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Expanding Your Volumes Lori Blackner, D.Ph. Jordan Marshall Jeremy Wycherly Case Study Wanda B. Young is a 47-year-old white female who, over the past ten years: • spent $10,000 on a face lift • spent $5,000 on liposuction • had laser resurfacing at $2,000 • had her hair highlighted and conditioned • had her nails done and pedicures weekly She spares no expense to try and keep her youthful appearance, including all of the most expensive skin care products she can find at department stores . Wanda B. is not Happy Still Wanda B. Young struggles. Despite all she does for the outside she looks in the mirror and still does not have that “healthy youthful glow.” She seems to lose ground faster than she can make an appointment for a new expensive procedure! Wanda B. is not Healthy Wanda B. is not even trying to be healthy: • She refuses to pay $30.00 a month on a multivitamin • Every Monday she starts the newest fad diet • She smokes on occasion • She consumes alcohol regularly • She views a gym membership as a waste of money • She thinks sodas and chocolate are part of the food pyramid • She never wears a sunscreen and visits the tanning bed weekly. Wanda B. is Clueless Unfortunately, Wanda B. Young does not know about Pharmanex. She wants to feel like this. She does not know that nutrition and lifestyle affect beauty, youthfulness, and well-being. Health is more than Skin Deep The skin is the largest organ in the body and is of primary importance to our survival. It reflects to the outside the state of health on the inside. In fact, your skin is an outward reflection of your inward commitment to health. Healthy Skin = Healthy Living The skin has many important clinical functions • Body temperature maintenance • Excretion of waste and toxins • Photochemical action promotes the production of vitamin D • Sensory function, pressure, texture, temperature and pain • Pigmentation, melanin pigments develop to protect against UV light damage • First line of defense to the outside world/pathogens Healthy Skin = Healthy Living • The skin reflects the health and nutrition that is put into the body • All of the outside treatments can not make up for poor nutrition and poor lifestyle choices that affect the inside Tēgreen 97® • Provides potent antioxidant defense against cellular free radical impairment* • Supports healthy cell function while protecting cell structures, including DNA* • Increases the body’s metabolic rate through a thermogenic effect* • Helps promote healthy skin collagen and elastin integrity* *These statements have not been evaluated by the Food and Drug Administration. This product Is not intended to diagnose, treat, cure, or prevent any disease. Stanford Study Title: A Double-blinded, Placebo-controlled Trial to Determine the Role of Green Tea Extracts in Clinical and Histological Appearance of Photoaging Skin Participants: 35 women Treatment group : Green tea supplement 300mg bid Duration: 8 weeks Results: Skin showed a significant improvement in elastic tissue content for the green tea treated group when compared to placebo* *These statements have not been evaluated by the Food and Drug Administration. This product Is not intended to diagnose, treat, cure, or prevent any disease. Estera™ •Promotes a healthy balance of favorable estrogen metabolites* •Promotes normal hormone balance* •Addresses phase-specific symptoms* *These statements have not been evaluated by the Food and Drug Administration. This product Is not intended to diagnose, treat, cure, or prevent any disease. Estera™ • Hormone receptors in the skin indicate a direct link between skin health, appearance, and hormone balance • Increase of androgens compared to estrogens cause increased sebum production • Estrogens are correlated with brown splotches • Elasticity and collagen production is linked with estrogen and genistein Genistein Poster Presentation NAMS Convention 2004 • Brazilian University group • Study covered 40 postmenopausal women consuming 40mg/day of genistein for six months • Biopsies of face were taken before and after • Participants saw a significant increase in collagen and elastin in facial tissue* *These statements have not been evaluated by the Food and Drug Administration. This product Is not intended to diagnose, treat, cure, or prevent any disease. DHEA • Women 25-50mg daily: Men 50-100mg daily • JAMA 2004, Men and women, 50mg daily for 6 months. Reduced fat around belly, increased lean muscle mass, increased insulin sensitivity • MENOPAUSE 2004, Postmenopausal women, 50mg daily, six week study. Increasing DHEA levels revealed significant decrease in sexual distress and significant increase in sexual function in desire, arousal, lubrication, satisfaction, and orgasm. • Also studies on cardiovascular health, immune system, bone health, emotional outlook, and quality of life Topical DHEA • J Invest Dermatol. 2005 Feb • Modulation of collagen metabolism by topical application of DHEA to human skin • DHEA may be related to the process of skin aging through the regulation and degradation of extracelluar matrix protein • DHEA was applied to skin of buttocks of 12 volunteers for 4 weeks • DHEA increased procollagen synthesis and inhibited collagen degradation. Stress and Skin Title: The interaction between acne vulgaris and the psyche. Author: Baldwin HE. Publication: Cutis 2002 Aug;70(2):133-9. Department of Dermatology, State University of New York at Brooklyn, USA. Title: Stressful life events and skin diseases: disentangling evidence from myth. Authors: Picardi A, and Abeni D. Publication: Psychother Psychosom 2001 May-Jun;70(3):118-36. Clinical Epidemiology Unit, Istituto Dermopatico dell'Immacolata IDI-IRCCS, Rome, Italy. Title: An epidemiological study of acne in female adults: results of a survey conducted in France. Authors: Poli F, et al. Publication: J Eur Acad Dermatol Venereol 2001 Nov;15(6):541-5. Hjpital Henri Mondor, Service de Dermatologie, Creteil, France. Stress and Skin Title: Pathogenesis of acne. Authors: Toyoda M, and Morohashi M. Publication: Med Electron Microsc 2001 Mar;34(1):29-40. Department of Dermatology, Toyama Medical and Pharmaceutical University, Toyama, Japan. Title: Corticotropin-releasing hormone: an autocrine hormone that promotes lipogenesis in human sebocytes. Authors: Zouboulis CC et al. Publication: Proc Natl Acad Sci U S A 2002 May 14;99(10):7148-53. Department of Dermatology, The Free University of Berlin, Germany. Diet and Skin Title: Participants: Methods: Conclusion: Skin wrinkling: can food make a difference? 177 Greek-born subjects living in Melbourne (GRM) 69 Greek subjects living in rural Greece (GRG) 48 Anglo-Celtic Australian (ACA) elderly living in Melbourne 159 Swedish subjects living in Sweden (SWE) Dietary intakes measured & skin wrinkling assessed High intake of vegetables, legumes and olive oil appear to be protective against skin wrinkling. J Am Coll Nutr 2001 Feb;20(1):71-80 Back to Wanda B. Young Wanda B. Young found that her neighbor is a Pharmanex/Nu Skin Personal Care Distributor. She is now enlightened to the facts of “beauty from the inside out.” Wanda B. Young is Happy • She takes Pharmanex® Tēgreen 97®, LifePak®, MarineOmega, Estera™ Phase III, and Estera™ Topical Cream • She joined a gym and is exercising • She is using Nu Skin skin care, and has drastically cut her beauty treatment expenses • She is eating a nutritional diet • She is starting to see signs of “that healthy youthful glow” • Everyone is happy except her “Plastic Surgeon!” Summary You need all the pieces of the puzzle to achieve your goals: nutrition and lifestyle for health and wellness, as well as topical application of skin-beneficial ingredients