role of LFA‐1, Mac‐1 and a4 integrin in the inflammatory response of neutrophils. (* joint first author) J. Exp Med. 194 (2):219‐226. 2001 Lim LHK, Burdick MM, Hudson S, Bte Mustafa F, Konstatopoulos K, Bochner BS. Stimulation of human endothelium with interleukin 3 (IL‐3) induces selective basophil accumulation in vitro. J Immunol 2006 176: 5346‐5353 Lim LHK, Pervaiz S. Annexin 1: the new face of an old molecule. Review. Faseb journal. 2007;21:968‐975. Mustafa FB, Ng FSP, Nguyen TH, Lim LHK. Honeybee venom secretory phospholipase A2 induces leukotriene production but not histamine release from human basophils. Clinical and Experimental Immunology, 2008 151: 94–100 Nguyen TH, Mustafa FB, Pervaiz S, Ng FSP, Lim LHK. ERK1/2 activation is required for Resveratrol‐induced apoptosis in metastatic breast cancer cells. 2008 Int J Oncol 33(1): 81‐92. Kong KV, Leong WK, Ng SP, Nguyen TH, Lim LH. Osmium carbonyl clusters: a new class of apoptosis inducing agents. ChemMedChem. 2008 Aug;3(8):1269‐75. Tan YW, Lim LHK. Anti‐inflammatory effects of Resveratrol on human eosinophils. (Advanced publication, Sept 2008, Brit J Pharmacol) Ang ZF, Sim HL, Nguyen TH, Putti TC, Lim LHK. Annexin‐1 regulates growth arrest induced by high levels of estrogen in MCF‐7 breast cancer cells (Accepted, Molecular Cancer Research) Leow SC, Nguyen TH, Ng FSP , Lim LHK Annexin‐1 Is Functionally Upregulated In Metastatic Cells And Promotes Breast Cancer Migration And Invasion (Submitted).