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Backgrounder on Military Health Surveillance April 1, 2015 Public Health Overview Our Vision: Reshaping a cutting-edge, word-class Public Health capability that is lean, efficient, effective, forward leaning and strategically positioned to fully meet MHS and customer needs. Our Mission: •Support the move from a health care system to a system of health by focusing on the prevention of disease, disability, and death in garrison and while deployed •Create timely, standardized execution guidance, in collaboration with the Services •Increase effectiveness and efficiencies (e.g., manpower and cost savings) through consolidation/re-engineering of functions •Develop a comprehensive portfolio management and DHA Public Health structure to best integrate the evolution of additional product lines 14 December 2011 Pre-decisional FOUO 2 Armed Forces Health Surveillance Center Our Vision: To be the central epidemiological resource and a global health surveillance proponent for the U.S. Armed Forces. Our Mission: Provide timely, relevant, actionable, and comprehensive health surveillance information in order to promote, maintain, and enhance the health of military and military-associated populations • Acquire, analyze/interpret, disseminate information, and recommend evidence-based policy • Develop, refine, and improve standardized surveillance methods • Serve as focal point for sharing health surveillance products, expertise, and information • Coordinate a global program of militarily relevant infectious disease surveillance 14 December 2011 Pre-decisional FOUO 3 AFHSC Overview: Key Capabilities and Products • Data Management and Technical Support – Design, operation and management of the Defense Medical Surveillance System (DMSS) – Operation of the DoD Serum Repository • Epidemiology and Analysis – Utilizes the DMSS – Periodic reporting of DoD health statistics and surveillance – Customized analysis and reports for military leadership • GEIS – Management of DoD global infectious disease and surveillance portfolio – Coordination among overseas laboratories and other partners in the global surveillance network – Response to outbreak alerts and emergency notifications • Integrated Biosurveillance – Serves a key role in biosurveillance; augment operational health surveillance information – Focuses on detecting disease in people, plants, and animals, to understand the threats from emerging infectious diseases and other hazards relevant to U.S. DoD, allies, and civilians for offensive, defensive, and stability operations – Single Source for Biosurveillance data activities –integration of DoD “one health” data Health Surveillance Responsibilities All Hazards! 5 Physical Injuries Mental Health Mortality Cold/heat-related injuries Motor vehicle accidents Traumatic brain injury Exertional hyponatremia PTSD Alcohol abuse Depressive disorders Anxiety Combat Training Suicide Natural Infectious Diseases Chronic Diseases Tuberculosis Gastrointestinal infections Malaria All manner of STIs Diabetes Malignancies Arthritis Obesity Epidemiology & Analysis Division The Division performs comprehensive surveillance and analysis of health-related information regarding DoD Service members (AD, reserves, separated), and military-associated populations (government civilians (garrison or deployed), contractors (deployed), family members/retirees (garrison, previous deployment) as pertains to public health/outbreaks. • Single source for DoD-level health surveillance information • Unify surveillance efforts across the Military Health System • Acquire and integrate population, health event, and exposure data from across the Services • Products support and inform active military operations, medical readiness 22 February 2013 CAPT Sharon L.standardize Ludwig • Normalize surveillance data collection, methods, delineate Divisionamong Directorall MHS health surveillance roles and supporting relationships Epidemiology and Analysis Division activities Defense Medical Surveillance System (DMSS) Structure and Functional Relationships All DoD Beneficiaries DMSS: Longitudinal Database Active Duty / Reserve Component Ambulatory Data 319 million records MEPS 13.6 million persons 31 million records Immunizations 111 million records In-Patient Hospitalizations 3.0 million records Personnel Data 10.4 million persons 134.9 million records Health Risk Assessments 575,000 records Chemistry 54.1 million records PostDischarge PreInduction Deployments 5.5 million records Serum Specimens (DoD Serum Repository) 58.4 million specimens All counts current as of December 2014 Reportable Diseases 432,760 records Microbiology 5.5 million records Prescriptions 12.9 million records Pre / Post-Deployment Surveys 12,129,412 surveys Casualty Data 54,202 AD Deaths Periodic Reports • Weekly – Influenza Surveillance Report – USFK Biosurveillance Report – DoD Communicable Disease Report • Monthly – Injury Installation Reports – Malaria Case-Finding Report • Quarterly – DoD Eye Injury Report – DoD Hearing Injury Report – FHP&R Council Metric (includes DD2795, DD2796, DD2900 completion, and MH and TBI referrals and follow-up health encounters) – MHS Dashboard (includes PTSD and depression screen, referrals) • Annually – AFPMB Arthropod-borne Hemorrhagic Fever Report (WNV, Dengue, Leishmaniasis) – Annual Injury, Eye Injury, Hearing Reports 9 Customized Reports • USS REAGAN analysis on adverse health outcomes (Report to Congress) • DoD Japanese Encephalitis cases 10 years: 2004-2013 (MILVAX, USAPHC) • Incidence of erectile dysfunction, 2012-2013 (FHP & R) • Service members receiving dialysis, U.S. Armed Forces, 20112013 (Army OTSG) • Acute hepatitis in active component, 1 Jan 2008-30 Nov 2013 (outbreak investigation related to association between dietary supplement and hepatic injury) Medical Surveillance Monthly Report – – – The MMWR of the military health system Over 150 issues since April 1995 • First full-color issue— August 2011 1,067 subscribers to the print edition • 175 new requests per year • 500 email subscribers – – – – 21% of 2011 articles were outside submissions Archives accessible online Average MSMR issue viewed 1,483 times during its first 60 days online Indexed in MEDLINE since Jan 2011 • Searchable using PubMed Percentage distribution, burden “conditions” that accounted for the most medical encounters among U.S. service members, 2014 12 Defense Medical Epidemiology Database • • • • • • • • • Remote access (via internet) to a subset of data contained within the DMSS No personal identifiers or link to specific individuals allowed Software distributed via Armed Forces Health Surveillance Center Web site http://www.AFHSC.mil Active duty only Monthly updates Rapid query response Inpatient data Outpatient data Reportable Events DoD Serum Repository (DoDSR) •Central archive of US Armed Forces sera collected for medical surveillance purposes •Specimens stored in large walk-in –30 °C freezers, precisely documented locations •Over 57 million serum specimens on >10 million individuals •Specimens linked to demographic, military, & medical information via the DMSS Total Specimens Used in Studies (bars) Aliquots Produced (line), DoDSR, Jan 2002-Dec 2014 Standard Surveillance Case Definition 16 ESSENCE is… Electronic Surveillance System for the Early Notification of Community-based Epidemics • Web-based disease surveillance information system developed to alert Health Authorities of infectious disease outbreaks and provide situational awareness of population health DoD ESSENCE operational scope • Surveys the entire direct care Military Health population, excluding deployed forces • Used at approximately 500 Military Treatment Facilities and 100 regional sites • Receives and analyzes data for nearly 90,000 daily outpatient visits and pharmacy transactions from DoD health care facilities worldwide • Receives approximately 50,000-2 million outpatient files, 200,000-600,000 pharmacy records, and 100,000-300,000 lab and rad orders per day • Updates outpatient data 6 times every 24 hours on average • Updates pharmacy data every 24 hours • Demographics data updated monthly Case Definitions for Syndromic Surveillance • International Classification of Disease – Version 9 – Clinical Modification (ICD9) – Used by US military in the electronic healthcare record – Outpatient codes entered by provider (doctor, nurse, therapist) at the time the patient is seen – Update to ICD-10 ready when US converts in 2015 • Grouped to describe multiple disease presentations and diagnostic variability – Early signs/symptoms of disease often non-specific – Availability of confirmatory testing highly variable • Chief complaints, pharmacy transaction data, laboratory orders and radiology orders help to inform alerts • Besides syndromes, also used for routine Disease & Injury surveillance and notification of potential Reportable Medical Events Comparison of Lab-based Surveillance with Syndromic Surveillance Syndromic surveillance LaboratoryConfirmed From Marsden-Haug N, Foster VB, Gould PL, Elbert E, Wang H, Pavlin JA. Code-based syndromic surveillance for influenzalike illness by International Classification of Diseases, Ninth Revision. Emerg Infect Dis. Feb 2007;13(2):207-216. 20 Statistical Alert Notifications Based on Expected Case Counts 21 Individual-level Data Available for Certified Public Health Officers MTF name removed for privacy Syndromic Surveillance Alert List 23 Time Series 24 Data Details 25 Rep Event Surveillance 26 Lab Results 27 Upcoming Upgrade with ESSENCE “Fusion” • Automatically merge data streams to provide a more specific signal • Use additional data sources that provide an indication of severity • Look over a very short time range vs. a whole (incremental) day • Facilitate in-depth investigation of individual data sources • Reduce the alert burden by corroborating weighted evidence • Current studies indicated reduction of false alerts could be as much as 97% each year Fusion Results • Detection algorithms run on individual data sources can generate a large number of alerts • By combining evidence from multiple data sources, it is possible to reduce alerts and more 29 easily identify outbreaks ICD-9 Counts for ILI 01May09 to 04Jul09 ILI Syndromic Alert 6 July 2009 30 Fusion Elements 31 Fusion Elements 32 Progression of the ILI Event in the Summer of 2009 33 Additional ESSENCE Capabilities Features of Enterprise ESSENCE not currently in DoD ESSENCE myESSENCE Dashboard GIS Maps & Spatial Detection 34 myAlerts Crosstab & Pivots Overview Graphs Event Communication Time of Arrival Detection Multi-Datasource & Denominator Queries Free-text & Advanced Querying Data Quality Reports Statistical Report Builder Report Generation DoD/VA Joint Incentive Fund Section 721 of the FY 2003 NDAA required establishment of JIF to identify, provide incentives to, implement, fund and evaluate creative DoD/VA coordination and sharing initiatives at the facility, regional and national levels. Analysis of combined datasets DoD data dominant VA data dominant 37 DoD alert earlier VA alert earlier Summary • Coverage demonstrates 2 complementary surveillance systems • VA has higher patient volume and better geographic coverage • DoD has younger population, better metropolitan area coverage and more pre-diagnostic ILI coding • Relative timeliness could be improved by combining systems in 92% of regions that have coverage by both Extended-NCR-BSP Prototype Project Extended-NCR ESSENCE AFHSC ESSENCE E-NCR-BSP Data Sharing Access Control E-NCR-BSP – Knowledge Sent to E-NCR-BSP – Federated Query Request – Federated Query Result Architecture: Data flow from the perspective of ESSENCE The role of the E-NCR-BSP ESSENCE Module National Syndromic Surveillance Program Vision A collaboration among local, state, and national public health programs that supports timely exchange of syndromic data and information for nation-wide and regional situational awareness and enhanced response to hazardous events and disease outbreaks. Some Major Dimensions of the NSSP 1. Syndromic Surveillance Platform (SyS-Platform) • Cloud based collaborative workspace where syndromic surveillance tools exist 2. Governance • • Leadership group representing BioSense users Advise CDC on platform enhancements 3. National Syndromic Surveillance Community of Practice (NSSCoP) • Supplement and support a national community focused on the science of syndromic surveillance 4. Future Development • Emerging technology, EHRs, Meaningful Use, etc. DoD Sharing with BioSense 2.0 – Connected Health As of 15 Oct 14 • Number of users: 901 • Number of jurisdictions sharing data with CDC/other jurisdictions: – County-level: 21/33 – State-level: 28/25 – Visit-level: 5/9 • Number of facilities actively contributing: 4,050 Shared Spaces Lab State County City VA/DoD BioSense Environment Hospital Public-Access Current Status of Civilian Syndromic Data 10 September 2013 Pre-decisional FOUO 47 10 September 2013 Pre-decisional FOUO 48 Plan for Data Integration Indicator-based surveillance (e.g. ESSENCE) Share queries and results across apps Raw Structured Data Data Identified risks DoD Reportable events Laboratory surveillance CDC Weekly MMWR trends Reports Capture Filter Collect Analyze Interpret Non-healthcare based Vector surveillance Veterinary surveillance Raw Unstructured Text and/or Aggregate Data Open source Media scanning/social media Health authority websites Published literature DoD/USG partners Emerging risks Syndromic surveillance of chief complaints and ICD codes NCR-BSP civ. syndromic data Pharmacy data Nurse call data TMDS Event-based surveillance (e.g. BSVE/BSP) Evaluate Verify Descriptive epidemiologic analysis Identify signal Coordinate/ Investigate Summary report/visualizations AFHSC/GEIS partners DoD epicom concept DHS-NBIC State public health entities (outbreak/HAN reports) International agencies Public health alert WHO and regional offices Ministries of health Dissemination/Collaboration Diagram is adapted from an ECDC report on epidemic intelligence Summary • DoD extensively uses the military Electronic Health Record and ancillary systems for disease surveillance • Surveillance includes robust retrospective and prospective studies in addition to near real-time monitoring • Multiple efforts to merge with civilian data to include – Efforts with the Veteran’s Administration – Extended surveillance in the National Capital Area with civilian public health – Sharing with the National Syndromic Surveillance Platform • Discussions on merging DoD and CDC platforms 14 December 2011 Pre-decisional FOUO 50