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Huntington’s Disease
Huntington's Disease is an autosomal dominant genetic disorder Meaning that
if a parent has Huntington's there is a 50% chance the child will have the
disease as well.
Huntington’s involves a degeneration of striatal GABAergic medium
spiny projection neurons in the subependymal layer lining the
ventricles.
The subependymal layer in lining the ventricles degenerates gradually
and constantly impacting the size and overall appearance of the brain.
Coordinative muscle and cognitive function become noticeable around middle
age. Characteristic manifestations of Huntington's Disease include uncontrolled
movements, loss of intellectual faculties, and emotional disturbance. The onset
as well as the progression of the disease is different for every patient.