Download Komparasi respons tumor terhadap radiasi antara radioterapi

Komparasi respons tumor terhadap radiasi antara radioterapi dengan radioterapi plus vaksinasi BCG pad
Komparasi respons tumor terhadap radiasi antara radioterapi dengan radioterapi plus vaksinasi
BCG pada karsinoma nasofaring
The comparison of tumor irradiation response between radiotherapy versus radiotherapy plus
BCG vaccination in nasopharyngeal carcinoma
JURNAL KEDOKTERAN YARSI 12 (3) : 007-016 (2004)
by
Widodo Ario Kentjono
Departement of Otolaryngology, Airlangga University School of Medicine, Dr. Soetomo
General Hospital, Surabaya
ABSTRACT The presence of nasopharyngeal tumor, which is resistant to irradiation
(radiotherapy), is unexpected, as it generally may develop to become recurrent tumor. Results
of radiation therapy, presenting as lower irradiation tumor response, may possibly result from
radiotherapy effect on immune system. Radiotherapy, which is primarily directed to eradicate
nasopharyngeal carcinoma (NPC) cells, often results in the reduction of cellular immunity.
Reduced quality of cancer immune surveillance, undertaken particularly by CD8 T cells (CTL),
NK cells, activated macrophage and LAK cells, will be very disadvantageous since tumor
growth may persist, and even becomes more progressive. BCG vaccine is known to increase
immunological effector cells, whose activity is influenced by the cytokine of Th1 lymphocyte
(Th1 response). BCG vaccination (as immunogenic stressor) given simultaneously with NPC
radiotherapy is expected to increase cancer cells eradication in the nasopharynx. This study
was aimed to prove that there was higher tumor irradiation response in nasopharyngeal
carcinoma patients receiving radiotherapy plus BCG vaccination than that in patients receiving
radiotherapy only. An experimental study (clinical trial) was carried out towards 77 patients,
consisting of 38 patients in the control group and 39 patients in the treatment group.
Radiotherapy was given in standard (conventional) dose and method, while BCG vaccination
was administered by means of modified multiple scarification technique. Results revealed that
significant difference was found between post-radiotherapy volume of nasopharyngeal tumor in
the control group and that in the treatment group (p
1/1