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The brain stem SHANDONG UNIVERSITY Liu Zhiyu The brain stem Consists of Midbrain Pons Medulla oblongata The brain stem Position The brain stem occupies the posterior cranial fossa of the skull Gross Appearance of the Brain Stem Ventral Surface of the Brain Stem Medulla oblongata Pyramid: Composed of bundles of nerve fiber, pyramidal tract Decussation of pyramid: Formed by crossing fibers of pyramidal tract Olive: Produced by underlying inferior olivary nucleus Anterolateral sulcus : Emerge the roots of hypoglossal nerve Retroolivary sulcus : Emerge the roots of glossopharyngeal, vagus and accessory nerves Ventral Surface of the Brain Stem Pons Basilar part Basilar sulcus Bulbopontine sulcus: There emerge, from medial to lateral, the abducent, facial and vestibulocochlear nerves Middle cerebellar peduncle Trigeminal nerve Emerges from the junction of basilar part and middle cerebellar peduncles Pontocerebellar trigone: The junction of medulla, pons and cerebellum Ventral Surface of the Brain Stem Midbrain Crus cerebri Interpeduncular fossa Oculomotor nerve emerges on the medial side crus cerebri Posterior perforated substance Dorsal Surface of the Brain Stem Medulla oblongata Lower portion Gracile tubercle: produced by underlying gracile nucleus Cuneate tubercle: produced by underlying cuneate nucleus Inferior cerebellar peduncle Obex Upper portion: forms the lower half of rhomboid fossa Dorsal Surface of the Brain Stem Pons Superior cerebellar peduncle Superior medullary velum Trochlear nerve Dorsal Surface of the Brain Stem Midbrain Superior colliculus Constitute centers for visual reflexes Inferior colliculus Associated with auditory pathway Brachium of superior colliculus Brachium of inferior colliculus Fourth ventricle Central canal →fourth ventricle →mesencephalic aqueduct→third ventricle Position Situated ventral to cerebellum, and dorsal to pons and cranial half of medulla Floor of the Fourth ventricle — Rhomboid Fossa Boundaries Inferolateral: gracile and cuneate tubercles, inferior cerebellar peduncle Superolateral: superior cerebellar peduncle Lateral recess Floor of the Fourth ventricle — Rhomboid Fossa Features Median sulcus Sulcus limitans Vestibular area Overlies vestibular nuclei Acoustic tubercle Overlying dorsal cochlear nucleus Medial eminence Striae medullares Floor of the Fourth ventricle — Rhomboid Fossa Facial colliculus Overlies nucleus of abducent n. and genu of facial nerve Hypoglossal triangle Overlies hypoglossal nucleus Vagal triangle Overlies dorsal nucleus of vagus nerve Funiculus separans Area postrema Locus ceruleus Bluish-gray in color, it owes its color to a group of deeply pigmented nerve cells Roof of the Fourth ventricle Anterior part: Formed by superior cerebellar peduncle and superior medullary velum Posterior part: Formed by inferior medullary velum and choroid plexus of fourth ventricle Three apertures Median aperture of fourth ventricle Two lateral apertures of fourth ventricle Tela choroidea and choroid plexus Internal structure of the brain Stem Internal structure of the brain Stem Central canal Gray matter Cranial nerve nuclei Relay nuclei General somatic motor nuclei Special visceral motor nuclei General visceral motor nuclei Visceral sensory nuclei ( general and special ) General somatic sensory nuclei Special visceral motor nuclei White matter Reticular formation of brain stem Cranial nerve nuclei General somatic motor nuclei Nucleus of oculomotor n. Nucleus of trochlear n. Nucleus of abducent n. Nucleus of hypoglossal n. General somatic motor nuclei Nucleus of oculomotor n. Nucleus of trochlear n. Nucleus of abducent n. Nucleus of hypoglossal n. General somatic motor nuclei Nucleus Site Cranial n. Function Nucleus of oculomotor n. Midbrain Ⅲ Supreior, inferior,and medial recti, inf. obliquus, levator palpebrae superioris Nucleus of trochlear n. Midbrain Ⅳ Superior obliquus Nucleus of abducent n. Pons Ⅵ Lateral rectus Medulla Ⅻ Muscles of tongue Nucleus of hypoglossal n. Special visceral motor nuclei Motor nucleus of trigeminal n. Nucleus of facial n. Nucleus ambiguus Accessory nucleus Special visceral motor nuclei Motor nucleus of trigeminal n. Nucleus of facial n. Nucleus ambiguus Accessory nucleus Special visceral motor nuclei Nucleus Site Cranial n. Function Motor nucleus of trigeminal n. Pons Ⅴ Masticatory muscles, anterior belly of digastric, mylohyoid Nucleus of facial n. Pons Ⅶ Facial m., platysma, posterior belly of digastric, stylohyoid, stapedius Nucleus ambiguus Medulla Ⅸ,Ⅹ, Ⅺ Accessory nucleus Medullacervical cord Ⅺ Skeletal m. of pharynx, larynx and upper part of esophagus Sternocleidomastoid, trapezius General visceral motor nuclei Accessory oculomotor nucleus Superior salivatory nucleus Inferior salivertory nucleus Dorsal nucleus of vagus n. General visceral motor nuclei Nucleus Site Cranial n. Function Accessory oculomotor nucleus Midbrain Ⅲ Sphincter pupillae and ciliary m. Superior salivatory nucleus Pons Ⅶ Submandibular, sublingual and lacrimal glands Inferior salivertory nucleus Medulla Ⅸ Parotid gland Dorsal nucleus of vagus n. medulla Ⅹ Many cervical, thoracic and abdominal viscera Visceral sensory nuclei ( general and special ) Nucleus of solitary tract Visceral sensory nuclei ( general and special ) Nucleus Nucleus of solitary tract Site Cranial n. Function Medulla Ⅶ,Ⅸ,Ⅹ Taste and visceral sensation General somatic sensory nuclei Mesencephalic nucleus of trigeminal n. Pontine nucleus of trigeminal n. Spinal nucleus of trigeminal n. General somatic sensory nuclei Nucleus Site Cranial n. Function Mesencephalic Midbrain nucleus of trigeminal n. Ⅴ Proprioception of head Pontine nucleus of trigeminal n. Pons Ⅴ Tactile sensation of head Spinal nucleus of trigeminal n. Medulla Ⅴ Pain and temperature sense of head Special somatic sensory nuclei Cochlear nuclei Vestibular nuclei Special somatic sensory nuclei Nucleus Site Cranial n. Function Pons and medulla Ⅷ Sense of hearing Vestibular nuclei Pons and medulla Ⅷ Sense of equilibrium Cochlear nuclei Relay nuclei Superior colliculus Nucleus of inferior colliculus Red nucleus Substantia nigra Pretectal area Superior olivery nucleus Pontine nucleus Nucleus ceruleus Gracile nucleus Cuneate nucleus Inferior olivary nucleus Non-cranial nerve nuclei Nucleus Site Superior colliculus Midbrain Nucleus of inferior colliculus Midbrain Red nucleus Midbrain Substantia nigra Midbrain Pretectal area Midbrain Superior olivery nucleus Pons Pontine nucleus pons Nucleus ceruleus pons Gracile nucleus Medulla (underneath gracile tubercle) Cuneate nucleus Medulla (underneath cuneate tubercle) Inferior olivary nucleus Medulla White matter Ascending tracts Medial lemniscus Spinothalamic tract (Spinal lemniscus ) Trigeminothalamic tract (Trigeminal lemniscus ) Lateral lemniscus Ascending tracts Central thalamic radiation VPL 3°neurons Medial lemniscus Medial lemniscus Gracile and cuneate nuclei 2°neuron Decussation of medial lemniscus Fasciculus cuneatus T4 Spinal ganglion 1°neuron Fasciculus gracilis Ascending tracts Spinothalamic tract Central thalamic radiation VPL 3°neurons (Spinal lemniscus) Spinal lemniscus anterior spinothalamic tract LaminaⅠ,Ⅳ~Ⅶ 2°neuron Spinal ganglia 1°neuron Lateral spinothalamic tract Ascending tracts Trigeminothalamic tract (Trigeminal lemniscus) Pontine nucleus of V 2°neuron Trigeminal ganglion 1°neuron Spinal tract of trigeminal n. Spinal nucleus of V 2°neuron Central thalamic radiation VPM 3°neurons Trigeminal lemniscus Ascending tracts Lateral lemniscus Descending tracts Pyromidal tract Corticospinal tract Corticonuclear tract Rubrospinal tract Tectospinal tract Vestibulospinal tract Reticulospinal tract Reticular Formation of Brain Stem Ascending reticular activating system (ARAS) Motor central and vital centres Reticulospinal tract Cardiovascular center Respiratory center Serotonergic rapheal nuclei The characters of internal structure of brain stem Medulla oblongata Lower part (closed part) Two decussations Decussations of medial lemniscus Decussations of pyramid Medulla oblongata Upper part (open part) Appearance of inferior olivary nuculeus and inferior cerebellar peduncle Enlargement of central canal to form the fourth ventricle floor Pons Tegmentum of pons Directed upward continuation of medulla oblongata Basilar part Contain both longitudinal and transverse fibers intermixed with pontine nuclei Midbrain Rectum of midbrain Includes superior and inferior colliculi Cerebral peduncle Tegmentum contain ascending tracts, mesencephalic aqueduct, central gray matter, recticular formation and so on Substentia nigra Crus cerebri Pyramidal tract middle three-fifths of the crus Frontopontine tract medial one-fifth Pariatotempopontine tract lateral one-fifth Midbrain Rectum of midbrain Includes superior and inferior colliculi Cerebral peduncle Tegmentum contain ascending tracts, mesencephalic aqueduct, central gray matter, red nucleus, recticular formation and so on Substentia nigra Crus cerebri Pyramidal tract middle three-fifths of the crus Frontopontine tract medial one-fifth Pariatotempopontine tract lateral one-fifth