Download YU Qiang

Qiang Yu
Ph.D (Queens)
Group Leader
Cancer Biology and Pharmacology
Genome Institute of Singapore
Adjunct Associate Professor
Physiology Department, NUS
Phone: 6478-8127
E-mail : [email protected]
MAJOR RESEARCH INTERESTS
Research in my laboratory concentrates on the molecular mechanisms leading to cancer cell death and
survival and how the mechanisms can be modulated and targeted. The lab is located in the Genome Institute
of Singapore, where we use integrative approach including genomics and large scale functional analysis to
dissect the aberrant genetic and epigenetic process operating in human cancer.
Current projects include
1. Cancer epigenetic mechanisms in gene silencing in human cancer
2. Epigenetic drug development targeting histone modifications
3. Oncogenic kinase signalling and pharmacological modulation in human cancer
4. Transcription factor E2F1-induced apoptosis and its regulation by epigenetic process.
5. Modulating p53-dependent apoptosis pathway in cancer cells.
RECENT PUBLICATIONS
Xia Jiang, Jing Tan, Jingsong Li, Saul Kivimäe, Xiaojing Yang1 Li Zhuang, Puay Leng Lee, Mark TW. Chan, Lawrence
Stanton, Edison T. Liu, Benjamin N.R.Cheyette and Qiang Yu. DACT3 is an epigenetic regulator of Wnt/β-catenin
signaling in colorectal cancer and is a therapeutic target of histone modifications. Cancer Cell, June 9, 2008.
Jingsong Li, Jing Tan, Li Zhuang, Birendranath Banerjee, Xiaojing Yang, Jenny Fung Ling Chau, Puay Leng Lee,
Manoor Prakash Hande, Baojie Li and Qiang YU. RPS27L, a p53-inducible modulator of cell fate in response to
genotoxic stress. Cancer Research, 2007, 67:11317.
Jing Tan, Xiaojing Yang, Li Zhuang, Xia Jiang, Wei Chen, Puay Leng Lee, RK Murthy Karuturi, Patrick Boon Ooi Tan,
Edison T. Liu and Qiang Yu. Pharmacologic disruption of Polycomb repressive complex 2-mediated gene repression
selectively induces apoptosis in cancer cells. Genes & Development. 2007 21:1050.
Xia Jiang, Ying Huang Tsang, Qiang Yu. c-Myc overexpression sensitizes Bim-mediated Bax activation for apoptosis
induced by histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) through regulating Bcl-2/Bcl-xL
expression. Int J Biochem Cell Biol. 2007;39(5):1016-25.
Wei CL, Wu Q, Vega VB, Chiu KP, Ng P, Zhang T, Shahab A, Yong HC, Fu Y, Weng Z, Liu J, Zhao XD, Chew JL,
Lee YL, Kuznetsov VA, Sung WK, Miller LD, Lim B, Liu ET, Yu Q, Ng HH, Ruan Y (2006). A global map of p53
transcription-factor binding sites in the human genome. Cell. 124(1):207-19.
Jing Tan, Li Zhuang, Xia Jiang, Kevin K. Yang, Krishna M. Karuturi, and Qiang Yu (2006). Apoptosis signalregulating kinase 1 is a direct target of E2F1 and contributes to histone deacetylase inhibitor- induced apoptosis through
positive feedback regulation of E2F1 apoptotic activity. J Biol Chem. 2006 Feb 13; [Epub ahead of print]
Qiang Yu (2006). Restoring p53-mediated Apoptosis in Cancer Cells: New Opportunities for Cancer Therapy. Drug
Resistance Updates. Review. 2006 Feb-Apr;9(1-2):19-25. Review.
Zhao Y, Tan J, Zhuang L, Jiang Xia, Liu ET, Qiang YU (2005). Inhibitors of histone deacetylases target the Rb-E2F1
pathway for apoptosis induction through activation of proapoptotic protein Bim. Proc Natl Acad Sci U S A. 102:160905.
Tan J, Zhuang L, Leong HS, Iyer NG, Liu ET, Qiang YU (2005) Pharmacologic modulation of glycogen synthase
kinase-3beta promotes p53-dependent apoptosis through a direct Bax-mediated mitochondrial pathway in colorectal
cancer cells. Cancer Research. 65:9012-20.
Kho PS, Wang Z, Zhuang L, Li Y, Chew JL, Ng HH, Liu ET, Qiang YU (2004) "p53-regulated transcriptional program
associated with genotoxic stress-induced apoptosis" J Biol Chem 279 21183