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Robert Ovadia’s 5x5 Engineering Viruses Stanford iGEM 2009 Meeting #4 by Robert Ovadia 2/4/09 The Problem 2 • Cancer • Too many cancers: lung, liver, stomach, skin… the list goes on • Brain Tumors • Over 200,000 people are diagnosed yearly (Central Brain Tumor Reg. of the US 2005) • Current therapy is costly and not effective Stanford iGEM 2009 Meeting #4 by Robert Ovadia 2/4/09 The Solution 3 • Brain Tumors • The brain is isolated from the immune system (Blood brain barrier) • If we engineered a microbe, could it really survive? • Probably not… • Most living organisms (except our cells) couldn’t survive in the brain, and if it did, it would be damaging to us. Stanford iGEM 2009 Meeting #4 by Robert Ovadia 2/4/09 The Solution 4 • Brain Tumors • Engineer a virus • Viruses are an ideal in targeting cells and delivering a gene • EX: Genentech’s Pulmozyme ® • EX: Vesicular Stomach Virus (VSV) by Dr. Van de pol of Yale Stanford iGEM 2009 Meeting #4 by Robert Ovadia 2/4/09 The Solution • Brain Tumor - 5 Projects 1. Target brain tumors 2. Regulation 3. Delivery 4. Marker 5. ______ NOTE: The idea of engineering viruses is open to ALL ideas! We don’t have to do cancer. 5 Stanford iGEM 2009 Meeting #4 by Robert Ovadia 2/4/09
