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Transcript
Syphilis Background • During first half of the century syphilis was major cause of blindness, mental illness, and contributed to heart disease and stroke • During WWII, 5% of military recruits had syphilis • By 1950’s it was eradicated! • But…we have seen a resurgence – 1996 reported 70,000 cases to CDC – 2004 reported 7,235 cases to CDC Treponema pallidum • Causative agent of syphilis • Motile spirochete which is about 20um in length • Cannot be grown in vitro, must be grown in tissue culture Symptoms • There are three clinical stages of syphilis – Primary: occurs 3 weeks after infection with a painless red ulcer, called a chancre – Secondary: occurs 2-10 weeks later runny nose, watery eyes, aches, sore throat, rash on the hands and feet, whitish patches on the mucous membranes – Tertiary: occurs up to ten years later..mental illness, blindness, stroke, and nervous system disorders Primary Syphilis • Less than 100 organisms necessary for infectious dose • This lesion is teeming with organisms Secondary syphilis • Characteristic rash • Syphilis can be transmitted by kissing at this stage, due to infections in the skin and mucous membranes Tertiary Syphilis • Gummas can form in any part of the body Congenital Syphilis • T. pallidum crosses the placenta and infects the fetus