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Curcumin Extreme™ Julian Blumenfeld, MD Chief Medical Officer Market America & nutraMetrix Curcumin Extreme™ Code: 13145 and 13145NM Curcumin Extreme™ • Curcumin (BCM-95®): 400 mg • Broccoli Seed Extract (6% Glucosinolates): 167 mg • Selenium (Selenomethionine): 100 mcg Curcumin •Turmeric root extract •3 major curcuminoids •Curcumin •Demethoxycurcumin •Bis-demethoxycurcumin Curcumin: Biological Activities • Powerful antioxidant •Reduces superoxide anions • Promotes normal activity of NF-kappaB •Reduces peroxides •Inhibits LDL oxidation and lipid peroxidation • Promotes normal cell cycle activity, normal cellular regeneration • Promotes neurological health, helps to maintain neurological health as we age Curcumin: Biological Activities • Powerful antioxidant • Promotes normal activity of NF-kappaB In unhealthy cells, curcumin has been shown to •interfere Promotes normal cell cycle activity, normal with multiple cell signaling pathways, including cellregeneration cycle (cyclin D1 and cyclin E) and cellular apoptosis. -Anand, P., etneurological al. Curcumin and cancer: an “old-age” diseaseto with • Promotes health, helps an “age-old” solution. Cancer Letters. 267: 133-164, 2008. maintain neurological health as we age Curcumin: Biological Activities Curcumin: Biological Activities • Powerful antioxidant • Promotes normal activity of NF-kappaB Curcumin can cross the blood-brain barrier and bind •directly Promotes normal cycle activity, normal to amyloid plaquescell and increase the uptake of amyloid-β protein by macrophages. cellular regeneration -Zhang, L., et al. Curcuminoids enhance amyloid-beta uptake by macrophages • ofPromotes neurological to1-7, 2006. Alzheimer’s disease patients. Journal ofhealth, Alzheimer’s helps Disease. 10: maintain neurological health as we age Curcumin: The BCM-95® Difference Broccoli Seed Extract (6% Glucosinolates) • Promotes the normal production of detoxification enzymes • Helps maintain healthy Cytosolglutathione levels H H Nucleus S S apoptosis in unhealthy • Promotes cells keap1c keap1m • Promotes a strong immune system nrf2 keap1m keap1c S H S H ARE GST’s, GR, GPx, HO-1 Broccoli Seed Extract (6% Glucosinolates) • Promotes the normal production of detoxification enzymes • Helps maintain healthy glutathione levels • Promotes apoptosis in unhealthy cells • Promotes a strong immune system – Enhance total white blood cell count – Enhance phagocytic activity – Reduced elevated TNFα from LPS stimulated macrophages -Thejass, P. and Kuttan, G. Immunomodulatory activity of sulforaphane, a naturally occuring isothiocyanate from broccoli (Brassica oleracea). Phytomedicine. 14: 538-545, 2006. Selenium (Selenomethionine) • Required cofactor for selenoproteins – Glutathione peroxidase enzymes Glutathione H H H Glutathione H O O H H – Iodothyronine deiodinase enzymes Thyroxine (T4) Thyroid Hormone (T3) -Brown, K. and Arthur, J. Selenium, selenoproteins and human health: a review. Public Health Nutrition. 4: 593-599, 2001. Curcumin Extreme™ Directions: Take one capsule per day, with or without a meal. Warning: If you are currently taking warfarin (Coumadin) or other anti-platelet/anti-coagulant medications, you should not take this product. If you are taking any other prescription drugs or have an ongoing medical condition, you should consult your physician before using this product. Women who are pregnant or nursing should not take this product. Summary • Curcumin Extreme™ – Curcumin (BCM-95®): 400 mg – Broccoli Seed Extract (6% Glucosinolates): 167 mg – Selenium (Selenomethionine): 100 mcg • Why curcumin? Why now? • Who would benefit? Curcumin Extreme™ Code: 13145 and 13145NM DC: $28.50 SR: $39.95 BV: 23