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NIH PCKD/Emory University MRI Imaging Report 1/31/2000 Overview • 2 Patients Scanned with NIH Protocol • Both: Comparison with “Old Protocol” – Visual comparison – No SNR measurements performed • No Breathhold Flow Quantification (Yet) – Philips scanner should be capable – Little experience; Validation experiments? T2-Weighted Multi-Slice (#1) Old Protocol (3 mm) Multiple Breathholds NIH Protocol (5 mm) Single Breathhold T2-Weighted Multi-Slice (#2) Old Protocol (3 mm) Multiple Breathholds NIH Protocol (5 mm) Single Breathhold T2-Weighted Imaging: Remarks • 3 mm slice thickness resolves cysts better • Fat Suppression useful, works well • Multiple-breathhold: registration needed – Kidney “rigid object”: overlap + affine Xform – Avoid misregistration between interlaced stacks • Role in image analysis? T1-Weighted 3-D (PRE-#1) Old Protocol (2.5/5 mm) =40 Single Breathhold NIH Protocol (2.5/5 mm) =12 Single Breathhold T1-Weighted 3-D (PRE-#2) Old Protocol (2.5/5 mm) =40 Single Breathhold NIH Protocol (2.5/5 mm) =12 Single Breathhold T1-Weighted 3-D (POST-#1) Old Protocol (2.5/5 mm) =40 90 s post-Gado NIH Protocol (2.5/5 mm) =12 120 s post-Gado T1-Weighted 3-D (POST-#2) Old Protocol (2.5/5 mm) =40 60 s post-Gado NIH Protocol (2.5/5 mm) =12 120 s post-Gado T1-Weighted 3-D heart liver Ghost artifact due to heart motion (?) Apply pre-saturation slab anterior to volume to reduce intensity? T1-Weighted Imaging: Remarks • NIH protocol (=12) better overall SNR – Pre- & post-contrast: more complex image – Segmentation easier? (CNR measurements) • Coil placement important! Difficult? • Pre-saturation slabs? Added acq. time? • Older patients: – Many breathholds taxing to patient – Only 90 or 120 s post contrast?