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Coronary Phantom Design for K-edge Angiography John Jorgensen Sarah Pachtman Punam Patel Marcus Spallek Advisor: Dr. Frank Carroll Project Background Monochromatic tunable X-ray: – Reduced radiation dose to patient – Reduced contrast agent concentrations • K-edge imaging Diagram of MX200’s laser paths and major elements FOR MORE INFO... http://www.mxisystems.com/mx200.html Free Electron Laser Laboratory http://www.vanderbilt.edu/fel/ . K-edge Effect Project Goals Design a coronary phantom Test contrast agent concentrations – hypersensitivity reaction to iodine (3-12% patients) – current clinical dilution is 1:16 – using monochromatic plain films it is possible to see 1:256 dilutions Determine optimal angle for stereo imaging Tan θ = 3/30 = 0.10 3” 30” θ θ ~ 6° Solution Description Radio Translucent at 35 keV Flexible material – Fluid perfusion Phantom Size – 7.5cm diameter Vasculature – Size Range 5 - 0.5 mm – Coronary arteries on surface – Curved channels – Hollow vessels Finger imaged at Finger imaged at 19 keV 26 keV Phantom Designs Shelley Medical Imaging Technologies www.simutech.com Preliminary Sketch Material - ReoFlex ™ Rubber Physical Properties • Flexible cured product • 2-component liquid resin system • Room-temperature cure • 20 Shore A durometer www.smooth-on.com Schedule Research Material Testing & Design Manufacturing Testing November December January February March April FOR MORE INFO... http://vubme.vuse.vanderbilt.edu/srdesign/2003/group12/NCIIA %20Grant%20Proposal.htm Current Status On-track • Material Selected • Preliminary Phantom Design Completed – Approved by Advisor • Researched Stereolithography Behind • Dosimetry Research Future Plans February – Complete Model SolidWorks – Prototype by University of Pittsburg – Start Final Report March & April – Test Dosimetry for Imaging – Test for Optimal Stereo Angle Team and Resources Advisor: Dr. Frank Carroll, M.D. Monochromatic x-ray machine W.M. Keck Free-electron Laser (FEL) Center at Vanderbilt University Materials and tools provided by BME Department and FEL Center – Polyurethane resins from outside contractors Photograph of device with laser cover removed http://www.vanderbilt.edu/fel/Xray/manuscripts/final%20report%20for%20ONR%20grant%2020021218.doc Questions? Home