Download human immunodeficiency virus

Conversation Starters…
1. Describe the steps of viral replication.
2. What is an obligate parasite?
3. Where did HIV come from?
4. What is a retrovirus?
HIV/AIDS AND OTHER
INFECTIOUS AGENTS
Modified with permission from a powerpoint
originally from Mrs. Jenn Boyd, Westlake High
School
I. Viruses:
The Human and Animal Impact
A. Virus: comes from Latin for “Poison”
B. Can be economically devastating by damaging crops,
domesticated animals
C. Ex. rabies
• humans get virus by animal bite (saliva) causes inflammation of CNS
I. Viruses:
The Human and Animal Impact
4. Myxomatosis in rabbits
• Ex. Australia
Rabbits were introduced to Australia. They increased in numbers
and were eating all of the grass. To control their population,
Myxoma virus spread by fleas or mosquitoes was used to kill
them.
II. Autoimmune Diseases
A. General Mechanism:
1. The immune system MISTAKES its own cells for
pathogens,
2. THE IMMUNE SYSTEM ATTACKS THE TISSUE OF THE BODY.
B. Examples:
1. RHEUMATOID ARTHRITIS: Destructive inflammation of the
joints.
2. MULTIPLE SCLEROSIS: Nerve disease that results from
destruction of myelin sheath of nerve fibers.
3. LUPUS: Inflammation of skin, joints, heart, brain, lungs, and
kidneys.
III. HIV and AIDS
A. AIDS
1.
2.
3.
Acquired Immunodeficiency Syndrome (AIDS)
Caused by the HUMAN IMMUNODEFICIENCY VIRUS or HIV
AIDS IS NOT A specific disease, but a condition in which the immune
system CANNOT protect the body against a variety of pathogens.
B. HIV
1.
Attacks the human immune system and destroys the body’s ability to fight
infection.
IV. HIV Mechanism of Infection
A. HIV enters the body and attaches to receptors on the surface of a
type of T Cell known as HELPER T CELLS.
• T Cells help other Lymphocytes respond to the early stages of an infection.
B. HIV destroys Helper T cells  body loses its ability to fight off disease
C. NET: HIV destroys body's ability to defend itself
QUICK CHECK:
1. What does AIDS stand for?
2. What does HIV stand for?
QUICK CHECK:
1. What type of cell is destroyed by HIV?
2. The process of DNA turning into mRNA is called t__________.
3. The process of mRNA being used to make proteins is called
t______________.
C. HIV is a Retrovirus
1. RNA genome
2. Contains Reverse Transcriptase: turns RNA sequence into a
DNA strand
3. Viral DNA is integrated into the host DNA (= provirus)
4. It is replicated whenever the host DNA replicates
5. New viruses are produced and released
QUICK CHECK
What does reverse transcriptase do?
V. Transmission of HIV
A. HIV can only be spread through direct contact of
certain body fluids (eg. blood, semen, breast milk).
1. Transmitted through sexual intercourse, sharing needles,
transfusion of contaminated blood.
B. Not spread by:
1. Casual contact (eg. holding hands, using dishes previously
used by a person with HIV)
2. Insects (mosquitoes, fleas, ticks)
VI. Treatment of HIV
A. No known cure for HIV infection
B. No vaccine (at present)
C. Only avoid behaviors that place you at risk of contracting
the virus.
D. Recently in the news:
1. Abzyme (antibody + enzyme): found in lupus patients is able to degrade
the part on HIV that binds to helper T cells.
2. Attempts to increase mutation rate of the virus
3. Bone marrow transplant:
• double CCR5 mutation bone marrow transplanted into a person with HIV
• bone marrow makes RBCs and WBCs
• going to be expensive to do human trials
• risky to do bone marrow transplants (1/3 survival rate)
E. CCR5
1. Signal receptor on outside of
helper T cells
2. 32-bp (base pair) deletion
• causes a shift during the making of the
proteins on the surface
Who is Most Likely to Have ΔCCR5?
VII. Stages of HIV Infection
A. HIV infection progresses in stages.
1.
2.
3.
When first infected by the virus, a person may have flu like symptoms or no
symptoms.
Within a few weeks to several months, antibodies to HIV begin to appear in
the blood.
Presence of antibodies in the blood used to:
• diagnose disease
• screen donated blood
VII. Stages of HIV Infection
B. HIV POSITIVE = HIV antibodies can be detected in and are
present in the blood.
C. Other symptoms of the syndrome may not appear for
months or even years.
QUICK CHECK
Does HIV follow the lytic or lysogenic cycle? How do you know?
VII. Stages of HIV Infection
D. AIDS = number of Helper T cells drops below
200/mL
• Immune system cannot fight disease
E. May take from a few to 20 years to get to this
point
F. People with AIDS may be susceptible to a
variety of diseases.
• Typically people with AIDS become sick when they are
infected by pathogens that do not normally cause
disease in people with healthy immune systems.
• These diseases are called OPPORTUNISTIC
INFECTIONS.
QUICK CHECK
1. When does somebody have AIDS?
2. Can someone have HIV and not have AIDS?
VIII. Viroid
A. Short circular pieces of RNA that infect plants.
• Do not code for proteins
B. Uses host’s enzymes to replicate and stunts host’s growth.
C. Can be transferred by insects.
• Ex. Potatoes, tomatoes, avocados
IX. Prion Disease: Mad Cow Disease
A. Caused by a prion
1. PRION: mis-folded protein that caused other proteins to
become mis-folded
B. Characteristics:
1. NO nucleic acid
2. Long incubation period
C. Examples:
1. Mad cow disease: brain wasting disease. Makes holes in
brain tissues.
2. Creutzfeldt-Jakob Disease (CJD): brain disease in humans.
3. Scrapie: neurodegenerative disease in sheep
4. Feline spongiform encephalopathy: in cats
X. Prion Disease: Kuru
A. Rare disease in New Guinea
B. Cultural Traditions: Cannibalism--ate the brains of dead people
as part of a funeral ritual
•
Practice stopped in 1960, but cases of kuru were reported for many
years afterward.
•
Why?
XI. Immunity & Vaccination
A. A person who becomes resistant to a specific pathogen is said to
have acquired immunity.
B. Vaccination: contains modified pathogens that can no longer
cause disease.
C. The antigens stimulate an immune response, producing memory
cells against it.
• Polio, measles, mumps, tetanus
Learning Log:
1. How does a vaccine work?
2. What is an autoimmune disease?
3. Describe how a retrovirus replicates.