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Clinical Governance Acute Care Unit 18/05/2009 Mrs. SB Admitted 02/04/09 • 56, admitted at 07.23 from Nursing Home • Diarrhoea, drowsiness, fever • Dense left hemiplegia and dysarthria following haemorrhagic stroke in 1995 • Function: – – – – – – • • • • Immobile Transfers with hoist Needs help with washing and dressing Feeds herself Communicates – no mention of cognitive problems Long-term urinary catheter ? continent of faeces DVT left leg 2006 Type 2 diabetes and Hypertension Chronic renal impairment and anaemia Recurrent UTIs (Allergic to Penicillin) Diagnosis • Sepsis – likely source: – catheter-associated UTI • IV fluids • IV sliding scale insulin • IV ciprofloxacin and IV gentamicin given (one dose each at 12.45 on 02/04) • Catheter changed Progress • Continued to have profuse, offensive diarrhoea • CSU and stool specimen sent • Remained pyrexial ~ 38 • Antibiotics changed to oral, but not given: “5. = patient nil by mouth” • Obs. at 18.00 on 03/04: HR 113, BP 140/75, urine output 20 ml/hour Cardiac Arrest • • • • 20.20 on 03/04 Became unresponsive mid-conversation EMD, briefly VT then asystole Death confirmed at 20.45 Microbiology • Urine – Pseudomonas and Enterococcus • Stool – Campylobacter • Coroner and Health Protection Agency notified Critique • Delay of > 5 hours in giving first doses of antibiotics • Only 1 dose of antibiotics received by patient • Discussion in notes about changing back to IV – no action taken Mr. MG Admitted 04/04/09 • • • • • 57, admitted at 06.22, from own home Increasingly painful, swollen legs Fluid leaking from skin 2 courses of antibiotics in past 3 months Dressings changed by Practice Nurse once / week • Type 2 diabetes and ischaemic heart disease (MI in 2000) • History of heart failure and AF (now in sinus rhythm) • Obesity Medication • • • • • • • Nifedipine Frusemide Frusemide Digoxin Carvedilol Metformin Rosiglitazone 10 mg 80 mg 40 mg 250 μg 3.125 mg 1g 4 mg tds o.d. lunchtime o.d. o.d. b.d. b.d. On Examination • • • • • • • • • Apyrexial HR 105 BP 117/87 Sat. 97% on air BM 11 GCS 15/15 Heart sounds: NAD Chest: NAD Abdomen: NAD • Legs: – Oedema to knees – Erythematous calves – Areas of broken skin – 2 ulcers on left calf (not deep) – Pedal pulses not palpable Investigations ECG – Sinus rhythm, rate 112, bifascicular block, poor R-wave progression CXR – Cardiomegaly, upper lobe venous distension • • • • • Hb WBC Neut. Plt. MCV • INR 12.1 8.7 6.55 254 84.2 1.6 • • • • • • • Na K Urea Creat. Bil. Alb. CRP 126 5.5 13.9 (6.7) 145 (105) 37 29 8.6 Management • • • • • Analgesia IV Tazocin – first dose given 2 p.m. IV fluids - had total of 1 litre Digoxin stopped, frusemide dose reduced Surgical opinion: – Pulses present on Doppler – ?DVT • Echocardiogram / renal tract ultrasound Cardiac Arrest • • • • 17.00 on 04/04/09 VF then asystole Death confirmed 17.20 Referred to coroner Cause of death 1.a. Left ventricular failure 1.b. Ischaemic heart disease 2. Hypertension, diabetes, congestive cardiac failure Critique • Diuretics were not given • IV fluids were given • Delay in giving first dose of antibiotics (? relevant) • Appropriateness of Tazocin (or any antibiotic) • Not prescribed prophylactic Clexane Mr. RR Admitted 18/04/09 • • • • 59, admitted at 07.05 from home Lives with wife Breathlessness and haemoptysis Known to oncologists at Stoke Mandeville: – Ca bladder diagnosed 18 months ago – Resected and ileal conduit fashioned – Adjuvant chemotherapy – 6 months – 3 weeks ago – cerebellar metastases – Completed 5 # DXT 4 days ago – On dexamethasone 8 mg o.d. • DVT left leg November ’08 – treated with Tinzaparin (stopped 3 weeks ago) On Examination • • • • • • • Apyrexial HR 155 BP 125/88 RR 24 Sat. 92% on 15L BM 25.4 GCS 15/15 • Heart sounds: NAD • Chest: NAD • Abdomen: distended, lower laparotomy scar, iliostomy • ECG – 136, sinus tachycardia Bloods Hb WBC Plt. 13.6 10.1 127 INR 1.1 D-dimer >1000 Na K U Cr. Bil Alb 134 4.9 13.0 156 28 28 CRP 283.8 pH pO2 pCO2 HCO3 BE Sat. 7.237 10.9 2.23 6.9 -19.5 93.7% Treatment • • • • IV fluids (received 3 litres in 12 hours) IV sliding scale insulin CT-PA requested – arranged for that evening Observations at 17.45: – T = 37.8 – HR 137 – BP 105/77 – RR 32 – Sat. 89% on 15L Course • Blood pressure continued to drop, despite fluid resuscitation • Discussed with ITU – not for intubation • Reteplase 10 units IV given – no improvement • Cardiac arrest ~ 18.15 • Death confirmed 18.27 Critique • No antibiotics given despite evident sepsis • Not given Tinzaparin despite suspicion of PE Discussion Common Theme: Should any of these patients have been subjected to a resuscitation attempt?