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CNS Gross Anatomy 1 Roles of the CNS • Functions of neurons in the CNS (brain and spinal cord) include: – Sensor: Receives environmental and body stimuli – Integrator: Combines information received – Effector: Initiates body movements – Regulator: Maintains homeostatic state for body function 2 Nervous System • The CNS is protected and isolated. – Bone offers protection from injury • Skull covers brain • Vertebral Column covers spinal cord – The is encased in soft-tissue membranes – The brain’s blood vessels stop many subastances from entering the brain (blood-brain barrier) • Protects from contamination/infection – The brain floats in cerebral spinal fluid • Offers protection from impact 3 The Meninges • Dura Mater: Tough outer covering • Arachnoid Mater: Middle layer • Pia Mater: Inner closely formed layer 4 Cerebrospinal Fluid (CSF) • Located between the meninges and in the ventricular cavities of the brain • Produced in the ventricular cavities by the choroid plexus • Functions – mechanical buffer – fluid for metabolic functions 5 "Copyright © 2005 by Thompson Delmar Learning, a division of Thomson Learning, Inc. ALL RIGHTS RESERVED" CSF • CSF is in ventricles, subarchnoid space, interventricular foramens, and around the spine. • Circulates from ventricles around brain and spinal column • Is finally absorbed by venous system • Replenishes at ventricles every 7 hours 6 Divisions of the PNS • Somatic Nervous System (under voluntary control) – Sensory and Motor – Skin and Muscles • Autonomic Nervous System (can not be voluntarily controlled). – – – – Sensory and Motor Visceral organs and glands Two main subdivisions: Sympathetic: Fight, Flight, Fear • Prepare to expend energy – Parasympathetic: Regulates normal function • Prepare to conserve energy 7 Major Structures of the Brain • Longitudinal Fissure – Separates Two Hemispheres of the Brain – Aka ‘Interhemispheric Fissure’ 8 • The folds of your brain are like a fingerprint – there are a few general patterns, with individual variability. • Two main folds – Central Sulcus Fissure of Rolando Rolandic sulcus – Lateral sulcus Sylvian fissure The central sulcus separates the frontal and parietal lobes. The lateral sulcus separates the temporal lobe from frontal, parietal, insula 9 The major cortical lobes Insular Lobe – Tucked away, but often injured in patients seen by speech pathologists 10 Major medial sulci Central Sulcus Parieto-occipital Sulcus Calcarine Sulcus Preoccipital Notch 11 Landmarks of the frontal lobe • • • • • • Frontal Pole Precentral Gyrus Precentral Sulcus Premotor Cortex Speech, Fine Motor Prefrontal Cortex 12 Frontal Lobe Functions • Motor Function • Cognitive Functions • Reasoning, Abstract Thinking, SelfMonitoring, Decision Making, Planning, Inhibition • Organization of Spoken Language Frontal Motoric Areas 13 Broca Area – speech production Pars triangularis (Inferior fronal gyrus) Pars orbitalis (Inferior frontal gyrus) Pars opercularis (Inferior frontal gyrus) 14 Parietal Lobe Landmarks • Post Central Gyrus (PoCG) – Primary Sensory Cortex • Superior and Inferior Parietal Lobules (SPL, AnG,SmG) – Perceptual Synthesis, Spatial Orientation, Memory • Angular Gyrus (AnG) Supramarginal Gyrus (SMG) – In Dominant Hemisphere: Reading, Writing and Calculation 15 The homunculus (little man) • The motor strip (red, frontal cortex) and primary sensory cortex (green, parietal) spatially map corresponding portions of the contralateral hemisphere. 16 Temporal Lobe – Major External Gyri • Superior Temporal Gyrus • Middle Temporal Gyrus • Inferior Temporal Gyri Temporal Pole 17 Temporal Operculum • Dorsal surface of STG is called the ‘Temporal Operculum’ (Lip) – Middle section: Heschel’s Gyri (Brodmann Areas 41 + 42) • Auditory Reception Cortex – Posterior section: Wernicke’s Area (Brodmann 22) • Auditory Association Cortex Heschl’s Gyrus • Primary auditory cortex found in Heschl’s gyrus • This is organized tonotopically – a high pitched sound excites a different region than low pitched sounds. 19 Superior Temporal Gyrus • Auditory Cortex lies inside the Superior Temporal Sulcus • Part of the superior temporal gyrus that is planum temporale imperative for the (nonprimary AC) Heschl’s gyrus perception of speech is (primary AC) Heschl’s gyrus planum polare (nonprimary AC) Ventral-Medial Structures • Temporal Lobe – Fusiform gyrys (Face Recognition) – Hippocampal Gyrus (places, memory) – Uncus (smell) • Occipital lobe – Cuneus and Lingual gyrus (primary vision) 21 Medial View Ventral-Medial Structures Uncus Parahippocampal Gyrus Fusiform Gyrus Lingual Gyrus Cerebellum and Brainstem removed 22 Occipital Lobe • Occipital Pole (medial) – Medially: cuneus and lingual gyrus: primary visual cortex – Clinically: field cuts, blindsight • Lateral occipital structures: – Superior, Lateral and Superior Occipital Gyris: Secondary Visual Cortex (Association) 23 Language Areas 24 Insular Lobe (Isle of Reil) • Deep in Lateral Fissure – Functions: Language(?), taste, disgust, cravings (e.g. smoking) Midsagittal Surface • Corpus Callosum – Connects Hemispheres • Limbic System – Emotions • • • • Cingulate Gyrus Fornix Thalamus Hypothalamus 26 Midsagittal Surface Corpus Callosum Cingulate Gyrus Septum Uncus Fornix 27 Transverse Slice Fornix Claustrum Putamen Caudate Nucleus Thalamus Globus Pallidus 28 Brain Stem Optic Nerve Midbrain Pons Medulla Optic Chiasm Optic Tract Pes Pedunculi Pituitary Stalk 29 Basal Ganglia • • • • Caudate Nucleus Putamen Globus Pallidus (Pallidum) Caudate Nucleus +Putamen = Striatum • Putamen + Globus Pallidus = Lenticular Nucleus 30 Striatum Head of Caudate Nucleus Cleft for Internal Capsule Thalmus Putamen Amygdaloid Nucleus Tail of Caudate Nucleus 31 Lateral View