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Efector functions of CD4+ and CD8+ T-cells Th1 Naive Naivna CD4+T Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production Organ-specific autoimmune diseases Defense- helmints Allergy Defense- extracellular bacteria, fungi Autoimmunity and chronic inflammation IL-12 Naive Naivna CD4+T IL-4 IL-23 Th1 IFN-γ Macrofage activation B-cells Th2 IL-4 IL-5 IL-13 Eosinophil activation B-cells… Th17 IL-17 IL-22 Neutrophil activation... T-bet GATA-3 RORgt TH1 response Efector functions of TH1 cells • Macrophage activation at the site of infection Efector functions of TH1 cells • Macrophage activation at the site of infection Efector functions of TH1 cells • Macrophage activation at the site of infection Efector functions of TH1 cells • Macrophage activation at the site of infection Efector functions of TH1 cells • Macrophage activation at the site of infection Efector functions of TH1 cells • Macrophage activation at the site of infection Efector functions of TH1 cells • B-cell activation Th1 Naive Naivna CD4+T Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production Organ-specific autoimmune diseases Defense- helmints Allergy Defense- extracellular bacteria, fungi Autoimmunity and chronic inflammation TH2 response Th1 Naive Naivna CD4+T Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production Organ-specific autoimmune diseases Defense- helmints Allergy Defense- extracellular bacteria, fungi Autoimmunity and chronic inflammation TH17 response Th1 Naive Naivna CD4+T Th2 Th17 Defense- intracellular pathogens, stimulation of IgG production Organ-specific autoimmune diseases Defense- helmints Allergy Defense- extracellular bacteria, fungi Autoimmunity and chronic inflammation CTL effector function Mechanisms of CD8+ T-cell cytotoxicity Mechanisms of CD8+ T-cell cytotoxicity Mechanisms of CD8+ T-cell cytotoxicity Mechanisms of CD8+ T-cell cytotoxicity Mechanisms of CD8+ T-cell cytotoxicity CD8+ Target cell CTL Mechanisms of CD8+ T-cell cytotoxicity perforin CD8+ CTL Target cell Mechanisms of CD8+ T-cell cytotoxicity perforin CD8+ granzimi Target cell CTL apoptosis Mechanisms of CD8+ T-cell cytotoxicity CD8+ Target cell CTL FasL Mechanisms of CD8+ T-cell cytotoxicity CD8+ Ciljna ćelija CTL FasL Fas apoptosis Pathogens avoid cellular immunity Inhibition of fusion of phagosome with lysosome Inhibition of presentation of viral antigens 0 Inhibition of immune response by virokines and viroreceptors 1. Subpopulations of efektor CD4+ Tcells are 2. TH1 effector function is a. production of IL-4, IL-5, IL-13 3. TH1 cells are important for defense against c. helminats 4. TH2 effector function is d. TH1, TH2 i TH17 5. TH2 cells are important for defense against b. Inflammatory reaction rich in eosinophils e. alternative macrophage activation f. mobilises and activates neutrophils 6. TH2 subpopulation induces g. IFN-γ production and macrophage activation 7. IL-4 and IL-13 induce also h. intracellular pathogens 8. IL-17 9. CTL effector function is i. perforin, granzymes, Fas-FasL interaction 10. CTL killing mechanisms are j. killing virus-infected and tumor cells d. g. 1._____ 2._____ h. a. 3._____ 4._____ c. b. e. 5._____ 6._____ 7._____ f. j. 8._____ 9._____ i. 10.____
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