Download Health @Warwick

Health @Warwick
11 March 2009
Professor John Davey
Warwick Medical School
Director of Clinical Sciences Research Institute
Associate Dean (Biomedical Research)
Clinical Sciences Research Institute
Centre for research into strategic areas of human health.
Major research themes:
•Metabolic Health (cardiovascular, obesity and diabetes).
•Reproduction (obstetrics, stem cell biology, genetics).
•Endocrinology (signalling, pathogenesis).
•Neurosciences (neurobiology, mental health).
•Infection (infectious agents, antibiotics, pathology).
•Musculoskeletal (trauma and orthopaedics).
CSRI Staff, Funding and Locations
Staff :
•35 full-time academics.
•20 research fellows and 15 postdoctoral fellows.
•45 postgraduate students.
Current funding:
•More than 60 externally funded projects.
•Total value exceeding £8.7 million.
Locations:
•Clinical Sciences Building (UHCW).
•Gibbet Hill Laboratories (University).
Research Approaches and Facilities
Full range of research approaches:
• Molecular and Cellular Biology.
• Animal Models.
• Patient-orientated Physiology.
Extensive range of research facilities:
• Purpose-built Laboratories (including cell culture).
• Imaging (electron, fluorescent, luminescent).
• Genomics and Transcriptomics.
• Structural Analysis (NMR, MS, X-ray crystallography).
• Containment Laboratories.
Biomedical Research at Warwick
Warwick Medical School
• Clinical Sciences Research Institute
• Health Sciences Research Institute (Clinical Trials Unit)
Biological Sciences
Systems Biology
Warwick Manufacturing Group
Chemistry
Digital Laboratory
External Partners
Funding Partners
NHS Trusts
• Acute Trusts (UHCW, HEFT)
• Mental Health Trusts
• Primary Care Trusts
• Ambulance Trust (West Midlands)
Strategic Health Authority
CLRN, West Midlands (South)
Royal Colleges
Funding Partners
Strategic Partnership (2007)
Strategic Chair Appointment
Doctoral Training Centre
Imaging – localisation analysis
Co-localisation in Pseudoislets
• Green = β-catenin
• Red = insulin (in vesicles)
• Yellow = co-localisation (at the adherens junctions)
Imaging – real-time analysis
Spontaneous Signalling in Human Myometrium
Centre for Cell Imaging
We require greater capacity and higher specification:
• Long-term, time-lapse, automated
• Multiparameter, fluorescent and luminescent
• Environmental control
Develop collaborations:
• Academics
• Instrumentation Companies (technological advances)
• Pharmaceutical Industry (projects and compounds)
Science City – Translational Medicine
Major initiative in translational medicine:
• Funded by Advantage West Midlands.
• WMS, Biological Sciences and Systems Biology.
• Collaboration with University of Birmingham.
• Expedite transfer of research to clinical practice.
• Benefit health, wealth and business in the region.
• Stimulate innovation, creativity and knowledge generation.
• Total funding of £19.7 million.
• Provides infrastructure and equipment (omics).
• Clinical Trials Building.
• Translational Medicine Laboratories.
Future Strategy
To recruit and develop international research leaders.
To establish World-class research facilities:
• Cell imaging.
• Whole animal imaging.
• Animal models (including transgenic animals).
• Pathology, infection and immunity.
• Mammalian development.
• Regenerative medicine.