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 Supply oxygen and dispose of carbon dioxide  Enable speech production To accomplish this, 4 independent processes, collectively called respiration must occur: 1. Pulmonary ventilation 2. External respiration 3. Transport of respiratory gases 4. Internal respiration (gas exchange between blood & tissue cells) Only the first two processes are the direct responsibility of the respiratory system. However, the other two must occur in order for oxygen to be obtained and for carbon dioxide to be removed.  Movement of air into an out of the lungs so that gases in the air sacs (alveoli) of the lungs are continuously changed and refreshed.  This air movement is known as ventilation or, more commonly, breathing.  Ventilation  exchange of air between lungs and atmosphere  Gas Exchange in pulmonary capillaries  Oxygen and Carbon Dioxide  Diffusion, based on concentration gradient  Breathing largely involuntary activity  Transport of O2 and CO2 between lungs and tissue cells of the body  Accomplished by cardiovascular system  Blood is the transporting fluid  All cells require oxygen for metabolism  All cells require means to remove carbon dioxide  Gas exchange occurs at cellular level  Also simple diffusion, based on concentration gradient  Upper respiratory tract  Nose/Mouth  Pharynx  Epiglottis  Lower respiratory tract  Larynx  Trachea  Bronchi  Lungs  Bronchioles  Alveoli  Nose is the only externally visible part of the respiratory system  Numerous functions:  Airway for respiration  Moistens and warms entering air  Filters inspired air and cleanses it of foreign matter  Resonating chamber for speech  Houses olfactory receptors  Mouth can be used in lieu of the nose as an airway for respiration.  Air will be less “treated”  Nasopharynx  adenoids or pharyngeal tonsils  oropharynx  palatine tonsils  laryngopharynx  larynx  Oropharynx and laryngopharynx serve as a common passageway for both food and air  Epiglottis acts as a lid or flap that covers the larynx and trachea (airway) so food does not enter the lungs.  “voice box”  Three main functions:  Patent (open) airway  Switching mechanism to route food and air into proper channels  Voice production (houses vocal cords)  Windpipe or airway  Mucous membrane lining with cilia  Smooth muscle with c-shaped cartilage rings  divides into two branches: bronchi  no gaseous exchange  Bronchus = singular  c-shaped cartilage rings with smooth muscle  Each bronchi divides into bronchioles  Terminate in air sacs called alveoli  Two circulations  Pulmonary circulation  Bronchial circulation  Innervated by parasympathetic and (rare) sympathetic motor fibers  Each lung enclosed in pleura  parietal pleura (outer)  visceral pleura (inner)  Lubricating pleura fluid  “air sacs”  Alveolar wall membranes one cell thick and surrounded by capillaries  Location of gaseous exchange