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Robert Ovadia’s 5x5
Engineering Viruses
Stanford iGEM 2009 Meeting #4 by Robert Ovadia
2/4/09
The Problem
2
•
Cancer
•
Too many cancers: lung, liver, stomach,
skin… the list goes on
•
Brain Tumors
•
Over 200,000 people are diagnosed yearly
(Central Brain Tumor Reg. of the US 2005)
•
Current therapy is costly and not effective
Stanford iGEM 2009 Meeting #4 by Robert Ovadia
2/4/09
The Solution
3
•
Brain Tumors
•
The brain is isolated from the immune
system (Blood brain barrier)
•
If we engineered a microbe, could it really
survive?
•
Probably not…
•
Most living organisms (except our cells)
couldn’t survive in the brain, and if it did, it
would be damaging to us.
Stanford iGEM 2009 Meeting #4 by Robert Ovadia
2/4/09
The Solution
4
•
Brain Tumors
•
Engineer a virus
•
Viruses are an ideal in targeting cells and
delivering a gene
•
EX: Genentech’s Pulmozyme ®
•
EX: Vesicular Stomach Virus (VSV) by Dr.
Van de pol of Yale
Stanford iGEM 2009 Meeting #4 by Robert Ovadia
2/4/09
The Solution
•
Brain Tumor - 5 Projects
1. Target brain tumors
2. Regulation
3. Delivery
4. Marker
5. ______
NOTE: The idea of engineering viruses is open to
ALL ideas! We don’t have to do cancer.
5
Stanford iGEM 2009 Meeting #4 by Robert Ovadia
2/4/09