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45 Beginning of the chapter Gluten intolerance and Genetics (Gluten Sensor) SENSORS GLUTEN SENSOR Celiac disease / Gluten Intolerance SENSORS GLUTEN SENSOR Gluten (Wheat protein) Incorrect programming of the immune system (it fights against gluten) digestive problems lactose intolerance 9x higher ENT tumor risk 80x higher lymphatic tumor risk On average, 11 years until diagnosis 12% of the untreated cases are fatal Gluten-free diet >>>Complete freedom from symptoms >>>Normalization of the other (tumor) risks GLUTEN INTOLERANCE Receptors and infections ALARM!!! The receptor is built and the bacterial proteins are integrated T-cell The receptor presents bacterial proteins Bacteria The bacteria is broken up Bacteria is absorbed DQ-A1 Receptor genes DQ-B1 APC-cell GLUTEN INTOLERANCE Receptors and infections Everything OK! The receptor cannot integrate gluten T-cell Proteins are broken up Wheat protein (gluten) is absorbed DQ-A1 Receptor gene DQ-B1 APC-cell GLUTEN INTOLERANCE Receptors and infections ALARM!!! Gluten is integrated into the receptor T-cell The receptor contains Gluten Proteins are broken up Wheat protein (gluten) is absorbed DQ-A1 Receptor gene DQ-B1 APC-cell GLUTEN INTOLERANCE Receptors and infections What can we find out from the genetic analysis? Negative -> The probability of gluten intolerance = ~0% Positive -> The probability of gluten intolerance = up to 40% Pay attention to symptoms > immediate, correct diagnosis Gluten Free Diet > absolute freedom from symptoms GLUTEN INTOLERANCE Counselling example EARLY DETECTION 1) Pay attention to the symptoms when eating gluten containing products DIETARY ADJUSTMENTS 1) Avoid gluten containing food Nutrition Sensor can help 45 End of the chapter Gluten intolerance and genetics (Gluten Sensor)