Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Read the full Resolving Batch-Processing Problems in Drug Manufacturing Application Note (M-2-130)
Document related concepts
no text concepts found
Transcript
Application Notes Resolving batch processing problems in drug manufacture as presented by M.W. Wood-Kaczmar GlaxoSmithKline at Lasentec® Users’ Forum 2001 - Barcelona Manufacture of an important pharmaceutical compound required a six-stage synthesis to the final drug substance. The two penultimate stages involved troublesome crystallizations that increased processing time and reduced throughput. Large-scale crystallization of the Stage 4 intermediate was variable, producing a thick and viscous magma that was difficult to stir and filter. A new seeding regime monitored with Lasentec® FBRM® showed a marked contrast in crystallization behavior and particle size that was beneficial to the process. Synthesis of the next stage involved purification of the intermediate by crystallization from isopropyl alcohol and isolation of the product in a filter dryer. Filter plate blinding during filtration necessitated cleaning of the filter dryer after every batch, which reduced the plant’s throughput. The use of a fines-reduction technique (Ostwald ripening) with gentle agitation increased the particle size distribution and eliminated the need for repeated cleaning of the filter dryer. Applying these modifications in the plant considerably reduced turnover time and increased throughput. Population (0% to 14%) Chord length (0.8 to 840.0 microns) ® Figure 1: FBRM data shows a decrease in mean particle size when Ostwald ripening is applied Population (0% to 14%) Application Notes Control Ostwald fast stir Control Ostwald fast stir Ostwald slow stir Chord length (0.8 to 840.0 microns) Figure 2: Mean particle size decreases even further when stirring is slowed Mettler-Toledo Mettler-Toledo Xxxxx AutoChem, Inc. Address 7075 Samuel Morse Drive Address Columbia, MD 21046 Address Tel: +1 410 910 8500 Address Fax: +1 410 910 8600 Email: [email protected] M-2-130 Rev E (03/2006) Printed in USA www.mt.com/lasentec www.mt.com Visit for more information
