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Lecture #23: Internal Flows Body Plan Evolution 1 cell cellular sheet cellular bilayer one way gut endoderm ectoderm bilayered canister mouth anus cephalization mesoderm Basic circulatory circuit lung/gill heart body diffusion in dedicated exchangers intestine convection In dedicated plumbing Convection vs. Diffusion x Fick’s Law: C1 S C2 mass C2 C1 J DS time x C= concentration in mass/volume D = diffusion coefficient Units = L2/T Basic strategy of circulatory systems: Pluming uses bulk flow (convection) to move fluids to capillary beds where diffusion can take place over short distances. Relative importance of bulk flow to diffusion given by Peclet number: ul Pe D Problems with gas exchange: consider simple gas exchanger: convection C2 C1 J DS x water DIFFUSION blood driving force partial pressure (02) equilibrium distance Problems with gas exchange: consider countercurrent gas exchanger: C2 C1 J DS x water blood driving force partial pressure (02) distance What about lungs? air blood partial pressure (02) distance C2 C1 J DS x Birds have more efficient system Birds have more efficient system What determines flow in pipes? L r P1 x P2 a If Re < 2000 (i.e. laminar flow): P (a r ) u x (r ) L 4 2 2 • flow ~ pressure gradient • flow ~ 1 / viscosity • parabolic flow distribution P (a ) u x max L 4 2 What is maximum flow velocity? At center of pipe, r=0: What determines flux through pipe? Flux (Q) = velocity x area: P a 2 1 2 P a 4 Q ( 2 a ) L 4 L 8 = Hagen-Poiseuille equation Flux through a system: • proportional to pressure gradient • inversely proportional to viscosity • has fourth order dependence on diameter lung heart Pressure is lost (drops) across network of pipes. 10% of our total metabolic cost! 5% of our total Weight in blood! body intestine pressure flow velocity heart lung intestine distance body Problems with blood From Hagen-Poiseuille Equation: ‘Resistance’ P 8L 4 Q a Blood is very viscous due to red blood cells Blood is not a ‘Newtonian’ fluid, Mostly because of red blood cells. optimum at 58% % hematocrit carrying capacity viscosity 02 carried/unit cost Thoughts about plumbing: Consider simple branch point: S1 If S1 = 2 S2 then velocity is same in all branches; flux is ½ the original value. S0 S1 Consider change in diameter: a0 a2 If a0 = 2 a1 then 16 times the pressure is required in small pipe for same flux! Circulatory systems cannot compensate with large trunks – Blood volume would become too large. Murray’s Law: what is geometry of branching network? 1) Cost to pump = Q x pressure gradient, or P Q 2 8 Q 4 L a Ma 2 2) Cost to make new pipe Total cost Q 2 8 2 M a 4 a 3) Find optimum as a function of diameter: 2 d Q 8 aopt da ( M a ) 4 a 2 16 1/ 6 aopt Q ( ) M 1/ 3 if 1/ 3 then aopt ~ Q Q ka 3 Mass flux ~ cube of vessel diameter But, by law of continuity, Q0 Q1 Q2 a1 Q1 a0 Q0 thus a a a Q2 3 0 a2 3 1 3 2 a.k.a. Murray’s Law For simple symmetrical branching case: a1 0.79a0 S1 0.63S0 u1 0.26u0 More generally…… a a a a ...a 3 0 3 1 3 2 3 3 3 n How does a growing vascular network ‘know’ to follow Murray’s Law? r x du/dr Shear stress at wall, It can be shown that: 4Q t 3 r t = du/dr But by Murray’s Law: Q ka a 3 So with r = a (at wall): t 4k Thus, shear stress at wall is constant in network obeying Murray’s Law. Algorithm could be: ‘Grow vessel until shear stress reaches certain value.’