Download Curriculum Vitae

CURRICULUM VITAE
Sarah P. Thayer, MD, PhD
Associate Director for Clinical Affairs
Physician-in-Chief, Fred & Pamela Buffett Cancer Center
Chief, Division of Surgical Oncology
Campus Address:
986345 Nebraska Medical Center
Omaha, NE 68198-6345
EDUCATION:
1985
1987
1991
1994-1999
BA
MS
MD
PhD
Earlham College, Richmond, IN
Physiology and Biophysics, Georgetown University, Washington, DC
University of Virginia School of Medicine, Charlotte, VA
Cornell University Graduate School of Medicine Sciences, Department of
Neuroscience, New York, NY
Postdoctoral Training
Internships and Residencies:
1991-1992
1992-1994
1994-1998
1998-2000
General Surgery Internship, Massachusetts General Hospital (MGH),
Boston, MA
General Surgery Junior Resident, MGH, Boston, MA
Surgical Research Fellow, Cornell University/Memorial Sloan-Kettering
Cancer Center, New York, NY
General Surgery Senior Resident, MGH, Boston, MA
ACADEMIC AND HOSPITAL APPOINTMENTS
20142014201420142014-2016
2010-2014
2009-2014
2008-2014
2004-2009
2003-2009
2001-2004
2001-2003
2000-2001
Chief, Division of Surgical Oncology, Nebraska Medicine, Omaha, NE
Active Academic Staff Surgeon, Nebraska Medicine, Omaha, NE
Professor, Eppley Institute for Research in Cancer, UNMC Joint
Appointment
Merle M. Musselman Centennial Professor of Surgery, UNMC
Visiting Scientist, MGH, Boston, MA
Associate Professor of Surgery, Harvard Medical School
Associate Visiting Surgeon, Surgery Service, MGH, Boston, MA
Director, Pancreatic Biology Laboratory, MGH, Boston, MA
Assistant Professor of Surgery, Harvard Medical School
Assistant Surgeon, Surgery Service, MGH, Boston, MA
Instructor in Surgery, Harvard Medical School
Assistant in Surgery, Surgery Service, MGH, Boston, MA
Chief, Surgical Services, Assistant in Surgery, MGH, Boston, MA
CERTIFICATIONS & LICENSES
19911994-1996
2001-2012
2010-2022
2014-
Commonwealth of Massachusetts License #203874
State of New York License #197481
American Board of Surgery Certification #46560
American Board of Surgery Recertification #046560
State of Nebraska License #27762
GRANTS AND CONTRACTS
Active:
Title:
ID Number:
Funding Agency:
Project Period:
Total Dollars:
Role:
F&PBCC Support Grant
P30CA036727
DHHS/NIH/NCI
2016-2021
$35,672,339
Program Leader GI Cancer Program (GICP)
Title:
ID Number:
Funding Agency:
Project Period:
Total Dollars:
Direct Costs:
Role:
UNMC Eppley Cancer Center Support Grant
3P30CA036727-29S1
DHHS/NIH/NCI
2011-2016
$34,613,080
$1,059,259
Co-Principal Investigator (PI)
Title:
CTCs as predictors of primary and metastatic tumor genetics and
biology of PDAC
1R21CA201886-01
DHHS/NIH/NCI
09/01/2015 – 08/31/2017
$413.875.00
$413,875.00
PI
ID Number:
Funding Agency:
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Total Dollars:
Direct Cost:
Role:
Title:
ID Number:
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Total Dollars:
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Role:
Title:
Polymeric Nanomedicines of Hedgehog Inhibitor and miRNA for
Treating Pancreatic Cancer
1R01GM113166-01A1
DHHS/NIH/NIGMS
2015 - 2019
$1,424,348
$237,000
Co-Investigator (Mahato)
PDG Links Stem Cell Niche to Pancreatic Epithelial Renewal,
Repair and Cancer
ID Number:
Funding Agency:
Project Period:
Total Dollars:
Direct Cost:
Role:
5R01CA169086-03
DHHS/NIH/NCI
2013 - 2018
$1,363,661
$207,500
PI
Title:
Funding Agency:
Project Period:
Total Dollars:
Direct Cost:
Role:
LB595 Tobacco Tax Center Research Grant
NE DHHS - LB595
2015 - 2016
$30,004,831
$1,300,000
Co-Investigator (Cowan)
Pending
Title:
ID Number:
Funding Agency:
Project Period:
Total Dollars:
Direct Cost:
Role:
Pancreatic Cancer Metastasis
1P01CA196545-01A1
DHHS/NIH/NCI
2016 - 2021
$1,932,720
$1,301,480
Co-Investigator (Batra)
Title:
ID Number:
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Role:
Submitted not funded:
Title:
Funding Agency:
Project Period:
Total Dollars:
Direct Cost:
Role:
Lutetium-177 labeled genetically-engineered theranostics against
pancreatic cancer
1R01CA206215-01
DHHS/NIH/NCI
2016 - 2021
$2,253,715
$1,500,000
Co-Investigator (Jain)
Variant-specific functions of DPYSL3 in pancreatic cancer.
Applications for Collaborative Pilot Project Grants-NCCS, Years
3-4 of Phase III
DHHS/NIH/NCI
08/17/2015 –
$100,000
$100,000
PI
PATENTS
1.
Method for Inducing Beta Cell Neogenesis from Epithelial Cells
Q&B Ref: 125141.00165
MGH Ref: 3767.02
HONORS AND AWARDS
1989
Alpha Omega Alpha, University of Virginia School of Medicine, Charlottesville,
VA
1991
Sandoz Award in recognition of superior academic achievement and contribution
to health care
1991
Janet M. Glasgow Memorial Award of the American Medical Women’s
Association
1991
Valedictorian, University of Virginia School of Medicine, Charlottesville, VA
2000
Resident/Fellow Award for Excellence in Clinical Teaching in Surgery, Harvard
Medical School
2002
Phillip H. Meyers, MD, Annual Research Grant award from the Society of
Gastrointestinal Radiologists, for Visionary Research in Medical Imaging (Acute
Mesenteric Ischemia) using Multi-detector CT and CT Angiography
2003
Hirshberg Award for Best Presentation, Annual Meeting American Pancreatic
Association (APA), Chicago, IL
2004
Investigator Award for Outstanding Publication (Nature 2003; 425 [Oct 23]:85156), Santa Cruz Biotechnology
2002-2014
W. Gerald Austen Scholar in Academic Surgery, MGH and Harvard Medical
School
2014Merle M. Musselman Centennial Professor of Surgery, UNMC
MEMBERSHIPS
199819982000200220022002200220052006200620062006200720092012201420152015-
American Medical Association (AMA)
MGH Surgical Alumni Society
APA
American Association for the Advancement of Science (AAAS)
International Association of Pancreatology (IAP)
New York Academy of Sciences
Society of Laparoendoscopic Surgeons (SLS)
American College of Surgeons (ACS), Fellow
American Hepato-pancreato-biliary Association (AHPBA)
NCI Cancer and Leukemia Group B (CALGB)
Society of University Surgeons
Boston Pancreas Study Group
Boston Surgical Society
New England Surgical Society
Society for Surgery of the Alimentary Tract (SSAT)
American Society of Clinical Oncology (ASCO)
Society of Surgical Oncology (SSO)
American Society of Breast Surgeons (ASBS)
COMMITTEES
Local/Regional
2001 - 2014
2003 - 2005
2004 - 2008
2004 - 2011
2005 - 2009
2005 - 2014
2005 - 2014
2007 - Present
2008 - 2009
2008 - 2014
2011 - 2014
Member, Executive Committee, Women's Health Coordinating Council,
MGH
Member, Executive Committee on Research Subcommittee on Review of
Research Proposals, Fund for Medical Discovery Study Section, MGH
Member, HMS Committee on Admissions
Member, Physician Nominating Committee of the MGH Physician
Organization (MGPO) Executive Committee
Faculty Advisor, HMS Oncology Interest Group Research Committee
Member, Surgical Research Council, MGH
Member, Resident Training and Education Committee, Surgical Research
Council, MGH
Associate Faculty, Center for Human Genetic Research, MGH and HMS
Member, Physician Nominating Committee of the MGPO Executive
Committee
Member, Clinical Referral Management Improvement Initiative Steering
Committee, MGH
Member, Fellowship Award Committee, MGH Department of Surgery,
MGH
National/International
2008 - Present
Member, Program Committee, Pancreas Club
2008 - Present
Member, International Cancer Genome Consortium
2008 - Present
Member, Scientific Advisory Board, The Lustgarten Foundation for
Pancreatic Cancer Research
2008 - 2011
Member, Committee on Social and Legislative Issues, Society of
University Surgeons
2008 - 2014
Member, Guidelines Panel, NCCN
2009 - Present
Member, Strategic Planning Committee, APA
2012 - Present
Member, Scientific Review Board, The Lustgarten Foundation for
Pancreatic Cancer Research
2013 - Present
Member, Clinical and Translational Cancer Research Committee, Cancer
Prevention & Research Institute of Texas
2014 - Present
Member, Clinical Operations Council
2015 - 2015
Member, Pancreatic Cancer Action Network, AACR Career Development
Awards Selection Call, Feb 4
2015Member, NCCN Panel for Pancreatic Adenocarcinoma
UNMC
2014 – Present
2014 – Present
2014 – Present
2014 – Present
Member, Executive Leadership Committee for Cancer Center Project
CHANGE year to 2014
Member, Cancer Center Senior Leadership Council
Member, Cancer Center Governance Committee
Member, Clinical Operations Council
2014 – 2015
2014 – Present
2014 – Present
2014 – 2015
20152015201520152015-
Member, Fred & Pamela Buffett Cancer Center Healing Arts Committee
Member, Practice Committee
Member, Chancellor’s Diversity Advisory Steering Committee
Member, Academic Variable Compensation Committee
Member, Cancer Clinical Operations Group
Member, Patient Access Oversight Council
Member, Cancer Prevention and Control Program
Member, Pancreatic SPORE Internal Advisory Board
Member, GI SPORE Internal Advisor
PRESENTATIONS
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Thayer SP. Gall Bladder and Bile Duct Cancer. Chief's Rounds, Department of Surgery,
MGH; 2001. Boston, MA
Thayer SP. Lymphangioma and Lymphatic Malformation. Grand Rounds, Department of
Surgery, MGH; 2002 Apr 11. Boston, MA
Thayer SP. Abnormal Expression of Developmental Signaling Pathways in Pancreatic
Cancer: The Role of Sonic Hedgehog. Grand Rounds, Department of Surgery, MGH;
2002 May 09. Boston, MA
Thayer SP. Abnormal Expression of Developmental Signaling Pathways in Pancreatic
Cancer: The Role of Sonic Hedgehog. Melton Laboratory of Molecular Embryology,
Department of Molecular and Cell Biology, Harvard University; 2002 Oct 30. Boston,
MA
Thayer SP. Abnormal Expression of Developmental Signaling Pathways in Pancreatic
Cancer: The Role of Sonic Hedgehog. Gastrointestinal SPORE Group Series, MGH; 2002
Nov 1. Boston, MA
Thayer SP. Pancreatic Cancer: Future Challenges for the Clinician and Scientist. Dana
Farber Cancer Institute (DFCI)/Harvard Cancer Center, Gastrointestinal Cancer
Program/Pancreatic Program Working Group; 2002 Nov 18. Boston, MA
Thayer SP. Preceptor, Introduction to Clinical Medicine, MGH Department of Surgery
Patient-Doctor II Course for Second-year HMS Medical Students. 2002 Apr 1. Boston,
MA
Thayer SP. Sonic Hedgehog and the Genetics of Pancreatic Cancer. Halsted Society,
77th Annual Meeting; 2003 Sep 4. Boston, MA
Thayer SP. Discussant, Surgical Oncology II Session, Surgical Forum Program. 89th
Annual Clinical Congress, ACS; 2003 Oct 21. Chicago, IL
Thayer SP. Pancreatic Cancer: Future Challenges for the Clinician and Scientist.
Pancreatic Think Tank, DFCI; 2003 Nov 4. Boston, MA
Thayer SP. Sonic Hedgehog and Pancreatic Cancer. DFCI/Harvard Cancer Center,
Gastrointestinal Cancer Program/Pancreatic Program Working Group; 2003 Nov 18.
Boston, MA
Thayer SP. The ICU Consult for Abdominal Pain. Post-graduate Course in General
Surgery, HMS, Department of Continuing Education, Department of Surgery, MGH;
2003 Sep 30. Boston, MA
Thayer SP. A Translational Approach to Pancreatic Cancer Therapy. Session: New
Concepts in Organ-site Research, 95th Annual Meeting, AACR; 2004 Mar 30. Orlando,
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Thayer SP. Abdominal Catastrophes in the ICU Patient. Grand Rounds, Department of
Surgery, MGH; 2004 Apr 8. Boston, MA
Thayer SP. Sonic Hedgehog and Pancreatic Cancer. Digestive Disease Week (DDW);
2004 May 16. New Orleans, LA
Thayer SP. Pancreatic Cancer: Unmasking the Mysteries. Grand Rounds, Department of
Surgery, MGH; 2004 Nov 18. Boston, MA
Thayer SP. Pancreatic Cancer in Mice and Men: The Penn Workshop 2004. NCI Mouse
Model of Human Cancer Consortium (MMHCC) and the University of Pennsylvania;
2004 Dec 2-3. Philadelphia, PA
Thayer SP. Post-graduate Course in General Surgery, HMS, Department of Continuing
Education, Department of Surgery, MGH. 2004 Sep 27. Boston, MA
Thayer SP. Developmental Pathways and Pancreatic Cancer. New Concepts in OrganSite Research Session: Toward Effective Management of Pancreatic Cancer, 96th Annual
Meeting AACR; 2005 Apr 20. Anaheim, CA
Thayer SP. Developmental Genes and Pancreatic Cancer. MGH Surgical Society 2005
Reunion; 2005 Jun 11. Boston, MA
Thayer SP. The Role of Developmental Genes in Pancreatic Cancer. Grand Rounds,
Department of Anesthesia and Critical Care, MGH; 2005 Aug 11. Boston, MA
Thayer SP. Hedgehog and Pancreatic Cancer. 5th Annual Dartmouth Conference on
Liver, Pancreas, and Biliary Disease, Dartmouth-Hitchcock Medical Center; 2005 Sep 24.
Lebanon, NH
Thayer SP; Leach S. Co-chair, Research Symposium, PANIn Lesions. American
Gastroenteroligcal Association/DDW; 2005 May 17. Chicago, IL
Thayer SP; Whang E. Oral Session 4: Pancreatic Cancer II. 36th Annual Meeting, APA;
2005 Oct 4. Chicago, IL
Thayer SP. Targeting Developmental Signaling Pathways. Basic Science Update
Symposium: Translational Biotherapies in HPB Malignancy 2006 Annual Meeting,
AHPBA; 2006 Mar 11. Miami Beach, FL
Thayer SP. Developmental Genes and Pancreatic Cancer. Lustgarten Foundation for
Pancreatic Cancer Research 8th Annual Scientific Conference; 2006 Jun 26-27. Chapel
Hill, NC
Thayer SP. Pancreatic Cancer. HMS Postgraduate Course in General Surgery, Advances
in Gastrointestinal Surgery; 2006 Sep 19. Boston, MA
Thayer SP. Keynote Speaker. Annual Boston Walk for Pancreatic Cancer, Lustgarten
Foundation for Pancreatic Cancer Research; 2006 Oct 15. Boston, MA
Hung YP; Thayer SP. Familial Pancreatic Disease Study. Soma Weiss Day, HMS; 2006
Sep 1. Boston, MA
Vagefi PA; Razo O; Deshpande V; McGrath DJ; Lauwers GY; Thayer SP; Warshaw
AL; Fernandez-del Castillo C. Evolving patterns in the detection of pancreatic
neuroendocrine tumors (PNETs): The Massachusetts General Hospital experience. 2006
Annual Meeting of the New England Surgical Society; 2006 Sep 15-17. Groton, CT
Thayer SP; Whang E. Surgical Forum Session, Alimentary Tract I: Stomach,
Hepatobiliary and Pancreas. 92nd Annual Clinical Congress, ACS; 2006 Oct 9. Chicago,
IL
Thayer SP. The Surgical Management of Early Pancreatic Cancer and/or Lesions with
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Malignant Potential. MGH Inaugural Pancreatic-Biliary Day, MGH Digestive Health
Care Center; 2007 May 3. Boston, MA
Thayer SP. The Surgical Management of Pancreatic Cancer. Chief's Rounds, Department
of Surgery, MGH; 2007 Jun 6. Boston, MA
Thayer SP. What is the Cell of Origin of Pancreatic Neoplasia: Acinar, Islet, Duct or
Stem Cells? APA/Lustgarten Foundation Symposium, Stem Cells, the Pancreas, and
Pancreatic Cancer, following the APA Annual Meeting; 2007 Nov 3. Chicago, IL
Fritz S; Thayer SP. Pancreatic Cancer Tumor Response to Hedgehog Pathway Inhibition
in a Xenograft Model. Karin Grunebaum Research Foundation, HMS; 2007 Jun 8.
Boston, MA
Strobel O; Dor Y; Alsina J; Stirman A; Lauwers G; Trainor A; Fernandez-del Castillo C;
Warshaw A; Thayer SP. In vivo Lineage Tracing Defines the Role of Acinar-to-ductal
Transdifferentiation in Inflammation-mediated Ductal Metaplasia. Annual Meeting APA;
2007 Nov 1-3. Chicago, IL
Thayer SP. Moderator, Basic Science Session; Organizer of Discussants, Basic Science
and Biliary II Sessions. Annual Meeting, AHPBA; 2007 Apr 21. Las Vegas, NV
Thayer SP; Leach S. Co-moderator, Session, Model Organisms. APA/Lustgarten
Foundation Symposium, Stem Cells, the Pancreas, and Pancreatic Cancer; 2007 Nov 3.
Chicago, IL
Thayer SP. Genetics and Biology of Pancreatic Duct Adenocarcinoma--Core C: Biobank
Core. Pancreatic Ductal Adenocarcinoma (PDAC) P01 Program Retreat, Annual Meeting
for AACR; 2008 Apr 13. San Diego, CA
Thayer SP. Pancreatic Cancer: From Bench to Bedside. Friends of the MGH Cancer
Center; 2008 May 14. Boston, MA
Thayer SP. Cell of Origin of Pancreatic Cancer. Symposium, Gastrointestinal Cancer
Research at Harvard, DFCI/Harvard Cancer Center Gastrointestinal Malignancies
Program; 2008 May 15. Boston, MA
Thayer SP. Pancreatic Cancer: Collaborative Opportunities. Representing DFCI/Partners
P01 Project on Pancreatic Adenocarcinoma, BioBank Core, Scientific Advisory Board
meeting, Genomics and Biocomputing Platforms, International Human Cancer Genome
Project, Ontario Institute for Cancer Research; 2008 Oct 3. Toronto, Canada
Fritz S; Fernandez-del Castillo C; Mino-Kenudson M; Crippa S; Batten JM; Nguyen AT;
Thayer SP. Recurrent chromosomal aberrations in intraductal papillary mucinous
neoplasms (IPMNs). 42nd Annual Meeting, Pancreas Club; 2008 May 18. San Diego, CA
Thayer SP. Genetics and Biology of Pancreatic Duct Adenocarcinoma. PDAC P01
Program Retreat, Annual Meeting for AACR; 2008 Apr 13. San Diego, CA
Thayer SP. Moderator, Early Events in Disease Development and Animal Models of
Chronic Pancreatitis and Pancreatic Cancer. APA/Lustgarten Foundation Symposium;
2008 Nov 8. Chicago, IL
Thayer SP. Pancreatic Cancer: Possible Research Strategies and Solutions. Department
of Surgery, Medical College of Wisconsin; 2009 May 22. Milwaukee, WI
Thayer SP. Invasive IPMC vs. PDAC: Are they Biologically and Genetically Distinct?
Mini-symposium 5 on IPMN, Joint Meeting, APA & Japan Pancreas Society; 2009 Nov
7. Honolulu, HI
Thayer SP. Pancreatic Cancer: Approaches to Future Therapies. Pancreatic Cancer:
Early Diagnosis and Innovative Treatments, Washington University, St. Louis School of
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Medicine/Siteman Cancer Center; 2009 Nov 14. St. Louis, MO
Thayer SP. Pancreatic Cancer: Enrichment and Advances in Sample Acquisition.
International Cancer Genome Consortium Meeting; 2009 Nov 4. Honolulu, HI
Thayer SP. Potential Drugs and Targets along the Hedgehog Signaling Cascade in
Pancreatic Cancer and Other Solid Tumors, session: Potential Therapeutic Targets for
Clinical Trials. 63rd Annual Cancer Symposium, SSO; 2010 Mar 6. St. Louis, MO
Thayer SP. Invited Participant. Third Scientific Workshop of the International Cancer
Genome Consortium (ICGC); 2010 Mar 21-23. Madrid, Spain
Thayer SP. The Role of Shh in Pancreatic Metaplasia and Malignancy. 11th Annual
Symposium, The Biology of Pancreatic Development, Regeneration and Malignancy,
NIH Center for Molecular Studies in Digestive and Liver Diseases and the Penn/CHOP
Center for Digestive, Liver, and Pancreatic medicine, Division of Gastroenterology,
University of Pennsylvania; 2010 May 10. Philadelphia, PA
Thayer SP. Moderator, Session, Pancreatic Cancer. Annual Meeting APA; 2010 Nov 4.
Chicago, IL
Thayer SP. Duct Cell Progenitors. Research Symposium, Pancreatic Stem Cells,
American Gastroenterological Association, DDW; 2011 May 9. Chicago, IL
Thayer SP. Hedgehog signaling. Harvard Catalyst Clinical and Translational Science
Center, Harvard Medical School; 2011 Jun 14. Boston, MA
Thayer SP. Observation: Which Pancreatic Cystic Lesions Can Be Safely Followed?
Session: Management of Cystic Lesions of the Pancreas, 97th Annual Clinical Congress,
ACS; 2011 Oct 26. San Francisco, CA
Thayer SP. Moderator Session, Basic and Clinical Pancreatic Cancer. Annual Meeting
APA; 2011 Nov 4. Chicago, IL
Thayer SP. Pancreatic cancer risks and solutions. Dr. Oz Show broadcast, Your Biggest
Cancer Risks: The Biggest Solution; 2012 Nov 8. New York, NY
Thayer SP. Invited Participant. 3rd Annual Meeting World Circulating Tumor Cells
Summit; 2012 Nov 12-15. Boston, MA
Thayer SP. The Capture, Growth and Genetic Analysis of CTC in PDAC. Session:
Circulating Tumor Cells: Future of Cancer Management, Cambridge Healthtech Institute
Molecular Medicine Tri-conference; 2013 Feb 13. San Francisco, CA
Thayer SP. Diagnosis Can Be Achieved by Screen Cell CTC Cytology. Screen Cell;
2013 Apr 22. Paris, France
Thayer SP. The Capture, Growth and Genetic Analysis of CTC in PDAC. Session:
Latest Insights on Capture, Enumeration and Characterization World CTC; 2013 Apr 24.
Berlin, Germany
Thayer SP. Pancreatic Duct Glands (PDG): An Epithelial Progenitor Stem Cell
Compartment Important in Regeneration and Cancer. Harvard Pancreas Group Dinner,
Harvard Club; 2013 May 13. Boston, MA
Thayer SP. Pancreatic Duct Glands (PDG): An Epithelial Progenitor Stem Cell
Compartment Important in Regeneration and Cancer. Gordon Research Conference:
Pancreatic Diseases 2013, Mount Holyoke College; 2013 July 21-26. South Hadley, MA
Thayer SP. Update in the Management of Pancreatic Cystic Neoplasms. 9th Annual Fall
Midwest Thoracic and GI Oncology Conference; 2014 Oct 2-3. Omaha, NE
Thayer SP. Co-presenter, Biomarkers for Early Detection. Early Detection of Sporadic
Pancreatic Cancer Summit Conference; 2014 Nov 5. Big Island, HI
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Thayer SP. Co-moderator, Necrotizing Pancreatitis: The Devil is in the Details. ACS
Clinical Congress 2014; 2014 Oct 26-30. San Francisco, CA
Thayer SP. Moderator, Innovation in Pancreatic Cancer Treatment. 45th Anniversary
Meeting APA; 2014 Nov 7. Big Island, HI
Thayer SP. Testimony before the Appropriations Committee of the Nebraska
Legislature, 2015, Mar 3
Thayer SP. UNMC Grand Rounds, Service Introduction by Chiefs, 2015 Jul 8
Thayer SP. Breast Cancer is a Global Disease: Is Global Screening Appropriate for All?
7th Muscat International Oncology & 4th Oman Cancer Association; 2015 Sep 13.
Muscat, Oman
Thayer SP. The Ampulla is a Reservoir for Lgr5-derived Secretory Cells That Migrate to
the Pancreas Following Injury. 46th Annual Meeting of the APA; 2015 Nov 4-7. San
Diego, CA
Thayer SP. Operative Treatment for Pancreatic Cancer Patients with Metastatic Disease.
GI Thoracic Conference, UNMC; 2015 Oct. Omaha, NE
Thayer SP. Topic: Nipple Sparing Mastectomies. Invited Speaker. Winter Workshop of
the Nebraska State Assembly for Surgical Technologists; 2016 Mar 5. College of Public
Health, UNMC, Omaha, NE
Thayer SP. Invited Speaker, Current management of breast cancer: A multidisciplinary
approach. 7th Extraordinary Innovations and Emerging Trends in Transplantation and
Oncology from Nebraska Medicine, Optum Health Conference; 2016 July 13. Omaha,
NE
COMMUNITY SERVICE AND OUTREACH
2008-2014
11/2014
01/22/2015
03/02/2015
03/02/2015
03/07/2015
03/21/2015
03/25/2015
04/17/2015
04/18/2015
10/09/2015
10/27/2015
01/13/2015
01/13/2016
02/13-15/2016
Advisor, Students on the Forefront of Science Program, Brooks School
“Interview with an Expert: Surgery.” Published in Cure Pancreatic
Cancer, Lustgarten Foundation. www.lustgarten.org
Opening remarks at the Pre-radio-thon Meeting for NRG Media, Omaha,
NE
Interview for video for NRG Media Radio-thon
Interview for NET program, “Living with Cancer in Nebraska”
Represented the F&PBCC at the Team Jack Gala in Lincoln, NE
Attended the Ambassador of Hope Gala
Participated in a Panel Discussion for NET program on cancer in
Nebraska
Represented the F&PBCC at Kicks for a Cure
Represented the F&PBCC at the Omaha Symphony Gala
Interview for the Midlands Business Journal
Participated/Photos for the UNe Campaign
Interviewed by the Omaha World Herald for an article which appeared on
Jan 14, 2016
Interviewed by KETV for video story: “Cancer cure plays important role
with local family”
Presentation concerning the F&PBCC at the NU Foundation event in
Scottsdale, AZ
03/08/2016
Participated in a physician recruitment video shoot for Provider Network
Services
Mentoring/Advising:
2015 –
2015 –
2013-2014
2013-2014
2013-2014
2013-2014
2009-2014
2012-2013
2010-2013
2013
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2010-2012
2009-2011
2011
2007-2010
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2008-2009
2007-2009
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Class of 2008
2005-2007
2005-2007
2004-2006
2003-2005
2002-2005
MD/PhD Candidate, Beth Clymer UNMC
MD/PhD Candidate, Richard Sleightholm UNMC
Research Fellow, Akifumi Nakagawa, MD, PhD, Nagoya, Japan
Intern, Curtis Adams Tufts University
Research Fellow, James Perkins, MD, Pennsylvania State
University
Research Fellow, Yinshi Huang, MD, Shanghai, China
Research Fellow, Andrew S. Liss, PhD, University of Texas
Austin
Research Fellow, Jiahua Zhou, MD, PhD, Nanjing, China
Research Fellow, Junpei Yamaguchi, MD, Nagoya, Japan
Intern, Joachim Vaturi Lycee Francais de New York
Intern, Alexandra Sontheimer University of Freiburg
Research Fellow, Naoki Ikenaga, MD, PhD, Fukuoka, Japan
Summer Student, Gabriel DiNatale Dickinson College
Summer Student, Lorena Ceci, BS, University of Massachusetts
Research Fellow, Nakul Valsangkar, MD, New Delhi, India
Research Fellow, Joo Kyung Park, MD, Seoul, Korea
Research Fellow, Birte Kulemann, MD, University of Freiburg
Research Fellow, Dirk Bausch, MD, University of Freiburg
Summer Student, Cecile Harmange Brooks School Class of 2012
Brooks School Program, "Students on the Frontiers of Science"
Summer Student, Cheng Hui Bryan Chang Brooks School Class of
2010 Brooks School Program, "Students on the Frontiers of
Science"
Research Fellow, Avais M. Chatha, MD, University of Lahore
Research Fellow, Vasiliki Androutsopoulos, MD, Caracas,
Venezuela
Summer Student, Brian Bernier, Brooks School Program,
"Students on the Frontiers of Science"
Research Fellow, Stefan Fritz, MD, Heidelberg University
Research Fellow, Jennifer LaFemina, MD, UCLA
Summer Student, Michael Hendrickson, Brooks School Program,
"Students on the Frontiers of Science"
Summer Student, Steven Poon Tufts University, Class of 2008
HMS Student, Yin Pun (Rex) Hung HMS
Research Fellow (T32), Janivette Alsina, MD, PhD, UMDNJ
Research Fellow, Elena Rakhlin, MD, Harvard University
Research Fellow (T32) Denise Long, MD, Georgetown University
Research Fellow, Oliver Strobel, MD, Heidelberg University
HMS Student, David E. Rosow, MD
PUBLICATIONS
Published Articles:
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Dubois M, Chen J, Thayer SP, Narang P, Kaufman J, Hatendi A. Pharmacokinetics of
alfentanil continuous IV infusion in neurosurgical patients. Anesth Analg 1987; 66:S44.
Thayer SP, Fernández-del Castillo C, Balcom JH, Warshaw AL. Complete dorsal
pancreatectomy with preservation of the ventral pancreas: A new surgical technique.
Surgery 2002; 131(5):577-580. PMID: 12019413.
Fernández-del Castillo C, Targarona J, Thayer SP, Rattner DW, Brugge WR, Warshaw
AL. Incidental pancreatic cysts: clinicopathologic characteristics and comparison with
symptomatic patients. Arch Surg 2003; 138(4):427-433; discussion 433-434. PMID:
12686529; PMCID: PMC4403874.
Thayer SP, Pasca di Magliano M, Heiser P, Roberts DJ, Nielsen CM, Lauwers GY, Qi
YP, Gysin S, Fernández-del Castillo C, Yajnik V, Antoniu B, McMahon M, Warshaw
AL, Hebrok M. Hedgehog is an early and late mediator of pancreatic cancer
tumorigenesis. Nature 2003; 425(6960/October 23):851-856. PMID: 14520413; PMCID:
PMC3688051.
Thayer SP. The emerging role of the Hedgehog signaling pathway in gastrointestinal
cancers. Clin Adv Hematol Oncol 2004; 2(1):17-63. PMID: 16163153.
Salvia R, Fernández-del Castillo C, Bassi C, Thayer SP, Falconi M, Mantovani W,
Pederzoli P, Warshaw AL. Main-duct intraductal papillary mucinous neoplasms of the
pancreas: Clinical predictors of malignancy and long-term survival following resection.
Ann Surg 2004; 239(5):678-685; discussion 685-687. PMID: 15082972; PMCID:
PMC1356276.
Warshaw AL, Thayer SP. Pancreaticoduodenectomy. J Gastrointest Surg 2004;
8(6):733-741. PMID: 15358336; PMCID: PMC3811050.
Alsfasser G, Antoniu B, Thayer SP, Warshaw AL, Fernández-del Castillo C.
Degradation and inactivation of plasma tumor necrosis factor-alpha by pancreatic
proteases in experimental acute pancreatitis. Pancreatology 2005; 5(1):37-43; discussion
43. PMID: 15775698; PMCID: PMC3817566.
Ferrone CR, Kattan MW, Thayer SP, Brennan MF, Warshaw AL. Validation of a postresection pancreatic adenocarcinoma nomogram for disease-specific survival. J Clin
Oncol 2005; 23(30):7529-7535. PMID: 16234519; PMCID: PMC3903268.
Rosow DE, Sahani DV, Strobel O, Kalva S, Mino-Kenudson M, Holalkere NS, Alsfasser
G, Saini S, Lee SI, Mueller PR, Fernández-del Castillo C, Warshaw AL, Thayer SP.
Imaging of acute mesenteric ischemia using multi-detector CT and CT angiography in a
porcine model. J Gastrointest Surg 2005; 9(9):1262-1274; discussion 1274-1275. PMID:
16332482; PMCID: PMC3807105.
Rodriguez JR, Soto Germes S, Pandharipande PV, Gazelle GS, Thayer SP, Warshaw
AL, Fernández-del Castillo C. Implications and cost of pancreatic leak following distal
pancreatic resection. Arch Surg 2006; 141(4):361-365; discussion 366. PMID: 16618893;
PMCID: PMC3998722.
Ferrone CR, Finkelstein D, Thayer SP, Muzikansky A, Fernández-del Castillo C,
Warshaw AL. Perioperative CA19-9 levels can predict stage and survival in patients with
resectable pancreatic adenocarcinoma. J Clin Oncol 2006; Jun 20;24(18):2897-2902.
PMID: 16782929.
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Alsfasser G, Warshaw AL, Thayer SP, Antoniu B, Laposata M, Lewandrowski KB,
Fernández-del Castillo C. Decreased inflammation and improved survival with
recombinant human activated protein C treatment in experimental acute pancreatitis.
Arch Surg 2006;141(7):670-676; discussion 670-676. PMID: 16847238; PMCID:
PMC3972126.
Kwak EL, Jankowski J, Thayer SP, Lauwers GY, Brannigan BW, Harris PL, Okimoto
RA, Haserlat SM, Driscoll DR, Ferry D, Muir B, Settleman J, Fuchs CS, Kulke MH,
Ryan DP, Clark JW, Sgroi DC, Haber DA, Bell DW. Epidermal growth factor receptor
kinase domain mutations in esophageal and pancreatic adenocarcinomas. Clin Cancer
Res 2006;12(14 Pt 1):4283-4287. PMID: 16857803; PMID: 16857803.
Mao J, Ligon KL, Rakhlin EY, Thayer SP, Bronson RT, Rowitch D, McMahon AP. A
novel somatic mouse model to survey tumorigenic potential applied to the Hedgehog
pathway. Cancer Res 2006; 66(20):10171-10178. PMID: 17047082; PMCID:
PMC3806052.
Strobel O, Dor Y, Stirman A, Trainor A, Fernández-del Castillo C, Warshaw AL, Thayer
SP. β cell transdifferentiation does not contribute to preneoplastic/metaplastic ductal
lesions of the pancreas by genetic lineage tracing in vivo. PNAS 2007; 104:4419-4424.
PMID: 1736053; PMCID: PMC1815470.
Vagefi PA, Razo O, Deshpande V, McGrath DJ, Lauwers GY, Thayer SP, Warshaw AL,
Fernández-del Castillo C. Evolving patterns in the detection and outcomes of pancreatic
neuroendocrine neoplasms. Arch Surg 2007; 142:347-354. PMID: 17438169; PMCID:
PMC3979851.
Crippa S, Bassi C, Warshaw AL, Falconi M, Partelli S, Thayer SP, Pederzoli P,
Fernández-del Castillo C. Middle pancreatectomy: Indications, short- and long-term
operative outcomes. Ann Surg 2007; 246(1):69-76. PMID: 17592293; PMCID:
PMC1899210.
Rodriguez JR, Salvia R, Crippa S, Warshaw AL, Bassi C, Falconi M, Thayer SP,
Lauwers GY, Capelli P, Mino-Kenudson M, McGrath D, Pederzoli P, Fernández-del
Castillo C. Branch-duct intraductal papillary mucinous neoplasms: observations in 145
resected patients. Gastroenterology 2007; 133:72-79. PMID: 17631133; PMCID:
PMC3807096.
Rodriguez JR, Madanat MG, Healy BC, Thayer SP, Warshaw AL, Fernández-del
Castillo C. Distal pancreatectomy with splenic preservation revisited. Surgery 2007;
141:619-625. PMID: 17462461; PMCID: PMC3807103.
Strobel O, Dor Y, Alsina J, Stirman A, Lauwers G, Trainor A, Fernández-del Castillo C,
Warshaw AL, Thayer SP. In vivo lineage tracing defines the role of acinar-to-ductal
transdifferentiation in inflammatory ductal metaplasia. Gastroenterol 2007; 133:19992009. PMID: 18054571; PMCID: PMC2254582.
Nikfarjam M, Warshaw AL, Axelrod L, Deshpande V, Thayer SP, Ferrone CR,
Fernández-del Castillo C. Improved contemporary surgical management of insulinomas:
a 25-year experience at the Massachusetts General Hospital. Ann Surg 2008; 247(1):165172. PMID: 18156937; PMCID: PMC3806046.
Rodriguez JR, Razo O, Targorona J, Thayer SP, Rattner DW, Warshaw AL, Fernándezdel Castillo C. Debridement and closed packing for sterile or infected necrotizing
pancreatitis — insights into indications and outcomes in 167 patients. Ann Surg 2008;
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247(2):294-299. doi: 10.1097/SLA.0b013e31815b6976. PMID: 18216536; PMCID:
PMC3806106.
Crippa S, Salvia R, Warshaw AL, Dominguez I, Bassi C, Falconi M, Thayer SP,
Zamboni G, Lauwers G, Mino-Kenudson M, Germenia S, Pederzoli P, Fernández-del
Castillo C. Mucinous cystic neoplasm of the pancreas is not an aggressive entity: lessons
from 163 resected patients. Ann Surg 2008;247(4):571-579. doi:
10.1097/SLA.0b013e31811f4449. PMID: 18362619; PMCID: PMC3806104.
Veillette G, Dominguez I, Ferrone C, Thayer SP, McGrath D, Warshaw AL, Fernándezdel Castillo C. Implications and management of pancreatic fistulas following
pancreaticoduodenectomy: The Massachusetts General Hospital experience. Arch Surg
2008;143(5):476-481. doi: 10.1001/archsurg.143.5.476. PMID: 18490557; PMCID:
PMC3806102.
Dominguez I, Crippa S, Thayer SP, Hung YP, Ferrone CR, Warshaw AL, Fernández-del
Castillo C. Preoperative platelet count and survival prognosis in resected pancreatic
ductal adenocarcinoma. World J Surg 2008; 32(6):1051-1056. doi: 10.1007/s00268-0079423-6. PMID: 18224462; PMCID: PMC3806089.
Crippa S, Dominguez I, Rodriguez JR, Razo O, Thayer SP, Ryan DP, Warshaw AL,
Fernández-del Castillo C. Quality of life in pancreatic cancer: analysis by stage and
treatment. J Gastrointest Surg 2008; 12(5):783-794. doi: 10.1007/s11605-007-0391-9.
Epub 2008 March 4. PMID: 18317851; PMCID: PMC3806099.
Guimaraes AR, Rakhlin E, Weissleder R, Thayer SP. Magnetic resonance imaging
monitors physiologic changes with anti-hedgehog therapy in pancreatic adenocarcinoma
xenograft model. Pancreas 2008; 37(4):440-444. doi: 10.1097/MPA.0b013e31817c5113.
PMID: 18953259; PMCID: PMC3806135.
Ferrone CR, Warshaw AL, Rattner DW, Berger D, Zheng H, Rawal B, Rodriguez R,
Thayer SP, Fernández-del Castillo C. Pancreatic fistula rates after 462 distal
pancreatectomies: Staplers do not decrease fistula rates. J Gastrointest Surg 2008;
12:1691-1698. doi: 10.1007/s11605-008-0636-2. Epub 2008 August 13. PMID:
18704597; PMCID: PMC3806097.
Fritz S, Fernández-del Castillo CF, Mino-Kenudson M, Crippa S, Batten JM, Nguyen
AT, Deshpande V, Lauwers GY, Warshaw AL, Thayer SP, Iafrate AJ. Global genomic
analyses of intraductal papillary mucinous neoplasms of the pancreas reveal significant
molecular differences compared to ductal adenocarcinoma. Ann Surg 2009; 249(3):440-7.
doi: 10.1097/SLA.0b013e31819a6e16. PMID: 19247032; PMCID: PMC3957431.
Fritz S, Warshaw AL, Thayer SP. Management of mucin-producing cystic neoplasms of
the pancreas. The Oncologist 2009 Feb; 14(2):125-136. doi: 10.1634/theoncologist.20080200. PMID: 19211618; PMCID: PMC3806054.
LaFemina J, Roberts PA, Hung YP, Gusella JF, Sahani D, Fernández-del Castillo C,
Warshaw AL, Thayer SP. Identification of a novel kindred with familial pancreatitis and
pancreatic cancer. Pancreatology 2009; 9:273-279. doi: 10.1159/000201553. PMID:
19407482; PMCID: PMC3713708.
Bausch D, Mino-Kenudson M, Fernández-del Castillo C, Warshaw AL, Kelly KA,
Thayer SP. Plectin-1 is a biomarker of malignant pancreatic intraductal papillary
mucinous neoplasms. J Gastrointest Surg 2009; 13:1948-1954. doi: 10.1007/s11605-0091001-9. PMID: 19760374; PMCID: PMC3806105.
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Ferrone CR, Correa-Gallego C, Warshaw AL, Brugge WR, Forcione DG, Thayer SP,
Fernández-del Castillo C. Current trends in pancreatic cystic neoplasms. Arch Surg 2009
May; 144(5):448-454. doi: 10.1001/archsurg.2009.36. PMID: 19451487; PMCID:
PMC3806091.
Strobel O, Rosow DE, Rakhlin EY, Lauwers GY, Trainor AG, Alsina J, Fernández-del
Castillo C, Warshaw AL, Thayer SP. Pancreatic duct glands are distinct ductal
compartments that react to chronic injury and mediate Shh-induced metaplasia.
Gastroenterology 2010 March; 138(3):1166-1177. doi: 10.1053/j.gastro.2009.12.005.
PMID: 20026066; PMCID: PMC3806111.
Fritz S, Fernández-del Castillo C, Iafrate AJ, Mino-Kenudson M, Neyhard N, LaFemina
J, Stirman A, Warshaw AL, Thayer SP. Novel xenograft and cell line derived from an
invasive intraductal papillary mucinous neoplasm of the pancreas gives new insights into
molecular mechanisms. Pancreas 2010 Apr; 39(3):308-314. doi:
10.1097/MPA.obo13e3181bd5c10. PMID: 19924021; PMCID: PMC3086384.
Rovira M, Scott S-G, Liss AS, Jensen J, Thayer SP, Leach SD. Isolation and
characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas.
PNAS 2010; 107 (Jan 5):75-80. doi: 10.1073/pnas.0912589107. PMID: 20018761;
PMCID: PMC2806716.
Iyer VR, Hahn PF, Blaszkowsky LS, Thayer SP, Halpern EF, Harisinghani MG. Added
value of selected images embedded into radiology reports to referring clinicians. J Am
Coll Radiol 2010; 7:205-210. doi: 10.1016/j.jacr.2009.10.014. PMID: 20193926;
PMCID: PMC3086392.
Crippa S, Fernández-del Castillo C, Salvia R, Finkelstein D, Bassi C, Dominguez I,
Muzikansky A, Thayer SP, Falconi M, Mino-Kenudson M, Capelli P, Lauwers GY,
Partelli S, Pederzoli P, Warshaw AL. Mucin-producing neoplasms of the pancreas: an
analysis of distinguishing clinical and epidemiologic characteristics. Clin Gastroenterol
Hepatol 2010 Feb; 8(2):213-219. doi: 10.1016/j.cgh.2009.10.001. PMID: 19835989;
PMCID: PMC31353354.
Konstantinidis IT, Deshpande V, Zheng H, Wargo JA, Fernández-del Castillo C, Thayer
SP, Androutsopoulos V, Lauwers GY, Warshaw AL, Ferrone CR. Does the mechanism
of lymph node invasion affect survival in patients with pancreatic ductal
adenocarcinoma? J Gastrointest Surg 2010 Feb; 14(2):261-267. Epub 2009 Nov 25. doi:
10.1007/s11605-009-1096-z. PMID: 19937477; PMCID: PMC3135335.
Partelli S, Fernández-del Castillo C, Bassi C, Mantovani W, Thayer SP, Crippa S,
Ferrone CR, Falconi M, Pederzoli P, Warshaw AL, Salvia R. Invasive intraductal
papillary mucinous carcinomas of the pancreas: Predictors of survival and the role of
lymph node ratio. Ann Surg 2010 Mar; 251(3):477-482. doi:
10.1097/SLA.0b013e3181cf9155. PMID: 20142730; PMCID: PMC3535381.
International Cancer Genome Consortium (collective authorship, Hudson TJ et al.,
including Thayer SP). International network of cancer genome projects. Nature 2010
April 15; 464(7291):993-998. doi: 10.1038/nature08987. PMID: 20393554; PMCID:
PMC2902243.
Correa-Gallego C, Ferrone CR, Thayer SP, Wargo JA, Warshaw AL, Fernández-del
Castillo C. Incidental pancreatic cysts: do we really know what we are watching?
Pancreatology 2010 May 17; 10(2-3):144-150. doi: 10.1159/000243733. PMID:
20484954; PMCID: PMC3214832.
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Tempero MA, Arnoletti JP, Behrman S, Ben-Josef E, Benson AB 3rd, Berline JD,
Cameron JL, Casper ES, Cohen SJ, Duff M, Ellenhorn JD, Hawkins WG, Hoffman JP,
Kuvshinoff BW 2nd, Malafa MP, Muscarella P 2nd, Nakakura EK, Sasson AR, Thayer
SP, Tyler DS, Warren RS, Whiting S, Willett C, Wolff RA; NCCN Pancreatic
Adenocarcinoma. Pancreatic adenocarcinoma. JNCCN 2010 Sep 1; 8(9):972-1017.
PMID: 20876541; PMCID: PMC3135380.
Konstantinidis IT, Dursun A, Zheng H, Wargo JA, Thayer SP, Fernández-del Castillo C,
Warshaw AL, Ferrone CR. Metastatic tumors in the pancreas in the modern era. J Am
Coll Surg 2010 December; 211(6):749-753. doi: 10.1016/j.jamcollsurg.2010.08.017.
PMID: 21109158; PMCID: PMC3135384.
Bausch D, Thomas S, Mino-Kenudson M, Fernández-del Castillo C, Bauer TW, Williams
M, Warshaw AL, Thayer SP, Kelly KA. Plectin-1 as a novel biomarker for pancreatic
cancer. Clin Cancer Res 2011 Jan 15; 17(2):302-309. Epub 2010 Nov 23. doi:
10.1158/1078-0432.CCR-10-0999. PMID: 21098698; PMCID: PMC3044444.
Bausch D, Pausch T, Krauss T, Hopt UT, Fernández-del Castillo C, Warshaw AL,
Thayer SP, Keck T. Neutrophil granulocyte derived MMP-9 is a VEGF independent
functional component of the angiogenic switch in pancreatic ductal adenocarcinoma.
Angiogenesis 2011 Sep; 14(3):235-243. Epub 2011 Apr 20. doi: 10.1007/s10456-0119207-3. PMID: 21442180; PMCID: PMC3688040.
Haynes AB, Deshpande V, Ingkakul T, Vagefi PA, Szymonifka J, Thayer SP, Ferrone
CR, Wargo JA, Warshaw AL, Fernández-del Castillo C. Implications of incidentally
discovered, nonfunctioning pancreatic endocrine tumors: Short-term and long-term
patient outcomes. Arch Surg 2011 May; 146(5):534-538. doi:
10.1001/archsurg.2011.102. PMID: 21576607; PMCID: PMC3688044.
Mino-Kenudson M, Fernández-del Castillo C, Baba Y, Valsangkar NP, Liss AS, Hsu M,
Correa-Gallego C, Ingkakul T, Perez Johnston R, Turner BG, Androutsopoulos V,
Deshpande V, McGrath D, Sahani DV, Brugge WR, Ogino S, Pitman MB, Warshaw AL,
Thayer SP. Prognosis of invasive intraductal papillary mucinous neoplasm depends on
histological and precursor epithelial subtypes. Gut 2011 Dec; 60(12):1712-1720. [Epub
2011 April 20]. doi: 10.1136/gut.2010.232272. PMID: 21508421; PMCID:
PMC3806085.
Genevay M, Mino-Kenudson M, Yaeger KA, Konstantinidis YT, Ferrone CR, Thayer
SP, Fernández-del Castillo C, Sahani D, Bounds B, Forcione D, Brugge WR, Pitman
MB. Cytology adds value to imaging studies for risk assessment of malignancy in
pancreatic mucinous cysts. Ann Surg 2011; 254(6):977-983. doi:
10.1097/SLA.0b013e3182383118. PMID: 22041510; PMCID: PMC3817564.
Ying H, Elpek KG, Vinjamoori A, Zimmerman SM, Chu GC, Yan H, FletcherSananikone E, Zhang H, Liu Y, Wang W, Ren X, Zheng H, Kimmelman AC, Paik J-h,
Lim C, Perry SR, Jiang S, Malinn B, Protopopov A, Colla S, Xiao Y, Hezel AF,
Bardeesy N, Turley SJ, Wang YA, Chin L, Thayer SP, DePinho RA. Pten is a major
tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-kappaBcytokine network. Cancer Discovery 2011 Jul 1; 1(2):158-169 (published OnlineFirst
May 23, 2011). doi: 10.1158/2159-8290.CD-11-0031. PMID: 21984975; PMCID:
PMC3186945.
Tempero MA, Arnoletti JP, Behrman SW, Ben-Josef E, Benson AB, Casper ES, Cohen
SJ, Czito B, Ellenhorn JD, Hawkins WG, Herman J, Hoffman JP, Ko A, Komanduri S,
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Koong A, Ma WW, Malafa MP, Merchant NB, Mulvihill SJ, Muscarella P, Nakakura
EK, Obando J, Pitman MB, Sasson AR, Tally A, Thayer SP, Whiting S, Wolff RA,
Wolpin BM, Freedman-Cass DA, Shead DA. Pancreatic adenoma, version 2.2012:
featured updates to the NCCN Guidelines. JNCCN 2012 Jun 1; 10(61):703-713. PMID:
22679115; PMCID: PMC3807091.
Scherber C, Aranyosi AJ, Kulemann B, Thayer SP, Toner M, Iliopoulos O, Irimia D.
Epithelial cell guidance by self-generated EGF gradients. Integr Biol (Camb) 2012 March
1; 4(3):259-269. Epub Feb 8. doi: 10.1039/c2ib00106c. PMID: 22314635; PMCID:
PMC3440622.
Nehra D, Morales-Oyarvide V, Mino-Kenudson M, Thayer SP, Ferrone CR, Wargo JA,
Muzikansky A, Finkelstein D, Warshaw AL, Fernández-del Castillo C. Intraductal
papillary mucinous neoplasms: Does a family history of pancreatic cancer matter?
Pancreatology 2012 Jul; 12(4):358-363. Epub 2012 Jun 15. doi:
10.1016/j.pan.2012.05.011. PMID: 22898638; PMCID: PMC3806100.
Valsangkar NP, Morales-Oyarvide V, Thayer SP, Ferrone CR, Wargo JA, Warshaw AL,
Fernández-del Castillo C. 851 resected cystic tumors of the pancreas: a 33-year
experience at the Massachusetts General Hospital. Surgery 2012 Sep; 152(3 Suppl 1):S4S12. Epub 2012 July 6. doi: 10.1016/j.surg.2012.05.033. PMID: 22770958; PMCID:
PMC3806101.
Cogdill AP, Frederick DT, Cooper ZA, Garber HR, Ferrone CR, Fiedler A, Rosenberg L,
Thayer SP, Warshaw AL, Wargo JA. Targeting the MAGE A3 antigen in pancreatic
cancer. Surgery 2012 Sep; 152(3 Suppl 1): S13-18. doi: 10.1016/j.surg.2012.05.031.
PMID: 22770803; PMCID: PMC3806055.
Ferrone CR, Pieretti-Vanmarcke R, Bloom JP, Zheng H, Szymonifka J, Wargo JA,
Thayer SP, Lauwers GY, Deshpande V, Mino-Kenudson M, Fernández-del Castillo C,
Lillemoe KD, Warshaw AL. Pancreatic ductal adenocarcinoma: long-term survival does
not equal cure. Surgery 2012 Sep; 152(3 Suppl 1):S43-49. doi:
10.1016/j.surg.2012.05.020. PMID: 22763261; PMCID: PMC3806092.
Fernández-del Castillo C, Morales-Oyarvide V, McGrath D, Wargo JA, Ferrone CR,
Thayer SP, Lillemoe KD, Warshaw AL. Evolution of the Whipple procedure at the
Massachusetts General Hospital. Surgery 2012 Sep; 152(3 Suppl 1):S56-63. Epub 2012
July 6. doi: 10.1016/j.surg.2012.05.022. PMID: 22770961; PMCID: PMC3806095.
Rosow DE, Liss AS, Strobel O, Fritz S, Bausch D, Valsangkar NP, Alsina J, Kulemann
B, Park JK, Yamaguchi J, LaFemina J, Thayer SP. Sonic hedgehog in pancreatic cancer:
From bench to bedside, then back to the bench. Surgery 2012 Sep; 152(3 Suppl 1):S1932. Epub 2012 Jul 6. doi: 10.1016/j.surg.2012.05.030. PMID: 22770959; PMCID:
PMC3806061.
Valsangkar NP, Bush DM, Michaelson JS, Ferrone CR, Wargo JA, Lillemoe KD,
Fernández-del Castillo C, Warshaw AL, Thayer SP. N0/N1, PNL, or LNR? The effect of
lymph node number on accurate survival prediction in pancreatic ductal adenocarcinoma.
J Gastrointest Surg 2013 Feb; 17(2):257-266. Epub 2012 Dec 11. doi: 10.1007/s11605012-1974-7. PMID: 23229885; PMCID: PMC3806050.
Faris JE, Blaszkowsky LS, McDermott S, Guimaraes AR, Szymonifka J, Huynh MA,
Ferrone CR, Wargo JA, Allen JN, Dias LE, Kwak EL, Lillemoe KD, Thayer SP,
Murphy JE, Zhu AX, Sahani DV, Wo JY, Clark JW, Fernández-del Castillo C, Ryan DP,
Hong TS. FOLFIRINOX in locally advanced pancreatic cancer: The Massachusetts
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General Hospital Cancer Center experience. Oncologist 2013; 18(5):543-548. Epub May
8. doi: 10.1634/theoncologist.2012-0435. PMID: 23657686; PMCID: PMC3662845.
Sahora K, Mino-Kenudson M, Brugge W, Thayer SP, Ferrone CR, Sahani D, Pitman M,
Warshaw AL, Lillemoe KD, Fernández-del Castillo C. Branch duct intraductal papillary
mucinous neoplasms: Does cyst size change the top of the scale? A critical analysis of the
reviewed international consensus guidelines in a large single-institutional series. Ann
Surg 2013 September; 258(3):466-475. doi: 10.1097/SLA.0b013e3182a18f48. PMID:
24022439.
Cai S, Hong TS, Goldberg SI, Fernández-del Castillo C, Thayer SP, Ferrone CR, Ryan
DP, Blaszkowsky LS, Kwak EL, Willett C, Lillemoe KD, Warshaw AL, Wo, JY.
Updated long-term outcomes and prognostic factors for unresectable locally advanced
pancreatic cancer patients treated with intraoperative radiation therapy at MGH (19782010). Cancer 2013 Dec; 113(23):4196-204. Epub 2013 Sep 4. doi:
10.1002/cncr.28329. PMID: 24006012; PMCID: PMC4403862.
Fong ZV, Ferrone CR, Thayer SP, Wargo JA, Sahora K, Seefeld KJ, Warshaw AL,
Lillemoe KD, Hutter MM, Fernández-del Castillo C. Understanding hospital
readmissions after pancreaticoduodenectomy: Can we prevent them? A 10-year
contemporary experience with 1,173 patients at the Massachusetts General Hospital. J
Gastrointest Surg 2014 Jan; 18(1):137-44;discussion 144-5. Epub 2013 Sep 4. doi:
10.1007/s11605-013-2336-9. PMID: 24002770.
Fernández-del Castillo C, Thayer SP, Ferrone CR, Wargo J. Surgery for small and
asymptomatic branch-duct IPMNs. Ann Surg 2014 Mar; 259:e4.Epub 2013 October 3.
doi: 10.1097/SLA.0000000000000270. PMID: 24096750.
McDermott S, Thayer SP, Fernandez-Del Castillo C, Mino-Kenudson M, Weissleder R,
Harisinghani MG. Accurate prediction of nodal status in preoperative patients with
pancreatic ductal adenocarcinoma using next-gen nanoparticle. Transl Oncol 2013 Dec;
6(6):670-5. eCollection 2013 Dec 1. PMID: 24466369; PMCID: PMC3890701.
Hedgire SS, Mino-Kenudson M, Elmi A, Thayer SP, Fernandez-del Castillo C,
Harisinghani MG. Enhanced primary tumor delineation in pancreatic adenocarcinoma
using ultrasmall super paramagnetic iron oxide nanoparticle-ferumoxytol: an initial
experience with histopathologic correlation. Int J Nanomed 2014; 9:1891-1896. Epub
2014 April 17. doi: 10.2147/IJN.S59788. PMID: 24790431; PMCID: PMC4000182.
Lee GC, Fong ZV, Ferrone CR, Thayer SP, Warshaw AL, Lillemoe KD, Fernández-del
Castillo C. High performing whipple patients: Factors associated with short length of stay
after open pancreaticoduodenectomy. J Gastrointest Surg 2014 October; 18(10):1760-9.
Epub 2014 Aug 5. doi: 10.1007/s11605-014-2604-3. PMID: 25091843.
Marchegiani G, Mino-Kenudson M, Sahora K, Morales-Oyarvide V, Thayer S, Ferrone
C, Warshaw A, Lillemoe K, Fernandez-del Castillo C. IPMN Involving the Main
Pancreatic Duct Biology, Epidemiology, and Long-Term Outcomes Following Resection.
Ann Surg 2015 May;261(5):976-86. doi: 10.1097/SLA.0000000000000813. PMID:
24979607.
Sahora K, Morales-Oyarvide V, Thayer, SP, Ferrone CR, Warshaw AL, Lillemoe, KD,
Fernandez-Del Castillo C. The effect of antecolic versus retrocolic reconstruction on
delayed gastric emptying after classic non-pylorus-preserving pancreaticoduodenectomy.
Am J Surg 2015 Jun;209(6):1028-35. doi: 10.1016/j.amjsurg.2014.04.015. PMID:
25124295.
71.
72.
73.
74.
75.
77.
78.
79.
80.
81.
Sahora K, Fernandez-del Castillo C, Dong F, Marchegiani G, Thayer SP, Ferrone CR,
Sahani DV, Brugge WR. Warshaw AL, Lillemoe KD, Mino-Kenudson M. Not all mixedtype intraductal papillary mucinous neoplasms behave like main-duct lesions:
Implications of minimal involvement of the main pancreatic duct. Surgery 2014 Sep;
156(3):611-21. doi: 10.1016/j.surg.2014.04.023. Epub 2014 Jul 28. PMID: 25081232.
Tempero MA, Malafa MP, Behrman SW, Benson AB, Casper ES, Chiorean EG, Chung
V, Cohen SJ, Czito B, Engebretson A, Feng M, Hawkins WG, Herman J, Hoffman JP,
Ko A, Komanduri S, Koong A, Lowy AM, Ma WW, Merchant NB, Mulvihill SJ,
Muscarella P, Nakakura EK, Obando J, Pitman MB, Reddy S, Sasson AR, Thayer SP,
Weekes CD, Wolff RA, Wolpin BM, Burns JL, Freedman-Cass DA. Pancreatic
adenocarcinoma, version 2.2014: Featured updates to the NCCN guidelines. JNCCN
2014 Aug; 12(8):1083-93. PMID: 25099441
Naraghi L, Peev MP, Esteve R, Chang Y, Berger DL, Thayer SP, Rattner DW, Lillemoe
KD, Kaafarani H, Yeh DD, de Moya MA, Fagenholz PJ, Velmahos GS, King DR. The
influence of anesthesia on heart rate complexity during elective and urgent surgery in 128
patients. J Crit Care 2015 Feb; 30(1), 145-149. doi: 10.1016/j.jcrc.2014.08.0082. PMID:
25239820.
Valsangkar NP, Ingkakul T, Correa-Gallego C, Mino-Kenudson M, Lillemoe KD,
Fernández-del Castillo C, Warshaw AL, Liss AS, Thayer SP. Survival in ampullary
cancer: Potential role of different KRAS mutations. Surgery 2015 Feb; 157(2):260-8.
doi: 10.1016/j.surg.2014.08.092. PMID: 25616942.
Kulemann B, Pitman MB, Liss AS, Valsangkar N, Fernandez-del Castillo C, Lillemoe
KD, Hoeppner J, Mino-Kenudson M, Warshaw AL, Thayer, SP. Circulating tumor cells
found in patients with localized and advanced pancreatic cancer. Pancreas 2015
May;44(4), 547-50. doi: 10.1097/MPA.0000000000000324. PMID: 25822154.
Herman J, Thayer SP, Hoffman J, Wolff R. Management of the Primary Pancreatic
Tumor in Metastatic Disease. JNCCN, 2015 May;13(5):e29-36. PMID: 26158133.
Yamaguchi J, Liss A, Sontheimer A, Mino-Kenudson M, Fernandez-del Castillo C,
Warshaw A, Thayer SP. Pancreatic Duct Glands (PDG) are a progenitor compartment
responsible for pancreatic epithelial repair. Stem Cell Res, 2015 July;15(1):190-202. doi:
10.1016/j.scr.2015.05.006. PMID: 26100232.
Chari ST, Kelly K, Hollingsworth MA, Thayer SP, Ahlquist DA, Andersen DK, Batra
SK, Brentnall TA, Canto M, Cleeter D, Firpo MA, Gambhir SS, Go VL, Hines OJ,
Kenner B, Klimstra DS, Lerch MM, Levy MJ, Maitra A, Mulvihill SJ, Petersen GM,
Rhim AD, Simeone, DM, Srivastava S, Tanaka M, Vinik AI, Wong D. Early detection of
sporadic pancreatic cancer: summative review. Pancreas 2015 Jul;44(5):693-712. doi:
10.1097/MPA.0000000000000368. PMID: 25931254; PMCID: PMC4467589.
Cauley CE, Pitman MB, Zhou J, Cayre Y, Valsangkar NP, Nahar S, Perkins J, Kuleman
B, Liss AS, Fernandez-del Castillo C, Warshaw, AL, Lillemoe KD, Thayer SP.
Circulating epithelial cells in patients with pancreatic lesions: Clinical and pathological
findings. J Am Coll Surg, 2015 Sep;221(3):699-707. doi:
10.1016/j.jamcollsurg.2015.05.014. PMID: 26209458; PMCID: PMC4546900.
Huang Y; Nahar S; Nakagawa A; Fernandez de Barrena M; Mertz J; Bryant B; Adams C;
Mino-Kenudson M; von Alt K; Chang K; Conery A; Hatton C; Sims R; FernandezZapico M; Wang X; Lillemoe K; Fernandez-del Castillo C; Warshaw AL; Thayer SP;
82.
Liss A. Regulation of GLI underlies a role for BET bromodomains in pancreatic cancer
growth and the tumor microenvironment. (Accepted, Apr 15, 2016, Clin Cancer Res
Sahora K; Morales-Oyarvide V; Thayer SP; Ferrone CR; Warshaw AL; Lillemoe KD;
Fernández-Del Castillo C. The effect of antecolic versus retrocolic reconstruction on
delayed gastric emptying after classic non-pylorus-preserving pancreaticoduodenectomy.
Am J Surg. 209: 1028-35. 2015
Articles Submitted:
1.
Yamaguchi J, Mino-Kenudson M, Liss AS, Chowdhury S, Wang, TC, Fernandez-del
Castillo C, Lillemoe, KD, Warshaw AL, Thayer SP. Loss of trefoil factor 2 from
pancreatic duct glands accelerates formation of intraductal papillary mucinous
neoplasms. Provisionally accepted with revision to Gastroenterology.
Book Chapters:
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7.
Thayer SP; Warshaw AL. Current Surgical Therapy. 8. Philadelphia, PA: Elsevier
Mosby; 2004. Periampullary Cancer; 494-504
Alsfasser G; Warshaw AL; Thayer SP; Antoniu B; Laposata M; Lewandrowski K; Klar
E; Fernandez-del Castillo C. Chirurgisches Forum 2005. 2005. Berlin/Heidelberg,
Germany: Springer; 2005. Activated Protein C Decreases Inflammation and Improves
Survival in Experimental Acute Pancreatitis; 235-236
Thayer SP. Pancreatic Cancer. Sudbury, Massachusetts: Jones and Bartlett Publishers;
2005. Chapter 5, Commentary on: Lin JW, Leach SD. Pancreatic development; 84-86
Boland GM; Thayer SP. Pancreatic Cancer. New York, NY: Springer; 2008. Chapter 11,
Molecular Signaling Pathways in Pancreatic Cancer; 181-228
Alsina J; Thayer SP. MGH Guide to Clinical Cancer Genetics. New York, NY: Springer;
2010. Hereditary Pancreatic Cancer; 89-96
Liss AS; Thayer SP. Pancreatic Cancer and the Tumor Microenvironment:
Mesenchyme's Role in Pancreatic Carcinogenesis. Trivandrum, India: Transworld
Research Network; 2012. Chapter 9, "Therapeutic Targeting of Pancreatic Stroma"
Thayer SP; Valsangkar N. Current Surgical Therapy. 11. New York, NY: Elsevier; 2014.
Chapter 11, The Management of Acute Pancreatitis
Abstracts:
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Lee V; Chen; Dubois M; Thayer SP; McNamara S. Continuous muscle relaxant infusion
with EMG monitoring. Annual Meeting, Southern Medical Association, Atlanta, GA
1986
Thayer SP. An upstream binding element is required for retinoic acid-stimulated
transcription of the MDR1 promoter in human neuroblastoma cells. Annual Meeting,
AACR; San Diego, CA. 1997
Friedman D; Thayer SP; Scotto KW. Activation of MDR1 gene in retinoic acidstimulated neuroblastoma cells involves depression and activation by multiple Sp family
members. Annual Meeting AACR; Philadelphia, PA. 1999
Balcom JH; Keck T; Warshaw AL; Thayer SP; Antoniu B; Graeme-Cook F; Fernandezdel Castillo C. Prevention of clinically significant pancreatic fistulae with a new,
absorbable hydrogel sealant after distal pancreatectomy in the dog. Annual Meeting,
5.
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SSAT; Atlanta, GA. 2001
Fernandez-del Castillo C; Targarona J; Thayer SP; Brugge WR; Warshaw AL. Incidental
Pancreatic Cysts: Clinicopathological Characteristics and Comparison to Symptomatic
Patients. Annual Meeting, New England Surgical Society, Sep 27-29; Dixville, NH. 2002
Sep
Thayer SP; Roberts D; Nielsen C; Fernandez-del Castillo C; Warshaw AL. The
developmental signaling factor Sonic Hedgehog is abnormally expressed in neoplastic
pancreata and drives an intestinal metaplasia of the adult human pancreas. Annual
Meeting, APA; Chicago, IL. 2002 Nov
Thayer SP; Roberts D; Nielsen C; Fernandez-del Castillo C; Warshaw AL. To
characterize the contribution of Sonic hedgehog to pancreatic neoplasia. Scientific
Advisory Committee Symposium, MGH; Boston, MA. 2003
Salvia R; Fernandez-del Castillo C; Bassi C; Thayer SP; Falconi M; Federzoli P;
Warshaw AL. Can malignancy be predicted in main duct intraductal papillary mucinous
tumors of the pancreas (IPMNs)? Pancreas Club; Orlando, FL. 2003 May
Alfasser G; Targarona J; Thayer SP; Warshaw AL; Fernandez-del Castillo C. Is serum
CA-19-9 useful in the evaluation of patients with cystic lesions of the pancreas. Annual
Meeting APA; Chicago, IL. 2003 Nov
Thayer SP; Roberts DJ; Nielsen CM; Lauwers GY; Fernandez-del Castillo C; Antoniu
B; Yajnik V; Alsfasser G; Warshaw AL. Hedgehog, an early mediator of pancreatic
cancer tumorigenesis, links altered developmental programs to pancreatic neoplasia.
Annual Meeting APA; Chicago, IL. 2003 Nov
Rosow DE; Balcom JH; Fernandez-del Castillo C; Warshaw AL; Thayer SP. Chemically
induced pancreatic ductal adenocarcinomas in mice express Sonic hedgehog. 94th Annual
Meeting Molecular Targets and Cancer Therapeutics, AACR; Boston, MA. 2003 Nov
Salvia R; Fernandez-del Castillo C; Bassi C; Thayer SP; Falconi M; Pederzoli P;
Warshaw AL. Main duct intraductal papillary mucinous neoplasms (IPMNs) of the
pancreas: Clinical predictors of malignancy and long-term survival following resection.
Annual Meeting, Southern Surgical Association; Hot Springs, VA. 2003 Dec
Rosow D; Balcom JH; Trainor AG; Strobel O; Antoniu B; Li L; Fernandez-del Castillo
C; Warshaw AL; Thayer SP. Implantation of dimethylbenzanthracene in mice induces
pancreatic ductal adenocarcinomas that misexpress the sonic hedgehog pathway. 11th
Meeting of the IAP and 35th Annual Meeting of the Japan Pancreas Society; Sendai,
Japan. Journal of the Japan Pancreas Society. 2004, Vol. 19: 285
Strobel O; Trainor A; Antoniu B; Rosow DE; Fernandez-del Castillo C; Warshaw AL;
Thayer SP. Sonic hedgehog is upregulated in response to inflammation in the epithelium
of main duct branches: Role in pancreatic carcinogenesis. 11th Meeting of the IAP and
35th Annual Meeting of the Japan Pancreas Society; Sendai, Japan. Journal of the Japan
Pancreas Society. 2004, Vol. 19: 241-42
Thayer SP; Dor Y; Melton D; Strobel O; Rosow DE; Fernandez-del Castillo C; Trainor
A; Li L; Warshaw AL. Carcinogen-induced tubular formations are not of islet cell origin.
11th Meeting of the IAP and 35th Annual Meeting of the Japan Pancreas Society; Sendai,
Japan. Journal of the Japan Pancreas Society. 2004, Vol. 19: 241
Alsfasser G; Warshaw AL; Thayer SP; Laposata M; Lewandrowski KB; Fernandez-del
Castillo C. Activated protein C decreases inflammation and improves survival in
experimental acute pancreatitis. 11th Meeting of the IAP and 35th Annual Meeting of the
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Japan Pancreas Society; Sendai, Japan. 2004
Strobel O; Rosow DE; Trainor AG; Lauwers AG; Li L; Antoniu B; Fernandez-del
Castillo C; Warshaw AL; Thayer SP. Duct glands of the pancreatic head up-regulate
Shh, GI mucins and rate of proliferation in response to chronic injury and inflammation:
Possible origin of pancreatic cancer? Annual Meeting APA; Chicago, IL. Pancreas. 2004,
Vol. 29: 338-39
Rosow DE; Balcom JH; Fernandez-del Castillo C; Warshaw AL; Thayer SP. Chemically
induced pancreatic ductal adenocarcinomas in mice misexpress the Sonic hedgehog
pathway. Scientific Advisory Committee Symposium, MGH; Boston, MA. 2004 Feb
Rosow DE; Balcom JH; Trainor AG; Strobel O; Antoniu B; Li L; Fernandez-del Castillo
C; Warshaw AL; Thayer SP. Sonic hedgehog is abnormally expressed in
dimethylbenzanthracene (DMBA)-induced pancreatic neoplasia and drives a
gastrointestinal metaplasia of the adult mouse pancreas. 95th Annual Meeting AACR;
Orlando, FL. 2004 Mar
Strobel O; Trainor A; Li L; Antoniu B; Rosow DE; Fernandez-del Castillo C; Warshaw
AL; Thayer SP. Sonic hedgehog is misexpressed in the epithelium of branches of the
pancreatic main duct in response to inflammation: role in pancreatic carcinogenesis. 95th
Annual Meeting AACR; Orlando, FL. 2004 Mar
Thayer SP; Roberts DJ; Nielsen CM; Lauwers GY; Strobel O; Rosow DE; Fernandezdel Castillo C; Warshaw AL. The Hedgehog pathway: An initiator and maintenance
factor for pancreatic cancer. Lustgarten Foundation for Pancreatic Cancer
Research/AACR Research Meeting, Pancreatic Cancer 2004: Advances and Challenges;
San Francisco, CA. 2004 Jun
Rosow DE; Strobel O; Trainor AG; Fernandez-del Castillo C; Warshaw AL; Thayer SP.
Hedgehog and its pathway members are misexpressed and active in the majority of
sporadic human pancreatic adenocarcinomas: A biologically important pathway and
potential therapeutic target. Annual Meeting APA; Chicago, IL. Pancreas. 2004 Nov, Vol.
29: 338
Strobel O; Rosow DE; Trainor AG; Lauwers GY; Fernandez-del Castillo C; Warshaw
AL; Thayer SP. Duct glands of the pancreatic head upregulate sonic hedgehog and GIspecific mucins in response to chronic injury: stem cells of pancreatic cancer?. 96th
Annual Meeting AACR; Anaheim, CA. 2005
Ferrone CP; Thayer SP; Finkelstein DM; Muzikansky A; Mino-Kenudson M; Lauwers
G; Warshaw AL. A decrease in preoperative to postoperative CA19-9 level is a
significant predictor of survival in patients with pancreatic adenocarcinoma. Annual
Meeting, ASCO; Orlando, FL. J Clin Oncol. 2005, Vol. 23: 4034
Strobel O; Rosow DE; Trainor AG; Lauwers GY; Fernandez-del Castillo C; Warshaw
AL; Thayer SP. Duct glands of the pancreatic head upregulate sonic hedgehog as well as
gastric and intestinal mucins in response to chronic inflammation: gastrointestinal
metaplasia an early event in pancreatic carcinogenesis. American Gastroenterological
Association, DDW; Chicago, IL. 2005
Rosow DE; Sahani DV; Strobel O; Alsfasser G; Mino-Kenudson M; Kalva S; Saini S;
Lee SI; Wittenberg J; Mueller PR; Fernandez-del Castillo; Warshaw AL; Thayer SP.
Imaging of acute mesenteric ischemia using 16-multi-detector row CT and CT
angiography in a porcine model: description of disease evolution with surgical
correlation. Presidential Plenary Session, SSAT, DDW; Chicago, IL. 2005
27.
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Thayer SP; Dor Y; Melton D; Strobel O; Mino-Kenudson M; Lauwers G; Rosow DE;
Fernandez-del Castillo C; Warshaw AL. Carcinogen-induced tubular formations are not
of acinar cell origin. Pancreas Club, DDW; Chicago, IL. 2005
Strobel O; Lauwers GY; Fernandez-del Castillo C; Warshaw AL; Thayer SP.
Differential expression of the developmental factors Sonic Hedgehog and Pdx-1 appears
to determine the phenotype of pancreatic ductal epithelium in response to chronic injury.
Pancreas Cancer 2005: State of the Art, Lustgarten Foundation for Pancreatic Cancer
Research/Memorial Sloan-Kettering Cancer Center; New York, NY. 2005
Rodriguez R; Soto Germes S; Pandharipande PV; Gazelle GS; Thayer SP; Warshaw AL;
Fernandez-del Castillo C. Implications and cost of pancreatic leak following distal
pancreatic resection. 12th Annual Surgical Resident and Fellow Research Presentation
Day, New England Surgical Society; Boston, MA. 2005
Long DD; Munn LL; Mino-Kenudson M; Antoniu B; Strobel O; Fernandez-del Castillo
C; Warshaw AL; Thayer SP. Sonic hedgehog (Shh): A potent angiogenic factor
necessary for tumor growth? Annual Meeting APA; Chicago, IL. 2005
Stirman A; Strobel O; Mikhaylova E; Fernandez-del Castillo C; Warshaw AL; Thayer
SP. Generation of a mouse model, Pdx-Shh, which develops precursor lesions of
pancreatic cancer (PanINs) from normal ducts. Annual Meeting APA; Chicago, IL. 2005
Strobel O; Dor Y; Stirman A; Mikhaylova E; Trainor A; Fernandez-del Castillo C;
Warshaw AL; Thayer SP. Tubular complexes are not of beta-cell origin: Genetic lineage
tracing in a mouse model of pancreatitis. Annual Meeting APA; Chicago, IL. 2005
Strobel O; Lauwers GY; Fernandez-del Castillo C; Warshaw AL; Thayer SP. PanIN 1A
or duct glands of the pancreas? Anatomic proof and characterization of a specialized
compartment of the ductal system. Annual Meeting APA; Chicago, IL. Pancreas. 2005,
Vol. 31: 471-72
Rakhlin EY; Rosow DE; Mino-Kenudson M; Stirman AM; Mikhaylova EA; Long D;
Fernandez-del Castillo C; Warshaw AL; Thayer SP. Differentiation status may predict
response to Hedgehog pathway inhibition in pancreatic adenocarcinoma. Annual Meeting
APA; Chicago, IL. Pancreas. 2005, Vol. 31: 464
Rakhlin EY; Rosow DE; Mino-Kenudson M; Stirman AM; Mikhaylova EA; Long D;
Fernandez-del Castillo C; Warshaw AL; Thayer SP. Poster/Abstract for the Annual
Meeting of the APA. Annual Meeting APA; Chicago, IL. Pancreas. 2005, Vol. 31: 464
Rakhlin EY; Mino-Kenudson M; Warshaw AL; Thayer SP. Characterization of Sonic
hedgehog expression and Hedgehog pathway activity in Barrett's esophagus and
esophageal adenocarcinoma. 97th Annual Meeting AACR; Washington, DC. 2006
Vagefi PA; Razo O; Deshpande V; McGrath DJ; Lauwers GY; Thayer SP; Warshaw
AL; Fernandez-del Castillo C. Evolving patterns in the detection of pancreatic
neuroendocrine tumors (PNETs): The Massachusetts General Hospital experience. APAIAP Joint Meeting; Chicago, IL. 2006
Alsina J; Stirman A; Mino-Kenudson M; Fernandez-del Castillo C; Warshaw A; Thayer
SP. Shh misexpression in the adult pancreas results in the expansion of both a mucinous
ductal metaplasia and a fibrosing mesenchyme. 2006 APA-IAP Joint Meeting; Chicago,
IL. Pancreas. 2006, Vol. 33: 443
Guimaraes AR; Rakhlin EY; Long D; Weissleder R; Thayer SP. Noninvasive MRI
imaging: a sensitive indicator of physiologic changes accompanied with anti-hedgehog
therapy in a pancreatic ductal adenocarcinoma (PDAC) xenograft model. 2006 APA-IAP
40.
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Joint Meeting; Chicago, IL. Pancreas. 2006, Vol. 33: 465-66
LaFemina J; Stirman A; Alsina J; Mino-Kenudson M; Fernandez-del Castillo C;
Warshaw AL; Thayer SP. Challenging the role of the p16 mutation in the development
of pancreatic adenocarcinoma. 41st Annual Meeting, Pancreas Club; Washington, DC.
2007
Alsina J; Stirman A; Mino-Kenudson M; Fernandez-del Castillo C; Warshaw A; Thayer
SP. Sonic hedgehog misexpression directs epithelial and mesenchymal changes important
in initiation of the pancreatic cancer phenotype. 41st Annual Meeting Pancreas Club;
Washington, DC. 2007
Crippa S; Salvia R; Warshaw AL; Dominguez I; Bassi C; Falconi M; Thayer SP;
Zamboni G; Lauwers G; Mino-Kenudson M; Pederzoli P; Fernandez-del Castillo C.
Mucinous cystic neoplasm of the pancreas is not an aggressive entity. Lessons from 163
resected patients. 41st Annual Meeting Pancreas Club; Washington, DC. 2007
LaFemina J; Roberts P; Hung Y; Gusella J; Sahani D; Fernandez-del Castillo C;
Warshaw A; Thayer SP. Identification of a novel kindred with familial pancreatitis and
pancreatic cancer. DDW & SSAT; Washington, DC. 2007
LaFemina J; Stirman A; Alsina J; Mino-Kenudson M; Fernandez-del Castillo C;
Warshaw AL; Thayer SP. Paradoxical inhibition of ductal proliferation due to SHH
misexpression with p16-/- is accompanied by pluripotential cell expansion. Annual
Meeting APA; Chicago, IL. Pancreas. 2007, Vol. 35: 409-10
LaFemina J; Stirman A; Alsina J; Mino-Kenudson M; Fernandez-del Castillo C;
Warshaw A; Thayer SP. Shh misexpression with p16-/- results in stimulation of
pancreatic progenitor cells and paradoxical normalization of pancreatic neoplastic
phenotype. 54th Annual Meeting, Massachusetts Chapter, ACS; Boston, MA. 2007
Fritz S; Fernandez-del Castillo C; Mino-Kenudson M; Crippa S; Miller JM; Thayer SP;
Deshpande V; Lauwers GY; Warshaw AL; Iafrate AJ. Detection of chromosomal
aberrations in intraductal papillary mucinous neoplasms by comparative genomic
hybridization. DDW & 49th Annual Meeting, SSAT; San Diego, CA. 2008
Fritz S; Fernandez-del Castillo C; Iafrate AJ; Mino-Kenudson M; Neyhard N; LaFemina
J; Stirman A; Warshaw AL; Thayer SP. A xenograft model and cell line deriving from
invasive intraductal papillary mucinous neoplasm of the pancreas. DDW & 49th Annual
Meeting, SSAT; San Diego, CA. 2008
Ferrone CR; Warshaw AL; Rodriguez JR; Thayer SP; Fernandez-del Castillo C.
Pancreatic fistula rates after 442 distal pancreatectomies: Staplers do not decrease fistula
rates. 49th Annual Meeting, SSAT; San Diego, CA. 2008
LaFemina J; Roberts P; Hung Y; Gusella J; Sahani D; Fernandez-del Castillo C;
Warshaw A; Thayer SP. Identification of a novel kindred with familial pancreatitis and
pancreatic cancer. Annual Meeting, Pancreas Club; San Diego, CA. 2008
Strobel O; Rosow DE; Rakhlin EY; Lauwers GY; Trainor AG; Fernandez-del Castillo C;
Warshaw AL; Thayer SP. Pancreatic duct glands, a specialized ductal compartment
reactive to chronic injury and involved in Shh-driven mucinous metaplasia. Joint Meeting
of the European Pancreatic Club (EPC) and the IAP; Lodz, Poland. 2008
Androutsopoulos V; Dominguez I; Ferrone C; Fernandez-del Castillo C; Warshaw AL;
Thayer SP. Does gemcitabine improve survival in resected pancreatic cancer patients?
Annual Meeting APA; Chicago, IL. 2008
Nehra D; Mino-Kenudson M; Thayer SP; Ferrone C; Finkelstein D; Silver M; Warshaw
53.
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AL; Fernandez-del Castillo C. Intraductal papillary mucinous neoplasms: a genetic
disease? Annual Meeting APA; Chicago, IL. 2008
Konstantinidis I; Deshpande V; Catalano OA; Forcione DG; Sahani D; Fernandez-del
Castillo C; Thayer SP; Warshaw AL; Ferrone CR. Lymphoepithelial cysts of the
pancreas: report of a single institution experience of 8 cases. Annual Meeting APA;
Chicago, IL. 2008
Correa-Gallego C; Ferrone C; Sahani D; Forcione D; Brugge W; Thayer SP; Warshaw
AL; Fernandez-del Castillo C. Incidentally discovered pancreatic cysts: What evaluation
is useful?. Annual Meeting APA; Chicago, IL. 2008
Bausch D; Mino-Kenudson M; Fernandez-del Castillo C; Warshaw AL; Thayer SP;
Kelly K. Plectin-1 as a novel imaging marker in pancreatic cancer. Annual Meeting APA;
Chicago, IL. 2008
Bausch D; Mino-Kenudson M; Fernandez-del Castillo C; Warshaw AL; Thayer SP;
Kelly K. Plectin-1 as a novel imaging biomarker for pancreatic cancer. Pancreas Club;
Chicago, IL. 2009
Correa-Gallego C; Ferrone C; Thayer SP; Wargo JA; Warshaw AL; Fernandez-del
Castillo C. Incidental pancreatic cysts: Do we really know what we are watching?
Pancreas Club; Chicago, IL. 2009
Androutsopoulos V; Thayer SP. Does Gemzar improve survival in resected pancreatic
cancer patients? Pancreas Club; Chicago, IL. 2009
Konstantinidis I; Genevay M; Brugge WR; Thayer SP; Ferrone CR; Fernandez-del
Castillo C; Lauwers GY; Deshpande V. Cytology plays a key role in the identification of
malignancy in pancreatic cysts. An analysis of 175 histologically confirmed cases. DDW;
Chicago, IL. 2009
Konstantinidis I; Deshpande V; Fernandez-del Castillo C; Warshaw AL; Lauwers GY;
Androutsopoulos V; Thayer SP; Ferrone CR. Does the mechanism of lymph node
invasion affect survival in patients with pancreatic cancer? DDW; Chicago, IL. 2009
Crippa S; Fernandez-del Castillo C; Salvia R; Finkelstein DM; Bassi C; Dominguez I;
Capelli P; Mino-Kenudson M; Lauwers TY; Falconi M; Thayer SP; Partelli S; Pederzoli
P; Warshaw AL. Main-duct and combined IPMNs are the same clinical entity and distinct
from branch-duct IPMNs. DDW; Chicago, IL. 2009
Fritz S; Fernandez-del Castillo C; Mino-Kenudson M; Crippa S; Miller JM; Thayer SP;
Deshpande V; Lauwers GY; Warshaw AL; Iafrate AJ. Detection of chromosomal
aberrations in intraductal papillary mucinous neoplasms by comparative genomic
hybridization. DDW; Chicago, IL. 2009
Fritz S; Fernandez-del Castillo C; Mino-Kenudson M; Neyhard NL; LaFemina J; Stirman
A; Warshaw AL; Thayer SP. A xenograft model and cell line deriving from invasive
intraductal papillary mucinous neoplasm of the pancreas. DDW; Chicago, IL. 2009
Bausch D; Mino-Kenudson M; Fernandez-del Castillo C; Warshaw AL; Kelly K; Thayer
SP. Plectin-1 as a biomarker in malignant pancreatic intraductal papillary mucinous
tumors. SSAT, DDW; Chicago, IL. 2009
Boni A; Thayer SP; Ferrone C; Bausch D; Neyhard N; Cogdill A; Fernandez-del Castillo
C; Warshaw AL; Wargo JA. Immunotherapeutic and epigenetic approaches targeting
cancer-testis antigens in the treatment of pancreatic cancer. Annual Meeting APA and
Japanese Pancreas Society; Honolulu, HI. 2009
Konstantinidis IT; Dursun A; Bordeianou L; Wargo J; Thayer SP; Fernandez-del Castillo
67.
68.
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C; Warshaw AL; Ferrone CR. Metastatic tumors to the pancreas in the modern era.
Annual Meeting APA and the Japanese Pancreas Society; Honolulu, HI. 2009
Ferrone CR; Konstantinidis IT; Fernandez-del Castillo C; Wargo J; Thayer SP; Warshaw
AL. Fifteen years of the Warshaw technique. Annual Meeting APA and Japanese
Pancreas Society; Honolulu, HI. 2009
Correa-Gallego C; Ferrone CR; Thayer SP; Wargo JA; Warshaw AL; Fernandez-del
Castillo C. Are multifocal pancreatic cysts an indolent condition? Annual Meeting APA
and Japanese Pancreas Society; Honolulu, HI. 2009
Correa-Gallego C; Mino-Kenudson M; Ferrone C; Thayer SP; Wargo JA; Warshaw AL;
Fernandez-del Castillo C. Non-neoplastic cysts comprise 8% of resected pancreatic cysts
presumed to be neoplastic. Annual Meeting APA and Japanese Pancreas Society;
Honolulu, HI. 2009
Bausch D; Pausch T; Hopt UT; Fernandez-del Castillo C; Warshaw AL; Thayer SP;
Keck T. Granulocyte MMP-9 is a VEGF-independent component of the angiogenic
switch in PDAC. Annual Meeting APA and Japanese Pancreas Society; Honolulu, HI.
2009
Bausch D; Fritz S; Fernandez-del Castillo C; Warshaw AL; Thayer SP. Inhibition of
hedgehog signaling in a PDAC xenograft model inhibits the tumor and its
microenvironment. Joint Meeting, IAP and Japan Pancreas Society; Fukuoka, Japan.
2010
Park JK; Irimia D; Tomer M; Bausch D; Liss A; Fernandez-del Castillo C; Thayer SP.
Differences in migration between primary and metastatic PDAC cells. Joint Meeting, IAP
and Japan Pancreas Society; Fukuoka, Japan. 2010
Park JK; Toner M; Nagrath S; Komen J; Bausch D; Liss A; Fernandez-del Castillo C;
Warshaw AL; Thayer SP. Detection of circulating tumor cells (CTCs) in pancreatic
ductal adenocarcinoma (PDAC). Joint Meeting, IAP and Japan Pancreas Society;
Fukuoka, Japan. 2010
Bausch D; Fritz S; Fernandez-del Castillo C; Warshaw AL; Thayer SP. Inhibition of
hedgehog signaling in a PDAC xenograft model inhibits the tumor and its
microenvironment. Annual Meeting APA; Chicago, IL. 2010
Park J; Irimia D; Toner M; Bausch D; Liss A; Fernandez-del Castillo C; Warshaw AL;
Thayer SP. Differences in migration between PDAC stem cells and non-stem cells.
Annual Meeting APA; Chicago, IL. 2010
Valsangkar NP; Bush DM; Michaelson JS; Fernandez-del Castillo C; Warshaw AL;
Thayer SP. Race does not substantially affect outcomes in patients with pancreatic
cancer. Annual Meeting APA; Chicago, IL. 2010
Valsangkar NP; Bush DM; Michaelson JS; Fernandez-del Castillo C; Warshaw AL;
Thayer SP. Prognostic value of lymph node ratio increases with number of lymph nodes
examined: a concomitant review of SEER and a single institution's patients. Annual
Meeting, SSAT, DDW; Chicago, IL. 2011
Valsangkar NP; Bush DM; Michaelson JS; Fernandez-del Castillo C; Warshaw AL;
Thayer SP. Predicting survival in pancreatic cancer: A comparison of lymph node ratio
with number of metastatic nodes. Pancreas Club, DDW; Chicago, IL. 2011
Bausch D; Fritz S; Liss A; Fernandez-del Castillo C; Warshaw AL; Thayer SP.
Hedgehog signaling is required for tumor stroma maintenance and tumor angiogenesis in
pancreatic cancer. Pancreas Club, DDW; Chicago, IL. 2011
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Mino-Kenudson M; Fernandez-del Castillo C; Baba Y; Hsu M; Correa-Gallego C;
Ingkakul T; Perez Johnston R; Turner BG; Androutsopoulos V; McGrath D; Sahani DV;
Brugge WR; Ogino S; Pitman MB; Warshaw AL; Thayer SP. Prognostic significance of
histologic and precursor epithelial subtypes of invasive intraductal papillary mucinous
neoplasm: Improved survival rates compared to pancreatic ductal adenocarcinoma are
limited to indolent colloid and oncocytic types. Pancreas Club, DDW; Chicago, IL. 2011
Valsangkar NP; Ingkakul T; Correa-Gallego C; Warshaw AL; Fernandez-del Castillo C;
Liss AS; Thayer SP. The G12D mutation of KRAS predicts early recurrence and poor
overall survival in ampullary adenocarcinoma. Annual Meeting APA; Chicago, IL. 2011
Yamaguchi J; Mino-Kenudson M; Liss AS; Fernandez-del Castillo C; Warshaw AL;
Thayer SP. Pancreatic duct glands (PDG) are the origin of gastric-type IPMN. Annual
Meeting APA; Chicago, IL. 2011
Valsangkar NP; Ingkakul T; Correa-Gallego C; Liss AS; Mino-Kenudson M; Fernandezdel Castillo C; Warshaw AL; Thayer SP. The prognostic implication of KRAS mutation
in ampullary adenocarcinoma: only the KRASG12D genotype predicts poor survival.
46th Annual Meeting, Pancreas Club; San Diego, CA. 2012
Yamaguchi J; Mino-Kenudson M; Liss AS; Lillemoe KD; Fernandez-del Castillo C;
Warshaw AL; Thayer SP. Pancreatic duct glands (PDG) are the origin of gastric-type
IPMN. 46th Annual Meeting, Pancreas Club; San Diego, CA. 2012
Liss AS; Nahar S; Mertz JA; Sims RJ; Fernandez-del Castillo C; Lillemoe KD; Warshaw
AL; Thayer SP. The BET family of chromatin adaptors are key regulators of cell growth
and Shh expression in pancreatic ductal adenocarcinoma. 46th Annual Meeting, Pancreas
Club; San Diego, CA. 2012
Kulemann B; Liss AS; Valsangkar NP; Fernandez-del Castillo C; Lillemoe KD; MinoKenudson M; Warshaw AL; Pitman MB; Thayer SP. The capture of CTC for
cytological, molecular and cell culture evaluation in patients with pancreatic cancer. 46th
Annual Meeting, Pancreas Club; San Diego, CA. 2012
Hedgire Sandeep S; Fernandez-del Castillo C; Thayer SP; Mino-Kenudson M;
Weissleder R; Harisinghani Mukesh G. Delineating the tumor in pancreatic
adenocarcinoma using USPIO-ferumoxytol: preliminary findings. Annual Meeting,
Society of Computer Body Tomography and Magnetic Resonance; Boston, MA. 2012
Yamaguchi J; Mino-Kenudson M; Liss AS; Lillemoe KD; Fernandez-del Castillo C;
Warshaw AL; Thayer SP. Pancreatic duct glands (PDG), a progenitor stem cell niche
responsible for pancreatic epithelial renewal and repair in response to inflammatory
injury. Joint meeting APA and IAP; Miami, FL. 2013
Sahora K; Mino-Kenudson M; Thayer SP; Ferrone C; Brugge W; Sahani D; Pitman M;
Warshaw A; Lillemoe K; Fernandez-del Castillo C. Branch duct intraductal papillary
mucinous neoplasms: Does cyst size change at the tip of the scale? A critical analysis of
the revised international consensus guidelines in a large single-institutional series.
American Surgical Association 133rd Annual Meeting; Atlanta, GA. 2013
Fong ZV; Sahora K; Seefeld KJ; Wargo JA; Ferrone CR; Thayer SP; Warshaw AL;
Lillemoe KD; Hutter MM; Fernando-del Castillo C. Understanding hospital readmissions
after pancreaticoduodenectomy: Can we prevent them? A 10-year contemporary
experience with 1173 patients at the Massachusetts General Hospital. Annual Meeting
SSAT; Orlando, FL. 2013
Goldberg S; Hong TS; Fernandez-del Castillo C; Thayer SP; Ferrone CR; Willett C;
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Warshaw AL; Ryan DP; Cai S. IORT prognostic factors for locally advanced pancreatic
cancer. 55th Annual Meeting ASTRO; Atlanta, GA. 2013
Cauley CE; Pittman M; Zhou J; Valsangkar N; Liss A; Fernandez-del Castillo C;
Warshaw AL; Lillemoe KD; Thayer SP. Prognostic value of circulating tumor cells in
patients with pancreatic adenocarcinoma. 44th Annual Meeting APA; Miami Beach, FL.
2013
Yamaguchi J; Mino-Kenudson M; Liss AS; Lillemoe KD; Fernandez-del Castillo C;
Warshaw AL; Thayer SP. Loss of TFF2 in pancreatic duct glands (PDG) results in the
formation of IPMN, suggesting TFF2 may function as a tumor suppressor. 44th Annual
Meeting APA; Miami Beach, FL. 2013
Marchegiani G; Mino-Kenudson M; Morales-Oyarvide V; Thayer SP; Ferrone C;
Warshaw AL; Lillemoe K; Fernandez-del Castillo C. IPMN involving the main
pancreatic duct: Biology, epidemiology, and long-term outcomes following resection.
44th Annual Meeting APA; Miami Beach, FL. 2013
Liss AS; Nahar S; Mertz J; Bryant B; Sims R; Fernandez-del Castillo C; Lillemoe K;
Warshaw AL; Thayer SP. BET proteins are key mediators of tumor cell growth and the
microenvironment in pancreatic cancer. 44th Annual Meeting APA; Miami Beach, FL.
2013
Chowdhury S; Klinkebiel D; Yamaguchi J; Liss AS; Thayer SP. TFF2/Smad4 tumor
suppressor signaling in pancreatic cancer is regulated by promoter methylation. 46th
Annual Meeting APA; Miami Beach, FL. 2013
Chowdhury S; Yamaguchi J; Liss AS; Sontheimer A; Thayer SP. Novel TFF2/DPYSL3
interaction in Smad4-mediated tumor suppressor signaling in pancreatic cancer. 46th
Annual Meeting APA; San Diego, CA. 2015
Chowdhury S; Ali M; Maroni D; Woods N; Thayer SP. DPYSL3 variant 1 regulates cell
survival in pancreatic cancer. 46th Annual Meeting APA; San Diego, CA. 2015
Chowdhury S; Klinkebiel J; Thayer SP. TFF2/Smad4 tumor suppressor signaling in
pancreatic cancer is regulated by promotor methylation. 46th APA Annual Meeting; San
Diego, CA. 2015 Nov
Thayer SP. The ampulla is a reservoir for Lgr5-derived secretory cells that migrate to the
pancreas following injury. 46th APA Annual Meeting, San Diego, CA 2015 Nov
Chowdhury S; Ali MF; Yamaguchi J; Liss AS; Sontheimer A; Thayer SP. Novel
TFF2/DPYSL3 interaction in Smad4-mediated tumor suppressor signaling in pancreatic
cancer. 46th APA Annual Meeting; San Diego, CA. 2015 Nov
Chowdhury S; Ali MF; Maroni D; Woods N; Thayer SP. DPYSL3 variant 1 regulates
cell survival in pancreatic cancer. 46th APA Annual Meeting; San Diego, CA. 2015 Nov