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Chapter 6
The Muscular System
Lecture Presentation by
Patty Bostwick-Taylor
Florence-Darlington Technical College
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The Muscular System
 Muscles are responsible for all types of body
movement
 Three basic muscle types are found in the body
1. Skeletal muscle
2. Cardiac muscle
3. Smooth muscle
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Characteristics of Muscles
 Skeletal and smooth muscle cells are elongated
(muscle cell  muscle fiber)
 Contraction and shortening of muscles is due to the
movement of microfilaments
 All muscles share some terminology
 Prefixes myo and mys refer to “muscle”
 Prefix sarco refers to “flesh”
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Table 6.1 Comparison of Skeletal, Cardiac, and Smooth Muscles (1 of 3)
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Table 6.1 Comparison of Skeletal, Cardiac, and Smooth Muscles (2 of 3)
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Table 6.1 Comparison of Skeletal, Cardiac, and Smooth Muscles (3 of 3)
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Skeletal Muscle Characteristics
 Most are attached by tendons to bones
 Cells are multinucleate
 Striated—have visible banding
 Voluntary—subject to conscious control
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Connective Tissue Wrappings of Skeletal
Muscle
 Cells are surrounded and bundled by connective
tissue
 Endomysium—encloses a single muscle fiber
 Perimysium—wraps around a fascicle (bundle) of
muscle fibers
 Epimysium—covers the entire skeletal muscle
 Fascia—on the outside of the epimysium
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Figure 6.1 Connective tissue wrappings of skeletal muscle.
Muscle
fiber
(cell)
Blood vessel
Perimysium
Epimysium
(wraps entire
muscle)
Fascicle
(wrapped by
perimysium)
Endomysium
(between
fibers)
Tendon
Bone
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Skeletal Muscle Attachments
 Epimysium blends into a connective tissue
attachment
 Tendons—cordlike structures
 Mostly collagen fibers
 Often cross a joint because of their toughness and
small size
 Aponeuroses—sheetlike structures
 Attach muscles indirectly to bones, cartilages, or
connective tissue coverings
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Skeletal Muscle Attachments
 Sites of muscle attachment
 Bones
 Cartilages
 Connective tissue coverings
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Smooth Muscle Characteristics
 Lacks striations
 Spindle-shaped cells
 Single nucleus
 Involuntary—no conscious control
 Found mainly in the walls of hollow visceral organs
(such as stomach, urinary bladder, respiratory
passages)
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Figure 6.2a Arrangement of smooth and cardiac muscle cells.
Mucosa
Submucosa
(a)
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Circular layer
of smooth muscle
(longitudinal
view of cells)
Longitudinal
layer of
smooth muscle
(cross-sectional
view of cells)
Cardiac Muscle Characteristics
 Striations
 Usually has a single nucleus
 Branching cells
 Joined to another muscle cell at an intercalated disc
 Involuntary
 Found only in the walls of the heart
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Figure 6.2b Arrangement of smooth and cardiac muscle cells.
Cardiac
muscle
bundles
(b)
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Skeletal Muscle Functions
 Produce movement
 Maintain posture
 Stabilize joints
 Generate heat
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Microscopic Anatomy of Skeletal Muscle
 Sarcolemma—specialized plasma membrane
 Myofibrils—long organelles inside muscle cell
 Light (I) bands and dark (A) bands give the muscle
its striped appearance
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Figure 6.3a Anatomy of a skeletal muscle fiber (cell).
Sarcolemma
Myofibril
Light
Dark
Nucleus
(A) band (I) band
(a) Segment of a muscle fiber (cell)
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Microscopic Anatomy of Skeletal Muscle
 Banding pattern
 I band  light band
 Contains only thin filaments
 Z disc is a midline interruption
 A band  dark band
 Contains the entire length of the thick filaments
 H zone is a lighter central area
 M line is in center of H zone
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Figure 6.3b Anatomy of a skeletal muscle fiber (cell).
Z disc
H zone Z disc
Thin (actin)
myofilament
Thick (myosin)
myofilament
I band
A band I band
Sarcomere
M line
(b) Myofibril or fibril (complex organelle composed of bundles
of myofilaments)
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Microscopic Anatomy of Skeletal Muscle
 Sarcomere—contractile unit of a muscle fiber
 Organization of the sarcomere
 Myofilaments produce banding (striped) pattern
 Thick filaments  myosin filaments
 Thin filaments  actin filaments
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Microscopic Anatomy of Skeletal Muscle
 Thick filaments  myosin filaments
 Composed of the protein myosin
 Contain ATPase enzymes
 Possess myosin heads
 Heads are known as cross bridges when they link
thick and thin filaments during contraction
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Microscopic Anatomy of Skeletal Muscle
 Thin filaments  actin filaments
 Composed of the contractile protein actin
 Actin is anchored to the Z disc
 At rest, within the A band there is a zone that lacks
actin filaments
 Called the H zone
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Figure 6.3c Anatomy of a skeletal muscle fiber (cell).
Sarcomere
Z disc
Thin (actin)
myofilament
Thick (myosin)
myofilament
(c) Sarcomere (segment of a myofibril)
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M line
Z disc
Microscopic Anatomy of Skeletal Muscle
 Sarcoplasmic reticulum (SR)
 Specialized smooth endoplasmic reticulum
 Stores and releases calcium
 Surrounds the myofibril
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Stimulation and Contraction of Single Skeletal
Muscle Cells
 Irritability (also called responsiveness)—ability to
receive and respond to a stimulus
 Contractility—ability to shorten when an adequate
stimulus is received
 Extensibility—ability of muscle cells to be stretched
 Elasticity—ability to recoil and resume resting length
after stretching
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The Nerve Stimulus and Action Potential
 Skeletal muscles must be stimulated by a motor
neuron (nerve cell) to contract
 Motor unit—one motor neuron and all the skeletal
muscle cells stimulated by that neuron
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Figure 6.4a Motor units.
Axon terminals at
neuromuscular junctions
Spinal cord
Motor Motor
unit
unit
1
2
Nerve
Axon of
Motor neuron motor
cell bodies
neuron
Muscle
(a)
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Muscle
fibers
Figure 6.4b Motor units.
Axon terminals at
neuromuscular junctions
Branching
axon to
motor unit (b)
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Muscle
fibers
The Nerve Stimulus and Action Potential
 Neuromuscular junction
 Association site of axon terminal of the motor neuron
and sarcolemma of a muscle
 Neurotransmitter
 Chemical released by nerve upon arrival of nerve
impulse in the axon terminal
 Acetylcholine (ACh) is the neurotransmitter that
stimulates skeletal muscle
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The Nerve Stimulus and Action Potential
 Synaptic cleft
 Gap between nerve and muscle
 Nerve and muscle do not make contact
 Filled with interstitial fluid
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Transmission of Nerve Impulse to Muscle
 When a nerve impulse reaches the axon terminal of
the motor neuron,
1. Calcium channels open, and calcium ions enter the
axon terminal
2. Calcium ion entry causes some synaptic vesicles
to release acetylcholine (ACh)
3. ACh diffuses across the synaptic cleft and attaches
to receptors on the sarcolemma of the muscle cell
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Transmission of Nerve Impulse to Muscle
4. If enough ACh is released, the sarcolemma
becomes temporarily more permeable to sodium
(Na)
 Sodium rushes into the cell, and potassium leaves the
cell
5. Depolarization opens more sodium channels that
allow sodium ions to enter the cell
 Once started, the action potential cannot be stopped,
and contraction occurs
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Transmission of Nerve Impulse to Muscle
6. Acetylcholinesterase (AChE) breaks down
acetylcholine into acetic acid and choline
 AChE ends muscle contraction
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Transmission of Nerve Impulse to Muscle
 Cell returns to its resting state when:
1. Potassium ions diffuse out of the cell
2. Sodium-potassium pump moves sodium and
potassium ions back to their original positions
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Figure 6.5 Events at the neuromuscular junction.
Slide 5
1 Action potential reaches
axon terminal of motor neuron.
Synaptic vesicle containing ACh
Axon terminal of motor neuron
Mitochondrion
2 Calcium (Ca2+) channels open, and
Ca2+ enters the axon terminal.
3 Ca2+ entry causes some synaptic
vesicles to release their contents
(acetylcholine, a neurotransmitter)
by exocytosis.
4 Acetylcholine diffuses across the
synaptic cleft and binds to
receptors in the sarcolemma.
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Ca2+
ACh
receptor
Ca2+
Synaptic
cleft
ACh
Sarcolemma
Fusing synaptic
vesicle
Sarcoplasm
of muscle fiber
Folds of
sarcolemma
Figure 6.5 Events at the neuromuscular junction.
5 ACh binds and channels open that
allow simultaneous passage of Na+ into
the muscle fiber and K+ out of the
muscle fiber. More Na+ ions enter than
K+ ions leave, producing a local change
in the electrical conditions of the
membrane (depolarization). This
eventually leads to an action potential.
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Slide 6
Na+ K+
Ion channel in
sarcolemma opens;
ions pass.
Figure 6.5 Events at the neuromuscular junction.
Slide 7
ACh
6 The enzyme acetylcholinesterase
breaks down ACh in the synaptic cleft,
ending the process.
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Degraded ACh
Na+
AcetylcholineK+
sterase
Ion channel closed;
ions cannot pass.
Figure 6.8b Schematic representation of contraction mechanism: The sliding filament theory.
Myosin-binding site
(b)
Ca2+
Upper part of thick filament
only
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The flood of calcium acts as the final
trigger for contraction, because as calcium
binds to the regulatory proteins on the
actin filaments, the proteins undergo a
change in both their shape and their
position on the thin filaments. This action
exposes myosin-binding sites on the actin,
to which the myosin heads can attach (see
b), and the myosin heads immediately
begin seeking out binding sites.
Figure 6.8c Schematic representation of contraction mechanism: The sliding filament theory.
(c)
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The free myosin heads are “cocked,” much
like a set mousetrap. Myosin attachment to
actin “springs the trap,” causing the
myosin heads to snap (pivot) toward the
center of the sarcomere. When this
happens, the thin filaments are slightly
pulled toward the center of the sarcomere
(see c). ATP provides the energy needed to
release and recock each myosin head so
that it is ready to attach to a binding site
farther along the thin filament. When the
AP ends and calcium ions are returned to
SR storage areas, the regulatory proteins
resume their original shape and position,
and again block myosin binding to the thin
filaments. As a result, the muscle cell
relaxes and settles back to its original
length.
Contraction of Skeletal Muscle
 Muscle fiber contraction is “all or none”
 Within a skeletal muscle, not all fibers may be
stimulated during the same interval
 Different combinations of muscle fiber contractions
may give differing responses
 Graded responses—different degrees of skeletal
muscle shortening
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Contraction of Skeletal Muscle
 Graded responses can be produced by changing:
 The frequency of muscle stimulation
 The number of muscle cells being stimulated at one
time
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Types of Graded Responses
 Twitch
 Single, brief contraction
 Not a normal muscle function
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Tension (g)
Figure 6.9a A whole muscle’s response to different rates of stimulation.
(Stimuli)
(a) Twitch
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Types of Graded Responses
 Summing of contractions
 One contraction is immediately followed by another
 Because stimulations are more frequent, the muscle
does not completely return to a resting state
 The effects are “summed” (added)
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Tension (g)
Figure 6.9b A whole muscle’s response to different rates of stimulation.
(Stimuli)
(b) Summing of
contractions
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Types of Graded Responses
 Unfused (incomplete) tetanus
 Some relaxation occurs between contractions, but
nerve stimuli arrive at an even faster rate than during
summing of contractions
 Unless the muscle contraction is smooth and
sustained, it is said to be in unfused tetanus
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Tension (g)
Figure 6.9c A whole muscle’s response to different rates of stimulation.
(Stimuli)
(c) Unfused
(incomplete)
tetanus
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Types of Graded Responses
 Fused (complete) tetanus
 No evidence of relaxation before the following
contractions
 Frequency of stimulations does not allow for
relaxation between contractions
 The result is a smooth and sustained muscle
contraction
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Tension (g)
Figure 6.9d A whole muscle’s response to different rates of stimulation.
(Stimuli)
(d) Fused
(complete)
tetanus
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Muscle Response to Strong Stimuli
 Muscle force depends upon the number of fibers
stimulated
 Contraction of more fibers results in greater muscle
tension
 Muscles can continue to contract unless they run
out of energy
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Energy for Muscle Contraction
 ATP
 Immediate source of energy for muscle contraction
 Stored in muscle fibers in small amounts that are
quickly used up
 After this initial time, other pathways must be utilized
to produce ATP
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Energy for Muscle Contraction
 Three ways to generate ATP
1. Direct phosphorylation of ADP by creatine
phosphate
2. Aerobic respiration
3. Anaerobic glycolysis and lactic acid formation
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Energy for Muscle Contraction
 Direct phosphorylation of ADP by creatine
phosphate (CP)—fastest
 Muscle cells store CP, a high-energy molecule
 After ATP is depleted, ADP remains
 CP transfers a phosphate group to ADP to
regenerate ATP
 CP supplies are exhausted in less than 15 seconds
 About 1 ATP is created per CP molecule
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Figure 6.10a Methods of regenerating ATP during muscle activity.
(a) Direct phosphorylation
Coupled reaction of creatine
phosphate (CP) and ADP
Energy source: CP
CP
Creatine
ADP
ATP
Oxygen use: None
Products: 1 ATP per CP,
creatine
Duration of energy provision:
15 seconds
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Energy for Muscle Contraction
 Aerobic respiration
 Glucose is broken down to carbon dioxide and water,
releasing energy (about 32 ATP)
 A series of metabolic pathways occurs in the
mitochondria
 This is a slower reaction that requires continuous
oxygen
 Carbon dioxide and water are produced
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Figure 6.10c Methods of regenerating ATP during muscle activity.
(c) Aerobic pathway
Aerobic cellular respiration
Energy source: glucose; pyruvic
acid; free fatty acids from adipose
tissue; amino acids from protein
catabolism
Glucose (from
glycogen breakdown or
delivered from blood)
O2
Pyruvic acid
Fatty
acids
Amino
acids
Aerobic respiration
in mitochondria
O2
32 ATP
CO2
H2O
net gain
per
glucose
Oxygen use: Required
Products: 32 ATP per glucose,
CO2, H2O
Duration of energy provision:
Hours
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Energy for Muscle Contraction
 Anaerobic glycolysis and lactic acid formation
 Reaction that breaks down glucose without oxygen
 Glucose is broken down to pyruvic acid to produce
about 2 ATP
 Pyruvic acid is converted to lactic acid
 This reaction is not as efficient, but is fast
 Huge amounts of glucose are needed
 Lactic acid produces muscle fatigue
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Figure 6.10b Methods of regenerating ATP during muscle activity.
(b) Anaerobic pathway
Glycolysis and lactic acid
formation
Energy source: glucose
Glucose (from
glycogen breakdown or
delivered from blood)
Glycolysis
in cytosol
O2
2 ATP
net gain
Released
to blood
Pyruvic acid
O2
Lactic acid
Oxygen use: None
Products: 2 ATP per glucose,
lactic acid
Duration of energy provision:
40 seconds, or slightly more
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Muscle Fatigue and Oxygen Deficit
 If muscle activity is strenuous and prolonged,
muscle fatigue occurs because:
 Ionic imbalances occur
 Lactic acid accumulates in the muscle
 Energy (ATP) supply decreases
 After exercise, the oxygen deficit is repaid by rapid,
deep breathing
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Types of Muscle Contractions
 Isotonic contractions
 Myofilaments are able to slide past each other during
contractions
 The muscle shortens, and movement occurs
 Example: bending the knee; rotating the arm
 Isometric contractions
 Tension in the muscles increases
 The muscle is unable to shorten or produce
movement
 Example: pushing against a wall with bent elbows
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Muscle Tone
 Muscle tone keeps muscles healthy and ready to
react
 Result of a staggered series of nerve impulses
delivered to different cells within the muscle
 If the nerve supply is destroyed, the muscle loses
tone, becomes paralyzed, and atrophies
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Effect of Exercise on Muscles
 Exercise increases muscle size, strength, and
endurance
 Aerobic (endurance) exercise (biking, jogging)
results in stronger, more flexible muscles with
greater resistance to fatigue
 Makes body metabolism more efficient
 Improves digestion, coordination
 Resistance (isometric) exercise (weight lifting)
increases muscle size and strength
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Figure 6.11 The effects of aerobic training versus strength training.
(a)
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(b)
Table 6.2 The Five Golden Rules of Skeletal Muscle Activity.
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