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Soft Tissue Rheumatism Prof. Dr. Şansın Tüzün  " Soft tissue Rheumatism" refers to aches or pains which arise from structures surrounding the joint such as tendons, muscles, bursae and ligaments.  This may be localized when pain is felt in one region or generalized when pain is felt either all over or in many parts of the body. FIBROMYALGIA  Chronic musculoskeletal syndrome characterized by diffuse pain and tender points  No evidence that synovitis or myositis are causes  Occurs in the context of unrevealing physical examination, labaratory and radiologic examination  % 80-90 of patients are women, peak age is 30-50 years Clinical Features  Generalized chronic musculoskeletal pain  Diffuse tenderness at discrete anatomic locations termed tender points  Other features, diagnostic utility but not essential for classification of fibromyalgia are; fatique, sleep disturbances, headaches, irritable bowel syndrome, paresthesias, Raynaud’s-like syndromes, depression and anxiety Classification Criteria  For classification criteria, patients must have pain for at least 3 months involving the upper and lower body, right and left sides, as well as axial skeleton, and pain at least 11 of 18 tender points on digital examination Central Sensitization Syndromes MPS Irritable Bowel Syndrome Restless Leg Syndrome Fibromyalgia Chronic Fatigue Syndrome Gulf War Syndrome Tension-type Headache Migraine Primary dysmenorrhea OTHERS Central Sensitization An exaggerated response of the central nervous system to a peripheral stimulus that is normally painful (hyperalgesia) or non-nociceptive, such as touch (allodynia) Central Sensitization Hyperexcitability Hypersensitivity Prolonged or Persistence Pain The ability of CNS to undergo these changes is called “NEUROPLASTICITY” CNS function is not fixed but is capable of alterations depending on various peripheral and/or environmental factors “Common”s among CSSs  Gender (Female)  Family history  Chronic pain/fatigue  Abnormal neuroendocrine functions  Absence of pathological findings FMS and MPS  Myofascial pain syndromes....... (20 - 30%)  Fibromyalgia.............................. (3 - 5%) Are they part of a continuum? TrP PATHOGENESIS Trauma Stress MUSCLE SPASM (Taut Band) Endocrine Disorders ? Pain Central Sensitization Pain TRIGGER POINT Muscle Spasm Sympathetic Activation MPS & FMS Trigger points Tender points PAIN GENERATOR The most important criteria for differential diagnosis The presence of tender points (TeP) and widespread muscle pain in FMS compared with Regional and characteristic referred pain patterns with discrete muscular trigger points (TrP) and taut bands of skeletal muscle in MPS Myofascial Trigger Point Diagnosis Palpable Taut Band Local Twitch Response Jump Sign Referred pain Fibromyalgia Pain in 11 of 18 tender point sites on digital palpation “tender does not mean painful” Fibromyalgia Tender Points CHRONIC FATIGUE SYNDROME  CFS has recently emerged as a popular diagnostic label for a centuries-old disorders of fatigue and multiple somatic complaints.  “ Yuppie flue “  It shares many features with fibromyalgia including the lack of objective physical or laboratory abnormalities. Syndrome Relationship with Fibromyalgia Depression Irritable bowel Migraine Chronic fatiqe Syndrome Myofascial pain 25-60 % of FM cases 50-80 % of FM cases 50 % of FM cases 70 % of CFS cases meet FM May be localized form of FM Classify as CFS if;   Fatique persists or relapse for > 6 months History, physical examination and appropriate laboratory tests exclude any other cause for the chronic fatique Additionally;  Impaired memory of concentration, sore throat, tender cervical or axillary lymph nodes,muscle pain, multijoint pain, new headaches and unrefreshing sleep Treatment  Tricyclic antidepresants ( i.e. amitriptyline, desipramine 1-3h before bedtime)  Cardiovasculer fitness training  Biofeedback  Hypnotherapy  Cognitive behavioral therapy  Educating patient MYOFASCIAL PAIN SYNDROMES  Presence of trigger points, which include a localized area of deep muscle tenderness, located in a taut band in the muscle, and a characteristic reference zone of the perceived pain that is aggravated by the palpation of the trigger point Comparison of FM and MFS Variable Fibromyalgia Myofascial pain Examination Tender points Trigger points Location Generalized Regional Response to local therapy Not sustained Curative Sex Females vs Males 9:1 Systemic features characteristic F vs M 3:1 ? Treatment  Physical therapy  "Stretch and spray" technique: This treatment involves spraying the muscle and trigger point with a coolant and then slowly stretching the muscle.  Massage therapy  Trigger point injection Entrapment Neuropathies     Results from incresed pressure on a nerve as it passes through an enclosed space Knowledge of anatomy is essential for understanding of the clinical manifestations of these syndromes Splinting, NSAIDs and local corticosteroid injections usually suffice when symptoms are mild and of short time. Surgical procedures to decompress the nerve are indicated in more severe cases Thoracic Outlet Syndrome  Results from compression of one or more of the neurovasculer elements that pass through the superior thoracic aperture  Anatomic abnormalities and trauma to the shoulder girdle region play a far more pivotal role Potential narrowing areas  Between the scalenius anterior and scalenius medius  Costoclavicular space  Under the pectoralis minor tendon Signs and Symptoms   Paresthesias Pain, radiating to the neck, shoulder and arm  Motor weakness  Atrophy of thenar, hypotenar and intrinsic muscles of the hand  Vasomotor disturbances Diagnosis  Neurologic examination  Certain clinical stress tests (Adson and hyperabduction maneuvers)  A radiograph of cervicothoracic region (cervical rib, elongated transverse process of C7) Treatment  Exercise designed to improve posture by strengthening muscles  Avoidance of hyperabduction  Surgical intervention if; muscle wasting, paresthesias replaced by continous sensory loss, incapacitating pain,worsening of circulatory impairment Cubital Tunnel Syndrome  Compression neuropathy of the ulnar nerve as it transverses the elbow  Causes are; history of a trauma, chronic pressure by occupational stress or from unusual elbow positioning  Arthritic conditions that results in synovitis and osteophyte production Signs and symptoms  Paresthesias in the distribution of the ulnar nerve  Aggrevated by prolonged use of the elbow in flexed position  (+) Tinel’s sign  Atrophy of intrinsic muscles and weakness in grasp  Wasting of the hypothenar muscles and slight clawing of the 4th and 5th fingers  Weakness in adduction of the 5th finger Cubital Tunnel Syndrome Diagnosis  Physical examination (Tinel’s sign, Wartenberg’s sign i.e.)  Radiographs  Electrodiagnosis Treatment  Avoidance of prolonged elbow flexion  Local steroid injection along the ulnar groove  Surgical procedures to decompress the nerve Ulnar Tunnel Syndrome  Entrapment of the ulnar nerve in Guyon’s canal at the wrist (os hamatum-os pisiform)  Compression is due to ganglia  Causes are; RA, OA  Chronic trauma due to occupations Signs and Symptoms  Combined sensory and motor deficits  Hypoesthesia in the hypothenar region and 4th and 5th fingers  Weakness of the intrinsic muscles of the hand Diagnosis   Pyhsical examination Electrodiagnosis is helpful in determining the site of the entrapmant Treatment  Avoidance of trauma  Physical therapy  Surgical decompression Carpal Tunnel Syndrome  Most common entrapment neuroropathy  Compression of the median nerve at the wrist  Causes are; occupation, crystal-induced rheumatic disorders  Complication of connective tissue disorders  Uremia, metabolic and endocrine diseases, infections, pregnancy Signs and Semptoms  Sensory loss in the radial three finger and one-half of the ring finger  Burning, pins-and-needles sensations, numbness in the fingers  Pain may radiate to the antecubital region or to the lateral shoulder area  Awaken at night by abnormal sensation  (+)Tinel’s sign  (+) Phalen’s sign  Thenar atrophy Diagnosis  History and physical examination  Radiographs  Electrodiagnosis Treatment  Splints  Local corticosteroid injection  NSAIDs  Physical therapy  Surgery ; patients with progressive increases in distal motor latency times Tarsal tunnel syndrome  Entrapment neuropathy of the posterior tibial nerve as it passes through the tarsal tunnel beneath the flexor retinaculum on the medial side of the ankle Tarsal tunnel syndrome …Etiology  Fracture or dislocation involving the talus calcaneus,or medial malleolus  Rheumatoid arthritis  Tumors  Pronation related to the loss of the plantar arch Tarsal tunnel syndrome….Presentation  Burning or aching foot pain usually around the plantar surface, distal foot, toes  May radiate up to the calf  Worse at night, when standing  Feels better when barefoot Tarsal tunnel syndrome….diagnosis  Tinel test Nerve is tapped with a finger or reflex hammer at the flexor retinaculum posterior and inferior to the medial malleolus Tarsal tunnel syndrome… Management  Conservative       NSAIDs Arch support Orthoses to correct pronation Proper shoes (1 inch heel and cushioned sole) Avoid flat slippers If symptoms persistent   Local injections Decompression surgery