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Transcript
Organs affected with AIDS-lymphoid tissue HIV in the nervous system AIDS dementia Karposi Sarkoma • First reported by Hungarian physician: Moritz Karposi in 1872 • Multifocal cancer: dominant type is called spindle cells: endothelial origin • Typically in older man in Mediterranian rim • In HIV-1: very aggressive: occurs in 20% of infected homosexual man, only 2% in others • Evidence that Herpes virus (HHV8) is necessary is strong Karposi Sarkoma Karposi Sarkoma Treatment of AIDS • HAART: highly efficient triple combination therapy: (2x anti-reverse transcriptase, 1xprotease inhib.) Viral decay on drug treatment Resistance of HIV to protease inhibitors HIV Infection is spreading over all continents Immune Therapies/Prophylactic vaccine development • • • • • Difficulties: Rapid mutations in virus Danger to cause an inappropriate immune response Necessity to target privileged sites (mucosa, brain) Small animal models not available Ethical issues of vaccination: people should adjust behaviour Perspectives • Prevention!!!!! • Multiple steps in viral replication offer new targets “Innate Immunity” Adelheid Cerwenka, PhD, D080 Theodor Boveri-Group since April 2003 PhD students Norman Nausch Kai Zanzinger Anja Schmidtke Technician Sandra Kosten
