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Psychology 304: Brain and Behaviour Lecture 4 1 Research Methods 1. How do biological psychologists assess the structure and function of the nervous system? (continued) 2 By the end of today’s class, you should be able to: 1. describe the diverse methods used by biological psychologists to assess nervous system structure and function. 3 How do biological psychologists assess the structure and function of the nervous system? (continued) 3. Imaging Allows researchers to observe the structure and function of the living brain. A number of imaging techniques are available. Examples: 4 Computerized tomography (CT): Computers are used to enhance X-ray images of the nervous system. Provides images of brain structure. 5 CT Scans (Single Slice and 3D) 6 Positron emission tomography (PET): Subjects are administered a radioactive substance, often attached to glucose. A scanner detects the radioactive substance, indicating where glucose consumption and physiological activity are greatest. Provides images of brain activity. Red and yellow indicate areas of high activity. 7 PET Scans (Single Slice) 8 Functional magnetic resonance imaging (fMRI): Magnetic fields are used to detect changes in oxygen flow. A scanner detects brain regions where oxygen is delivered at higher concentrations, indicating where physiological activity is greatest. Provides images of brain structure and brain activity. Red and yellow indicate areas of high activity. 9 fMRI Scans (Single Slice) 10 fMRI Scan (3D) 11 4. Recording Allows researchers to record the electrical and magnetic output of the living brain. The small electrical charges and magnetic fields that nerve cells generate are measured using electrodes. A number of recording techniques are available. Examples: 12 Electroencephalography (EEG): Electrodes, placed on the scalp, measure the electrical activity of a large number of nerve cells. Changes in EEG signals that are elicited by the presentation of sensory stimuli are referred to as sensory evoked potentials. Provides a measure of brain activity. 13 EEG Recordings Associated with Different States of Consciousness 14 Presentation of visual stimulus Sensory Evoked Potentials 15 Image 2 Image 1 EEG Recordings for Comatose Patients Image 3 16 Single cell recordings: Surgically implanted microelectrodes measure the electrical activity of single nerve cells. Provides a measure of the activity of a single neuron. Typically conducted with nonhuman subjects. 17 Single Cell Recording 18 5. Electrical Stimulation Allows researchers to determine the functions of distinct brain regions (i.e., functional localization). Involves artificially stimulating distinct regions and assessing changes in behaviour. Electrical stimulation is delivered through electrodes; the electrical current increases the firing of neurons at the tip of the electrode. 19 Stimulation is applied during neurosurgery. Using this method, researchers have identified brain regions that produce distinct motor movements. These regions are depicted by the motor homunculus: 20 Primary motor cortex The Motor Homunculus 21 Research Methods 1. How do biological psychologists assess the structure and function of the nervous system? (continued) 22