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Medicinal Plants: Merging Science and Folklore P. Carr-Gumm, The Druid Plant Oracle Medicinal Plants: Merging Science and Folklore P. Carr-Gumm, The Druid Plant Oracle Purpose: to identify plants believed to have medicinal properties to test extracts of these plants for their ability to prevent growth of bacteria and yeast A Short History of Medicine <2000 B.C.E. "Here, eat this root." cookit.e2bn.org Neanderthals used herbal medicines 60-80,000 years ago wholeblossoms.com chestofbooks.com An early herbal success story: Willow Bark A Short History of Medicine, continued >2000 B.C.E. “Here, eat this root.” 1000 A.D. “That root is pagan nonsense. Here, say this prayer.” 1500 A.D. “That prayer is superstition. Here, drink this potion.” mentalfloss.com medievalists.net Another early herbal success story: Cinchona Bark Quinine livingorganisms-joshua.blogspot.com A Short History of Medicine, continued <2000 B.C.E. “Here, eat this root.” 1000 A.D. “That root is pagan nonsense. Here, say this prayer.” 1500 A.D. “That prayer is superstition. Here, drink this potion.” 1900 A.D. “That potion is snake oil. Here, swallow this pill.” sportingcollectibles.com Yet another early herbal success story: Foxglove Digitalis A Short History of Medicine, continued <2000 B.C.E. “Here, eat this root.” 1000 A.D. “That root is pagan nonsense. Here, say this prayer.” 1500 A.D. “That prayer is superstition. Here, drink this potion.” 1900 A.D. “That potion is snake oil. Here, swallow this pill.” 1945 A.D. “That pill is ineffective. Here, take this penicillin.” Penicillin attacks the bacterial cell wall Penicillin attacks the bacterial cell wall Penicillin Penicillin attacks the bacterial cell wall X X Origin of Antibiotic Resistance 1. Bacterium has a mutant cell wall that Penicillin can’t bind Penicillin resistant bacterium Origin of Antibiotic Resistance 1. Bacterium has a mutant cell wall that Penicillin can’t bind 2. Bacterium produce a compound that destroys Penicillin Penicillin resistant bacterium Why should we take all our antibiotics? [a simulation] Least resistant Somewhat resistant Highly resistant Step 1. Roll the die. Remove 5 chips, starting with the least resistant Do nothing Step 2. Add one chip for each color left in your pile. Step 3. Repeat Steps 1 and 2. A Short History of Medicine, final <2000 B.C.E. “Here, eat this root.” 1000 A.D. “That root is pagan nonsense. Here, say this prayer.” 1500 A.D. “That prayer is superstition. Here, drink this potion.” 1900 A.D. “That potion is snake oil. Here, swallow this pill.” 1945 A.D. “That pill is ineffective. Here, take this penicillin.” 1955 A.D. “Oops. . . Bugs fight back. Here, take this tetracycline.” 1960-2000 A.D. “More ‘oops.’ Here, take this more potent drug.” 2025 A.D. “Bugs have won! Here, eat this root.” Author unknown