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An unsuspected,
underdiagnosed Endocrine
PART I
Immune mechanism causing disease
in animals and humans.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
I have studied and treated as many
as 50,000
endocrine-immune cases in dogs,
cats and horses.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
What I have found is underdiagnosed
or perhaps unrecognized, or an
unsuspected mechanism that creates
disease.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
These cases vary from simple
allergies to autoimmunity
and cancer.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
It appears that a similar syndrome is
found in humans called CVID
(Common Variable
Immunodeficiency).
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
CVID appears to vary from allergies
to autoimmunity
and cancer.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
EI patients that I have
treated all have
(a).
(b).
(c).
(d).
Deficient or bound cortisol
Elevated total estrogen
Deficient or bound T3T4
Immunodeficient or
immunoderegulation of
B & T cells
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
Is there a first domino that falls
allowing for EI Syndrome or possible
CVID Syndrome?
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
In animals, the 1st domino to
fall is Cortisol.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
What causes this
Zona Fasciculata failure?
(a). Genetic damage
(b). Acquired damage
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
This EI Syndrome can be diagnosed
with blood tests in puppies, kittens &
foals as early as 4 to 6 weeks of age!
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
The parents of the offspring can be
tested and identified as the culprits
before Breeding, enabling the
prevention of
EI Syndrome in the offspring.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
Acquired damage to the
Zona Fasciculata may occur due to
toxicological sensitivity of
this layer.
(+/- environmental toxins, vaccines,
anesthesia, ingested
pharmaceuticals).
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
In animals, it is rare to see complete
adrenal cortex damage! Usually it is
the cortisol level that is affected
either temporarily or permanently.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
Quote Harvey on the toxicological sensitivity of
the adrenals and particularly the cortex as an
unappreciated factor. According to British
toxicology expert Philip Harvey, in The Adrenals
in Toxicity: Target Organ and Modulator of
Toxicity, the adrenal gland is the most
vulnerable organ in the endocrine system for
toxins, and within the adrenal gland “the
majority of effects” have been observed in the
cortex. Such disturbances can “fundamentally
affect the whole body physiology and
biochemistry”.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
In personal communication, Harvey
has told me that surveys of toxicity
within the endocrine system indeed
reveal that the adrenal cortex is a
very common target and factors
predisposing this are at its large
blood supply per unit mass,
Lipophilicity and
it is also rich in cytochrome
P450 enzymes.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
Hans Selye’s work on stress,
recognized in General Adaptation
Syndrome that chronic stress would
cause adrenal exhaustion and lead to
an EI Syndrome.
I also published these findings in
animals in 1978. In this published
paper, I theorized that in the
production from dopa to
norepinephrine, cortisol appeared to
be used as a catalyst.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
Selye prescribed cortisol to help
people, which was successful for a
while, but then moved into an over
adaptation phase which often
recreated the original syndrome with
the chronic stress it caused.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
In Dogs with chronic stress, thyroid
supplementation with cortisol for the
EI Syndrome will be necessary for
improvement.
Without thyroid supplementation, the
syndrome would improve temporarily
but eventually return, due to cortisol
replacement going from a
physiological dose level into a
pharmacological dose level, leading
to over adaptation.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
What is occurring with a defective
zona fasciculata?
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
What then does excess
estrogen do?
(a). Acts like histamine –
Therefore causing inflammation
(b). Binds T3T4
(c). Binds cortisol (bound cortisol
disallows transferance from
T4 – T3
(d). Deregulates B + T Cells
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
REMEMBER, THE ENDOCRINE
SYSTEM REGULATES THE
IMMUNE SYSTEM IN ANIMALS.
USUALLY THESE SYSTEMS DO
NOT ACT INDEPENDENTLY.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
If you find similarities between an EI
Syndrome on CVID common variable
syndrome, then your measuring stick
is identifying factual B cell antibody
levels and correcting them and the
disease with proper hormone
therapy. Remember, each patient will
and should be different.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
I had to create my own clinical norms
for IgG, IgM & IgA.
You will need to do this also.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
The IgA level will determine if
malabsorption is present and
whether oral hormone replacement
will effectively normalize the immune
system.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
T cell regulation usually
accompanies B cell regulation.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
Some of you here are familiar with
the concept of low-dosage, long term
cortisone.
Others may be appalled by any
thought of long-term cortisone.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
Among us here is William Jefferies, M.D., who has
pioneered for decades the practice of long-term,
low-dosage cortisone replacement that is both safe
and hugely effective for allergies, chronic fatigue,
and rheumatoid conditions. Other physicians have
started to realize as well that cortisone, at low
dosage, can be a major long term therapy modality.
At pharmacologic dosages, it is indeed
immunosuppressive. However, at physiologic lowdosage level, in the presence of a cortisol
deficiency, which I believe is extremely common
among people because of a combination of genetic,
toxicity, and prolonged stress, cortisone is a great
healing medicine.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
Dr’s Barnes and Hertoghe Identified
the importance of thyroid therapy in
humans.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
With my EI syndrome in animals, in
particular dogs, I have found that
proper thyroid supplementation will
guarantee keeping cortisol
supplementation at a physiological
regulatory level and correct this EI
Syndrome.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
The next hour will discuss clinical
testing and supplementation of the EI
Syndrome.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
An unsuspected,
underdiagnosed Endocrine
PART II
Immune mechanism causing disease
in animals and humans.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
Phase 1 protocol – Blood
FEMALE:
MALE:
Blood Cortisol
TSH
T3
T4
Total Estrogen
Testosterone
(total & free)
IgA, IgM, IgG
May 24, 2017
Blood Cortisol
TSH
T3
T4
Total Estrogen
Progesterone
Testosterone
(total & free)
Ferritin
IgA, IgM, IgG
Dr. Alfred J. Plechner DVM
Copyright 2008
Phase 1 protocol – Urine
MALE:
24 hour urine
collection
1. Active Cortisol
2. Free T3
3. Free T4
May 24, 2017
FEMALE:
24 hour urine
collection
1. Active Cortisol
2. Free T3
3. Free T4
Dr. Alfred J. Plechner DVM
Copyright 2008
Phase 1 protocol –
Basal Metabolic Temperature
MALE:
FEMALE:
Upon waking, place
thermometer in axilla for
10 minutes before
getting up.
Normal temperature
should be 97.8 – 98.2
degrees.
May 24, 2017
Upon waking, place
thermometer in axilla for
10 minutes before
getting up.
Normal temperature
should be 97.8 – 98.2
degrees.
Only accurate in a
menstruating woman
Dr. Alfred J. Plechnerfrom
DVM 2nd to 4th day.
Copyright 2008
In my experience with dogs,
I have found that a physiological
dose level of cortisol may become a
pharmacological dose level if used
without thyroid supplementation.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
If this fact is true, then what happens
to any hormone supplementation? In
canines and humans, that must be a
concern about a pharmacological
build up of a particular hormone
causing various hormone cycles
resulting in damage to our patients.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
If with CVID – common variable
immunodeficiency syndrome, how do
you determine a normal immune
measuring stick with the different
laboratory normals that are now
available?
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
I analyzed reference ranges from 15
major human medical labs. Many
laboratories used the same lab kits
for the immunoglobulin, yet there are
wide discrepancies in what these
laboratories regard as normal.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
These are the variable ranges for
normal ranges according to each to
each laboratory:
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
IgG results from various
human laboratories
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
IgM results from various
human laboratories
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
IgA results from various
human laboratories
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
Based upon these results, you
definitely need an international
standardized reference range
on an international basis that
you create!
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
By removing the high & low and
possibly removing 10% of the lower
and higher levels, your immune
measuring stick may be closer to
being accurate.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
IgG
700 - 1500mg/dl
IgM
50 - 200mg/dl
IgA
70 - 350mg/dl
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
Obviously, as you normalize
your patients, these values will
be modified based on your clinical
results.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
This is merely an attempt to show you
that depending on the variability of the
lab test results your patient may be
normal or highly abnormal, which
would lead to improper therapy based
upon inaccurate laboratory results.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
My EI Syndrome and possibly your
CVID Syndrome relates from simple
allergies to all autoimmune disorders
and all cancers in animals.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
Finally, remember, in all animals with
cancer, there is deficient or bound
cortisol, elevated total estrogen,
deficient transfer defect or bound
T3T4 and deregulated B & T cells.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008
Fortunately, you and I practice for
our patient first, and our profession
second.
May 24, 2017
Dr. Alfred J. Plechner DVM
Copyright 2008