Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Muscle Physiology
Document related concepts
no text concepts found
Transcript
Muscle Physiology Summer Prematriculation Program Summer 2004 Rahul Dave’ [email protected] (312) 996-7610 Rm 206 CMW Muscles act in many organ systems Muscles need a signal to contract Muscle Anatomy Motor Unit Main Nerve Nerve branch Muscle Skeletal Muscle Smooth Muscle Cardiac Muscle 1 Cardiac Muscle 2 Intercalated Disc 3 Fiber Types Fast White Fast Red Fuel Glyc Oxid ATP High High Fatigues? Hard Medium Slow Red Oxid Low Easy Fast White Fast Red Slow Red Motor Unit Recruitment Use Size Order Large Third Power Lift Medium Second Jogging Small First Postural mm Sarcomere Structure Z-disc M-line H-zone A-band Sliding Filament Theory Other Muscle Proteins Brown Tropomyosin Yellow Troponins Blue Actin Black Myosin Head Bind Site Pink Myosin Smooth Muscle Structure Muscle Structure • Describe the hierarchy of organization in muscle • Distinguish smooth, skeletal and cardiac muscle based on histology • Understand and rationalize the differences between fiber types • Know the skeletal muscle sarcomere structure cold. NerveMuscle Interface Excitation-Contraction Coupling Cross Bridge Cycle Smooth Muscle Nerve-Muscle Interface E-C Coupling (Smooth) Neurotransmitter G IP3 PIP2 Ca2+ SR Crossbridge Cycle (Smooth) Muscle Contraction • Know each step in transmission across the neuromuscular junction • Know each step in E-C Coupling for striated muscle • Know each step in the cross-bridge cycle for striated muscle • Know the differences between smooth and striated (skeletal + cardiac) muscle Preload and Afterload Preload The force (load) a muscle exerts prior to contraction. Pre-contraction Afterload Force muscle exerts during contraction. After [the start of] contraction Demonstration Frank-Starling Law Force-Velocity Curve Exercise Physiology These are all adaptations • Learning new motor patterns • Strength exercises: muscle hypertrophy • Endurance exercises: changes in muscle metabolism Muscle Diseases Metabolism • Lactic Acidosis • Glycogen Storage Diseases Muscle Function • Dilated Cardiomyopathy • Muscular Dystrophy • Malignant Hyperthermia Neurologic • Hirschsprung’s disease • Myesthenia Gravis • Multiple Sclerosis • Parkinson’s Disease • Polio
Related documents