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Paramedic Care: Principles & Practice Fourth Edition Volume 4: Medicine CHAPTER 9 Hematology Multimedia Directory Slide 71 Slide 111 Blood Type Animation Sickle Cell Anemia Animation ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Standard • Medicine (Hematology) ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Competency • Integrates assessment findings with principles of epidemiology and pathophysiology to formulate a field impression and implement a comprehensive treatment/disposition plan for a patient with a medical complaint. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Introduction • Hematology: study of blood and bloodforming organs. • Hematologic disorders: – Red blood cell disorders – White blood cell disorders – Platelet disorders – Coagulation problems ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Introduction • Some hematologic diseases genetic in origin – Hemophilia A classic example. • Some hematologic diseases more common in certain ethnic groups. – Sickle cell anemia among African Americans. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Introduction • Hematologic disorders may predispose patients to infection and intolerance to exercise, hypoxia, acidosis, blood loss. • Careful examination and history taking necessary to clarify diagnosis. • Often laboratory findings will be needed to confirm diagnosis. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Hematopoietic system consists of: – Blood (both cells and plasma) – Bone marrow – Liver – Spleen – Kidneys ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Cellular components of blood formed by differentiation of pluripotent stem cells (hematopoiesis). • Stem cells reproduce to maintain constant population of cells. • Mature into basophils, eosinophils, neutrophils, monocytes, erythrocytes, thrombocytes. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Kidneys (lesser extent liver) produce erythropoietin (hormone responsible for red blood cell production). • Liver removes toxins from blood and produces many clotting factors and proteins in plasma. • Spleen has cells that scavenge abnormal blood cells and bacteria. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Blood volume relatively constant at about 6% of total body weight. • Determinants of blood volume: red cell mass and plasma volume. • Red blood cells remain in intravascular compartment. • Only changes in rate of production can alter size of circulating red cell mass. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Plasma volume can rapidly change due to fluid shifts between intravascular and extravascular space. – Helps to preserve circulating blood volume in event of acute hemorrhage. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Other compensatory mechanisms: – Vasoconstriction – Tachycardia – Increased cardiac contractility • When compensatory measures fail, patient enters decompensated shock. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Plasma: thick, pale-yellow fluid; 90– 92% water; 6–7% proteins. – Plasma transports cellular components of blood and dissolved nutrients throughout body. – It also transports waste products from cellular metabolism to liver, kidneys, lungs, where removed from body. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Most plasma components can move back and forth across capillary membranes to interstitial fluid. – Plasma proteins have great difficulty diffusing across membranes. Remain in plasma to help retain water in capillaries (osmotic pull, or oncotic pressure). ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Plasma proteins' other functions: Clotting of blood Dismantling of clots Buffering of blood's acid-base balance Transporting hormones and regulating their effects Providing source of energy ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Electrolytes found in plasma. Chemical substances that dissociate into charged particles in water. Essential for nerve conduction, muscle contraction, water balance. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Carbohydrates in plasma in form of glucose; primary energy source. – Plasma performs role in gas transport. Carbon dioxide and oxygen dissolved and transported in plasma. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Red blood cells: transport oxygen from lungs to tissues. – Red blood cell (RBC), or erythrocyte: biconcave disc; does not have nucleus when mature. – Contains hemoglobin molecules that transport oxygen. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Scanning electron photomicrograph of red blood cells moving through a blood vessel. (Centers for Disease Control/Janice Haney Carr) ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Oxygen transport Greater number of red blood cells, greater potential oxygen-carrying capacity. Percentage of oxygen bound to hemoglobin increases as PO2 increases. Normal PO2 95–100 mmHg. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Oxygen transport Hemoglobin has affinity for oxygen. The lower the pH, the more readily hemoglobin will release oxygen. Bohr effect: waste CO2 from tissues diffuses into blood, causing hemoglobin to give up more oxygen to tissues. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Oxygen transport Except for hemoglobin, most abundant chemical in red blood cells is 2,3bisphosphoglycerate (2,3-BPG). During prolonged periods of hypoxia, level of 2,3-BPG increases. Increased 2,3-BPG makes it difficult for oxygen to combine with hemoglobin in lungs. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Oxygen transport Rise in body temperature causes decrease in hemoglobin's affinity for oxygen. Exercise: decrease in pH and increase in body temperature causes hemoglobin to release oxygen. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Oxygen transport The greater the substance's affinity for binding sites, the more readily substance will bind with hemoglobin. Carbon monoxide has 210–250 times oxygen's affinity for hemoglobin and competes for same binding sites. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Erythropoiesis: red blood cell production. – Erythropoietin (hormone produced by kidney): stimulates bone marrow's production of erythrocytes. – RBC lives approximately 120 days. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Hemorrhage, hemolysis (destruction of the RBC), or sequestration of RBCs by liver or spleen may significantly reduce their life span. – Hemorrhage may occur outside body or be hidden within body cavity, such as in peritoneum, retroperitoneum, gastrointestinal (GI) tract. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Hemolysis may occur within circulatory system in sickle cell disease and rare autoimmune anemias. – Spleen and liver contain scavenger cells called macrophages; remove damaged or abnormal RBCs from circulation. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – RBCs quantified or measured and reported in two ways: red blood cell count and hematocrit. – RBC count: total number of RBCs reported in millions per cubic millimeter (mm3) of blood. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Hematocrit: packed cell volume of red blood cells per unit of blood. – Measurement obtained by placing sample of blood in centrifuge and spinning it at high speed so that cellular elements separate from plasma. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Hematocrit: red blood cells heaviest because they carry iron-containing pigment hemoglobin; forced to bottom of tube. – Above red blood cells are white blood cells; on top specimen is plasma. – Normal values range between 40 and 52%. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Hematocrit, including plasma. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Measure concentration of hemoglobin present; number of grams of hemoglobin present per deciliter of whole blood. – Common to measure hemoglobin in addition to hematocrit (H&H). – Both values indicate RBC volume and capability. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – White blood cells (WBCs; leukocytes or white corpuscles): circulate through bloodstream and tissues, providing protection from foreign invasion. – Marginated leukocytes do not move freely within bloodstream; attach to blood vessels' walls. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Demargination: marginated leukocytes return to circulation in response to stress, corticosteroids, seizures, epinephrine, exercise. – Chemical signals (chemotaxis). – WBCs engulf and destroy invader by phagocytosis. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. White blood cells engulfing and destroying an invader in the process called phagocytosis. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Healthy people have 5,000 to 9,000 WBCs per microliter of blood. – Infection can increase number to more than 16,000 WBCs. – Increase in WBC number classic sign of bacterial infection. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – WBCs originate in bone marrow from undifferentiated stem cells. – Leukopoiesis: stem cells respond to growth factors that allow them to differentiate into three blasts: myeloblasts, monoblasts, lymphoblasts. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – WBCs categorized as granulocytes, monocytes, lymphocytes. – Granulocytes: classified by type of stain they absorb. Basophils: absorb basic stains; blue granules. Eosinophils: absorb acidic stains; red granules. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Granulocytes: classified by type of stain they absorb. Neutrophils: absorb neither acidic nor basic stains well; pale blue and pink granules. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Basophils: function in allergic reactions. Store histamine; contain heparin, which breaks down blood clots. – Eosinophils: inactivate chemical mediators of acute allergic reactions. Contain major basic protein (MBP), which fights parasitic infections. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Neutrophils: function to fight infection. Engulf and kill microorganisms that invade body. If neutrophil count low (neutropenia), body cannot mount appropriate response to infection. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Monocytes Macrophages ("garbage collectors" of immune system) engulf both foreign invaders and dead neutrophils. Monocytes and macrophages secrete growth factors to stimulate production of granulocytes and red blood cells. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Lymphocytes Primary cells involved in body's immune response. Located throughout body in circulating blood and in tissues. Small, round, white blood cells containing no granules on staining. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Immunity Two basic subpopulations of lymphocytes: T cells and B cells. T cells: responsible for developing cellmediated, or cellular, immunity. B cells: produce antibodies to combat infection (humoral immunity). ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Autoimmune disease Body makes antibodies against its own tissues. May be limited to specific organs or involve virtually every tissue type. Genetic factors and viral infections. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Alterations in immune response Organ transplant patients must take drugs that inhibit cellular immunity and prevent graft rejection. If they do not, T cells will recognize new organ as "not self" and begin attacking it; called rejection. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Alterations in immune response Human immunodeficiency virus (HIV) destroys cell-mediated immunity by selectively attacking and killing T cells. Cancer patients often immunocompromised by disease itself or chemotherapy agents that attack bone marrow. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Inflammatory process Nonspecific defense mechanism; wards off damage from microorganisms or trauma. Causes: infectious agent, trauma, chemical, immunologic. Results in redness, warmth, swelling, usually pain and fever. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Platelets, or thrombocytes Small fragments of large cells called megakaryocytes. Platelets from 150,000 to 450,000 per microliter of blood. Form plug at initial bleeding site; secrete factors important in clot formation. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Platelets, or thrombocytes Too few platelets (thrombocytopenia) can lead to bleeding problems and blood loss. Too many platelets (thrombocytosis) may cause abnormal clotting, plugs in vessels, and emboli that may travel to extremities, heart, lungs, brain. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Components of Blood – Platelets, or thrombocytes Survive 7 to 10 days; removed from circulation by spleen. Activated when they contact injured tissue. As platelets aggregate, they release chemical messengers that activate blood clotting system. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Hemostasis – Combined three mechanisms that work to prevent or control blood loss: Vascular spasms Platelet plugs Stable fibrin blood clots (coagulation) ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Hemostasis – When blood vessel tears, smooth muscle fibers in vessel walls contract. – Causes vasoconstriction and reduces size of tear. – Less blood flows through constricted area, limiting blood loss. – Smaller tear makes it easier for platelet plug to develop and stop blood loss. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Hemostasis – At any tear in blood vessel, platelets aggregate and adhere to collagen (connective tissue that supports blood vessels). – Forms platelet plug. – Formation of stable fibrin clot (blood coagulation) initiated by platelet plug. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Illustration of clot formation. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Hemostasis – Damage to cells or to vessel lining, starts coagulation cascade. – Sequence of events can be activated either by damage to vessels or by trauma to blood from turbulence. – Either results in cascade's progression to clot. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Hemostasis – Most clotting proteins produced in liver; circulate in inactive state (prothrombin and fibrinogen). – Damaged cells send out chemical message; activates specific clotting factor. – Activates each protein in turn until stable fibrin clot forms. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Hemostasis – To completely stop bleeding, coagulation cascade relies on platelet plug and clotting factors to interact. – Once bleeding stops, inflammatory and healing processes can begin. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. The coagulation cascade. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Hemostasis – Development of clot does not end coagulation cascade. – Dismantling (lysing) of clot through fibrinolysis; takes from hours to days. – By that time, scarring has begun. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Hemostasis – Thrombosis (clot formation), when in coronary arteries or cerebral vasculature, may lead to heart attack and stroke. – Fibrinolytics effective only against blockages whose components include fibrin clot. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Hemostasis – Patients who lack clotting factors can have bleeding disorders. – Patients who take medications that decrease effectiveness of platelets or coagulation cascade may have bleeding problems. – Both may complicate assessment and treatment. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Hemostasis – Medications examples: Aspirin Dipyridamole (Persantine) Ticlopidine (Ticlid) Heparin Warfarin (Coumadin) ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Hemostasis – Glycoprotein IIb/IIIa receptors on platelet membrane; major platelet surface receptor involved in final pathway of platelet aggregation. – Treat acute coronary syndrome, often in combination with angioplasty with or without stent placement. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Hemostasis – Glycoprotein IIb/IIIa inhibitors classified as potent platelet inhibitors. Abciximab (ReoPro) Eptifibatide (Integrilin) Tirofiban (Aggrastat) ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Hemostasis – All below may lead to increased clotting: Vitamin K (AquaMEPHYTON) Relative or complete immobility Trauma Polycythemia Cancer By-products of tobacco use ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Blood Products and Blood Typing – Blood transfusion: transplantation of blood or component of blood from one person to another. – Accomplished by IV infusion. – Various types of transfusions given for various purposes. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Blood Products and Blood Typing – Blood type A: A antigens on RBCs; antiB antibodies. – Blood type B: B antigens on RBCs; antiA antibodies. – Blood type AB: RBCs have both antigens, but neither antibody. – Blood type O: neither antigen, but both antibodies. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Blood Products and Blood Typing – Blood type inherited trait. – Type AB blood: universal recipient. – Type O blood: universal donor. – Crossmatching blood: checking samples from both donor and recipient to ensure greatest compatibility. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Blood Type Animation Click here to view an animation on the topic of blood types. Back to Directory ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Blood Products and Blood Typing – Rh factor: antigen with possible severe hemolytic reaction. Rh positive: person has Rh factor. Rh negative: person does not have Rh factor. Erythroblastosis fetalis (hemolytic disease of newborn): can lead to fatal hemolytic Rh reaction in neonates. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Transfusion Reactions – Hemolytic transfusion reaction: donor's and recipient's blood not compatible. – Signs and symptoms: facial flushing, hyperventilation, tachycardia, sense of dread, hives, chest pain, wheezing, fever, chills, cyanosis, flank pain. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Transfusion Reactions – Stop transfusion immediately. – Change IV tubing; IV therapy normal saline or lactated Ringer's solution. – Administer bolus as necessary. – Furosemide (Lasix) administered to promote diuresis. – In extreme cases of anaphylactic reaction, administer IV epinephrine. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Transfusion Reactions – Most common transfusion reaction is febrile nonhemolytic reaction. – Sensitization to antigens on white blood cells, platelets, plasma proteins. – Signs and symptoms: headache, fever, chills. – Always stop transfusion before attempting to treat it. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Transfusion Reactions – Change all tubing. – Initiate normal saline IV. – Diphenhydramine (Benadryl) and antipyretic (ibuprofen, acetaminophen) for fever. – In event of any transfusion reaction, return all blood bags, tubing, filters to blood bank for analysis. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Anatomy, Physiology, and Pathophysiology • Transfusion Reactions – Blood transfusion adds fluid to system. – Patient may experience signs and symptoms of circulatory overload. – Same as those for left ventricular failure; pulmonary edema, dyspnea, chest pain. – Hypotension not usually problem. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. General Assessment and Management • Patients with infection, WBC abnormalities, or transfusion reactions may present with febrile symptoms. • May develop hemodynamic instability. • Acute hemodynamic compromise found in patients with anemia secondary to acute blood loss, coagulation defects, autoimmune disease. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. General Assessment and Management • Treatment of patients with disorders of hematopoietic system is supportive. • Recognize need for rapid transport in patients with hemodynamic instability. • May require transfusion or other definitive care measures. • Always contact medical direction for questions or problems. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. General Assessment and Management • Perform scene size-up; take Standard Precautions. • Primary assessment for life threats. • Determine responsiveness; assess airway, breathing, circulation. • Alterations in hematopoietic system may present as life-threatening bleeds or overwhelming infections with septic shock. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. General Assessment and Management • Do not spend time obtaining complete set of vital signs during primary assessment. • Check ABCs; quickly determine priority for transport. • Critical or unstable patients candidates for expeditious transport. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. General Assessment and Management • Complete secondary assessment. • Trauma patients and unresponsive medical patients often present lifethreatening problems; noted in primary assessment. • For responsive medical patient, obtain SAMPLE history; perform physical exam. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. General Assessment and Management • Obtain set of vital signs; place pulse oximeter. • Ask for chief complaint; attention to generalized complaints. • Note dyspnea, palpitations, dizziness with changes in patient's position. • Patients with hematologic problems may suffer syncope. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. General Assessment and Management • Bleeding abnormalities may be disguised as gastrointestinal upset. • Ask about overt bleeding with vomiting or diarrhea. • Atraumatic bleeding of gums almost always points to underlying hematologic abnormality. • Ask about changes in urination, hematuria, menstrual pattern. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. General Assessment and Management • Determine any allergies. • Make note of all of patient's medications and compliance. • Ask about past medical history. • Ask about bloodborne infections. • Family history: hemophilia, sickle cell disease, cancer, or death at early age not trauma related. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. General Assessment and Management • Inquire about social habits. • Last oral intake and unusual events. • If history suggests hematopoietic problem, look for potential pathology during physical exam. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. General Assessment and Management • Nervous System – Determine level of consciousness using AVPU system. – Complaint of being "weak and dizzy." – Associated with possible anemia. – Determine whether patient had syncopal episode. – Always examine eyes for abnormalities. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. General Assessment and Management • Skin – Jaundice (yellow skin): liver disease or hemolysis of RBCs. – Florid (reddish) appearance associated with polycythemia. – Anemia typically exhibits pallor. – Petechiae (tiny red dots on skin). ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Jaundice. (© Edward T. Dickinson, MD) ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. General Assessment and Management • Skin – Purpura (large purplish blotches related to multiple hemorrhages into skin). – Bruising. – Inquire about pruritus (itching). ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. (a) Petechiae; (b) purpura. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. General Assessment and Management • Lymphatic – Affected early in hematopoietic diseases, especially those of immune system. – Pay particular attention to lymph nodes; note any enlargement; compare sides. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. General Assessment and Management • Gastrointestinal – Epistaxis (nosebleed) common. – Patients may swallow great deal of blood; become nauseated. – Blood acts as cathartic (laxative). Patients who swallow moderate amounts of blood report loose bowel movements. Often dark (melena); blood bright red or appears like coffee grounds. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. General Assessment and Management • Gastrointestinal – Bleeding of gums early findings of hematologic problems; note presence of gingivitis. – Liver disease can slow blood clotting. – As liver fails, bilirubin level will increase, resulting in jaundice. – Problems with spleen, liver, or both can lead to abdominal pain. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. General Assessment and Management • Gastrointestinal – Splenomegaly common in hematologic problems. – Spleen can become markedly enlarged. – Patients with sickle cell anemia will often develop splenic infarcts. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. General Assessment and Management • Musculoskeletal – Many hematopoietic problems autoimmune in nature. – Rheumatoid arthritis: body's immune system attacking tissues in joints. – Patients with blood clotting disorders such as hemophilia will often develop hemarthrosis (bleeding into joint). ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. General Assessment and Management • Cardiorespiratory – Patients with anemia often develop dyspnea, tachycardia, chest pain. – In severe cases, develop high-output heart failure to compensate for profound anemia. – Always auscultate for breath sounds; note crackles or rhonchi indicative of heart problems or infection. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. General Assessment and Management • Genitourinary – Due to bleeding disorders or infection. – Bleeding disorders can cause: Hematuria (blood in urine) Blood in scrotal sac in males Menorrhagia (heavy menstrual bleeding) Frank vaginal bleeding (dysfunctional uterine bleeding) ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. General Assessment and Management • Genitourinary – Immunocompromised patients at increased risk for developing infections. – Sickle cell anemia can cause priapism. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. General Assessment and Management • General Management of Hematopoietic Emergencies – Place on high-concentration supplemental oxygen; monitor breathing for difficulty or fatigue. – Be ready to assist ventilations with bag-valve mask. – Assess circulatory system. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. General Assessment and Management • General Management of Hematopoietic Emergencies – Consider fluid volume replacement. – Be alert for arrhythmias; treat accordingly. – Create optimum environment for blood to perform its tasks of oxygen delivery and waste product removal. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. General Assessment and Management • General Management of Hematopoietic Emergencies – Transport to appropriate facility. – Provide comfort measures: analgesia. – Provide psychological support to both patient and family. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the Red Blood Cells – RBC diseases: too many, too few, or improperly functioning RBCs. – Polycythemia: excess of RBCs. – Anemia: inadequate number of red blood cells; inadequate hemoglobin within RBCs. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the Red Blood Cells – Anemia Classified as hematocrit of less than 37% in women; less than 40% in men. Due to reduction in number of RBCs cells or amount or quality of hemoglobin in RBCs. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the Red Blood Cells – Anemia Sign of underlying disease process. Blood loss (acute or chronic) can cause anemia. Can be self-limiting disease or lifelong illness requiring periodic transfusions. Hemolytic anemia: destruction of RBCs; hereditary or acquired. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the Red Blood Cells – Anemia Acquired hemolytic anemias: immune system disorders, drug effects, environmental effects. Anemias caused by inadequate RBC production: iron deficiency anemia, pernicious anemia, anemia of chronic disease. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the Red Blood Cells – Anemia Sign, not disease process in itself. Results in hypoxia. Chronic anemias: pica, headache, dizziness, ringing in ears, irritability or difficulty concentrating, pallor, tachycardia. Angina pectoris important indicator. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the Red Blood Cells – Anemia If develops rapidly, body does not have time to compensate for change; signs and symptoms of shock. If onset slower, body can adjust to reduced availability of oxygen. Treat hypoxia with supplemental oxygen. Avoid hyperoxia. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the Red Blood Cells – Sickle cell disease (sickle cell anemia) Disorder of RBC production. Abnormal chemical sequence that gives red blood cells C, or sickle, shape when oxygen levels are low. Chronic anemia; results from destruction of abnormal RBCs. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Scanning electron photomicrograph of sickle cells. (Centers for Disease Control/Janice Haney Carr) ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Sickle Cell Anemia Animation Click here to view an animation on the topic of sickle cell anemia. Back to Directory ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the Red Blood Cells – Sickle cell disease (sickle cell anemia) Average life span of sickled RBCs 10–20 days; 120 days for normal RBCs. Blockage of blood flow to tissues and organs common; following period of stress. This process (vasoocclusive crisis) characteristic of sickle cell anemia. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the Red Blood Cells – Sickle cell disease (sickle cell anemia) Adult sickle cell patients have multiple organ problems. Disease inherited; primarily affects African Americans. Vasoocclusive crises: musculoskeletal and abdominal pain, priapism, pulmonary problems, renal crises, central nervous system (CNS) crises. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the Red Blood Cells – Sickle cell disease (sickle cell anemia) Hematologic crises: fall in hemoglobin level, sequestration of RBCs in spleen, problems with bone marrow function. Infectious crises: functionally immunosuppressed; vulnerable to encapsulated bacteria. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the Red Blood Cells – Sickle cell disease (sickle cell anemia) Prehospital primarily supportive. High-concentration oxygen to saturate as much hemoglobin as possible. IV therapy with isotonic crystalloid solution. May require large amounts of narcotics for pain control. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the White Blood Cells – Result from too few WBCs (leukopenia), too many WBCs (leukocytosis), or improper WBC function. – Reduction in number of neutrophils (neutropenia) predisposes patient to bacterial and fungal infections. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the White Blood Cells – Leukopenia/neutropenia Normal WBC count from 5,000 to 9,000 per cubic millimeter of blood. Absolute neutrophil count better indicator of immune system's status. Prehospital treatment supportive. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the White Blood Cells – Leukocytosis Increase in number of circulating white blood cells. Body exposed to infectious agent or particularly stressed. WBC count 10,800 to 23,000 per cubic millimeter of blood characteristic of bacterial infection. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the White Blood Cells – Leukocytosis Causes: bacterial infection, rheumatoid arthritis, diabetic ketoacidosis (DKA), leukemia, pain, exercise. Any patient with significantly elevated WBC count should be evaluated for possible leukemia. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the White Blood Cells – Leukemias Cancers of hematopoietic cells. Acute lymphocytic leukemia (ALL) Acute myelogenous leukemia (AML) Chronic lymphocytic leukemia (CLL) Chronic myelogenous leukemia (CML) Hairy cell leukemia ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the White Blood Cells – Leukemias Chemotherapy, radiation therapy, bone marrow transplantation have resulted in cures of certain types. Deaths secondary to infection/bleeding. Signs and symptoms vary; moderate to severe anemia. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the White Blood Cells – Leukemias Many patients present with bleeding; due to thrombocytopenia. Patients will appear acutely ill. Prehospital treatment primarily supportive. Place in position of comfort. Administer supplemental oxygen. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the White Blood Cells – Leukemias IV with isotonic crystalloid solution. Consider fluid bolus if dehydrated. Consider administration of analgesic. Increased risk of developing infection; employ proper isolation techniques. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the White Blood Cells – Lymphomas Cancers of lymphatic system. Malignant lymphoma classified: – Hodgkin's lymphoma – Non-Hodgkin's lymphoma Long-term survival rate better with Hodgkin's lymphoma. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the White Blood Cells – Lymphomas Presenting sign of non-Hodgkin's lymphoma: painless swelling of lymph nodes. Fever, night sweats, anorexia, weight loss, fatigue, pruritus. Treat patients with lymphomas symptomatically. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the Platelets/Blood Clotting Abnormalities – Thrombocytosis: increase in number of platelets; due to increased platelet production. Most patients asymptomatic; prehospital treatment supportive. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the Platelets/Blood Clotting Abnormalities – Thrombocytopenia: abnormal decrease in number of platelets. – Due to decreased platelet production, sequestration of platelets in spleen, destruction of platelets, or any combination of the three. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the Platelets/Blood Clotting Abnormalities – Acute idiopathic thrombocytopenia purpura (ITP): destruction of platelets by immune system. Most commonly seen in children following viral infection. Prehospital treatment supportive. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the Platelets/Blood Clotting Abnormalities – Hemophilia: blood disorder; one of the proteins necessary for blood clotting missing or defective. Deficiency of factor VIII: hemophilia A. Deficiency of factor IX: hemophilia B (Christmas disease). ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the Platelets/Blood Clotting Abnormalities – Hemophilia Hemophilia A most common inherited disorder of hemostasis. Hemophilia B more rare; more severe. When injured, bleeding will take longer to stop; body cannot form stable fibrin clots. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the Platelets/Blood Clotting Abnormalities – Hemophilia Occasionally life-threatening bleeds. Sex-linked, inherited bleeding disorder. Numerous bruises, deep muscle bleeding, joint bleeding called hemarthrosis. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the Platelets/Blood Clotting Abnormalities – Hemophilia Most patients aware of diagnosis will tell you; Medic-Alert bracelets or similar devices. Prehospital treatment comprehensive. Be attentive to prolonged bleeding or possible rebleeds. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the Platelets/Blood Clotting Abnormalities – Hemophilia Administer supplemental oxygen. IV therapy with isotonic crystalloid. Be careful to prevent additional trauma. If joint injury with hemarthrosis, splinting extremity will sometimes help control pain. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Diseases of the Platelets/Blood Clotting Abnormalities – von Willebrand's disease Component of factor VIII deficient. In addition to clotting problem, platelet function abnormal. Disease inherited; not sex linked. Excessive bleeding, primarily after surgery or injury. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Other Hematopoietic Disorders – Disseminated intravascular coagulation (DIC) (consumption coagulopathy): disorder of coagulation caused by systemic activation of coagulation cascade. Bleeding most frequent sign; due to reduced fibrinogen level, consumption of coagulation factors, thrombocytopenia. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Other Hematopoietic Disorders – Disseminated intravascular coagulation Disease is quite grave. Oozing blood at venipuncture and wound sites; purpuric rash. Prehospital care symptomatic. Administration of fresh frozen plasma and platelets. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Other Hematopoietic Disorders – Multiple myeloma: cancerous disorder of plasma cells. Rarely found in persons under 40. Change or mutation in plasma cell in bone marrow. Cancerous cells crowd out healthy cells; reduction in blood cell production. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Other Hematopoietic Disorders – Multiple myeloma Patient becomes anemic; prone to infection. First sign is pain in back or ribs. Treatment: chemotherapy, radiation, bone marrow transplants. Prehospital care is supportive. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Managing Specific Patient Problems • Other Hematopoietic Disorders – Multiple myeloma Establish IV of isotonic crystalloid solution. Consider fluid bolus if symptoms of dehydration. Consider analgesics if pain severe. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Summary • Hematology is study of blood and blood-forming organs. • Blood consists of a liquid portion, or plasma, and formed elements—red blood cells, white blood cells, platelets. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Summary • Each component of blood has various functions intrinsic to sustaining homeostasis. • Red blood cells, composed of hemoglobin, transport oxygen to body tissues and remove wastes such as carbon dioxide. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Summary • Plasma draws water into capillaries; assists in clotting blood, dismantling clots, buffering blood's acid-base balance, transporting hormones and regulating their effects, providing source of energy. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Summary • White blood cells protect body from foreign invasion through processes of chemotaxis and phagocytosis. • Platelets travel to site of damaged tissue and help to prevent blood loss. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Summary • Hemostasis is body's way of preventing or controlling blood loss. • Three phases of hemostasis: – Vascular spasm – Development of platelet plug – Formation of stable fibrin clot (blood coagulation) ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed. Summary • Some diseases interfere with aspects of hemostasis; people who have these diseases may incur life-threatening hemorrhages from minor injuries. • As a paramedic, you must understand hematology; breakdowns in hematologic system can complicate patient assessment and care. ©2013 Pearson Education, Inc. Paramedic Care: Principles & Practice, 4th Ed.