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SMOKING CESSATION Learning Objectives Understand the hazards of smoking Recognize the health benefits of smoking cessation Describe the rationale for treating tobacco dependence Explain why tobacco dependence is a chronic disease Initiate clinical interventions for tobacco users who are willing to quit as well as users who are not willing to make a quit attempt Assist users attempting to quit with strategies designed to prevent relapse The smoking epidemic 1 billion smokers Smoking represents the most readily preventable risk factor for morbidity and mortality. 5 million people die every year because of smoking related illnesses. By 2030, if current trends continue, smoking will kill one in 6 people. ( world health organization. 2008. The smoking epidemic 75% of smokers want to quit <2% of smokers quit each year The smoking epidemic Effective government policy: • • • • Bans on tobacco advertising and sponsorship Regular price rises Stronger public health warning labels Smoking bans in all public places Prevalence of Smoking in Saudi Arabia 2.4-52.3% (median = 17.5%) School students 12-29.8% (median = 16.5%), University students 2.4-37% (median = 13.5%), Adults 11.6-52.3% (median = 22.6%). Elderly people 25%. Males 13-38% (median = 26.5%) Females 1-16% (median = 9%). Prevalence of Smoking in Saudi Arabia 17% of primary health care physicians in Riyadh city were current smokers, 20% ex-smoker. Al- shahri M, Al Almaie S. promotion of non-smoking: The role of primary health care physicians. Ann Saudi Med 1997;17:515-17 Smoking Health Risks Short-term Shortness of breath Worsening asthma or bronchitis Increased risk of respiratory infection Harm to pregnancy Impotence Infertility Smoking Health Risks Long-term Heart attack and stroke Lung and other cancers larynx oral cavity pharynx Chronic obstructive pulmonary disease (COPD) Osteoporosis Disability (chronic bronchitis and emphysema) Need for extended care esophagus pancreas stomach kidney bladder cervix acute myelocytic leukemia Tobacco-based products: Cigarettes pipes cigars hookahs ((shisha/ narghile/ argileh/ hubble bubble and goza)) chewing tobacco etc. Why do people continue to smoke? Addiction to nicotine Perceived benefits (relaxation, stress relief, weight loss) Social context Mental health issues Smoking Cessation Barriers Withdrawal symptoms Fear of failure Weight gain Lack of support Depression Enjoyment of tobacco Being around other users Limited knowledge of effective treatment options Physician Barriers to Helping Patients Stop Smoking Time constraints of practice Lack of office systems Low expectation of success Lack of knowledge of what to do Reimbursement issues Frustration with smokers Smoke vs. Quit Common Reasons not to Quit Family and friends smoke Withdrawal symptoms Inability to cope with stress Connection with smoking Previous unsuccessful attempts to quit Common Reasons to Quit Encouragement from family and friends Health improvements To save money Pregnancy Smoke-free environment policies Desire to be a role model Medical treatment that requires abstinence Tobacco Dependence as a chronic disease What is a cigarette? Delivers nicotine to the lungs and brain within 7 sec each time a smoker inhales Frequent, small-dose stimulation makes smoking highly addictive Most cigarettes contain ≥ 10 mg of nicotine Average smoker absorbs 1-2 mg of nicotine per cigarette Cigarettes release carbon monoxide which adheres to red blood cells faster than oxygen • Reduced oxygen in the body causes increased heart rate What’s in a Cigarette? 4000 chemicals many of which are highly toxic. 40 known cancer-causing substances. Tobacco Carbon monoxide Hydrogen cyanide Nitrogen oxide Ammonia (sub-micron sized particles) Nicotine, phenol, polyaromatic hydrocarbons, tobacco specific nitrosamines. Tar total particulate matter (nicotine and water) Filter with titanium oxide accelerant Flavours Liquid vapour Benzene Formaldehyde Acrolein N-nitrosamines Non-particulate matter What is Nicotine Dependence? Chronic Nicotine consumption with the following characteristics: Substance abuse Continues self-administer substance despite perceived negative effects High tolerance towards the substance Manifests withdrawal symptoms when trying to stop use Effects of Nicotine Highly toxic drug Increase HR, BP Decrease body temp Slows circulation Affects appetite Increase BMR changes brain activity - improving reaction times, ability to pay attention and brings on euphoria Addiction Increases dopamine levels Creates a feeling of pleasure The addiction pathways ‘Reward’ pathway (mesolimbic dopamine system) ‘Withdrawal’ pathway (locus coeruleus) “Reward” Pathway Mesolimbic dopamine system has been characterized as a “reward "pathway Nicotine produces a dopamine surge in the nucleus accumbens Smoking cessation is followed by pathophysiologic withdrawal and craving Withdrawal Chronic drug use affects brainstem structures (locus ceruleus) Noradrenergic cells become more excitable When a person abstains, the firing rates become abnormally high – a possible basis of withdrawal symptoms Nicotine withdrawal syndrome acute/uncontrollable need to smoke (craving) irritability restlessness, anger, anxiety feelings tiredness increased appetite, especially for sweets and resultant weight gain trouble to concentrate and focus memory depression headaches insomnia dizziness Benefits of Quitting 20 mins: 8 hours: 24 hours: 48 hours: 72 hours: blood pressure and pulse rate return to normal blood nicotine & CO halved, oxygen back to normal CO eliminated; lungs start to clear mucus etc. nicotine eliminated; senses of taste & smell much improved. breathing easier; bronchial tubes begin to relax; energy levels increase Benefits of Quitting 2-12 weeks: 3-9 months: 5 years: 10 years: circulation improves lung function increased by <10% coughs, wheezing decrease risk of heart attack halved risk of lung cancer halved compared to continued smoking risk of heart attack equal to neversmoker’s Quitting- other benefits Improved health and physical performance Improved taste of food and sense of smell Better appearance, including reduced wrinkling/aging of skin and whiter teeth Healthier families, babies and children A good example for children and others More money in your pocket Treatment of Nicotine Addiction Combination of counseling and pharmacotherapy is more effective than either option alone The more intense the intervention, the better the outcome of abstinence Pharmacologic Options Clients/patients attempting to quit smoking should always be encouraged to use effective medications unless they are contraindicated in specific populations eg. pregnant women, smokeless tobacco users, light smokers, adolescents (Fiore, et al) Two categories of pharmaceutical options: Nicotine replacement therapy (NRT) Non-nicotine replacement therapy Nicotine Replacement Therapy (NRT) Nicotine Patch Nicotine Lozenges Nicotine Gum Nicotine Inhalers Provide nicotine to reduce withdrawal symptoms Take between 1-4 hours to reach maximum blood levels (unlike cigarettes, 7 seconds) Do not cause sudden boost to nicotine blood levels (prevents addiction to product) Dose depends on habits of the smoker but is reduced over a 12 week period Non-nicotine Therapy Bupropion Hydrochloride (Zyban) • Also marketed as the anti-depressant medication Wellbutrin • Presumed to alleviate cravings associated with nicotine withdrawal affecting noradrenaline and dopamine Varenicline Tartrate (Champix) • Targets nicotinic acetylcholine receptors to decrease cravings and withdrawal Clonidine & Nortriptyline • Second-line medications used in smoking cessation All of these medications require a prescription Counselling Intensive intervention that last a minimum of 10 minutes Commonly conducted by nurses in various health-care settings Motivational Interviewing Directive and client-centred standard counselling techniques Stages of Change theory Other options of treatment Hypnosis Herbal remedies Acupuncture Laser treatment No clinical evidence to verify results from these treatments Some clients/patients report that they are beneficial (Fiore, et al., 2008) Protection: Second-hand smoke Second-hand smoke: Also known as environmental tobacco smoke Combination of: ◦ Side stream smoke (smoke from the end of a cigarette) ◦ Smoke exhaled by the smoker 67% of smoke from a burning cigarette is not inhaled by the smoker and ends up in the surrounding environment Second-hand smoke (cont.) ‣ 4000 chemicals have been identified in second-hand smoke 50 of these are known carcinogens (United States Environmental Protection Agency, 2000) ‣ Examples: - Arsenic compounds - Benzene - Chromium compounds - Ethylene oxide (chemical to sterilize medical devices) - Vinyl Chloride (chemical used in plastics manufacture) - Polonium – 210 (radioactive species) Second-hand smoke (cont.) Labeled as a known human carcinogen Labeled as a class A cancer-causing substance (Class A = most dangerous) Model for treatment of tobacco use and dependence General Populatio n Patient presents to healthcare setting Relapse ASK: Current users screen all ADVISE patients for to quit tobacco use Non users Primary preventio n Prevent relapse Yes, willing ASSESS willingne ss to quit ASSIST with quitting ARRANG Ea follow-up No, unwilling Promote motivatio n to quit Patient now willing to quit Abstinent Where to begin? ASK- about smoking – understand your patient ASSESS - what is the next step? ADVISE - why cessation is important ASSIST - offer to help ARRANGE- follow-up process The 5 As apply to Those who: are willing to quit, aren’t willing to quit, and recently quit. Smoking Cessation Treatment Smoking Cessation Treatment for Those Willing to Quit Smoking Cessation Treatment for Those Willing to Quit ASK Identify and document tobacco use status of every patient at every visit. Example: When recording vital signs, include an area to note tobacco use. Smoking Cessation Treatment for Those Willing to Quit ADVISE In a clear, strong, and personalized manner advise every tobacco smoker to quit. Smoking Cessation Treatment for Those Willing to Quit Advise examples: Clear Strong Personalized “I think it’s important for you to quit smoking now, and I can help you.” “As your clinician, I need you to know that quitting smoking now is the most important thing you can do to protect your health.” asthma worse.” “Continuing to smoke makes your Smoking Cessation Treatment for Those Willing to Quit ASSESS Is the user willing to make a quit attempt at this time? YES Provide assistance to dependence treatments. NO Provide an intervention shown to increase future quit attempts, such as nicotine gum, quit lines and behavioral counseling. Smoking Cessation Treatment for Those Willing to Quit ASSIST Offer medication. Provide or refer for counseling or additional behavioral treatment. Medication examples: Nicotine lozenge Varenicline Smoking Cessation Treatment for Those Willing to Quit ASSIST Behavioral treatment examples: Recommend a quit plan, such as STAR. Set a quit date. Tell family, friends and coworkers. Anticipate challenges. Remove tobacco products. Smoking Cessation Treatment for Those Willing to Quit ARRANGE Arrange for follow-up soon after quit date, a second follow-up within the first month and others as needed. Identify problems and anticipate challenges. Remind patients of available sources, such as quit lines. Provide encouragement. Smoking Cessation Treatment Smoking Cessation Treatment for Those NOT Willing to Quit Smoking Cessation Treatment for Those NOT Willing to Quit ASK, ADVISE & ASSESS Use the same 5As for users unwilling to quit as those willing to quit. Smoking Cessation Treatment for Those NOT Willing to Quit ASSIST Provide motivational interventions designed to increase future quit attempts. Smoking Cessation Treatment for Those NOT Willing to Quit ASSIST Motivational examples: The 5 Rs Relevance Identify why it is personally relevant to get the patient to quit. Risks Ask the patient to identify negative consequences of smoking. Rewards Ask the patient to identify the benefits of stopping. Roadblocks Identify the patient’s barriers to success and how to approach them. Repetition Repeat motivational interventions. Smoking Cessation Treatment for Those NOT Willing to Quit ASSIST Motivational examples: Express empathy Use open-ended questions. “How important do you think it is for you to quit?” Use reflective listening. “So you think smoking helps you maintain your weight.” Normalize patient’s feelings. “Many people worry about managing without cigarettes.” Support their right to choose. when you are ready.” t to choose. “I’m here to help you Smoking Cessation Treatment for Those NOT Willing to Quit ASSIST Motivational examples: Develop discrepancy Highlight the discrepancy between the patient’s smoking versus the patient’s stated values. “You’re devoted to your family. How do you think your smoking affects them?” Reinforce change talk. “So, you realize how smoking is making it hard to keep up with your kids.” Deepen the commitment to change. “We would like to help you avoid a stroke like the one your father had.” Smoking Cessation Treatment for Those NOT Willing to Quit ASSIST Motivational examples: Roll with resistance Back off and use reflection. “Sounds like you’re feeling pressured about your tobacco use.” Express empathy. “I understand it’s hard to quit.” Ask permission to provide information. “Would you like to hear about some strategies that can help you quit?” Smoking Cessation Treatment for Those NOT Willing to Quit ASSIST Motivational examples: Support self-efficacy Help patients build on past successes. “You were fairly successful last time you tried to quit.” Offer options for small, achievable steps toward change. “Can you try smoking one less cigarette a day? A quit line can help you.” Smoking Cessation Treatment for Those NOT Willing to Quit ARRANGE More than one motivational intervention may be needed. Provide follow-up at the next visit. Offer additional interventions to motivate and support. Smoking Cessation Treatment Treatment for Those Who Recently Quit Treatment for Those Who Recently Quit ASK Determine if the smoker is still smoke-free. then, ASSESS relapse potential. Treatment for Those Who Recently Quit ASSESS Most relapses occur within the first two weeks, but the risk can persist for a long time; therefore, Identify and address challenges, including lack of support for cessation, negative mood or depression, strong or prolonged withdrawal symptoms, weight gain and smoking lapses. Treatment for Those Who Recently Quit ASSIST Provide encouragement and relapse prevention to address the challenges of staying smoke-free. Challenge example Lack of support Depression Prevention response Schedule follow-ups, urge use of quit lines, identify source of support Counsel or refer to counseling/support groups Smoking is a Complex Phenomenon Social Psychological Spiritual Biophysiological Physical and Psychological When “down”, smoking energizes When “anxious”, smoking calms Smoking focuses attention and conveys a sense of well-being, every time Psychological/Behavioural Conditioning occurs over many years after exposure to things in the environment which stimulate the smoker to want a cigarette People learn to manage their emotions with tobacco Patterns of behaviour are very difficult to change Physical and Emotional Pleasure, arousal, relaxation and the relief of tension and anxiety are therapeutic effects of nicotine Smoking also treats effects of withdrawal All of these effects are biological and molecular Emotional, Social & Spiritual A comforting completion of pleasurable rituals: friends, drinks, sex, meals and breaks A close, comforting friend that has always been there A way to cement certain social relationships and repel unwanted ones Part of identity and sense of self Bio-physiologic Nicotine is an addictive substance. The chemical effects of nicotine are strongly related to the conditioning that occurs in many smokers. It is this link between stimulation/triggers in the environment and the immediate chemical, pleasurable effect on the body that often makes stopping smoking so difficult Stages of Change PRECOMTEMPLATION o Unaware or unwilling to change CONTEMPLATION o Ambivalent, but thinking about changing PREPARATION o Decided to change and taking steps ACTION o Started to do things differently MAINTENANCE o Changed for sometime and integrating the change into their routine Prochaska and DiClemente Precontemplation Not thinking of quitting in the next six months Contemplation Thinking of quitting in the next six months Relapse Maintenance Quit for more than six months Preparation Planning to quit in the next month Action Quit in the last six months 2 Myths you may encounter as you work with your patients to help them stop smoking: Myth 1: Smoking is just a bad habit. Fact: Tobacco use is an addiction. According to the U.S. Public Health Service Clinical Practice Guideline, Treating Tobacco Use and Dependence, nicotine is a very addictive drug. For some people, it can be as addictive as heroin or cocaine. Myth 2: Quitting is just a matter of willpower. Fact: Because smoking is an addiction, quitting is often very difficult. A number of treatments are available that can help. Myth 3: If you can’t quit the first time you try, you will never be able to quit. Fact: Quitting is hard. Usually people make two or three tries, or more, before being able to quit for good. Myths you may encounter as you work with your patients to help them stop smoking: Myth 4: The best way to quit is “cold turkey.” Fact: The most effective way to quit smoking is by using a combination of counseling and nicotine replacement therapy (such as the nicotine patch, inhaler, gum, or nasal spray) or non-nicotine medicines (such as bupropion SR). Myth 5: Quitting is expensive. Fact: Treatments cost from $3 to $10 a day. A pack-a-day smoker spends almost $1,000 per year. Check with your health insurance plan to find out if smoking. cessation medications and/or counseling are covered. *Source: http://www.surgeongeneral.gov/tobacco