Download CD molecules & disease

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CD molecules
& Disease
制作团队：
资料：冯华 樊慧慧 崔晓霈 李金枝 何平
鲁建华 张泽立
整理：冯华
翻译：崔晓霈 李金枝 樊慧慧
制作：鲁建华 何平
2000级七年制一班
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CD molecules & disease
Concept
CD molecules,which are also called
leukocyte differentiation antigen,are the
surface markers appear or disappear on
leukocytes (also include platelet,blood
vessel endothelial cell etc) during the
process of differentiation and activation.
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CD molecules & disease
According to monoclonal antibody
identification method,the same
differentiated antigen that can be recognized
by monoclonal antibody coming from
different labs are called CD (cluster of
differentiation)
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CD molecules & disease
 Structure
Most CD molecules are transmembrane
protein or glycoprotein,including
extramembrancous,transmembranous and
intracellular areas.
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CD molecules & disease
Classifications
CD molecules are numbered according
to the time of discovery.So far,they
have been named from CD1 to CD166.
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Classification
T
cell
B
cell
Activated cell
Myeloid cell
CD
Serial Number
cd1～cd8，cd27,cd28,cd60,cd98~cdw101
cd10,cd19~cd24,cd37,cd39,cd40,cd72~cd86
cd25,cd26,cd30,cd69~cd71,cd95~cd97
cd9,cd11b~cd17,cd31~cd36,cd64~cd68,cd8
7~cd93,cd115
NK
cell cd11a,cd18,cd29,cd38,cd43,cd45~cd48,cd5
2~cd59,cd94
Platelet cell cd41,cd42,cd63,cd107
Endoepithelial cd105,cd106,cdw109
cell
Adhesion
cd11a,cd44,cd49~cd51,cd61,cd62,cd102~
molecule
cd104,cdw108
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Cytokine
cdw116,cd117,cd120~cd122,cd124,cd126~
CD molecules & disease
All of them are classified approximately into
9 groups:
T cell, B cell, activating cell, myeloid cell,
NK/non-lineage cell, platelet, endoepithelial
cell, adhesion molecule and cytokine
receptor .
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CD molecules & disease
 Function
1. CD molecules take part in the recognition
between immune cells and Ag or other
immune cells.They also participate the
activation,proliferation differentiation and
immune function.
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CD molecules & disease
2.Regulate the differentiation and migration of
hemopoietic cells.
3.Participate inflammation.
4.Cell migration.
eg.cancer matastasis
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CD molecules & disease
 Cdmolecules and disease
1.CD molecules’normal functions:
1)CD molecules related to activation of T
cell ,TCR/CD3 Complex,CD4 Coreceptor,CD8,CD2,CD58,CD28- Costimulators
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CD molecules & disease
2).CD molecules related to inflammatory reactions.
Firstly:CDb2I and CDb2E mediate neutrophiles to
roll and combine,the monoclonal Ab that untilselection can inhibit the reaction dramatically
When passing through endothelium, CD4/CD18
interacts with its ligand,playing an important role.
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CD molecules & disease
3).CD associated with blood cloting :
eg: GP16
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CD molecules & disease
2.Disease:
1)EB: LFA-3 lacking
2)Paroxys nocturnal hemoglosinvia（周期
夜现性血尿 ）
CD6+ CD28+ T cell MHC
CD8+ CD28- inhibit antibody
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CD molecules & disease
3)Disease associated with intracellular signals
transmission of
CD,CD3,CD45,CD115,CD125,CD117,CD1
30,their signals’abnormal transduction
cause hyperplastic disease,what’s more,they
are intimately involved in
tumor,papillomas,psoriasis,etc.
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CD molecules & disease
4)CD and tumors
(1) CD44 and cancer (tumor) metastasis
eg: * melanomatous cells express CD44
*The inflammayion products and some
cytokines promotes local vessels endothelial
cells to express more CAMs,which are
helpful to the adhesion of tumor cells
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CD molecules & disease
(2)Stimulation of CD40 can inhibit the
reproduction of tumor cells directly,promote
apoptosis and Fasgene expression
(3)The interaction between LFA-I and ICAM1 mediate the contant between NK cells and
tumor cells.
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CD molecules & disease
ICAM－2
Mutations
Affecting
LFA-1
Binding
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CD molecules & disease
5)CD and HIV.
HIV enters the T cell by combining with
CD4 molecules on T cells.In the blood of
the person infected by HIV-I,CD4 cell
appears positive.The CD4+ cells’obvious
decrease is associated with the disease
deterioration.
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CD molecules & disease
HIV
infecting
normal
human’s
tissues
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CD molecules & disease
6)CD and GSS (Granulomatous slack skin肉
芽肿性皮肤松弛症）
Mainly CD4+ CD8- T cells and CD45RO+
T cells antigen loss in different measures.
CD4+/CD45RO+ T cells, CD3, CD5 and
CD7 (marker of T cells) loss.
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CD molecules & disease
7)CD and CO poisoning
*CO poisoning damage the endothelial cells
*The activation of platelets increase and
CD116, CD18 are highly expressed.
*Thrombus in cerebral microarterial vessels
is induced to form.
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CD molecules & disease
8)CD and diabetes -I
Immune tolerance deficiency of insular
specific T cells is due to blockage of ICAMI/CFA-1 and loss CD8+ T cells at the
beginning of immune response,which lead
to insular antigen tolerance deficiency.
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CD molecules & disease
9)Others
*Increasing of activators of plateletCD62P,CD61,and CD41,especially
CD62P,are closely related to the disease
such as coronary heart disease,cerebral
infarction,hypertension,etc.
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CD molecules & disease
*Associated with endometriosis.（子宫内膜
异位）
eg:Periodical change of CD45+ cell group
become abnormal.
*The disease such as asthma,rhinitis,etc are
possibly associated with actiration of CD8+
and CD127+ cells
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CD molecules & disease
Anusual expression of CAM and SLE
*SLE (systemic lupus erythematosus系统性
红斑狼疮)
*CD11a and CD18 expression decline agree
with CD4+ T cell while increase with
CD8+ T cell.
*Expression of CD54 on CD20+ cells
increase
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CD molecules & disease
 CD molecules and clinical treatment
1.CD34 and Aplastic anemia (再生障碍性贫
血）
CD34 is expressed in most acute
lympholeukemia (急性淋巴细胞性白血病）
Detection of CD34 is helpful to the study of
Aplastic anemia
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CD molecules & disease
2.CD34 as marks of T cells
MACS is used to select and separate CD34+
T cells from peripheral blood
Reduced T cell-load is good for autoimmune
disease
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CD molecules & disease
3.Application of anti-CD40 McAb
anti-CD40 McAb can significantly inhibit
the development of Osseous rheumatism
（类风湿性关节炎）
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CD molecules & disease
4.Application of anti-CD3- Ab
anti-CD3-Ab is now widely used to cure
enograft rejection and is efficient
bispecific anti-CD3-/HSV Ab for treatment
of the immunodeficient newborn infected
by HSV
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CD molecules & disease
5.Anti-CD3 McAb
1)anti-CD3McAb in mice can reverse
enograft rejection
2)Mechanism
*anti-CD3 McAb can bind with CD3
molecules on T cells
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CD molecules & disease
*The interaction interfere with the
transduction of activating signals which
results in cytokine releasing
*The proliferation and functions of T cells be
blocked
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