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Urinary and Lymphatic Systems Functions of Lymphatic System Filters lymph fluid Returns leaked fluid to circulatory system Produces and modifies cells of immune system to fight infection Major Organs of the Lymphatic System Lymph Fluid Lymph Capillaries Lymph Vessels Lymph Nodes (nonsecreting "glands“) Thymus Spleen Tonsils Major Organs of the Lymphatic System Lymph Fluid: The clear fluid found outside the cells which bathes the tissues. It is collected, filtered, and transported by the lymphatic system from around the tissues to the blood of the circulatory system. Major Organs of the Lymphatic System Lymph Capillaries – collect lymph fluid from the tissues of the body Lymph Capillary Animation: http://www.lymphnotes.com/article.php/id/151/ Lymph Capillaries Thin walled - pick up and recycle extra tissue fluid During inflammation, lymph capillaries can absorb: – Cell debris – Pathogens – Cancer cells Lymph circulation due to ? Major Organs of the Lymphatic System Lymph Vessels transport lymph fluid to the circulatory system. Lymphatic vessels comparable in structure to veins Damaged valves or blocked lymph vessels ??? Lymph Transport • The lymphatic system lacks a pumping organ • To propel lymph, vessels rely on: – Pulsations of nearby arteries – Movement of muscles throughout the body – Contractions of smooth muscle in the walls of the lymphatic vessels Lymphoid Organs – aid in the production of lymphocytes (WBC) • • • • Lymph Nodes Spleen Thymus Tonsils Lymphocytes • White Blood Cells (Lymphocytes) are the main cells involved in the immune response • Two main varieties: – T cells – B cells White Blood Cells a.k.a Lymphocytes T cells and B cells protect the body against antigens 1. Antigen – anything the body perceives as foreign – Bacteria and their toxins; viruses – Mismatched RBCs or cancer cells Lymphocytes a.k.a. (White Blood Cells) 2. T cells – Manage the immune response – Attack and destroy foreign cells 3. B cells – Produce plasma cells, which secrete antibodies – Antibodies immobilize antigens Bone Marrow: Lymphopoiesis Lymphocytes are later also produced in thymus, spleen and tonsils Fig 23.7 Lymph Nodes • Primary lymphatic organs of the body • Found within connective tissue and along lymphatic vessels • 2 basic functions: – Filtration –remove microorganisms, dead cells, and debris – Immune system activation – monitor and attack antigens Lymph nodes Lymph Nodes Animation Spleen • Largest lymphatic organ • Functions: – Site of white blood cell production – Immune surveillance and response – Cleanses the blood by removing dead red blood cells Thymus Only lymphoid organ that does NOT fight antigens, it functions as “T-cell academy” – modifies T-cells Tonsils & Adenoids • Simplest lymphatic organs • Trap bacteria and other antigens which work their way into the follicles where they are destroyed Disorders of the Lymphatic System • Edema Accumulation of lymph fluid caused by blockages in the lymphatic vessels Disorders of the Lymphatic System • Severe combined immunodeficiency (SCID) syndrome – genetic disorder in which a person is born missing T cells (white blood cells that identify and attack perceived “invaders”) and affect the function of the B cells (white blood cells that produce antibodies against infection) Disorders of the Lymphatic System – An autoimmune disorder is a condition that occurs when the immune system mistakenly attacks and destroys healthy body tissue. There are more than 80 different types of autoimmune disorders. • • • • Rhuematoid Arthritis Type I Diabetes Psoriasis Vitiligo The Urinary System Functions of Urinary System ● Regulate fluid balance (fluid volume) of the body FILTER BLOOD ● Excrete waste products from the blood Stabilize blood pH Regulate ion concentrations in the blood Kidney Location Major Organs of the Urinary System – Kidneys– main organs of the urinary system; have specialized cells called Nephrons that filter harmful poisons like urea from the blood Major Organs of the Urinary System – Kidneys– main organs of the urinary system; have specialized cells called Nephrons that filter harmful poisons like urea from the blood Major Organs of the Urinary System – Bladder –stores urine Major Organs of the Urinary System – Bladder –stores urine Major Organs of the Urinary System – Ureters– tubes that connect kidneys to bladder Major Organs of the Urinary System – Ureters– tubes that connect kidneys to bladder Major Organs of the Urinary System – Urethra– tube thru which urine exits the body Major Organs of the Urinary System – Urethra– tube thru which urine exits the body Major Organs of the Urinary System – – – – Kidneys– main organs of the urinary system; have specialized cells called Nephrons that filter harmful poisons like urea from the blood Bladder –stores urine Ureters– tubes that connect kidneys to bladder Urethra– tube thru which urine exits the body 2 Categories of Waste Removed By the Kidneys (produced by cellular respiration) Excretion and other body systems Cross section Kidney Stones Renal failure • Acute (sudden) kidney failure is the sudden loss of the ability of the kidneys to remove waste and concentrate urine. – Can be caused by: Dehydration, Hemorrhage, Injury, Septic shock, Serious illness, Surgery