Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Diapositiva 1 - The EndoExperience
Document related concepts
Transcript
Pulpal and periapical immune responses to infection Carmen D. Cohn There is no evidence that necrotic pulp tissue per se can elicit periapical inflammation, in the absence of bacteria. Carmen D. Cohn Moller & Fabricius 1981 No apical inflammation 26 bacteria-free 7 months 78 monkey teeth with aseptically necrotized pulps 52 bacteria infected Apical periodontitis Carmen D. Cohn Periapical responses to pulpal infection Carmen D. Cohn Bacterial products IL-1, IL-6 TNFα PGE MF MHC-II Th IL-1 + Ag B IL-2 Periapical inflammation and bone destruction Carmen D. Cohn Periradicular lesions - barrier Microbial Epithelial plugs Complement Antibodies Microorganisms products PMNs Granulomatous tissue Defence elements Very few endodontopathogens can advance through the barrier. Carmen D. Cohn Extraradicular microorganisms Abscessed AP Actinomyces spp, Propionibacterium propionicum Infected radicular cysts Infected material displaced into the periapical tissues Possible factor in the failure of the endodontic therapy. Carmen D. Cohn
