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QuickTime™ and a TIFF (LZW) decompressor are needed to see this picture. Observe, record, tabulate, communicate. We should endeavor to determine what type of patient has a disease, instead of just what disease the patient has . RHEUMATIC DISEASES over 100 different arthritic diseases > 40 million Americans > 8 million disabled > $ 20 billion annually RHEUMATIC DISEASES – – – – – – modern : >1800 not equivalent to “arthritis” chronic degenerative joint diseases Female = 2.5 x Male genetic : HLA-DR4 socioeconomic, education, psychosocial stress RHEUMATIC DISEASES general characteristics( signs & symptoms) PAIN INFLAMMATION musculoskeletal stiffness musculoskeletal swelling musculoskeletal aches musculoskeletal limitations disability deformity RHEUMATIC DISEASES Laboratory tests increased RF ~80%; 1:1280; non-Dx higher = RA; poorer Px increased ESR increased ANA ~50% LE IgG SSA/SSB Rheumatic Fever and Rheumatic Heart Disease acute inflammatory condition following group A streptococci infection autoimmune reaction arthralgia > 75% < 20 y.o. ~95% of all heart disease in children third world = 30-40 % of all CVD all ages U.S. 100,000 cases; 6500 deaths per yr. RHEUMATOID ARTHRITIS chronic, inflammatory, destructive joint disease wide range of severity ankles, cervical spine, elbows; hips, knees, proximal interphalangeal joints shoulders, tarsals, TMJ, wrists RHEUMATOID ARTHRITIS MANAGEMENT COMPREHENSIVE MULTIDISCIPLINARY CORTICOSTERIODS – SYSTEMIC ; LOCAL INJECTIONS – PREDNISONE, PREDNISOLONE GOLD, ANTI-MALARIAL, PENICILLAMINE SULFASALAZINE BIOLOGICS- TNFa- antagonists IMMUNOSUPPRESSIVES – IMMURAN, METHOTREXATE RHEUMATOID ARTHRITIS TMD – pain, tenderness, stiffness, crepitus, – swelling, limited mandibular opening – fibrosis, ankylosis – bleeding, infection – neutropenia , thrombocytopenia, anemia – adrenal suppression Osteoarthritis of the TMJ degenerative joint disease most common intracapsular disorder 40% > 40 y.o. who were ASx osteophytes steroids ( intra-articular) surgery Sjögren’s syndrome QuickTime™ and a decompressor are needed to see this picture. Secondary Sjogren's Syndrome Xerophthalmia keratoconjunctivitis sicca Xerostomia salivary gland dysfunction Inflammatory connective tissue disease Diagnostic criteria for SS(EC) 4:6 * ocular symptoms(1:3) daily dry eye >3mos sand or gravel sens. tear substitutes >tid ocular signs (1:2) Shirmer’s test (<5mm/5min) Rose Bengal score (>4 - vBs) Diagnostic criteria for SS (EC) 4:6 * oral symptoms (1:3) daily dry >3 mos. swollen glands must drink liquids to swallow food salivary function (1:3) + scintigraphy + sialography WUSF <1.5ml/15 min. (0.1ml/min.) Diagnostic criteria for SS (EC) 4:6 * labial histology* focus score / 4mm >50 mononuclear cells Autoantibodies* anti-SS-Ro or anti-SS-La Sjögren’s syndrome (SS) on a histopathological level is a benign lymphosialadenopathy which includes autoimmune lymphocytic infiltration of the salivary glands. Oral clinical manifestations of SS typically include : hyposalivation, glossitis, mucositis, angular cheilosis, and increased caries rate. SLE renal disease cardiac valvular disease anemia thrombocytopenia leukopenia arthritis TMD 5-22 % 18-74 % 70 % 25 % 45 % 90 % 60 % SLE systemic complications : – – – – – lab tests: CBC, platelets, BUN, creatinine leukopenia, steriods, etc. = prone to infection need for antibiotics ( IE ?) adrenal suppression bleeding Paget’s, Osteomyelitis, Osteoporosis, Fibrous dysplasia osteolytic/osteoblastic bleeding bone deformities & tooth loss infection radiographs lab tests: CBC, Ca, P, alkaline phosphatase bone biopsy SCLERODERMA tightened, hard skin: face, hands, fingers internal organ involvement microstomia tightened perioral skin SGD periodontal disease painful RAS-type ulcerations TREATMENT CORTICOSTEROIDS topical systemic intralesional IMMUNOSUPPRESIVE agents topical systemic intralesional Corticosteroid use: routine dental procedures Rx>2 wks. d/c w/i 30 days= Rx previous d/c Rx > 30 days ago = none topical = none current Rx( any dose) = none alt. day Rx = tx on that day Monitor BP, good anesthesia, post-op analgesia, etc. Corticosteroid use: complex dental procedures Rx>2 wks. d/c w/i 30 days= Rx previous Rx d/c > 30 days ago = none topical = none current Rx( any dose) = double + alt. day Rx = double + tx on that day Monitor BP, good anesthesia, post-op + Rx + analgesia, etc. Dental management diagnosis; severity systemic complications musculoskeletal limitations pain medications; anti-inflammatory agents oral manifestations neutropenia ; thrombocytopenia; anemia Infections(LPJI) Prevention of late Prosthetic joint infections Joint ADA/AAOS guidelines 1997 Late Prosthetic Joint Infections Wahl’s myths: #1: There are similarities between IE (PVE) and LPJI. NO. #2: Dental treatment is a probable cause of LPJI. NO. #3: Animal experiments document dental bacteremias as cause of LPJI. NO. #4: To protect patients DDS should always cover patients with PJ. NO. Late Prosthetic Joint Infections infection rate > 1% >70% staph Pallusch >1000 PJ pts., 6 yrs. - no prophylaxis= 0 LPJIs Ainscow 4 cases of LPJI cultured= no oral pathogen Batzokas other prosthetic- synthetic implants Prevention of late Prosthetic joint infections: 1997 changes ADA/AAOS advisory statement medical consultation with Orthopod No prophylaxis for pins, rods, screws, plates, wires, implants, etc. healthy patient: < 2 yrs. after TJR chronic RA or other infection of TJR immunocompromised patients Prevention of late Prosthetic joint infections: 1997 changes Immunocompromised patients IDDM chronic CTD: RA, SLE, etc. immunosuppressive drugs or irradiation hemophilia or other blood dyscrasias malnourishment HIV Late Prosthetic Joint Infections Benefits of prophylaxis DO NOT necessarily outweigh potential risks especially considering antimicrobial resistance, costs, risk of anaphylaxis, etc. Little, Rhodus, et.al.; JADA 1991 …. Orthopedic surgeons ~ 90 % recommend antibiotic prophylaxis for dental Tx SO…BE CAREFUL WHAT YOU ASK FOR ! Prevention of late Prosthetic joint infections: 1997 changes Cephalexin ( Keflex) 2g ; po ; 1 hr. pre-op Cephazolin; 1 g; IM/IV; 1 hr. pre-op Clindamycin; 600mg.; po; 1 hr. pre-op Thanks!! QuickTime™ and a TIFF (LZW) decompressor are needed to see this picture. QUIZ fold sheet and put your name on back I know you do another course evaluation, but this is more for my own information in order to improve learning I will respect your confidentiality and my secretary will record your name and after the course is complete and the grade submitted, I’ll review your responses QUIZ fold sheet and put your name on back I liked the format of this course. A. true B. false QUIZ fold sheet and put your name on back I learned as much ( or MORE) from the peer presentations as I would have from the instructor A. true B. false QUIZ fold sheet and put your name on back I learned more from working on my group’s presentation. A. true B. false QUIZ fold sheet and put your name on back The book was very helpful. A. true B. false QUIZ fold sheet and put your name on back The group presentations were much better than straight lectures. A. true B. false QUIZ Please RANK the top three presentations. 1 2 3 Cases Problem-solving process GUIDES- when and where to get information (look it up !) Competencies…… Exam 40 objective( MC- TF ?s): form Midterm Allergies(5-6), Bleeding (5-6), Thyroid (34),blood dyscrasias(5-6), pregnancy (4-5), Neurological(4-5), HIV(4-5), Behavioral (2-3) Open book case…just like those in class Do the obj. first then you’ll get the case Friday, Dec. 7 at 7:30 am 1:30 ONLY !! **