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H1N1 information Dr Sangeeta Joshi Consultant Microbiologist Manipal Hospital Bangalore Govt guidelines • OPD case with symptoms of flu – if testing necessary – refer to RGICD/ NIMHANS/VICTORIA/ Lakeside. • Need not admit if it is not severe. Can be sent home • IP and ICU cases – throat swab to be collected and sent to NIMHANS along with requisition • Tamiflu can be given (tablets to be prescribed by the consultant and issued directly by Dayanand of Pharmacy.) Tablets are to be accounted for. Transmission • Incubation period: 1-7 days • Communicability : From 1 day before to 7 days after the onset of symptoms / or until cure • Best time to collect is when the patient presents. Day 1 has maximum shedding of the virus Diagnosis Specimens . Full personal protective equipment – mask, gown, cap, goggles – to be worn while collecting. Samples to be sent in cold . • • • • • throat swab nasal swab, wash or aspirate Tracheal aspirate / BAL Specimens kept at 4°C in viral transport media until transport The samples should be transported to NIMHANS, within 24 hours. If they cannot be transported then it needs to be stored at -70°C. • • • • • • • Prioritisation of the samples to be done before sending: Category A – Referred from airport Children with rapidly worsening symptoms Pregnancy with symptoms of flu Elderly (>65 years) with symptoms Symptoms with h/o chronic pulmonary disease, COPD, asthma Symptoms in a k/c/o diabetes and HIV Category A • • • • Admission, isolation Routine investigations Treat secondary infection Chemoprophylaxis till results arrive 75 mg OD 10 days Treatment 75 mg BD 5 days • Category B • Children with h/o contact with minimal symptoms • Adults with h/o contact with minimal symptoms • Symptoms in Health care worker • Category C – flu like symptoms but does not fit into A and B criteria Category B • Home quarantine • Restrict movement outdoors • Chemoprophylaxis Category C • No prophylaxis • Stay at home till symptoms subsides • Wait and watch • • • • • • • The tests will be done as per the priority status. Results for category A – 24-36 hours Category B – 3-4 days Category C 4-5 days All samples to be accompanied by H1N1 requisition form Each test costs Rs 10,000/- (done free of cost ) Cost of special swab and transport medium to patient Rs 250/- • Blood test for antibodies not done at NIMHANS • Rapid test sensitivity varies from 10 to 70%. • Specificity is 50-70% • The rapid tests detect influenza A and B How long do viruses survive outside the body? • Some viruses can survive upto 2 to 8 hrs on surfaces. • Frequent handwashing is the solution to prevent infection after touching the surfaces Hand Hygiene • It is the single most important measure to reduce the risk of transmitting infectious organism from one person to other. • Hands should be washed frequently with soap and water / alcohol based hand rubs/ antiseptic hand wash and thoroughly dried preferably using disposable tissue/ paper/ towel. • After contact with respiratory secretions or such contaminated surfaces. • Any activity that involves hand to face contact such as eating/ normal grooming / smoking etc. • HCW’s attending to patients with suspected H1N1 to wear triple layer mask or N95 mask. Can be worn for 4 hours , needs to be changed later. Adequate handwashing facilities and handrub to be provided to the HCW’s Chemoprophylaxis • All close contacts of confirmed cases. Close contacts include household /social contacts, family members, workplace or school contacts, fellow travelers etc. • Oseltamivir is the drug of choice. • Prophylaxis should be provided till 10 days after last exposure (maximum period of 6 weeks) Resources • http://www.cdc.gov/h1n1flu/ • http://www.cdc.gov/h1n1flu/espanol/ • 1-800-CDC-INFO (1-800-232-4636) • http://www.who.int/csr/disease/swineflu/en/ index.html