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+ What occurs during the M phase? Sections 8.6 and 8.7 + Mitosis and Cytokinesis + Prophase (including prometaphase) Nuclear membrane breaks down Chromatin condenses into chromosomes Spindle fibers appear Centriole + spindle fibers = centrosome Centrosomes move to poles Nucleolus disappears Kinetochore of centromere on each sister chromatid attaches to spindle fiber + Prophase… + Metaphase Spindle is fully formed Chromosomes line up in the “middle” of the cell (at the metaphase plate – which is between the poles of the cell) + Anaphase Nonkinetochore microtubules elongate the cell Centromeres of sister chromatids split Motor proteins of kinetochores pull daughter chromosomes to the poles centromere 1st along microtubules Ends when chromosomes reach the poles + Telophase Nuclear membranes reappear (one around each set of chromosomes) Chromosomes uncoil to chromatin Nucleolus reappears Spindle breaks down Cytokinesis begins during this stage + Cytokinesis Division of cytoplasms Starts during telophase Animal Cells – pinching inward forms a cleavage furrow Plant cells – vesicles align between the two nuclei; vesicles fuse to form a cell plate; cell plate grows outward