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Transcript
Aeromonas hydrophila Jennifer Palmer Carolinas College of Health Science School of Clinical Laboratory Sciences July 12, 2010 Objectives After completion of the presentation, the participant will: Identify the causative agent, Aeromonas hydrophila by biochemical reactions, growth requirements and colony morphology. Describe the symptoms associated with an Aeromonas hydrophila infection. Understand the route of transmission and the populations affected. Interpret how this infection is diagnosed. Evaluate the prognosis of the infection. Explain the risk factors and prevention of the infection. Etiologic Agent Aeromonas hydrophila Facultative anaerobe Gram negative rod Motile with polar flagella Beta hemolytic on BAP Tolerates temperatures from 4-42oC Humans and fish are known hosts Resistant to chlorine http://www.buddycom.com/bacteria/gnr/gnrgluox.html http://www.microbiologyatlas.kvl.dk/biologi/showmorf.asp?articleid=4 Route of Transmission Waterborne- distributed in freshwater and marine environments all over the world. * Reaches a peak in the Summer months when the water temperatures are warmer. * May be transmitted from eating infected seafood, meat, or even sprouts. Transmitted when a person enters contaminated water with an open wound. Also, drinking the contaminated water. http://www.blog.thesietch.org/2009/03/23/ibm-rolls-out-more-energy-efficient-water-purification/ Symptoms May range from wound infections to septicemia to gastroenteritis. * Wound infections caused by Aeromonas hydrophila can be classified into 2 categories: cellulitis and myonecrosis. http://www.rd.com/clean-jokes-and-laughs/silly-docotor-cartoons/article116871-5.html Cellulitis and Myonecrosis http://web.mst.edu/~microbio/BIO221_2007/A_hydrophiila_2.htm Gastroenteritis There may be two forms: a disease similar to traveler’s diarrhea, and dysenteric gastroenteritis. The dysenteric diarrhea will have blood and mucus, and may last for days to weeks. http://helpfulhealthtips.com/Images/D/diarrhea1.jpg Diagnosis Can be diagnosed by a combination of the Gram stain, and a myriad of biochemical reactions. Also, the patient’s history and presenting symptoms will help the doctor in diagnosis. http://www.stopdizziness.com/patients_billing.asp Biochemical Reactions KIA/TSI=K/Ag, Oxidase POSITIVE! H2S positive ONPG positive Indole positive Nitrate positive Gel Positive DNase positive BE positive Ornithine positive http://bodylogicmd.files.wordpress.com/2009/11/1074test_tubes1.jpg Prognosis If immunocompetent, the mild gastroenteritis is usually self-clearing. In immunocompromised people who have the dysenteric diarrhea may need a course of antibiotics, and fluids. In the wound infections, antibiotics may need to be administered and the wound needs to be kept very clean. Risk Factors This is an opportunistic pathogen so the population affected is the immunocompromised. Most people who are affected by Aeromonas have cirrhosis, or other predisposing disease.* Occurs all over the world, mainly in coastal cities, and all ages can be affected. http://www.hawaiimagazine.com/images/content/two_Hawaii_Dr_Beach_top_ten/Hamoa%20Beach.jpg Treatment The drugs of choice are 2nd and 3rd generation Cephalosporins, and Aminoglycosides.* Has resistance to Penicillin, Ampicillin, Carbenicillin, and Ticarcillin. * http://online.pillslib.com/cefdinir/cefdinir-medicine Prevention Take proper care of wounds, washing with sterile water, not river water. May be killed using 1% sodium hypochlorite and two percent calcium hypochlorite solution. http://apptemp.houstonisd.org/procurement//WarehouseCatalog1/PictureCatalog.aspx References Book sources: Mahon, Connie, Donald Lehman, and George Manuselis. Textbook of Diagnostic Microbiology. St. Louis: Saunders, 2007 Gantz, et al.. Manual of clinical problems in infectious disease. Philadelphia: Lippincott, Williams &Wilkins, 2006. Internet sources: Guntly, Lisa. "Microbe of the week 2007". Missouri S&T biology department. Accessed 06/27/2010 <http://web.mst.edu/~microbio/bio221_2007/a_hydrophiila_2.htm "BBB-Aeromonas hydrophila". USFDA. Accessed 06/27/2010 <http://www.fda.Gov/food/FoodSafety/FoodborneIllness/Foodborn eIllnessFoodbornePathogensNaturalToxins/BadBugBook/ucm070523 .htm>. Journal source*: Chang, et al.. "Recurrent dialysis-associated Aeromonas hydrophila peritonitis: reports of two cases and review of the literature". Peritoneal dialysis international 2005: 496-502. http://outlookportland.wordpress.com/2009/10/