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Critical Concepts NICU Brian M. Barkemeyer, MD LSUHSC Division of Neonatology 2011-12 At birth • 100% of infants need someone present dedicated to the infant and capable of initial steps in neonatal resuscitation • 10% of infants require some level of resuscitation at birth • 1% of infants require major resuscitation “Golden hour” • At no other time in one’s life will necessary critical concepts in resuscitation have a potential lifelong impact – Appropriate interventions (or the lack thereof) can make the difference between life or death, or normal life vs. life of disability Preparation • NRP - Neonatal Resuscitation Program – Evidence-based, standardized program jointly sponsored by American Academy of Pediatrics and American Heart Association • Proper equipment • Knowledge – In most cases, the need for neonatal resuscitation is predictable – But not always! Risk Factors Predictive of Need for Neonatal Resuscitation • Maternal illness – Hypertension – Diabetes – Infection • • • • • • Prematurity Post-maturity Multiple gestation Maternal bleeding Maternal drug abuse No prenatal care • • • • • • • • Fetal distress Abnormal fetal position Abnormal labor Fetal anomalies Macrosomia IUGR Placental abnormalities Meconium-stained amniotic fluid Transition to Extrauterine Life • Fluid-filled alveoli to air-filled alveoli • Circulatory changes – Decreased pulmonary vascular resistance resulting in increased pulmonary blood flow and cessation of flow through foramen ovale and ductus arteriosus – Cessation of flow to placenta resulting in increased systemic vascular resistance Lack of Appropriate Resuscitation • Interrupts normal transition to extrauterine life • Hypoxia • Respiratory and metabolic acidosis • Ischemia • Potential for death or long term adverse outcome Three Basic Questions • Term infant? • Breathing/crying at birth? • Normal tone at birth? • If the answer to these three questions is yes, infant doesn’t need resuscitation, but does deserve initial steps Initial Steps • • • • • Drying Warming Stimulation Positioning Clear airway • Necessary for all newborns! Warming • • • • • • Appropriate room temperature Rapid drying to avoid evaporative heat loss Remove wet towels Mother – skin to skin Radiant heat warmer Blankets, cap • Premature infants and IUGR infants at highest risk for hypothermia Establishment of the Airway • Suction mouth then nose (“M before N”) • Shoulder roll to aid in positioning • Head positioned in slight extension, or “sniffing position” – Not too extended – Not too flexed ABC’s • Airway – Suction secretions, assess for anomalies • Breathing – Stimulate respiratory effort • Tactile • Bag-mask positive pressure ventilation (PPV) • Circulation – Assess heart rate • Chest compressions if PPV ineffective at restoring heart rate Skills to Learn • Neonatal assessment • Use of bulb suction • Administration of positive pressure ventilation by bag-mask • Intubation and assistance with intubation • Chest compressions Assessment/Reassessment: Sequential steps in resuscitation • Initial steps [30 seconds] • PPV [30 seconds] • Chest compressions [30 seconds] • Medications [30 seconds] Neonatal Assessment • Respirations – Normal rate and depth, good chest movement • Heart rate – Normal > 100 – Count for 6 seconds, multiply x 10 • Color – Pink lips and trunk – Acrocyanosis vs. central cyanosis Indications for PPV • If after initial steps in resuscitation [30 sec], assessment reveals – Apnea – Gasping respirations – Heart rate < 100 Indications for Chest Compressions • If after initial steps in resuscitation [30 sec] and effective PPV [30 sec], assessment reveals – Heart rate < 60 Indications for Epinephrine • Heart rate persists < 60 after – Initial steps – PPV – Chest compressions [30 seconds] [30 seconds] [30 seconds] • Dosage given IV (UVC preferred), or endotracheal (higher dose given) Indications for Volume Administration • History of blood loss at delivery suggesting hypovolemia AND • Infant appears to be in shock (pallor, poor perfusion, failure to respond appropriately to resuscitation efforts) • IV, 10-20 mL/kg, Normal saline, Ringer’s lactate, or Oblood Meconium-stained Amniotic Fluid • 15% of deliveries; at risk for meconium aspiration syndrome • Suctioning of upper airway and trachea in infants who are not vigorous may help prevent meconium aspiration syndrome – Vigorous defined by • Heart rate > 100 • Normal respiratory effort • Normal tone Positive Pressure Ventilation • • • • • Appropriate size mask and bag Self-inflating vs. flow-inflating bag Forming a good seal with mask Achieve adequate chest rise 40-60 breaths per minute • When done appropriately, PPV should result in improvement in heart rate and color Ineffective PPV • • • • • • • Reposition mask on face Reposition head Suction upper airway Ventilate with mouth open Increase ventilatory pressure Replace bag Endotracheal intubation Self-inflating bag Flow-inflating bag Chest Compressions • Should be coordinated with PPV • 2 thumb method preferred • Compression of sternum 1/3 depth of AP diameter of chest • 120 events per minute (compressions and respirations combined) • “One and two and three and breathe” Chest Compressions Endotracheal Intubation • ET tube size similar to size of patient’s little finger • • • • < 28 wks, < 1000 g 28-34 wks, 1000-2000 g 34-38 wks, 2000-3000 g 38-42 wks, > 3000 g = 2.5 ETT = 3.0 ETT = 3.5 ETT = 4.0 ETT • Insertion depth – “Tip to lip” measurement = weight in kg plus 6 • 2 kg patient should have ETT secure at 8 cm mark at lip Endotracheal Intubation Unique Aspects of Endotracheal Intubation in Infants • Narrowest part of airway is subglottic area • Uncuffed ET tubes typically utilized • Increased airway resistance associated with more narrow airway diameter • Relative lack of structural support for neonatal airway Unique Anatomic Challenges • Choanal atresia – Endotracheal intubation may be required • Pierre-Robin sequence – Prone positioning – NG tube into posterior pharynx • Congenital diaphragmatic hernia – Endotracheal intubation – Gastric decompression Key Points • Appropriate resuscitation requires a rapid series of assessments, interventions, and reassessments • All infants deserve basic steps of resuscitation – Drying, warming, positioning, clear airway • Prompt initiation of respiratory support with positive pressure ventilation by bag-mask is the key to successful resuscitation of most infants